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Q96DM3 (MIC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C18orf8
Alternative name(s):
Colon cancer-associated protein Mic1
Short name=Mic-1
Gene names
Name:C18orf8
Synonyms:MIC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Mic1 family.

Contains 1 Mic1 domain.

Sequence caution

The sequence AAD33909.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentlysosomal membrane

Inferred from direct assay PubMed 17897319. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 657657Uncharacterized protein C18orf8
PRO_0000096481

Regions

Domain471 – 637167Mic1

Experimental info

Sequence conflict1631S → R in BAB71377. Ref.1
Sequence conflict1781Q → L in AAD33909. Ref.3
Sequence conflict4701E → DFFLYGVFKHYRQ in AAD33909. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q96DM3 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: DFDC8B304ADCA88C

FASTA65774,975
        10         20         30         40         50         60 
MGEEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG PDDRNPISFR 

        70         80         90        100        110        120 
MDDKGEVKCI KFSLENKILA VQRTSKTVDF CNFIPDNSQL EYTQECKTKN ANILGFCWTS 

       130        140        150        160        170        180 
STEIVFITDQ GIEFYQVLPE KRSLKLLKSH NLNVNWYMYC PESAVILLST TVLENVLQPF 

       190        200        210        220        230        240 
HFRAGTMSKL PKFEIELPAA PKSTKPSLSE RDIAMATIYG QLYVLFLRHH SRTSNSTGAE 

       250        260        270        280        290        300 
VVLYHLPREG ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI KLRGEFDGSV 

       310        320        330        340        350        360 
TFHHPVLPAR SIQPYQIPIT GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS ASQGYLWNLQ 

       370        380        390        400        410        420 
VKLEPIVNLL PDKGRLMDFL LQRKECKMVI LSVCSQMLSE SDRASLPVIA TVFDKLNHEY 

       430        440        450        460        470        480 
KKYLDAEQSY AMAVEAGQSR SSPLLKRPVR TQAVLDQSDV YTHVLSAFVE KKEMPHKFVI 

       490        500        510        520        530        540 
AVLMEYIRSL NQFQIAVQHY LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL 

       550        560        570        580        590        600 
ESFYPPAHQL SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA 

       610        620        630        640        650 
KQTEDNMLFY TIFRFFEQRN QRLRGSPNFT PGEHCEEHVA FFKQIFGDQA LMRPTTF 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Synovium.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"Identification of colon-cancer associated sequences by SSH."
Linnebacher M., Meuer S.C., Rudy W.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-657.
Tissue: Colon carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057192 mRNA. Translation: BAB71377.1.
BC002950 mRNA. Translation: AAH02950.2.
BC008305 mRNA. Translation: AAH08305.2.
AF143536 mRNA. Translation: AAD33909.1. Different initiation.
RefSeqNP_037458.3. NM_013326.4.
UniGeneHs.464779.

3D structure databases

ProteinModelPortalQ96DM3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118961. 10 interactions.
IntActQ96DM3. 3 interactions.

PTM databases

PhosphoSiteQ96DM3.

Polymorphism databases

DMDM47605918.

Proteomic databases

PaxDbQ96DM3.
PRIDEQ96DM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269221; ENSP00000269221; ENSG00000141452.
GeneID29919.
KEGGhsa:29919.
UCSCuc010xaw.2. human.

Organism-specific databases

CTD29919.
GeneCardsGC18P021083.
H-InvDBHIX0020388.
HGNCHGNC:24326. C18orf8.
HPAHPA043589.
neXtProtNX_Q96DM3.
PharmGKBPA134862561.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG244614.
HOGENOMHOG000006772.
HOVERGENHBG052473.
InParanoidQ96DM3.
OMAITVQHYL.
OrthoDBEOG7VB2FB.
PhylomeDBQ96DM3.
TreeFamTF105850.

Gene expression databases

ArrayExpressQ96DM3.
BgeeQ96DM3.
CleanExHS_C18orf8.
GenevestigatorQ96DM3.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR009755. Mic1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF07035. Mic1. 1 hit.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi29919.
NextBio52516.

Entry information

Entry nameMIC1_HUMAN
AccessionPrimary (citable) accession number: Q96DM3
Secondary accession number(s): Q9BU17, Q9Y5M0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: February 19, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM