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Q96DH6

- MSI2H_HUMAN

UniProt

Q96DH6 - MSI2H_HUMAN

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Protein
RNA-binding protein Musashi homolog 2
Gene
MSI2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei217 – 2182Breakpoint for translocation to form MSI2/HOXA9 fusion protein

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
  3. poly(U) RNA binding Source: Ensembl

GO - Biological processi

  1. stem cell development Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Musashi homolog 2
Short name:
Musashi-2
Gene namesi
Name:MSI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18585. MSI2.

Subcellular locationi

Cytoplasm
Note: Associated with polysomes By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. polysome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).

Organism-specific databases

PharmGKBiPA38590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328RNA-binding protein Musashi homolog 2
PRO_0000081652Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Post-translational modificationi

Phosphorylated By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96DH6.
PaxDbiQ96DH6.
PRIDEiQ96DH6.

PTM databases

PhosphoSiteiQ96DH6.

Expressioni

Tissue specificityi

Ubiquitous; detected at low levels.1 Publication

Inductioni

Up-regulated in astrocytes after brain injury By similarity.

Gene expression databases

ArrayExpressiQ96DH6.
BgeeiQ96DH6.
CleanExiHS_MSI2.
GenevestigatoriQ96DH6.

Organism-specific databases

HPAiCAB022300.

Interactioni

Protein-protein interaction databases

BioGridi125873. 13 interactions.
IntActiQ96DH6. 3 interactions.
STRINGi9606.ENSP00000284073.

Structurei

3D structure databases

ProteinModelPortaliQ96DH6.
SMRiQ96DH6. Positions 22-188.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 11191RRM 1
Add
BLAST
Domaini110 – 18778RRM 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi253 – 2608Poly-Ala

Sequence similaritiesi

Belongs to the Musashi family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
HOGENOMiHOG000234441.
HOVERGENiHBG002295.
InParanoidiQ96DH6.
KOiK14411.
OMAiISDCTIM.
PhylomeDBiQ96DH6.
TreeFamiTF325419.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96DH6-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEANGSQGTS GSANDSQHDP GKMFIGGLSW QTSPDSLRDY FSKFGEIREC    50
MVMRDPTTKR SRGFGFVTFA DPASVDKVLG QPHHELDSKT IDPKVAFPRR 100
AQPKMVTRTK KIFVGGLSAN TVVEDVKQYF EQFGKVEDAM LMFDKTTNRH 150
RGFGFVTFEN EDVVEKVCEI HFHEINNKMV ECKKAQPKEV MFPPGTRGRA 200
RGLPYTMDAF MLGMGMLGYP NFVATYGRGY PGFAPSYGYQ FPGFPAAAYG 250
PVAAAAVAAA RGSGSNPARP GGFPGANSPG PVADLYGPAS QDSGVGNYIS 300
AASPQPGSGF GHGIAGPLIA TAFTNGYH 328
Length:328
Mass (Da):35,197
Last modified:December 1, 2001 - v1
Checksum:i6E2FC929491748A2
GO
Isoform 2 (identifier: Q96DH6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEANGSQGTSGSANDSQHDPG → MADLTSVLTSVMFSPSS
     243-255: GFPAAAYGPVAAA → DYLPVSQDIIFIN
     256-328: Missing.

Note: Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. Contains a phosphoserine at position 14.

Show »
Length:251
Mass (Da):28,421
Checksum:i288CBB2F6E0A2870
GO
Isoform 3 (identifier: Q96DH6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     243-255: GFPAAAYGPVAAA → DYLPVSQDIIFIN
     256-328: Missing.

Show »
Length:151
Mass (Da):17,238
Checksum:iF05CDAD5A60DC5B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 104104Missing in isoform 3.
VSP_011169Add
BLAST
Alternative sequencei1 – 2121MEANG…QHDPG → MADLTSVLTSVMFSPSS in isoform 2.
VSP_011168Add
BLAST
Alternative sequencei243 – 25513GFPAA…PVAAA → DYLPVSQDIIFIN in isoform 2 and isoform 3.
VSP_011170Add
BLAST
Alternative sequencei256 – 32873Missing in isoform 2 and isoform 3.
VSP_011171Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC001526 mRNA. Translation: AAH01526.1.
BC017560 mRNA. Translation: AAH17560.1.
AK093888 mRNA. Translation: BAC04244.1.
CCDSiCCDS11596.1. [Q96DH6-1]
CCDS11597.1. [Q96DH6-2]
RefSeqiNP_620412.1. NM_138962.2. [Q96DH6-1]
NP_733839.1. NM_170721.1. [Q96DH6-2]
UniGeneiHs.658922.

Genome annotation databases

EnsembliENST00000284073; ENSP00000284073; ENSG00000153944. [Q96DH6-1]
ENST00000322684; ENSP00000313616; ENSG00000153944. [Q96DH6-2]
ENST00000579180; ENSP00000462264; ENSG00000153944. [Q96DH6-3]
GeneIDi124540.
KEGGihsa:124540.
UCSCiuc002iuz.1. human. [Q96DH6-1]
uc002iva.3. human. [Q96DH6-2]

Polymorphism databases

DMDMi51316513.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC001526 mRNA. Translation: AAH01526.1 .
BC017560 mRNA. Translation: AAH17560.1 .
AK093888 mRNA. Translation: BAC04244.1 .
CCDSi CCDS11596.1. [Q96DH6-1 ]
CCDS11597.1. [Q96DH6-2 ]
RefSeqi NP_620412.1. NM_138962.2. [Q96DH6-1 ]
NP_733839.1. NM_170721.1. [Q96DH6-2 ]
UniGenei Hs.658922.

3D structure databases

ProteinModelPortali Q96DH6.
SMRi Q96DH6. Positions 22-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125873. 13 interactions.
IntActi Q96DH6. 3 interactions.
STRINGi 9606.ENSP00000284073.

PTM databases

PhosphoSitei Q96DH6.

Polymorphism databases

DMDMi 51316513.

Proteomic databases

MaxQBi Q96DH6.
PaxDbi Q96DH6.
PRIDEi Q96DH6.

Protocols and materials databases

DNASUi 124540.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000284073 ; ENSP00000284073 ; ENSG00000153944 . [Q96DH6-1 ]
ENST00000322684 ; ENSP00000313616 ; ENSG00000153944 . [Q96DH6-2 ]
ENST00000579180 ; ENSP00000462264 ; ENSG00000153944 . [Q96DH6-3 ]
GeneIDi 124540.
KEGGi hsa:124540.
UCSCi uc002iuz.1. human. [Q96DH6-1 ]
uc002iva.3. human. [Q96DH6-2 ]

Organism-specific databases

CTDi 124540.
GeneCardsi GC17P055334.
HGNCi HGNC:18585. MSI2.
HPAi CAB022300.
MIMi 607897. gene.
neXtProti NX_Q96DH6.
PharmGKBi PA38590.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0724.
HOGENOMi HOG000234441.
HOVERGENi HBG002295.
InParanoidi Q96DH6.
KOi K14411.
OMAi ISDCTIM.
PhylomeDBi Q96DH6.
TreeFami TF325419.

Miscellaneous databases

ChiTaRSi MSI2. human.
GenomeRNAii 124540.
NextBioi 81316.
PROi Q96DH6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96DH6.
Bgeei Q96DH6.
CleanExi HS_MSI2.
Genevestigatori Q96DH6.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 2 hits.
[Graphical view ]
SMARTi SM00360. RRM. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Trachea.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Placenta and Skin.
  3. "A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23)."
    Barbouti A., Hoeglund M., Johansson B., Lassen C., Nilsson P.-G., Hagemeijer A., Mitelman F., Fioretos T.
    Cancer Res. 63:1202-1206(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH HOXA9, TISSUE SPECIFICITY.
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMSI2H_HUMAN
AccessioniPrimary (citable) accession number: Q96DH6
Secondary accession number(s): Q7Z6M7, Q8N9T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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