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Q96DM3

- MIC1_HUMAN

UniProt

Q96DM3 - MIC1_HUMAN

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Protein

Uncharacterized protein C18orf8

Gene

C18orf8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C18orf8
Alternative name(s):
Colon cancer-associated protein Mic1
Short name:
Mic-1
Gene namesi
Name:C18orf8
Synonyms:MIC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:24326. C18orf8.

Subcellular locationi

GO - Cellular componenti

  1. lysosomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134862561.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Uncharacterized protein C18orf8PRO_0000096481Add
BLAST

Proteomic databases

MaxQBiQ96DM3.
PaxDbiQ96DM3.
PRIDEiQ96DM3.

PTM databases

PhosphoSiteiQ96DM3.

Expressioni

Gene expression databases

BgeeiQ96DM3.
CleanExiHS_C18orf8.
ExpressionAtlasiQ96DM3. baseline and differential.
GenevestigatoriQ96DM3.

Organism-specific databases

HPAiHPA043589.

Interactioni

Protein-protein interaction databases

BioGridi118961. 13 interactions.
IntActiQ96DM3. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96DM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini471 – 637167Mic1Add
BLAST

Sequence similaritiesi

Belongs to the Mic1 family.Curated
Contains 1 Mic1 domain.Curated

Phylogenomic databases

eggNOGiNOG244614.
GeneTreeiENSGT00390000009127.
HOGENOMiHOG000006772.
HOVERGENiHBG052473.
InParanoidiQ96DM3.
OMAiITVQHYL.
OrthoDBiEOG7VB2FB.
PhylomeDBiQ96DM3.
TreeFamiTF105850.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR009755. Mic1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07035. Mic1. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96DM3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG
60 70 80 90 100
PDDRNPISFR MDDKGEVKCI KFSLENKILA VQRTSKTVDF CNFIPDNSQL
110 120 130 140 150
EYTQECKTKN ANILGFCWTS STEIVFITDQ GIEFYQVLPE KRSLKLLKSH
160 170 180 190 200
NLNVNWYMYC PESAVILLST TVLENVLQPF HFRAGTMSKL PKFEIELPAA
210 220 230 240 250
PKSTKPSLSE RDIAMATIYG QLYVLFLRHH SRTSNSTGAE VVLYHLPREG
260 270 280 290 300
ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI KLRGEFDGSV
310 320 330 340 350
TFHHPVLPAR SIQPYQIPIT GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS
360 370 380 390 400
ASQGYLWNLQ VKLEPIVNLL PDKGRLMDFL LQRKECKMVI LSVCSQMLSE
410 420 430 440 450
SDRASLPVIA TVFDKLNHEY KKYLDAEQSY AMAVEAGQSR SSPLLKRPVR
460 470 480 490 500
TQAVLDQSDV YTHVLSAFVE KKEMPHKFVI AVLMEYIRSL NQFQIAVQHY
510 520 530 540 550
LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL ESFYPPAHQL
560 570 580 590 600
SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA
610 620 630 640 650
KQTEDNMLFY TIFRFFEQRN QRLRGSPNFT PGEHCEEHVA FFKQIFGDQA

LMRPTTF
Length:657
Mass (Da):74,975
Last modified:May 24, 2004 - v2
Checksum:iDFDC8B304ADCA88C
GO

Sequence cautioni

The sequence AAD33909.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631S → R in BAB71377. (PubMed:14702039)Curated
Sequence conflicti178 – 1781Q → L in AAD33909. 1 PublicationCurated
Sequence conflicti470 – 4701E → DFFLYGVFKHYRQ in AAD33909. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057192 mRNA. Translation: BAB71377.1.
BC002950 mRNA. Translation: AAH02950.2.
BC008305 mRNA. Translation: AAH08305.2.
AF143536 mRNA. Translation: AAD33909.1. Different initiation.
CCDSiCCDS32803.1.
RefSeqiNP_037458.3. NM_013326.4.
UniGeneiHs.464779.

Genome annotation databases

EnsembliENST00000269221; ENSP00000269221; ENSG00000141452.
GeneIDi29919.
KEGGihsa:29919.
UCSCiuc010xaw.2. human.

Polymorphism databases

DMDMi47605918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057192 mRNA. Translation: BAB71377.1 .
BC002950 mRNA. Translation: AAH02950.2 .
BC008305 mRNA. Translation: AAH08305.2 .
AF143536 mRNA. Translation: AAD33909.1 . Different initiation.
CCDSi CCDS32803.1.
RefSeqi NP_037458.3. NM_013326.4.
UniGenei Hs.464779.

3D structure databases

ProteinModelPortali Q96DM3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118961. 13 interactions.
IntActi Q96DM3. 3 interactions.

PTM databases

PhosphoSitei Q96DM3.

Polymorphism databases

DMDMi 47605918.

Proteomic databases

MaxQBi Q96DM3.
PaxDbi Q96DM3.
PRIDEi Q96DM3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269221 ; ENSP00000269221 ; ENSG00000141452 .
GeneIDi 29919.
KEGGi hsa:29919.
UCSCi uc010xaw.2. human.

Organism-specific databases

CTDi 29919.
GeneCardsi GC18P021083.
H-InvDB HIX0020388.
HGNCi HGNC:24326. C18orf8.
HPAi HPA043589.
neXtProti NX_Q96DM3.
PharmGKBi PA134862561.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG244614.
GeneTreei ENSGT00390000009127.
HOGENOMi HOG000006772.
HOVERGENi HBG052473.
InParanoidi Q96DM3.
OMAi ITVQHYL.
OrthoDBi EOG7VB2FB.
PhylomeDBi Q96DM3.
TreeFami TF105850.

Miscellaneous databases

GenomeRNAii 29919.
NextBioi 52516.

Gene expression databases

Bgeei Q96DM3.
CleanExi HS_C18orf8.
ExpressionAtlasi Q96DM3. baseline and differential.
Genevestigatori Q96DM3.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR009755. Mic1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF07035. Mic1. 1 hit.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Synovium.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "Identification of colon-cancer associated sequences by SSH."
    Linnebacher M., Meuer S.C., Rudy W.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-657.
    Tissue: Colon carcinoma.

Entry informationi

Entry nameiMIC1_HUMAN
AccessioniPrimary (citable) accession number: Q96DM3
Secondary accession number(s): Q9BU17, Q9Y5M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3