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Protein

NXPE family member 2

Gene

NXPE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NXPE family member 2
Alternative name(s):
Protein FAM55B
Gene namesi
Name:NXPE2
Synonyms:FAM55B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000204361.8.
HGNCiHGNC:26331. NXPE2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204361.

Polymorphism and mutation databases

BioMutaiNXPE2.
DMDMi317373363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002975921 – 559NXPE family member 2Add BLAST559

Proteomic databases

PaxDbiQ96DL1.
PeptideAtlasiQ96DL1.
PRIDEiQ96DL1.

Expressioni

Gene expression databases

BgeeiENSG00000204361.
CleanExiHS_FAM55B.

Organism-specific databases

HPAiHPA039744.
HPA039876.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SCRIBQ141602EBI-11791121,EBI-357345

Protein-protein interaction databases

IntActiQ96DL1. 5 interactors.
STRINGi9606.ENSP00000374237.

Structurei

3D structure databases

ProteinModelPortaliQ96DL1.
SMRiQ96DL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NXPE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF0E. Eukaryota.
ENOG410YBMF. LUCA.
GeneTreeiENSGT00530000062893.
HOGENOMiHOG000172065.
InParanoidiQ96DL1.
OMAiFHRSNIG.
OrthoDBiEOG091G05H8.
PhylomeDBiQ96DL1.
TreeFamiTF329555.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR026845. NXPH/NXPE.
PfamiView protein in Pfam
PF06312. Neurexophilin. 1 hit.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEKILIHRI LTLFPNAIAR KLLLMLTFIL IFWIIYLASK DHTKFSFNLE
60 70 80 90 100
NHIILNQGNI FKKYSHSETP LCPAVSPKET ELRIKDIMEK LDQQIPPRPF
110 120 130 140 150
THVNTTTSAT HSTATILNPQ DTYCRGDQLD ILLEVRDHLG HRKQYGGDFL
160 170 180 190 200
RARMYSTALM AGASGKVTDF NNGTYLVSFT LFWEGQVSLS LLLIHPSEGV
210 220 230 240 250
SALWRARNQG CDRIIFTGLF ANRSSNVFTE CGLTLNTNAE LCQYMDDRDQ
260 270 280 290 300
EAFYCVRPQH MPCEALTHMT TRTRNISYLS KEEWRLFHRS NIGVEMMKNF
310 320 330 340 350
TPIEVIPCNK SENIKKNCQI GMKTPFPSGY TLKKMWITAF CKQIKFNETK
360 370 380 390 400
NINDCLERKL IYLMGDSTLH QWIYYLQKAV KTLKYFDHHG AGIFKTHVLL
410 420 430 440 450
DVERHILIQW KKHGHPFVTK KLFSVKDENY IPREIDQVAG DKNTAIVITL
460 470 480 490 500
GQHFRPFPIN IFIRRAINIQ KAIERLFLRS PETKVILKTE NTREIEQNAE
510 520 530 540 550
MFSDFHGYIQ NLIIRDIFVD LNVGIIDAWD MTIAYCTNNA HPPDYVIQNQ

IGMFLNYIC
Note: No experimental confirmation available. Gene prediction based on EST data and similarity to mouse ortholog.
Length:559
Mass (Da):64,901
Last modified:January 11, 2011 - v2
Checksum:i41BDB50754B82757
GO
Isoform 2 (identifier: Q96DL1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-365: NKSENIKKNC...LERKLIYLMG → PALFYFIFRD...ITSVQRHTWL
     366-559: Missing.

Show »
Length:365
Mass (Da):41,601
Checksum:iF003D476A1F0F67D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034647103V → A. Corresponds to variant dbSNP:rs11215158Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040454309 – 365NKSEN…IYLMG → PALFYFIFRDSLTLSPRLEC SGMISAHCNLCLPGSSDSPD SASHVAGITSVQRHTWL in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_040455366 – 559Missing in isoform 2. 1 PublicationAdd BLAST194

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057953 mRNA. Translation: BAB71621.1.
AP002774 Genomic DNA. No translation available.
CCDSiCCDS44738.1. [Q96DL1-1]
RefSeqiNP_872301.2. NM_182495.5. [Q96DL1-1]
UniGeneiHs.446760.

Genome annotation databases

EnsembliENST00000389586; ENSP00000374237; ENSG00000204361. [Q96DL1-1]
GeneIDi120406.
KEGGihsa:120406.
UCSCiuc009yyy.3. human. [Q96DL1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNXPE2_HUMAN
AccessioniPrimary (citable) accession number: Q96DL1
Secondary accession number(s): Q2NKI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: January 11, 2011
Last modified: September 27, 2017
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families