Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96DM3

- MIC1_HUMAN

UniProt

Q96DM3 - MIC1_HUMAN

Protein

Uncharacterized protein C18orf8

Gene

C18orf8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C18orf8
    Alternative name(s):
    Colon cancer-associated protein Mic1
    Short name:
    Mic-1
    Gene namesi
    Name:C18orf8
    Synonyms:MIC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:24326. C18orf8.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosomal membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134862561.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 657657Uncharacterized protein C18orf8PRO_0000096481Add
    BLAST

    Proteomic databases

    MaxQBiQ96DM3.
    PaxDbiQ96DM3.
    PRIDEiQ96DM3.

    PTM databases

    PhosphoSiteiQ96DM3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96DM3.
    BgeeiQ96DM3.
    CleanExiHS_C18orf8.
    GenevestigatoriQ96DM3.

    Organism-specific databases

    HPAiHPA043589.

    Interactioni

    Protein-protein interaction databases

    BioGridi118961. 10 interactions.
    IntActiQ96DM3. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96DM3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini471 – 637167Mic1Add
    BLAST

    Sequence similaritiesi

    Belongs to the Mic1 family.Curated
    Contains 1 Mic1 domain.Curated

    Phylogenomic databases

    eggNOGiNOG244614.
    HOGENOMiHOG000006772.
    HOVERGENiHBG052473.
    InParanoidiQ96DM3.
    OMAiITVQHYL.
    OrthoDBiEOG7VB2FB.
    PhylomeDBiQ96DM3.
    TreeFamiTF105850.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR009755. Mic1.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF07035. Mic1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96DM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG    50
    PDDRNPISFR MDDKGEVKCI KFSLENKILA VQRTSKTVDF CNFIPDNSQL 100
    EYTQECKTKN ANILGFCWTS STEIVFITDQ GIEFYQVLPE KRSLKLLKSH 150
    NLNVNWYMYC PESAVILLST TVLENVLQPF HFRAGTMSKL PKFEIELPAA 200
    PKSTKPSLSE RDIAMATIYG QLYVLFLRHH SRTSNSTGAE VVLYHLPREG 250
    ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI KLRGEFDGSV 300
    TFHHPVLPAR SIQPYQIPIT GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS 350
    ASQGYLWNLQ VKLEPIVNLL PDKGRLMDFL LQRKECKMVI LSVCSQMLSE 400
    SDRASLPVIA TVFDKLNHEY KKYLDAEQSY AMAVEAGQSR SSPLLKRPVR 450
    TQAVLDQSDV YTHVLSAFVE KKEMPHKFVI AVLMEYIRSL NQFQIAVQHY 500
    LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL ESFYPPAHQL 550
    SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA 600
    KQTEDNMLFY TIFRFFEQRN QRLRGSPNFT PGEHCEEHVA FFKQIFGDQA 650
    LMRPTTF 657
    Length:657
    Mass (Da):74,975
    Last modified:May 24, 2004 - v2
    Checksum:iDFDC8B304ADCA88C
    GO

    Sequence cautioni

    The sequence AAD33909.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631S → R in BAB71377. (PubMed:14702039)Curated
    Sequence conflicti178 – 1781Q → L in AAD33909. 1 PublicationCurated
    Sequence conflicti470 – 4701E → DFFLYGVFKHYRQ in AAD33909. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057192 mRNA. Translation: BAB71377.1.
    BC002950 mRNA. Translation: AAH02950.2.
    BC008305 mRNA. Translation: AAH08305.2.
    AF143536 mRNA. Translation: AAD33909.1. Different initiation.
    CCDSiCCDS32803.1.
    RefSeqiNP_037458.3. NM_013326.4.
    UniGeneiHs.464779.

    Genome annotation databases

    EnsembliENST00000269221; ENSP00000269221; ENSG00000141452.
    GeneIDi29919.
    KEGGihsa:29919.
    UCSCiuc010xaw.2. human.

    Polymorphism databases

    DMDMi47605918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057192 mRNA. Translation: BAB71377.1 .
    BC002950 mRNA. Translation: AAH02950.2 .
    BC008305 mRNA. Translation: AAH08305.2 .
    AF143536 mRNA. Translation: AAD33909.1 . Different initiation.
    CCDSi CCDS32803.1.
    RefSeqi NP_037458.3. NM_013326.4.
    UniGenei Hs.464779.

    3D structure databases

    ProteinModelPortali Q96DM3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118961. 10 interactions.
    IntActi Q96DM3. 3 interactions.

    PTM databases

    PhosphoSitei Q96DM3.

    Polymorphism databases

    DMDMi 47605918.

    Proteomic databases

    MaxQBi Q96DM3.
    PaxDbi Q96DM3.
    PRIDEi Q96DM3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269221 ; ENSP00000269221 ; ENSG00000141452 .
    GeneIDi 29919.
    KEGGi hsa:29919.
    UCSCi uc010xaw.2. human.

    Organism-specific databases

    CTDi 29919.
    GeneCardsi GC18P021083.
    H-InvDB HIX0020388.
    HGNCi HGNC:24326. C18orf8.
    HPAi HPA043589.
    neXtProti NX_Q96DM3.
    PharmGKBi PA134862561.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG244614.
    HOGENOMi HOG000006772.
    HOVERGENi HBG052473.
    InParanoidi Q96DM3.
    OMAi ITVQHYL.
    OrthoDBi EOG7VB2FB.
    PhylomeDBi Q96DM3.
    TreeFami TF105850.

    Miscellaneous databases

    GenomeRNAii 29919.
    NextBioi 52516.

    Gene expression databases

    ArrayExpressi Q96DM3.
    Bgeei Q96DM3.
    CleanExi HS_C18orf8.
    Genevestigatori Q96DM3.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR009755. Mic1.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF07035. Mic1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Synovium.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "Identification of colon-cancer associated sequences by SSH."
      Linnebacher M., Meuer S.C., Rudy W.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-657.
      Tissue: Colon carcinoma.

    Entry informationi

    Entry nameiMIC1_HUMAN
    AccessioniPrimary (citable) accession number: Q96DM3
    Secondary accession number(s): Q9BU17, Q9Y5M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3