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Protein

FXYD domain-containing ion transport regulator 5

Gene

FXYD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • cadherin binding Source: UniProtKB
  • ion channel activity Source: InterPro
  • sodium channel regulator activity Source: GO_Central

GO - Biological processi

  • microvillus assembly Source: UniProtKB
  • negative regulation of calcium-dependent cell-cell adhesion Source: UniProtKB
  • regulation of sodium ion transmembrane transporter activity Source: GO_Central

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.27.3.1 the phospholemman (plm) family

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 5
Alternative name(s):
Dysadherin
Gene namesi
Name:FXYD5
Synonyms:DYSAD, IWU1
ORF Names:HSPC113, UNQ2561/PRO6241
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000089327.14
HGNCiHGNC:4029 FXYD5
MIMi606669 gene
neXtProtiNX_Q96DB9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 145ExtracellularSequence analysisAdd BLAST124
Transmembranei146 – 164HelicalSequence analysisAdd BLAST19
Topological domaini165 – 178CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53827
OpenTargetsiENSG00000089327
PharmGKBiPA28445

Polymorphism and mutation databases

BioMutaiFXYD5
DMDMi311033386

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001036922 – 178FXYD domain-containing ion transport regulator 5Add BLAST157

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96DB9
PaxDbiQ96DB9
PeptideAtlasiQ96DB9
PRIDEiQ96DB9
ProteomicsDBi76270
76271 [Q96DB9-2]

PTM databases

iPTMnetiQ96DB9
PhosphoSitePlusiQ96DB9

Expressioni

Gene expression databases

BgeeiENSG00000089327
CleanExiHS_FXYD5
ExpressionAtlasiQ96DB9 baseline and differential
GenevisibleiQ96DB9 HS

Organism-specific databases

HPAiHPA010817

Interactioni

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • cadherin binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ96DB9, 1 interactor
STRINGi9606.ENSP00000344254

Structurei

3D structure databases

ProteinModelPortaliQ96DB9
SMRiQ96DB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCU8 Eukaryota
ENOG4111E7R LUCA
GeneTreeiENSGT00410000026316
HOGENOMiHOG000081775
HOVERGENiHBG051678
InParanoidiQ96DB9
KOiK13362
PhylomeDBiQ96DB9
TreeFamiTF338182

Family and domain databases

InterProiView protein in InterPro
IPR000272 Ion-transport_regulator_FXYD
PfamiView protein in Pfam
PF02038 ATP1G1_PLM_MAT8, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005989 PD005989, 1 hit
PROSITEiView protein in PROSITE
PS01310 FXYD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPSGRLCLL TIVGLILPTR GQTLKDTTSS SSADSTIMDI QVPTRAPDAV
60 70 80 90 100
YTELQPTSPT PTWPADETPQ PQTQTQQLEG TDGPLVTDPE THKSTKAAHP
110 120 130 140 150
TDDTTTLSER PSPSTDVQTD PQTLKPSGFH EDDPFFYDEH TLRKRGLLVA
160 170
AVLFITGIII LTSGKCRQLS RLCRNRCR
Length:178
Mass (Da):19,472
Last modified:November 2, 2010 - v2
Checksum:i7429C04838B75AA1
GO
Isoform 2 (identifier: Q96DB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MSPSGRLCLL...DPETHKSTKA → MQTLSNIPCFCLHGSLLPSTDLATLS

Show »
Length:107
Mass (Da):11,888
Checksum:i121958DF3334315C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140 – 141HT → SH in AAF29077 (PubMed:11042152).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01234935S → A. Corresponds to variant dbSNP:rs1688005Ensembl.1
Natural variantiVAR_027959176R → H5 PublicationsCorresponds to variant dbSNP:rs12110Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0015841 – 97MSPSG…KSTKA → MQTLSNIPCFCLHGSLLPST DLATLS in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177940 mRNA Translation: AAG09301.1
AB072911 mRNA Translation: BAB83766.1
AF161462 mRNA Translation: AAF29077.1
AY358991 mRNA Translation: AAQ89350.1
BT007343 mRNA Translation: AAP36007.1
AC002390 Genomic DNA No translation available.
AC020907 Genomic DNA No translation available.
BC009642 mRNA Translation: AAH09642.1
CCDSiCCDS12447.1 [Q96DB9-1]
RefSeqiNP_001158077.1, NM_001164605.1 [Q96DB9-1]
NP_001307842.1, NM_001320913.1
NP_054883.3, NM_014164.5 [Q96DB9-1]
NP_659003.1, NM_144779.2 [Q96DB9-1]
UniGeneiHs.333418

Genome annotation databases

EnsembliENST00000342879; ENSP00000344254; ENSG00000089327 [Q96DB9-1]
ENST00000392217; ENSP00000376051; ENSG00000089327 [Q96DB9-2]
ENST00000392219; ENSP00000376053; ENSG00000089327 [Q96DB9-1]
ENST00000423817; ENSP00000393848; ENSG00000089327 [Q96DB9-1]
ENST00000541435; ENSP00000443390; ENSG00000089327 [Q96DB9-1]
ENST00000590686; ENSP00000465667; ENSG00000089327 [Q96DB9-1]
GeneIDi53827
KEGGihsa:53827
UCSCiuc002nyg.3 human [Q96DB9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFXYD5_HUMAN
AccessioniPrimary (citable) accession number: Q96DB9
Secondary accession number(s): B7WNZ8
, Q6UW44, Q9HC34, Q9P039
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 2, 2010
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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