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Protein

FXYD domain-containing ion transport regulator 5

Gene

FXYD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • cadherin binding Source: UniProtKB
  • ion channel activity Source: InterPro
  • sodium channel regulator activity Source: GO_Central

GO - Biological processi

  • microvillus assembly Source: UniProtKB
  • negative regulation of calcium-dependent cell-cell adhesion Source: UniProtKB
  • regulation of sodium ion transmembrane transporter activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.27.3.1. the phospholemman (plm) family.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 5
Alternative name(s):
Dysadherin
Gene namesi
Name:FXYD5
Synonyms:DYSAD, IWU1
ORF Names:HSPC113, UNQ2561/PRO6241
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4029. FXYD5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 145124ExtracellularSequence analysisAdd
BLAST
Transmembranei146 – 16419HelicalSequence analysisAdd
BLAST
Topological domaini165 – 17814CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28445.

Polymorphism and mutation databases

BioMutaiFXYD5.
DMDMi311033386.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 178157FXYD domain-containing ion transport regulator 5PRO_0000010369Add
BLAST

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96DB9.
PaxDbiQ96DB9.
PRIDEiQ96DB9.

PTM databases

iPTMnetiQ96DB9.
PhosphoSiteiQ96DB9.

Expressioni

Gene expression databases

BgeeiQ96DB9.
CleanExiHS_FXYD5.
ExpressionAtlasiQ96DB9. baseline and differential.
GenevisibleiQ96DB9. HS.

Organism-specific databases

HPAiHPA010817.

Interactioni

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • cadherin binding Source: UniProtKB

Protein-protein interaction databases

STRINGi9606.ENSP00000344254.

Structurei

3D structure databases

ProteinModelPortaliQ96DB9.
SMRiQ96DB9. Positions 135-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCU8. Eukaryota.
ENOG4111E7R. LUCA.
GeneTreeiENSGT00410000026316.
HOGENOMiHOG000081775.
HOVERGENiHBG051678.
InParanoidiQ96DB9.
KOiK13362.
PhylomeDBiQ96DB9.
TreeFamiTF338182.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPSGRLCLL TIVGLILPTR GQTLKDTTSS SSADSTIMDI QVPTRAPDAV
60 70 80 90 100
YTELQPTSPT PTWPADETPQ PQTQTQQLEG TDGPLVTDPE THKSTKAAHP
110 120 130 140 150
TDDTTTLSER PSPSTDVQTD PQTLKPSGFH EDDPFFYDEH TLRKRGLLVA
160 170
AVLFITGIII LTSGKCRQLS RLCRNRCR
Length:178
Mass (Da):19,472
Last modified:November 2, 2010 - v2
Checksum:i7429C04838B75AA1
GO
Isoform 2 (identifier: Q96DB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MSPSGRLCLL...DPETHKSTKA → MQTLSNIPCFCLHGSLLPSTDLATLS

Show »
Length:107
Mass (Da):11,888
Checksum:i121958DF3334315C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1412HT → SH in AAF29077 (PubMed:11042152).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351S → A.
Corresponds to variant rs1688005 [ dbSNP | Ensembl ].
VAR_012349
Natural varianti176 – 1761R → H.5 Publications
Corresponds to variant rs12110 [ dbSNP | Ensembl ].
VAR_027959

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797MSPSG…KSTKA → MQTLSNIPCFCLHGSLLPST DLATLS in isoform 2. 1 PublicationVSP_001584Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177940 mRNA. Translation: AAG09301.1.
AB072911 mRNA. Translation: BAB83766.1.
AF161462 mRNA. Translation: AAF29077.1.
AY358991 mRNA. Translation: AAQ89350.1.
BT007343 mRNA. Translation: AAP36007.1.
AC002390 Genomic DNA. No translation available.
AC020907 Genomic DNA. No translation available.
BC009642 mRNA. Translation: AAH09642.1.
CCDSiCCDS12447.1. [Q96DB9-1]
RefSeqiNP_001158077.1. NM_001164605.1. [Q96DB9-1]
NP_054883.3. NM_014164.5. [Q96DB9-1]
NP_659003.1. NM_144779.2. [Q96DB9-1]
UniGeneiHs.333418.

Genome annotation databases

EnsembliENST00000342879; ENSP00000344254; ENSG00000089327. [Q96DB9-1]
ENST00000392217; ENSP00000376051; ENSG00000089327. [Q96DB9-2]
ENST00000392219; ENSP00000376053; ENSG00000089327. [Q96DB9-1]
ENST00000423817; ENSP00000393848; ENSG00000089327. [Q96DB9-1]
ENST00000541435; ENSP00000443390; ENSG00000089327. [Q96DB9-1]
ENST00000590686; ENSP00000465667; ENSG00000089327. [Q96DB9-1]
GeneIDi53827.
KEGGihsa:53827.
UCSCiuc002nyg.3. human. [Q96DB9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177940 mRNA. Translation: AAG09301.1.
AB072911 mRNA. Translation: BAB83766.1.
AF161462 mRNA. Translation: AAF29077.1.
AY358991 mRNA. Translation: AAQ89350.1.
BT007343 mRNA. Translation: AAP36007.1.
AC002390 Genomic DNA. No translation available.
AC020907 Genomic DNA. No translation available.
BC009642 mRNA. Translation: AAH09642.1.
CCDSiCCDS12447.1. [Q96DB9-1]
RefSeqiNP_001158077.1. NM_001164605.1. [Q96DB9-1]
NP_054883.3. NM_014164.5. [Q96DB9-1]
NP_659003.1. NM_144779.2. [Q96DB9-1]
UniGeneiHs.333418.

3D structure databases

ProteinModelPortaliQ96DB9.
SMRiQ96DB9. Positions 135-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344254.

Protein family/group databases

TCDBi1.A.27.3.1. the phospholemman (plm) family.

PTM databases

iPTMnetiQ96DB9.
PhosphoSiteiQ96DB9.

Polymorphism and mutation databases

BioMutaiFXYD5.
DMDMi311033386.

Proteomic databases

MaxQBiQ96DB9.
PaxDbiQ96DB9.
PRIDEiQ96DB9.

Protocols and materials databases

DNASUi53827.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342879; ENSP00000344254; ENSG00000089327. [Q96DB9-1]
ENST00000392217; ENSP00000376051; ENSG00000089327. [Q96DB9-2]
ENST00000392219; ENSP00000376053; ENSG00000089327. [Q96DB9-1]
ENST00000423817; ENSP00000393848; ENSG00000089327. [Q96DB9-1]
ENST00000541435; ENSP00000443390; ENSG00000089327. [Q96DB9-1]
ENST00000590686; ENSP00000465667; ENSG00000089327. [Q96DB9-1]
GeneIDi53827.
KEGGihsa:53827.
UCSCiuc002nyg.3. human. [Q96DB9-1]

Organism-specific databases

CTDi53827.
GeneCardsiFXYD5.
H-InvDBHIX0015022.
HGNCiHGNC:4029. FXYD5.
HPAiHPA010817.
MIMi606669. gene.
neXtProtiNX_Q96DB9.
PharmGKBiPA28445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCU8. Eukaryota.
ENOG4111E7R. LUCA.
GeneTreeiENSGT00410000026316.
HOGENOMiHOG000081775.
HOVERGENiHBG051678.
InParanoidiQ96DB9.
KOiK13362.
PhylomeDBiQ96DB9.
TreeFamiTF338182.

Miscellaneous databases

ChiTaRSiFXYD5. human.
GeneWikiiFXYD5.
GenomeRNAii53827.
PROiQ96DB9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96DB9.
CleanExiHS_FXYD5.
ExpressionAtlasiQ96DB9. baseline and differential.
GenevisibleiQ96DB9. HS.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP11/PLM/MAT8 family of transmembrane proteins."
    Omasa T., Chen Y.G., Mantalaris A., Wu J.H.D.
    Biochim. Biophys. Acta 1517:307-310(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT HIS-176.
    Tissue: Bone marrow.
  2. "Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis."
    Ino Y., Gotoh M., Sakamoto M., Tsukagoshi K., Hirohashi S.
    Proc. Natl. Acad. Sci. U.S.A. 99:365-370(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, GLYCOSYLATION, VARIANT HIS-176.
    Tissue: Leukocyte.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-176.
    Tissue: Umbilical cord blood.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-176.
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-176.
    Tissue: Pancreas.

Entry informationi

Entry nameiFXYD5_HUMAN
AccessioniPrimary (citable) accession number: Q96DB9
Secondary accession number(s): B7WNZ8
, Q6UW44, Q9HC34, Q9P039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 2, 2010
Last modified: June 8, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.