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Protein

Transmembrane and coiled-coil domain-containing protein 6

Gene

TMCO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein transporter activity Source: InterPro

GO - Biological processi

  1. protein import into nucleus Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 6
Gene namesi
Name:TMCO6
ORF Names:PRO1580
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:28814. TMCO6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei338 – 35821HelicalSequence AnalysisAdd
BLAST
Transmembranei386 – 40621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
  3. nucleus Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Transmembrane and coiled-coil domain-containing protein 6PRO_0000305157Add
BLAST

Proteomic databases

MaxQBiQ96DC7.
PaxDbiQ96DC7.
PRIDEiQ96DC7.

Expressioni

Gene expression databases

BgeeiQ96DC7.
CleanExiHS_TMCO6.
ExpressionAtlasiQ96DC7. baseline and differential.
GenevestigatoriQ96DC7.

Organism-specific databases

HPAiHPA037473.
HPA037474.

Interactioni

Protein-protein interaction databases

BioGridi120647. 7 interactions.
IntActiQ96DC7. 1 interaction.
MINTiMINT-1453411.
STRINGi9606.ENSP00000378166.

Structurei

3D structure databases

ProteinModelPortaliQ96DC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili15 – 8470Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 7978Arg-richAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45598.
GeneTreeiENSGT00390000008104.
HOGENOMiHOG000154636.
HOVERGENiHBG108588.
InParanoidiQ96DC7.
OMAiCNIAEKG.
OrthoDBiEOG7G7KPD.
PhylomeDBiQ96DC7.
TreeFamiTF331378.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96DC7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSRRQGRLR PTVCGVEELR RRRREREAAL RKARREQQLV SKRLLRNDAP
60 70 80 90 100
EEAGEGCVAA ILGETEVQQF LRQAQRGTEE KEREGALVSL RRGLQHPETQ
110 120 130 140 150
QTFIRLEGSM RTLVGLLTSN QALLQLEAAR CLHELSHSEQ STVAEACLPA
160 170 180 190 200
TSYLLTYLSS HSSDFIELCL YTLGNLIVES EAVRRQLLPQ GIVPALAACI
210 220 230 240 250
QSPHVAVLEA LGYALSQLLQ AEEAPEKIIP SILASTLPQH MLQMLQPGPK
260 270 280 290 300
LNPGVAVEFA WCLHYIICSQ VSNPLLIGHG ALSTLGLLLL DLAGAVQKTE
310 320 330 340 350
DAGLELLACP VLRCLSNLLT EAAVETVGGQ MQLRDERVVA ALFILLQFFF
360 370 380 390 400
QKQPSLLPEG LWLLNNLTAN SPSFCTSLLS LDLIEPLLQL LPVSNVVSVM
410 420 430 440 450
VLTVLCNVAE KGPAYCQRLW PGPLLPALLH TLAFSDTEVV GQSLELLHLL
460 470 480 490
FLYQPEAVQV FLQQSGLQAL ERHQEEAQLQ DRVYALQQTA LQG
Length:493
Mass (Da):54,442
Last modified:October 2, 2007 - v2
Checksum:i0B50C721866613B2
GO
Isoform 2 (identifier: Q96DC7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-230: P → PPASASS

Note: No experimental confirmation available.

Show »
Length:499
Mass (Da):54,943
Checksum:i4919A06FD6BA580F
GO

Sequence cautioni

The sequence AAF69602.1 differs from that shown.Chimeric cDNA.Curated
The sequence AAH01910.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH09618.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAW62034.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti442 – 4421Q → R in AAF69602. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti299 – 2991T → S.1 Publication
Corresponds to variant rs17208187 [ dbSNP | Ensembl ].
VAR_035171

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei230 – 2301P → PPASASS in isoform 2. 1 PublicationVSP_028249

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097088 mRNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62034.1. Sequence problems.
BC001910 mRNA. Translation: AAH01910.1. Different initiation.
BC009618 mRNA. Translation: AAH09618.1. Different initiation.
AF119848 mRNA. Translation: AAF69602.1. Sequence problems.
CCDSiCCDS4233.2. [Q96DC7-1]
CCDS75320.1. [Q96DC7-2]
RefSeqiNP_001287909.1. NM_001300980.1. [Q96DC7-2]
NP_001287911.1. NM_001300982.1.
NP_060972.3. NM_018502.4. [Q96DC7-1]
UniGeneiHs.534333.

Genome annotation databases

EnsembliENST00000252100; ENSP00000252100; ENSG00000113119. [Q96DC7-2]
ENST00000394671; ENSP00000378166; ENSG00000113119. [Q96DC7-1]
GeneIDi55374.
KEGGihsa:55374.
UCSCiuc003lgl.3. human. [Q96DC7-1]
uc003lgm.3. human. [Q96DC7-2]

Polymorphism databases

DMDMi158706351.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097088 mRNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62034.1. Sequence problems.
BC001910 mRNA. Translation: AAH01910.1. Different initiation.
BC009618 mRNA. Translation: AAH09618.1. Different initiation.
AF119848 mRNA. Translation: AAF69602.1. Sequence problems.
CCDSiCCDS4233.2. [Q96DC7-1]
CCDS75320.1. [Q96DC7-2]
RefSeqiNP_001287909.1. NM_001300980.1. [Q96DC7-2]
NP_001287911.1. NM_001300982.1.
NP_060972.3. NM_018502.4. [Q96DC7-1]
UniGeneiHs.534333.

3D structure databases

ProteinModelPortaliQ96DC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120647. 7 interactions.
IntActiQ96DC7. 1 interaction.
MINTiMINT-1453411.
STRINGi9606.ENSP00000378166.

Polymorphism databases

DMDMi158706351.

Proteomic databases

MaxQBiQ96DC7.
PaxDbiQ96DC7.
PRIDEiQ96DC7.

Protocols and materials databases

DNASUi55374.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252100; ENSP00000252100; ENSG00000113119. [Q96DC7-2]
ENST00000394671; ENSP00000378166; ENSG00000113119. [Q96DC7-1]
GeneIDi55374.
KEGGihsa:55374.
UCSCiuc003lgl.3. human. [Q96DC7-1]
uc003lgm.3. human. [Q96DC7-2]

Organism-specific databases

CTDi55374.
GeneCardsiGC05P140019.
HGNCiHGNC:28814. TMCO6.
HPAiHPA037473.
HPA037474.
neXtProtiNX_Q96DC7.
PharmGKBiPA162405810.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45598.
GeneTreeiENSGT00390000008104.
HOGENOMiHOG000154636.
HOVERGENiHBG108588.
InParanoidiQ96DC7.
OMAiCNIAEKG.
OrthoDBiEOG7G7KPD.
PhylomeDBiQ96DC7.
TreeFamiTF331378.

Miscellaneous databases

ChiTaRSiTMCO6. human.
GenomeRNAii55374.
NextBioi59768.
PROiQ96DC7.

Gene expression databases

BgeeiQ96DC7.
CleanExiHS_TMCO6.
ExpressionAtlasiQ96DC7. baseline and differential.
GenevestigatoriQ96DC7.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 223-493 (ISOFORM 1), VARIANT SER-299.
    Tissue: Lung and Pancreas.
  4. "Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 241-493.
    Tissue: Fetal liver.

Entry informationi

Entry nameiTMCO6_HUMAN
AccessioniPrimary (citable) accession number: Q96DC7
Secondary accession number(s): Q9BUU0, Q9P198
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 7, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.