Q96DA0 (ZG16B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zymogen granule protein 16 homolog B

Gene names

Name:	ZG16B
ORF Names:	UNQ773/PRO1567

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the jacalin lectin family.
Caution	It is uncertain whether Met-1, Met-13 or Met-31 is the initiator.
Sequence caution	The sequence AAQ89380.1 differs from that shown. Reason: Erroneous initiation. The sequence BAG34753.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Lectin
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 52

52

Potential

Chain

53 – 208

156

Zymogen granule protein 16 homolog B

PRO_0000248073

Regions

Compositional bias

38 – 46

9

Poly-Leu

Amino acid modifications

Glycosylation

197

1

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

133

1

M → V.
Corresponds to variant rs35533993 [ dbSNP | Ensembl ].

VAR_060067

Secondary structure

1

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208

Helix Strand Turn

Details...

Beta strand

56 – 58

3

Beta strand

61 – 65

5

Beta strand

74 – 81

8

Beta strand

83 – 97

15

Beta strand

106 – 112

7

Beta strand

119 – 137

19

Beta strand

142 – 146

5

Beta strand

150 – 155

6

Beta strand

163 – 172

10

Beta strand

175 – 184

10

Sequences

	Sequence		Length	Mass (Da)
	Q96DA0 [UniParc]. Last modified July 10, 2007. Version 3. Checksum: 313B0ED64B24CDB2	FASTA	208	22,739
	10 20 30 40 50 60 MGAQGAQESI KAMWRVPGTT RRPVTGESPG MHRPEAMLLL LTLALLGGPT WAGKMYGPGG 70 80 90 100 110 120 GKYFSTTEDY DHEITGLRVS VGLLLVKSVQ VKLGDSWDVK LGALGGNTQE VTLQPGEYIT 130 140 150 160 170 180 KVFVAFQAFL RGMVMYTSKD RYFYFGKLDG QISSAYPSQE GQVLVGIYGQ YQLLGIKSIG 190 200 FEWNYPLEEP TTEPPVNLTY SANSPVGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung carcinoma.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-208. Tissue: Trachea.
[6]	"Mass spectrometry allows direct identification of proteins in large genomes." Kuster B., Mortensen P., Andersen J.S., Mann M. Proteomics 1:641-650(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
[7]	"Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold." Kanagawa M., Satoh T., Ikeda A., Nakano Y., Yagi H., Kato K., Kojima-Aikawa K., Yamaguchi Y. Biochem. Biophys. Res. Commun. 404:201-205(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 53-208.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY359021 mRNA. Translation: AAQ89380.1. Different initiation.
AC005361 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85462.1.
BC009722 mRNA. Translation: AAH09722.2.
AK311810 mRNA. Translation: BAG34753.1. Different initiation.

IPI

IPI00060800.

RefSeq

NP_660295.2. NM_145252.2.

UniGene

Hs.105887.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3AQG	X-ray	2.75	A/B	53-208	[»]

ProteinModelPortal

Q96DA0.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q96DA0. 2 interactions.

MINT

MINT-2878507.

STRING

9606.ENSP00000371715.

PTM databases

PhosphoSite

Q96DA0.

Polymorphism databases

DMDM

152031723.

Proteomic databases

PaxDb

Q96DA0.

PRIDE

Q96DA0.

Protocols and materials databases

DNASU

124220.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000382280; ENSP00000371715; ENSG00000162078.
ENST00000572863; ENSP00000461740; ENSG00000162078.

GeneID

124220.

KEGG

hsa:124220.

UCSC

uc002cru.3. human.

Organism-specific databases

CTD

124220.

GeneCards

GC16P002881.

HGNC

HGNC:30456. ZG16B.

HPA

HPA041125.

neXtProt

NX_Q96DA0.

PharmGKB

PA164727732.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG73975.

HOGENOM

HOG000155786.

InParanoid

Q96DA0.

OMA

NYPLEEP.

OrthoDB

EOG4HQDKV.

Gene expression databases

ArrayExpress

Q96DA0.

Bgee

Q96DA0.

Genevestigator

Q96DA0.

GermOnline

ENSG00000162078. Homo sapiens.

Family and domain databases

Gene3D

2.100.10.30. 1 hit.

InterPro

IPR001229. Mannose-bd_lectin.
[Graphical view]

SMART

SM00915. Jacalin. 1 hit.
[Graphical view]

SUPFAM

SSF51101. Mannose-bd_lectin. 1 hit.

ProtoNet

Search...

Other

GenomeRNAi

124220.

NextBio

81240.

Entry information

Entry name

ZG16B_HUMAN

Accession

Primary (citable) accession number: Q96DA0
Secondary accession number(s): A6NIY1, B2R4F6, Q6UW28

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	July 10, 2007
Last modified:	May 1, 2013
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.