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Protein

Zymogen granule protein 16 homolog B

Gene

ZG16B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • retina homeostasis Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162078-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zymogen granule protein 16 homolog B
Gene namesi
Name:ZG16B
ORF Names:UNQ773/PRO1567
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30456. ZG16B.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi124220.
OpenTargetsiENSG00000162078.
ENSG00000283056.
PharmGKBiPA164727732.

Polymorphism and mutation databases

BioMutaiZG16B.
DMDMi152031723.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 52Sequence analysisAdd BLAST52
ChainiPRO_000024807353 – 208Zymogen granule protein 16 homolog BAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96DA0.
MaxQBiQ96DA0.
PaxDbiQ96DA0.
PeptideAtlasiQ96DA0.
PRIDEiQ96DA0.

PTM databases

iPTMnetiQ96DA0.
PhosphoSitePlusiQ96DA0.

Expressioni

Gene expression databases

BgeeiENSG00000162078.
ExpressionAtlasiQ96DA0. baseline and differential.
GenevisibleiQ96DA0. HS.

Organism-specific databases

HPAiHPA041125.
HPA053549.

Interactioni

Protein-protein interaction databases

BioGridi125855. 54 interactors.
IntActiQ96DA0. 2 interactors.
MINTiMINT-2878507.
STRINGi9606.ENSP00000371715.

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi56 – 58Combined sources3
Beta strandi61 – 65Combined sources5
Beta strandi74 – 81Combined sources8
Beta strandi83 – 97Combined sources15
Beta strandi106 – 112Combined sources7
Beta strandi119 – 137Combined sources19
Beta strandi142 – 146Combined sources5
Beta strandi150 – 155Combined sources6
Beta strandi163 – 172Combined sources10
Beta strandi175 – 184Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AQGX-ray2.75A/B53-208[»]
ProteinModelPortaliQ96DA0.
SMRiQ96DA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 185Jacalin-type lectinPROSITE-ProRule annotationAdd BLAST133

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 46Poly-Leu9

Sequence similaritiesi

Belongs to the jacalin lectin family.PROSITE-ProRule annotationCurated
Contains 1 jacalin-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVC. Eukaryota.
ENOG41115HP. LUCA.
GeneTreeiENSGT00530000063886.
HOGENOMiHOG000155786.
InParanoidiQ96DA0.
OMAiWNYPLEE.
OrthoDBiEOG091G0Y3H.
PhylomeDBiQ96DA0.
TreeFamiTF333440.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
[Graphical view]
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQGAQESI KAMWRVPGTT RRPVTGESPG MHRPEAMLLL LTLALLGGPT
60 70 80 90 100
WAGKMYGPGG GKYFSTTEDY DHEITGLRVS VGLLLVKSVQ VKLGDSWDVK
110 120 130 140 150
LGALGGNTQE VTLQPGEYIT KVFVAFQAFL RGMVMYTSKD RYFYFGKLDG
160 170 180 190 200
QISSAYPSQE GQVLVGIYGQ YQLLGIKSIG FEWNYPLEEP TTEPPVNLTY

SANSPVGR
Length:208
Mass (Da):22,739
Last modified:July 10, 2007 - v3
Checksum:i313B0ED64B24CDB2
GO

Sequence cautioni

The sequence AAQ89380 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG34753 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060067133M → V.Corresponds to variant rs35533993dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359021 mRNA. Translation: AAQ89380.1. Different initiation.
AC005361 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85462.1.
BC009722 mRNA. Translation: AAH09722.2.
AK311810 mRNA. Translation: BAG34753.1. Different initiation.
CCDSiCCDS10479.2.
RefSeqiNP_660295.2. NM_145252.2.
UniGeneiHs.105887.

Genome annotation databases

EnsembliENST00000382280; ENSP00000371715; ENSG00000162078.
ENST00000634500; ENSP00000489035; ENSG00000283056.
GeneIDi124220.
KEGGihsa:124220.
UCSCiuc002cru.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359021 mRNA. Translation: AAQ89380.1. Different initiation.
AC005361 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85462.1.
BC009722 mRNA. Translation: AAH09722.2.
AK311810 mRNA. Translation: BAG34753.1. Different initiation.
CCDSiCCDS10479.2.
RefSeqiNP_660295.2. NM_145252.2.
UniGeneiHs.105887.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AQGX-ray2.75A/B53-208[»]
ProteinModelPortaliQ96DA0.
SMRiQ96DA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125855. 54 interactors.
IntActiQ96DA0. 2 interactors.
MINTiMINT-2878507.
STRINGi9606.ENSP00000371715.

PTM databases

iPTMnetiQ96DA0.
PhosphoSitePlusiQ96DA0.

Polymorphism and mutation databases

BioMutaiZG16B.
DMDMi152031723.

Proteomic databases

EPDiQ96DA0.
MaxQBiQ96DA0.
PaxDbiQ96DA0.
PeptideAtlasiQ96DA0.
PRIDEiQ96DA0.

Protocols and materials databases

DNASUi124220.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382280; ENSP00000371715; ENSG00000162078.
ENST00000634500; ENSP00000489035; ENSG00000283056.
GeneIDi124220.
KEGGihsa:124220.
UCSCiuc002cru.4. human.

Organism-specific databases

CTDi124220.
DisGeNETi124220.
GeneCardsiZG16B.
HGNCiHGNC:30456. ZG16B.
HPAiHPA041125.
HPA053549.
neXtProtiNX_Q96DA0.
OpenTargetsiENSG00000162078.
ENSG00000283056.
PharmGKBiPA164727732.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCVC. Eukaryota.
ENOG41115HP. LUCA.
GeneTreeiENSGT00530000063886.
HOGENOMiHOG000155786.
InParanoidiQ96DA0.
OMAiWNYPLEE.
OrthoDBiEOG091G0Y3H.
PhylomeDBiQ96DA0.
TreeFamiTF333440.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162078-MONOMER.

Miscellaneous databases

GeneWikiiLOC124220.
GenomeRNAii124220.
PROiQ96DA0.

Gene expression databases

BgeeiENSG00000162078.
ExpressionAtlasiQ96DA0. baseline and differential.
GenevisibleiQ96DA0. HS.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Jacalin-like_lectin_dom.
[Graphical view]
PfamiPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.
PROSITEiPS51752. JACALIN_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZG16B_HUMAN
AccessioniPrimary (citable) accession number: Q96DA0
Secondary accession number(s): A6NIY1, B2R4F6, Q6UW28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-13 or Met-31 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.