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Q96DC7 (TMCO6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane and coiled-coil domain-containing protein 6
Gene names
Name:TMCO6
ORF Names:PRO1580
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence caution

The sequence AAF69602.1 differs from that shown. Reason: Chimeric cDNA.

The sequence AAH01910.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH09618.1 differs from that shown. Reason: Erroneous initiation.

The sequence EAW62034.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96DC7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96DC7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     230-230: P → PPASASS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Transmembrane and coiled-coil domain-containing protein 6
PRO_0000305157

Regions

Transmembrane338 – 35821Helical; Potential
Transmembrane386 – 40621Helical; Potential
Coiled coil15 – 8470 Potential
Compositional bias2 – 7978Arg-rich

Natural variations

Alternative sequence2301P → PPASASS in isoform 2.
VSP_028249
Natural variant2991T → S. Ref.3
Corresponds to variant rs17208187 [ dbSNP | Ensembl ].
VAR_035171

Experimental info

Sequence conflict4421Q → R in AAF69602. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: 0B50C721866613B2

FASTA49354,442
        10         20         30         40         50         60 
MWSRRQGRLR PTVCGVEELR RRRREREAAL RKARREQQLV SKRLLRNDAP EEAGEGCVAA 

        70         80         90        100        110        120 
ILGETEVQQF LRQAQRGTEE KEREGALVSL RRGLQHPETQ QTFIRLEGSM RTLVGLLTSN 

       130        140        150        160        170        180 
QALLQLEAAR CLHELSHSEQ STVAEACLPA TSYLLTYLSS HSSDFIELCL YTLGNLIVES 

       190        200        210        220        230        240 
EAVRRQLLPQ GIVPALAACI QSPHVAVLEA LGYALSQLLQ AEEAPEKIIP SILASTLPQH 

       250        260        270        280        290        300 
MLQMLQPGPK LNPGVAVEFA WCLHYIICSQ VSNPLLIGHG ALSTLGLLLL DLAGAVQKTE 

       310        320        330        340        350        360 
DAGLELLACP VLRCLSNLLT EAAVETVGGQ MQLRDERVVA ALFILLQFFF QKQPSLLPEG 

       370        380        390        400        410        420 
LWLLNNLTAN SPSFCTSLLS LDLIEPLLQL LPVSNVVSVM VLTVLCNVAE KGPAYCQRLW 

       430        440        450        460        470        480 
PGPLLPALLH TLAFSDTEVV GQSLELLHLL FLYQPEAVQV FLQQSGLQAL ERHQEEAQLQ 

       490 
DRVYALQQTA LQG 

« Hide

Isoform 2 [UniParc].

Checksum: 4919A06FD6BA580F
Show »

FASTA49954,943

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Spleen.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 223-493 (ISOFORM 1), VARIANT SER-299.
Tissue: Lung and Pancreas.
[4]"Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 241-493.
Tissue: Fetal liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK097088 mRNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62034.1. Sequence problems.
BC001910 mRNA. Translation: AAH01910.1. Different initiation.
BC009618 mRNA. Translation: AAH09618.1. Different initiation.
AF119848 mRNA. Translation: AAF69602.1. Sequence problems.
RefSeqNP_060972.3. NM_018502.3.
XP_005268533.1. XM_005268476.1.
UniGeneHs.534333.

3D structure databases

ProteinModelPortalQ96DC7.
SMRQ96DC7. Positions 79-220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120647. 2 interactions.
IntActQ96DC7. 1 interaction.
MINTMINT-1453411.
STRING9606.ENSP00000378166.

Polymorphism databases

DMDM158706351.

Proteomic databases

PaxDbQ96DC7.
PRIDEQ96DC7.

Protocols and materials databases

DNASU55374.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252100; ENSP00000252100; ENSG00000113119. [Q96DC7-2]
ENST00000394671; ENSP00000378166; ENSG00000113119. [Q96DC7-1]
ENST00000537378; ENSP00000444474; ENSG00000113119.
GeneID55374.
KEGGhsa:55374.
UCSCuc003lgl.3. human. [Q96DC7-1]
uc003lgm.3. human. [Q96DC7-2]

Organism-specific databases

CTD55374.
GeneCardsGC05P140019.
HGNCHGNC:28814. TMCO6.
HPAHPA037473.
HPA037474.
neXtProtNX_Q96DC7.
PharmGKBPA162405810.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45598.
HOGENOMHOG000154636.
HOVERGENHBG108588.
OMAASTLPQH.
OrthoDBEOG7G7KPD.
PhylomeDBQ96DC7.
TreeFamTF331378.

Gene expression databases

ArrayExpressQ96DC7.
BgeeQ96DC7.
CleanExHS_TMCO6.
GenevestigatorQ96DC7.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
[Graphical view]
SMARTSM00185. ARM. 3 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

ChiTaRSTMCO6. human.
GenomeRNAi55374.
NextBio59768.
PROQ96DC7.

Entry information

Entry nameTMCO6_HUMAN
AccessionPrimary (citable) accession number: Q96DC7
Secondary accession number(s): Q9BUU0, Q9P198
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM