Reviewed, UniProtKB/Swiss-Prot Q96DM3 (MIC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C18orf8
Alternative name(s):
    Colon cancer-associated protein Mic1
      Short name=Mic-1

Gene names

Name:	C18orf8
Synonyms:	MIC1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	657 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the Mic1 family. Contains 1 Mic1 domain.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 657	657	Uncharacterized protein C18orf8		PRO_0000096481
Regions
	Domain	471 – 637	167	Mic1
Amino acid modifications
	Modified residue	233	1	Phosphothreonine Ref.4
	Modified residue	234	1	Phosphoserine Ref.4
Experimental info
	Sequence conflict	163	1	S → R in BAB71377. Ref.1
	Sequence conflict	178	1	Q → L in AAD33909. Ref.3
	Sequence conflict	470	1	E → DFFLYGVFKHYRQ in AAD33909. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q96DM3-1 [UniParc]. Last modified May 24, 2004. Version 2. Checksum: DFDC8B304ADCA88C	FASTA	657	74,975
	10 20 30 40 50 60 MGEEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG PDDRNPISFR 70 80 90 100 110 120 MDDKGEVKCI KFSLENKILA VQRTSKTVDF CNFIPDNSQL EYTQECKTKN ANILGFCWTS 130 140 150 160 170 180 STEIVFITDQ GIEFYQVLPE KRSLKLLKSH NLNVNWYMYC PESAVILLST TVLENVLQPF 190 200 210 220 230 240 HFRAGTMSKL PKFEIELPAA PKSTKPSLSE RDIAMATIYG QLYVLFLRHH SRTSNSTGAE 250 260 270 280 290 300 VVLYHLPREG ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI KLRGEFDGSV 310 320 330 340 350 360 TFHHPVLPAR SIQPYQIPIT GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS ASQGYLWNLQ 370 380 390 400 410 420 VKLEPIVNLL PDKGRLMDFL LQRKECKMVI LSVCSQMLSE SDRASLPVIA TVFDKLNHEY 430 440 450 460 470 480 KKYLDAEQSY AMAVEAGQSR SSPLLKRPVR TQAVLDQSDV YTHVLSAFVE KKEMPHKFVI 490 500 510 520 530 540 AVLMEYIRSL NQFQIAVQHY LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL 550 560 570 580 590 600 ESFYPPAHQL SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA 610 620 630 640 650 KQTEDNMLFY TIFRFFEQRN QRLRGSPNFT PGEHCEEHVA FFKQIFGDQA LMRPTTF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Synovium.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Identification of colon-cancer associated sequences by SSH." Linnebacher M., Meuer S.C., Rudy W. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-657. Tissue: Colon carcinoma.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-233 AND SER-234, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK057192 mRNA. Translation: BAB71377.1. BC002950 mRNA. Translation: AAH02950.2. BC008305 mRNA. Translation: AAH08305.2. AF143536 mRNA. Translation: AAD33909.1. Different initiation.
IPI	IPI00149964.
RefSeq	NP_037458.3.
UniGene	Hs.529006
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q96DM3.
Genome annotation databases
Ensembl	ENST00000269221; ENSP00000269221; ENSG00000141452; Homo sapiens. [Genome view]
GeneID	29919.
KEGG	hsa:29919.
UCSC	uc010dlt.1. human.
Organism-specific databases
CTD	29919.
GeneCards	GC18P019337.
HGNC	HGNC:24326. C18orf8.
PharmGKB	PA134862561.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96DM3.
HOVERGEN	Q96DM3.
OMA	YTQECKT
OrthoDB	EOG9P5NVS
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000015190-MON.
Gene expression databases
ArrayExpress	Q96DM3.
Bgee	Q96DM3.
CleanEx	HS_C18orf8.
Genevestigator	Q96DM3.
GermOnline	ENSG00000141452. Homo sapiens.
Family and domain databases
InterPro	IPR009755. Mic1. [Graphical view]
Pfam	PF07035. Mic1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	52516.

Entry information

Entry name

MIC1_HUMAN

Accession

Primary (citable) accession number: Q96DM3
Secondary accession number(s): Q9BU17, Q9Y5M0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 24, 2004
Last modified:	November 24, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.