Q96DC7 (TMCO6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane and coiled-coil domain-containing protein 6

Gene names

Name:	TMCO6
ORF Names:	PRO1580

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence caution	The sequence AAF69602.1 differs from that shown. Reason: Chimeric cDNA. The sequence AAH01910.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH09618.1 differs from that shown. Reason: Erroneous initiation. The sequence EAW62034.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein import into nucleus Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96DC7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96DC7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     230-230: P → PPASASS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Transmembrane and coiled-coil domain-containing protein 6		PRO_0000305157
Regions
	Transmembrane	338 – 358	21	Helical; Potential
	Transmembrane	386 – 406	21	Helical; Potential
	Coiled coil	15 – 84	70	Potential
	Compositional bias	2 – 79	78	Arg-rich
Natural variations
	Alternative sequence	230	1	P → PPASASS in isoform 2.		VSP_028249
	Natural variant	299	1	T → S. Ref.3 Corresponds to variant rs17208187 [ dbSNP | Ensembl ].		VAR_035171
Experimental info
	Sequence conflict	442	1	Q → R in AAF69602. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: 0B50C721866613B2	FASTA	493	54,442
	10 20 30 40 50 60 MWSRRQGRLR PTVCGVEELR RRRREREAAL RKARREQQLV SKRLLRNDAP EEAGEGCVAA 70 80 90 100 110 120 ILGETEVQQF LRQAQRGTEE KEREGALVSL RRGLQHPETQ QTFIRLEGSM RTLVGLLTSN 130 140 150 160 170 180 QALLQLEAAR CLHELSHSEQ STVAEACLPA TSYLLTYLSS HSSDFIELCL YTLGNLIVES 190 200 210 220 230 240 EAVRRQLLPQ GIVPALAACI QSPHVAVLEA LGYALSQLLQ AEEAPEKIIP SILASTLPQH 250 260 270 280 290 300 MLQMLQPGPK LNPGVAVEFA WCLHYIICSQ VSNPLLIGHG ALSTLGLLLL DLAGAVQKTE 310 320 330 340 350 360 DAGLELLACP VLRCLSNLLT EAAVETVGGQ MQLRDERVVA ALFILLQFFF QKQPSLLPEG 370 380 390 400 410 420 LWLLNNLTAN SPSFCTSLLS LDLIEPLLQL LPVSNVVSVM VLTVLCNVAE KGPAYCQRLW 430 440 450 460 470 480 PGPLLPALLH TLAFSDTEVV GQSLELLHLL FLYQPEAVQV FLQQSGLQAL ERHQEEAQLQ 490 DRVYALQQTA LQG
	Isoform 2 [UniParc]. Checksum: 4919A06FD6BA580F	FASTA	499	54,943
	10 20 30 40 50 60 MWSRRQGRLR PTVCGVEELR RRRREREAAL RKARREQQLV SKRLLRNDAP EEAGEGCVAA 70 80 90 100 110 120 ILGETEVQQF LRQAQRGTEE KEREGALVSL RRGLQHPETQ QTFIRLEGSM RTLVGLLTSN 130 140 150 160 170 180 QALLQLEAAR CLHELSHSEQ STVAEACLPA TSYLLTYLSS HSSDFIELCL YTLGNLIVES 190 200 210 220 230 240 EAVRRQLLPQ GIVPALAACI QSPHVAVLEA LGYALSQLLQ AEEAPEKIIP PASASSSILA 250 260 270 280 290 300 STLPQHMLQM LQPGPKLNPG VAVEFAWCLH YIICSQVSNP LLIGHGALST LGLLLLDLAG 310 320 330 340 350 360 AVQKTEDAGL ELLACPVLRC LSNLLTEAAV ETVGGQMQLR DERVVAALFI LLQFFFQKQP 370 380 390 400 410 420 SLLPEGLWLL NNLTANSPSF CTSLLSLDLI EPLLQLLPVS NVVSVMVLTV LCNVAEKGPA 430 440 450 460 470 480 YCQRLWPGPL LPALLHTLAF SDTEVVGQSL ELLHLLFLYQ PEAVQVFLQQ SGLQALERHQ 490 EEAQLQDRVY ALQQTALQG

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Spleen.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 223-493 (ISOFORM 1), VARIANT SER-299. Tissue: Lung and Pancreas.
[4]	"Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver." Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 241-493. Tissue: Fetal liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK097088 mRNA. No translation available. CH471062 Genomic DNA. Translation: EAW62034.1. Sequence problems. BC001910 mRNA. Translation: AAH01910.1. Different initiation. BC009618 mRNA. Translation: AAH09618.1. Different initiation. AF119848 mRNA. Translation: AAF69602.1. Sequence problems.
IPI	IPI00644486. IPI00791699.
RefSeq	NP_060972.3. NM_018502.3.
UniGene	Hs.534333.
3D structure databases
ProteinModelPortal	Q96DC7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96DC7. 1 interaction.
MINT	MINT-1453411.
STRING	9606.ENSP00000378166.
Polymorphism databases
DMDM	158706351.
Proteomic databases
PaxDb	Q96DC7.
PRIDE	Q96DC7.
Protocols and materials databases
DNASU	55374.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252100; ENSP00000252100; ENSG00000113119. ENST00000394671; ENSP00000378166; ENSG00000113119. ENST00000537378; ENSP00000444474; ENSG00000113119.
GeneID	55374.
KEGG	hsa:55374.
UCSC	uc003lgl.3. human. uc003lgm.3. human.
Organism-specific databases
CTD	55374.
GeneCards	GC05P140019.
HGNC	HGNC:28814. TMCO6.
HPA	HPA037473. HPA037474.
neXtProt	NX_Q96DC7.
PharmGKB	PA162405810.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45598.
HOGENOM	HOG000154636.
HOVERGEN	HBG108588.
OMA	ASTLPQH.
OrthoDB	EOG4GHZQ7.
Gene expression databases
ArrayExpress	Q96DC7.
Bgee	Q96DC7.
CleanEx	HS_TMCO6.
Genevestigator	Q96DC7.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. IPR002652. Importin-a_IBB. [Graphical view]
SMART	SM00185. ARM. 3 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	TMCO6. human.
GenomeRNAi	55374.
NextBio	59768.

Entry information

Entry name

TMCO6_HUMAN

Accession

Primary (citable) accession number: Q96DC7
Secondary accession number(s): Q9BUU0, Q9P198

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.