Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone deacetylase 11

Gene

HDAC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.1 Publication

Miscellaneous

Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei143By similarity1

GO - Molecular functioni

  • histone deacetylase activity Source: UniProtKB
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • chromatin organization Source: UniProtKB
  • histone deacetylation Source: UniProtKB
  • oligodendrocyte development Source: Ensembl
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BRENDAi3.5.1.98 2681
ReactomeiR-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 11 (EC:3.5.1.98)
Short name:
HD11
Gene namesi
Name:HDAC11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163517.14
HGNCiHGNC:19086 HDAC11
MIMi607226 gene
neXtProtiNX_Q96DB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79885
OpenTargetsiENSG00000163517
PharmGKBiPA38793

Chemistry databases

ChEMBLiCHEMBL3310
DrugBankiDB05015 Belinostat
DB06603 Panobinostat
GuidetoPHARMACOLOGYi2615

Polymorphism and mutation databases

BioMutaiHDAC11
DMDMi26394832

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147151 – 347Histone deacetylase 11Add BLAST347

Proteomic databases

PaxDbiQ96DB2
PeptideAtlasiQ96DB2
PRIDEiQ96DB2

PTM databases

iPTMnetiQ96DB2
PhosphoSitePlusiQ96DB2

Expressioni

Tissue specificityi

Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.

Gene expression databases

BgeeiENSG00000163517
CleanExiHS_HDAC11
ExpressionAtlasiQ96DB2 baseline and differential
GenevisibleiQ96DB2 HS

Interactioni

Subunit structurei

Interacts with HDAC6.1 Publication

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122970, 147 interactors
IntActiQ96DB2, 130 interactors
MINTiQ96DB2
STRINGi9606.ENSP00000295757

Chemistry databases

BindingDBiQ96DB2

Structurei

3D structure databases

ProteinModelPortaliQ96DB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 326Histone deacetylaseAdd BLAST313

Sequence similaritiesi

Belongs to the histone deacetylase family.Curated

Phylogenomic databases

eggNOGiKOG1344 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00910000144047
HOGENOMiHOG000280018
HOVERGENiHBG051893
InParanoidiQ96DB2
KOiK11418
OMAiRVFTFSM
OrthoDBiEOG091G0EQP
PhylomeDBiQ96DB2
TreeFamiTF106176

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLHTTQLYQH VPETRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK
60 70 80 90 100
EEKLLSDSML VEAREASEED LLVVHTRRYL NELKWSFAVA TITEIPPVIF
110 120 130 140 150
LPNFLVQRKV LRPLRTQTGG TIMAGKLAVE RGWAINVGGG FHHCSSDRGG
160 170 180 190 200
GFCAYADITL AIKFLFERVE GISRATIIDL DAHQGNGHER DFMDDKRVYI
210 220 230 240 250
MDVYNRHIYP GDRFAKQAIR RKVELEWGTE DDEYLDKVER NIKKSLQEHL
260 270 280 290 300
PDVVVYNAGT DILEGDRLGG LSISPAGIVK RDELVFRMVR GRRVPILMVT
310 320 330 340
SGGYQKRTAR IIADSILNLF GLGLIGPESP SVSAQNSDTP LLPPAVP
Length:347
Mass (Da):39,183
Last modified:December 1, 2001 - v1
Checksum:i0D976CAF6EAC7A15
GO
Isoform 2 (identifier: Q96DB2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     85-107: Missing.

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):33,124
Checksum:i60C0E21BA00DF261
GO

Sequence cautioni

The sequence BAB15127 differs from that shown. Reason: Erroneous termination at position 107. Translated as Gln.Curated
The sequence CAB70712 differs from that shown. Reason: Frameshift at positions 177, 198 and 200.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15R → P in BAB15272 (PubMed:14702039).Curated1
Sequence conflicti113P → A in CAB70712 (PubMed:17974005).Curated1
Sequence conflicti212D → Y in CAB70712 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430821 – 28Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_04308385 – 107Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025426 mRNA Translation: BAB15127.1 Sequence problems.
AK025890 mRNA Translation: BAB15272.1
AK293223 mRNA Translation: BAG56762.1
AC027124 Genomic DNA No translation available.
BC009676 mRNA Translation: AAH09676.1
AL137362 mRNA Translation: CAB70712.1 Frameshift.
CCDSiCCDS2615.1 [Q96DB2-1]
CCDS46760.1 [Q96DB2-2]
RefSeqiNP_001129513.1, NM_001136041.2 [Q96DB2-2]
NP_079103.2, NM_024827.3 [Q96DB2-1]
XP_011532437.1, XM_011534135.1
UniGeneiHs.744132

Genome annotation databases

EnsembliENST00000295757; ENSP00000295757; ENSG00000163517 [Q96DB2-1]
ENST00000522202; ENSP00000429794; ENSG00000163517 [Q96DB2-2]
GeneIDi79885
KEGGihsa:79885
UCSCiuc003bxy.4 human [Q96DB2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHDA11_HUMAN
AccessioniPrimary (citable) accession number: Q96DB2
Secondary accession number(s): B4DDK1
, Q9H6I7, Q9H6X3, Q9NTC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health