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Protein

RNA-binding protein Musashi homolog 2

Gene

MSI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).By similarity

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • poly(U) RNA binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

SIGNORiQ96DH6.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Musashi homolog 2
Short name:
Musashi-2
Gene namesi
Name:MSI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18585. MSI2.

Subcellular locationi

  • Cytoplasm

  • Note: Associated with polysomes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei217 – 218Breakpoint for translocation to form MSI2/HOXA9 fusion protein2

Organism-specific databases

DisGeNETi124540.
OpenTargetsiENSG00000153944.
PharmGKBiPA38590.

Polymorphism and mutation databases

BioMutaiMSI2.
DMDMi51316513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816521 – 328RNA-binding protein Musashi homolog 2Add BLAST328
Isoform 2 (identifier: Q96DH6-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei228Omega-N-methylarginineCombined sources1
Modified residuei261Omega-N-methylarginineCombined sources1
Isoform 2 (identifier: Q96DH6-2)
Modified residuei2N-acetylalanineCombined sources1
Modified residuei14PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ96DH6.
MaxQBiQ96DH6.
PaxDbiQ96DH6.
PeptideAtlasiQ96DH6.
PRIDEiQ96DH6.

PTM databases

iPTMnetiQ96DH6.
PhosphoSitePlusiQ96DH6.

Expressioni

Tissue specificityi

Ubiquitous; detected at low levels.1 Publication

Inductioni

Up-regulated in astrocytes after brain injury.By similarity

Gene expression databases

BgeeiENSG00000153944.
CleanExiHS_MSI2.
ExpressionAtlasiQ96DH6. baseline and differential.
GenevisibleiQ96DH6. HS.

Organism-specific databases

HPAiCAB022300.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPH2P557955EBI-2462339,EBI-352823
MEOX2A4D1273EBI-2462339,EBI-10172134

Protein-protein interaction databases

BioGridi125873. 37 interactors.
IntActiQ96DH6. 10 interactors.
STRINGi9606.ENSP00000284073.

Structurei

3D structure databases

ProteinModelPortaliQ96DH6.
SMRiQ96DH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 111RRM 1PROSITE-ProRule annotationAdd BLAST91
Domaini110 – 187RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi253 – 260Poly-Ala8

Sequence similaritiesi

Belongs to the Musashi family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4205. Eukaryota.
ENOG410YA8Z. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234441.
HOVERGENiHBG002295.
InParanoidiQ96DH6.
KOiK14411.
OMAiQEMESSP.
OrthoDBiEOG091G1CPI.
PhylomeDBiQ96DH6.
TreeFamiTF325419.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DH6-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEANGSQGTS GSANDSQHDP GKMFIGGLSW QTSPDSLRDY FSKFGEIREC
60 70 80 90 100
MVMRDPTTKR SRGFGFVTFA DPASVDKVLG QPHHELDSKT IDPKVAFPRR
110 120 130 140 150
AQPKMVTRTK KIFVGGLSAN TVVEDVKQYF EQFGKVEDAM LMFDKTTNRH
160 170 180 190 200
RGFGFVTFEN EDVVEKVCEI HFHEINNKMV ECKKAQPKEV MFPPGTRGRA
210 220 230 240 250
RGLPYTMDAF MLGMGMLGYP NFVATYGRGY PGFAPSYGYQ FPGFPAAAYG
260 270 280 290 300
PVAAAAVAAA RGSGSNPARP GGFPGANSPG PVADLYGPAS QDSGVGNYIS
310 320
AASPQPGSGF GHGIAGPLIA TAFTNGYH
Length:328
Mass (Da):35,197
Last modified:December 1, 2001 - v1
Checksum:i6E2FC929491748A2
GO
Isoform 2 (identifier: Q96DH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEANGSQGTSGSANDSQHDPG → MADLTSVLTSVMFSPSS
     243-255: GFPAAAYGPVAAA → DYLPVSQDIIFIN
     256-328: Missing.

Show »
Length:251
Mass (Da):28,421
Checksum:i288CBB2F6E0A2870
GO
Isoform 3 (identifier: Q96DH6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.
     243-255: GFPAAAYGPVAAA → DYLPVSQDIIFIN
     256-328: Missing.

Show »
Length:151
Mass (Da):17,238
Checksum:iF05CDAD5A60DC5B1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0111691 – 104Missing in isoform 3. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_0111681 – 21MEANG…QHDPG → MADLTSVLTSVMFSPSS in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011170243 – 255GFPAA…PVAAA → DYLPVSQDIIFIN in isoform 2 and isoform 3. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_011171256 – 328Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001526 mRNA. Translation: AAH01526.1.
BC017560 mRNA. Translation: AAH17560.1.
AK093888 mRNA. Translation: BAC04244.1.
CCDSiCCDS11596.1. [Q96DH6-1]
CCDS11597.1. [Q96DH6-2]
RefSeqiNP_620412.1. NM_138962.3. [Q96DH6-1]
NP_733839.1. NM_170721.1. [Q96DH6-2]
UniGeneiHs.658922.
Hs.685314.
Hs.745088.

Genome annotation databases

EnsembliENST00000284073; ENSP00000284073; ENSG00000153944. [Q96DH6-1]
ENST00000322684; ENSP00000313616; ENSG00000153944. [Q96DH6-2]
ENST00000579180; ENSP00000462264; ENSG00000153944. [Q96DH6-3]
GeneIDi124540.
KEGGihsa:124540.
UCSCiuc002iuz.2. human. [Q96DH6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001526 mRNA. Translation: AAH01526.1.
BC017560 mRNA. Translation: AAH17560.1.
AK093888 mRNA. Translation: BAC04244.1.
CCDSiCCDS11596.1. [Q96DH6-1]
CCDS11597.1. [Q96DH6-2]
RefSeqiNP_620412.1. NM_138962.3. [Q96DH6-1]
NP_733839.1. NM_170721.1. [Q96DH6-2]
UniGeneiHs.658922.
Hs.685314.
Hs.745088.

3D structure databases

ProteinModelPortaliQ96DH6.
SMRiQ96DH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125873. 37 interactors.
IntActiQ96DH6. 10 interactors.
STRINGi9606.ENSP00000284073.

PTM databases

iPTMnetiQ96DH6.
PhosphoSitePlusiQ96DH6.

Polymorphism and mutation databases

BioMutaiMSI2.
DMDMi51316513.

Proteomic databases

EPDiQ96DH6.
MaxQBiQ96DH6.
PaxDbiQ96DH6.
PeptideAtlasiQ96DH6.
PRIDEiQ96DH6.

Protocols and materials databases

DNASUi124540.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284073; ENSP00000284073; ENSG00000153944. [Q96DH6-1]
ENST00000322684; ENSP00000313616; ENSG00000153944. [Q96DH6-2]
ENST00000579180; ENSP00000462264; ENSG00000153944. [Q96DH6-3]
GeneIDi124540.
KEGGihsa:124540.
UCSCiuc002iuz.2. human. [Q96DH6-1]

Organism-specific databases

CTDi124540.
DisGeNETi124540.
GeneCardsiMSI2.
HGNCiHGNC:18585. MSI2.
HPAiCAB022300.
MIMi607897. gene.
neXtProtiNX_Q96DH6.
OpenTargetsiENSG00000153944.
PharmGKBiPA38590.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4205. Eukaryota.
ENOG410YA8Z. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234441.
HOVERGENiHBG002295.
InParanoidiQ96DH6.
KOiK14411.
OMAiQEMESSP.
OrthoDBiEOG091G1CPI.
PhylomeDBiQ96DH6.
TreeFamiTF325419.

Enzyme and pathway databases

SIGNORiQ96DH6.

Miscellaneous databases

ChiTaRSiMSI2. human.
GenomeRNAii124540.
PROiQ96DH6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153944.
CleanExiHS_MSI2.
ExpressionAtlasiQ96DH6. baseline and differential.
GenevisibleiQ96DH6. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSI2H_HUMAN
AccessioniPrimary (citable) accession number: Q96DH6
Secondary accession number(s): Q7Z6M7, Q8N9T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.