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Q96DC7

- TMCO6_HUMAN

UniProt

Q96DC7 - TMCO6_HUMAN

Protein

Transmembrane and coiled-coil domain-containing protein 6

Gene

TMCO6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein transporter activity Source: InterPro

    GO - Biological processi

    1. protein import into nucleus Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 6
    Gene namesi
    Name:TMCO6
    ORF Names:PRO1580
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:28814. TMCO6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleus Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162405810.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Transmembrane and coiled-coil domain-containing protein 6PRO_0000305157Add
    BLAST

    Proteomic databases

    MaxQBiQ96DC7.
    PaxDbiQ96DC7.
    PRIDEiQ96DC7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96DC7.
    BgeeiQ96DC7.
    CleanExiHS_TMCO6.
    GenevestigatoriQ96DC7.

    Organism-specific databases

    HPAiHPA037473.
    HPA037474.

    Interactioni

    Protein-protein interaction databases

    BioGridi120647. 2 interactions.
    IntActiQ96DC7. 1 interaction.
    MINTiMINT-1453411.
    STRINGi9606.ENSP00000378166.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96DC7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili15 – 8470Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 7978Arg-richAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45598.
    HOGENOMiHOG000154636.
    HOVERGENiHBG108588.
    OMAiASTLPQH.
    OrthoDBiEOG7G7KPD.
    PhylomeDBiQ96DC7.
    TreeFamiTF331378.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR002652. Importin-a_IBB.
    [Graphical view]
    SMARTiSM00185. ARM. 3 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96DC7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWSRRQGRLR PTVCGVEELR RRRREREAAL RKARREQQLV SKRLLRNDAP    50
    EEAGEGCVAA ILGETEVQQF LRQAQRGTEE KEREGALVSL RRGLQHPETQ 100
    QTFIRLEGSM RTLVGLLTSN QALLQLEAAR CLHELSHSEQ STVAEACLPA 150
    TSYLLTYLSS HSSDFIELCL YTLGNLIVES EAVRRQLLPQ GIVPALAACI 200
    QSPHVAVLEA LGYALSQLLQ AEEAPEKIIP SILASTLPQH MLQMLQPGPK 250
    LNPGVAVEFA WCLHYIICSQ VSNPLLIGHG ALSTLGLLLL DLAGAVQKTE 300
    DAGLELLACP VLRCLSNLLT EAAVETVGGQ MQLRDERVVA ALFILLQFFF 350
    QKQPSLLPEG LWLLNNLTAN SPSFCTSLLS LDLIEPLLQL LPVSNVVSVM 400
    VLTVLCNVAE KGPAYCQRLW PGPLLPALLH TLAFSDTEVV GQSLELLHLL 450
    FLYQPEAVQV FLQQSGLQAL ERHQEEAQLQ DRVYALQQTA LQG 493
    Length:493
    Mass (Da):54,442
    Last modified:October 2, 2007 - v2
    Checksum:i0B50C721866613B2
    GO
    Isoform 2 (identifier: Q96DC7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         230-230: P → PPASASS

    Note: No experimental confirmation available.

    Show »
    Length:499
    Mass (Da):54,943
    Checksum:i4919A06FD6BA580F
    GO

    Sequence cautioni

    The sequence AAF69602.1 differs from that shown. Reason: Chimeric cDNA.
    The sequence AAH01910.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH09618.1 differs from that shown. Reason: Erroneous initiation.
    The sequence EAW62034.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti442 – 4421Q → R in AAF69602. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti299 – 2991T → S.1 Publication
    Corresponds to variant rs17208187 [ dbSNP | Ensembl ].
    VAR_035171

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei230 – 2301P → PPASASS in isoform 2. 1 PublicationVSP_028249

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097088 mRNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62034.1. Sequence problems.
    BC001910 mRNA. Translation: AAH01910.1. Different initiation.
    BC009618 mRNA. Translation: AAH09618.1. Different initiation.
    AF119848 mRNA. Translation: AAF69602.1. Sequence problems.
    CCDSiCCDS4233.2. [Q96DC7-1]
    RefSeqiNP_060972.3. NM_018502.3. [Q96DC7-1]
    XP_005268533.1. XM_005268476.1. [Q96DC7-2]
    UniGeneiHs.534333.

    Genome annotation databases

    EnsembliENST00000252100; ENSP00000252100; ENSG00000113119. [Q96DC7-2]
    ENST00000394671; ENSP00000378166; ENSG00000113119. [Q96DC7-1]
    GeneIDi55374.
    KEGGihsa:55374.
    UCSCiuc003lgl.3. human. [Q96DC7-1]
    uc003lgm.3. human. [Q96DC7-2]

    Polymorphism databases

    DMDMi158706351.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097088 mRNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62034.1 . Sequence problems.
    BC001910 mRNA. Translation: AAH01910.1 . Different initiation.
    BC009618 mRNA. Translation: AAH09618.1 . Different initiation.
    AF119848 mRNA. Translation: AAF69602.1 . Sequence problems.
    CCDSi CCDS4233.2. [Q96DC7-1 ]
    RefSeqi NP_060972.3. NM_018502.3. [Q96DC7-1 ]
    XP_005268533.1. XM_005268476.1. [Q96DC7-2 ]
    UniGenei Hs.534333.

    3D structure databases

    ProteinModelPortali Q96DC7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120647. 2 interactions.
    IntActi Q96DC7. 1 interaction.
    MINTi MINT-1453411.
    STRINGi 9606.ENSP00000378166.

    Polymorphism databases

    DMDMi 158706351.

    Proteomic databases

    MaxQBi Q96DC7.
    PaxDbi Q96DC7.
    PRIDEi Q96DC7.

    Protocols and materials databases

    DNASUi 55374.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252100 ; ENSP00000252100 ; ENSG00000113119 . [Q96DC7-2 ]
    ENST00000394671 ; ENSP00000378166 ; ENSG00000113119 . [Q96DC7-1 ]
    GeneIDi 55374.
    KEGGi hsa:55374.
    UCSCi uc003lgl.3. human. [Q96DC7-1 ]
    uc003lgm.3. human. [Q96DC7-2 ]

    Organism-specific databases

    CTDi 55374.
    GeneCardsi GC05P140019.
    HGNCi HGNC:28814. TMCO6.
    HPAi HPA037473.
    HPA037474.
    neXtProti NX_Q96DC7.
    PharmGKBi PA162405810.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45598.
    HOGENOMi HOG000154636.
    HOVERGENi HBG108588.
    OMAi ASTLPQH.
    OrthoDBi EOG7G7KPD.
    PhylomeDBi Q96DC7.
    TreeFami TF331378.

    Miscellaneous databases

    ChiTaRSi TMCO6. human.
    GenomeRNAii 55374.
    NextBioi 59768.
    PROi Q96DC7.

    Gene expression databases

    ArrayExpressi Q96DC7.
    Bgeei Q96DC7.
    CleanExi HS_TMCO6.
    Genevestigatori Q96DC7.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR002652. Importin-a_IBB.
    [Graphical view ]
    SMARTi SM00185. ARM. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 223-493 (ISOFORM 1), VARIANT SER-299.
      Tissue: Lung and Pancreas.
    4. "Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 241-493.
      Tissue: Fetal liver.

    Entry informationi

    Entry nameiTMCO6_HUMAN
    AccessioniPrimary (citable) accession number: Q96DC7
    Secondary accession number(s): Q9BUU0, Q9P198
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3