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Protein

Regulator of MON1-CCZ1 complex

Gene

WDR98

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162).1 Publication

GO - Biological processi

  • regulation of autophagy Source: UniProtKB

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of MON1-CCZ1 complex1 Publication
Alternative name(s):
Colon cancer-associated protein Mic1
Short name:
Mic-1
WD repeat-containing protein 98Curated
Gene namesi
Name:WDR98Imported
Synonyms:C18orf8Imported, MIC1, RMC11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000141452.9.
HGNCiHGNC:24326. WDR98.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29919.
OpenTargetsiENSG00000141452.
PharmGKBiPA134862561.

Polymorphism and mutation databases

DMDMi47605918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964811 – 657Regulator of MON1-CCZ1 complexAdd BLAST657

Proteomic databases

EPDiQ96DM3.
MaxQBiQ96DM3.
PaxDbiQ96DM3.
PeptideAtlasiQ96DM3.
PRIDEiQ96DM3.

PTM databases

iPTMnetiQ96DM3.
PhosphoSitePlusiQ96DM3.

Expressioni

Gene expression databases

BgeeiENSG00000141452.
CleanExiHS_C18orf8.
ExpressionAtlasiQ96DM3. baseline and differential.
GenevisibleiQ96DM3. HS.

Organism-specific databases

HPAiHPA043589.

Interactioni

Subunit structurei

Found in a complex with WDR98, CCZ1 MON1A and MON1B.1 Publication

Protein-protein interaction databases

BioGridi118961. 15 interactors.
IntActiQ96DM3. 5 interactors.
STRINGi9606.ENSP00000269221.

Structurei

3D structure databases

ProteinModelPortaliQ96DM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini471 – 637Mic1Add BLAST167

Sequence similaritiesi

Belongs to the Mic1 family.Curated

Phylogenomic databases

eggNOGiKOG2377. Eukaryota.
ENOG410YC1K. LUCA.
GeneTreeiENSGT00390000009127.
HOGENOMiHOG000006772.
HOVERGENiHBG052473.
InParanoidiQ96DM3.
OMAiKLNHEYK.
OrthoDBiEOG091G05FE.
PhylomeDBiQ96DM3.
TreeFamiTF105850.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR009755. Mic1.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF07035. Mic1. 1 hit.
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96DM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG
60 70 80 90 100
PDDRNPISFR MDDKGEVKCI KFSLENKILA VQRTSKTVDF CNFIPDNSQL
110 120 130 140 150
EYTQECKTKN ANILGFCWTS STEIVFITDQ GIEFYQVLPE KRSLKLLKSH
160 170 180 190 200
NLNVNWYMYC PESAVILLST TVLENVLQPF HFRAGTMSKL PKFEIELPAA
210 220 230 240 250
PKSTKPSLSE RDIAMATIYG QLYVLFLRHH SRTSNSTGAE VVLYHLPREG
260 270 280 290 300
ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI KLRGEFDGSV
310 320 330 340 350
TFHHPVLPAR SIQPYQIPIT GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS
360 370 380 390 400
ASQGYLWNLQ VKLEPIVNLL PDKGRLMDFL LQRKECKMVI LSVCSQMLSE
410 420 430 440 450
SDRASLPVIA TVFDKLNHEY KKYLDAEQSY AMAVEAGQSR SSPLLKRPVR
460 470 480 490 500
TQAVLDQSDV YTHVLSAFVE KKEMPHKFVI AVLMEYIRSL NQFQIAVQHY
510 520 530 540 550
LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL ESFYPPAHQL
560 570 580 590 600
SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA
610 620 630 640 650
KQTEDNMLFY TIFRFFEQRN QRLRGSPNFT PGEHCEEHVA FFKQIFGDQA

LMRPTTF
Length:657
Mass (Da):74,975
Last modified:May 24, 2004 - v2
Checksum:iDFDC8B304ADCA88C
GO

Sequence cautioni

The sequence AAD33909 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163S → R in BAB71377 (PubMed:14702039).Curated1
Sequence conflicti178Q → L in AAD33909 (Ref. 4) Curated1
Sequence conflicti470E → DFFLYGVFKHYRQ in AAD33909 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057192 mRNA. Translation: BAB71377.1.
BC002950 mRNA. Translation: AAH02950.2.
BC008305 mRNA. Translation: AAH08305.2.
AF143536 mRNA. Translation: AAD33909.1. Different initiation.
AC010853 Genomic DNA. No translation available.
AC026634 Genomic DNA. No translation available.
CCDSiCCDS32803.1.
RefSeqiNP_001305636.1. NM_001318707.1.
NP_001305637.1. NM_001318708.1.
NP_001305638.1. NM_001318709.1.
NP_037458.3. NM_013326.4.
UniGeneiHs.464779.

Genome annotation databases

EnsembliENST00000269221; ENSP00000269221; ENSG00000141452.
GeneIDi29919.
KEGGihsa:29919.
UCSCiuc021uie.3. human.

Similar proteinsi

Entry informationi

Entry nameiRMC1_HUMAN
AccessioniPrimary (citable) accession number: Q96DM3
Secondary accession number(s): Q9BU17, Q9Y5M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: January 31, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families