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Protein

Transmembrane and coiled-coil domain-containing protein 6

Gene

TMCO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 6
Gene namesi
Name:TMCO6
ORF Names:PRO1580
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113119.12
HGNCiHGNC:28814 TMCO6
neXtProtiNX_Q96DC7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113119
PharmGKBiPA162405810

Polymorphism and mutation databases

BioMutaiTMCO6
DMDMi158706351

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051571 – 493Transmembrane and coiled-coil domain-containing protein 6Add BLAST493

Proteomic databases

EPDiQ96DC7
MaxQBiQ96DC7
PaxDbiQ96DC7
PeptideAtlasiQ96DC7
PRIDEiQ96DC7

PTM databases

iPTMnetiQ96DC7
PhosphoSitePlusiQ96DC7

Expressioni

Gene expression databases

BgeeiENSG00000113119
CleanExiHS_TMCO6
ExpressionAtlasiQ96DC7 baseline and differential
GenevisibleiQ96DC7 HS

Organism-specific databases

HPAiHPA037473
HPA037474

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120647, 10 interactors
IntActiQ96DC7, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96DC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 84Sequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 79Arg-richAdd BLAST78

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE0G Eukaryota
ENOG41126GB LUCA
GeneTreeiENSGT00390000008104
HOGENOMiHOG000154636
HOVERGENiHBG108588
InParanoidiQ96DC7
OMAiMWSRRQG
OrthoDBiEOG091G055O
PhylomeDBiQ96DC7
TreeFamiTF331378

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR002652 Importin-a_IBB
SMARTiView protein in SMART
SM00185 ARM, 5 hits
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSRRQGRLR PTVCGVEELR RRRREREAAL RKARREQQLV SKRLLRNDAP
60 70 80 90 100
EEAGEGCVAA ILGETEVQQF LRQAQRGTEE KEREGALVSL RRGLQHPETQ
110 120 130 140 150
QTFIRLEGSM RTLVGLLTSN QALLQLEAAR CLHELSHSEQ STVAEACLPA
160 170 180 190 200
TSYLLTYLSS HSSDFIELCL YTLGNLIVES EAVRRQLLPQ GIVPALAACI
210 220 230 240 250
QSPHVAVLEA LGYALSQLLQ AEEAPEKIIP SILASTLPQH MLQMLQPGPK
260 270 280 290 300
LNPGVAVEFA WCLHYIICSQ VSNPLLIGHG ALSTLGLLLL DLAGAVQKTE
310 320 330 340 350
DAGLELLACP VLRCLSNLLT EAAVETVGGQ MQLRDERVVA ALFILLQFFF
360 370 380 390 400
QKQPSLLPEG LWLLNNLTAN SPSFCTSLLS LDLIEPLLQL LPVSNVVSVM
410 420 430 440 450
VLTVLCNVAE KGPAYCQRLW PGPLLPALLH TLAFSDTEVV GQSLELLHLL
460 470 480 490
FLYQPEAVQV FLQQSGLQAL ERHQEEAQLQ DRVYALQQTA LQG
Length:493
Mass (Da):54,442
Last modified:October 2, 2007 - v2
Checksum:i0B50C721866613B2
GO
Isoform 2 (identifier: Q96DC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-230: P → PPASASS

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):54,943
Checksum:i4919A06FD6BA580F
GO

Sequence cautioni

The sequence AAF69602 differs from that shown. Chimeric cDNA.Curated
The sequence AAH01910 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH09618 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW62034 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti442Q → R in AAF69602 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035171299T → S1 PublicationCorresponds to variant dbSNP:rs17208187Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028249230P → PPASASS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097088 mRNA No translation available.
CH471062 Genomic DNA Translation: EAW62034.1 Sequence problems.
BC001910 mRNA Translation: AAH01910.1 Different initiation.
BC009618 mRNA Translation: AAH09618.1 Different initiation.
AF119848 mRNA Translation: AAF69602.1 Sequence problems.
CCDSiCCDS4233.2 [Q96DC7-1]
CCDS75320.1 [Q96DC7-2]
RefSeqiNP_001287909.1, NM_001300980.1 [Q96DC7-2]
NP_001287911.1, NM_001300982.1
NP_060972.3, NM_018502.4 [Q96DC7-1]
XP_011535970.1, XM_011537668.2
XP_016865109.1, XM_017009620.1
UniGeneiHs.534333

Genome annotation databases

EnsembliENST00000252100; ENSP00000252100; ENSG00000113119 [Q96DC7-2]
ENST00000394671; ENSP00000378166; ENSG00000113119 [Q96DC7-1]
GeneIDi55374
KEGGihsa:55374
UCSCiuc003lgl.4 human [Q96DC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTMCO6_HUMAN
AccessioniPrimary (citable) accession number: Q96DC7
Secondary accession number(s): Q9BUU0, Q9P198
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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