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Protein

Regulator of MON1-CCZ1 complex

Gene

RMC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162).1 Publication

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • regulation of autophagy Source: UniProtKB

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of MON1-CCZ1 complex1 Publication
Alternative name(s):
Colon cancer-associated protein Mic1
Short name:
Mic-1
WD repeat-containing protein 98Curated
Gene namesi
Name:RMC1Imported
Synonyms:C18orf8, MIC1, WDR98
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000141452.9
HGNCiHGNC:24326 RMC1
neXtProtiNX_Q96DM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29919
OpenTargetsiENSG00000141452
PharmGKBiPA134862561

Polymorphism and mutation databases

DMDMi47605918

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964811 – 657Regulator of MON1-CCZ1 complexAdd BLAST657

Proteomic databases

EPDiQ96DM3
MaxQBiQ96DM3
PaxDbiQ96DM3
PeptideAtlasiQ96DM3
PRIDEiQ96DM3

PTM databases

iPTMnetiQ96DM3
PhosphoSitePlusiQ96DM3

Expressioni

Gene expression databases

BgeeiENSG00000141452
CleanExiHS_C18orf8
ExpressionAtlasiQ96DM3 baseline and differential
GenevisibleiQ96DM3 HS

Organism-specific databases

HPAiHPA043589

Interactioni

Subunit structurei

Found in a complex with RMC1, CCZ1 MON1A and MON1B.1 Publication

Protein-protein interaction databases

BioGridi118961, 15 interactors
IntActiQ96DM3, 5 interactors
MINTiQ96DM3
STRINGi9606.ENSP00000269221

Structurei

3D structure databases

ProteinModelPortaliQ96DM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini471 – 637Mic1Add BLAST167

Sequence similaritiesi

Belongs to the RMC1 family.Curated

Phylogenomic databases

eggNOGiKOG2377 Eukaryota
ENOG410YC1K LUCA
GeneTreeiENSGT00390000009127
HOGENOMiHOG000006772
HOVERGENiHBG052473
InParanoidiQ96DM3
OMAiKLNHEYK
OrthoDBiEOG091G05FE
PhylomeDBiQ96DM3
TreeFamiTF105850

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR009755 Mic1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF07035 Mic1, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit

Sequencei

Sequence statusi: Complete.

Q96DM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG
60 70 80 90 100
PDDRNPISFR MDDKGEVKCI KFSLENKILA VQRTSKTVDF CNFIPDNSQL
110 120 130 140 150
EYTQECKTKN ANILGFCWTS STEIVFITDQ GIEFYQVLPE KRSLKLLKSH
160 170 180 190 200
NLNVNWYMYC PESAVILLST TVLENVLQPF HFRAGTMSKL PKFEIELPAA
210 220 230 240 250
PKSTKPSLSE RDIAMATIYG QLYVLFLRHH SRTSNSTGAE VVLYHLPREG
260 270 280 290 300
ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI KLRGEFDGSV
310 320 330 340 350
TFHHPVLPAR SIQPYQIPIT GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS
360 370 380 390 400
ASQGYLWNLQ VKLEPIVNLL PDKGRLMDFL LQRKECKMVI LSVCSQMLSE
410 420 430 440 450
SDRASLPVIA TVFDKLNHEY KKYLDAEQSY AMAVEAGQSR SSPLLKRPVR
460 470 480 490 500
TQAVLDQSDV YTHVLSAFVE KKEMPHKFVI AVLMEYIRSL NQFQIAVQHY
510 520 530 540 550
LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL ESFYPPAHQL
560 570 580 590 600
SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA
610 620 630 640 650
KQTEDNMLFY TIFRFFEQRN QRLRGSPNFT PGEHCEEHVA FFKQIFGDQA

LMRPTTF
Length:657
Mass (Da):74,975
Last modified:May 24, 2004 - v2
Checksum:iDFDC8B304ADCA88C
GO

Sequence cautioni

The sequence AAD33909 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163S → R in BAB71377 (PubMed:14702039).Curated1
Sequence conflicti178Q → L in AAD33909 (Ref. 4) Curated1
Sequence conflicti470E → DFFLYGVFKHYRQ in AAD33909 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057192 mRNA Translation: BAB71377.1
BC002950 mRNA Translation: AAH02950.2
BC008305 mRNA Translation: AAH08305.2
AF143536 mRNA Translation: AAD33909.1 Different initiation.
AC010853 Genomic DNA No translation available.
AC026634 Genomic DNA No translation available.
CCDSiCCDS32803.1
RefSeqiNP_001305636.1, NM_001318707.1
NP_001305637.1, NM_001318708.1
NP_001305638.1, NM_001318709.1
NP_037458.3, NM_013326.4
UniGeneiHs.464779

Genome annotation databases

EnsembliENST00000269221; ENSP00000269221; ENSG00000141452
GeneIDi29919
KEGGihsa:29919
UCSCiuc021uie.3 human

Similar proteinsi

Entry informationi

Entry nameiRMC1_HUMAN
AccessioniPrimary (citable) accession number: Q96DM3
Secondary accession number(s): Q9BU17, Q9Y5M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: May 23, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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