Q96DE5 (APC16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anaphase-promoting complex subunit 16
Short name=APC16

Alternative name(s):
Cyclosome subunit 16

Gene names

Name:	ANAPC16
Synonyms:	C10orf104

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Ref.3
Pathway	Protein modification; protein ubiquitination.
Subunit structure	The APC/C is composed of at least 12 subunits. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11. Ref.3
Subcellular location	Cytoplasm. Nucleus Ref.3.
Sequence similarities	Belongs to the APC16 family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW protein ubiquitination Inferred from direct assay Ref.3. Source: UniProtKB
Cellular component	anaphase-promoting complex Inferred from direct assay Ref.3. Source: UniProtKB cytoplasm Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 110	110	Anaphase-promoting complex subunit 16		PRO_0000089816
Regions
	Compositional bias	4 – 26	23	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	Q96DE5 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F348FA92F4B89E4F	FASTA	110	11,667
	10 20 30 40 50 60 MAASSSSSSA GGVSGSSVTG SGFSVSDLAP PRKALFTYPK GAGEMLEDGS ERFLCESVFS 70 80 90 100 110 YQVASTLKQV KHDQQVARME KLAGLVEELE ADEWRFKPIE QLLGFTPSSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Systematic analysis of human protein complexes identifies chromosome segregation proteins." Hutchins J.R., Toyoda Y., Hegemann B., Poser I., Heriche J.K., Sykora M.M., Augsburg M., Hudecz O., Buschhorn B.A., Bulkescher J., Conrad C., Comartin D., Schleiffer A., Sarov M., Pozniakovsky A., Slabicki M.M., Schloissnig S., Steinmacher I. , Leuschner M., Ssykor A., Lawo S., Pelletier L., Stark H., Nasmyth K., Ellenberg J., Durbin R., Buchholz F., Mechtler K., Hyman A.A., Peters J.M. Science 328:593-599(2010) [PubMed: 20360068] [Abstract] Cited for: FUNCTION, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL607035 Genomic DNA. Translation: CAI15909.1. BC009530 mRNA. Translation: AAH09530.1.
IPI	IPI00060893.
RefSeq	NP_001229475.1. NM_001242546.1. NP_001229476.1. NM_001242547.1. NP_775744.1. NM_173473.3.
UniGene	Hs.426296.
3D structure databases
ProteinModelPortal	Q96DE5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96DE5. 20 interactions.
STRING	Q96DE5.
PTM databases
PhosphoSite	Q96DE5.
Proteomic databases
PRIDE	Q96DE5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299381; ENSP00000299381; ENSG00000166295.
GeneID	119504.
KEGG	hsa:119504.
UCSC	uc001jsv.1. human.
Organism-specific databases
CTD	119504.
GeneCards	GC10P073975.
HGNC	HGNC:26976. ANAPC16.
HPA	HPA037815.
MIM	613427. gene.
neXtProt	NX_Q96DE5.
PharmGKB	PA134953507.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21127.
GeneTree	ENSGT00390000018109.
HOGENOM	HBG280183.
HOVERGEN	HBG054279.
InParanoid	Q96DE5.
OMA	GAGEMME.
OrthoDB	EOG45QHFT.
PhylomeDB	Q96DE5.
Gene expression databases
ArrayExpress	Q96DE5.
Bgee	Q96DE5.
CleanEx	HS_C10orf104.
Genevestigator	Q96DE5.
GermOnline	ENSG00000166295. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	80429.
SOURCE	Search...

Entry information

Entry name

APC16_HUMAN

Accession

Primary (citable) accession number: Q96DE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.