Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96DA0

- ZG16B_HUMAN

UniProt

Q96DA0 - ZG16B_HUMAN

Protein

Zymogen granule protein 16 homolog B

Gene

ZG16B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (10 Jul 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. retina homeostasis Source: UniProt

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zymogen granule protein 16 homolog B
    Gene namesi
    Name:ZG16B
    ORF Names:UNQ773/PRO1567
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:30456. ZG16B.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164727732.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5252Sequence AnalysisAdd
    BLAST
    Chaini53 – 208156Zymogen granule protein 16 homolog BPRO_0000248073Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ96DA0.
    PaxDbiQ96DA0.
    PRIDEiQ96DA0.

    PTM databases

    PhosphoSiteiQ96DA0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96DA0.
    BgeeiQ96DA0.
    GenevestigatoriQ96DA0.

    Organism-specific databases

    HPAiHPA041125.
    HPA053549.

    Interactioni

    Protein-protein interaction databases

    BioGridi125855. 4 interactions.
    IntActiQ96DA0. 2 interactions.
    MINTiMINT-2878507.
    STRINGi9606.ENSP00000371715.

    Structurei

    Secondary structure

    1
    208
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi56 – 583
    Beta strandi61 – 655
    Beta strandi74 – 818
    Beta strandi83 – 9715
    Beta strandi106 – 1127
    Beta strandi119 – 13719
    Beta strandi142 – 1465
    Beta strandi150 – 1556
    Beta strandi163 – 17210
    Beta strandi175 – 18410

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AQGX-ray2.75A/B53-208[»]
    ProteinModelPortaliQ96DA0.
    SMRiQ96DA0. Positions 54-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi38 – 469Poly-Leu

    Sequence similaritiesi

    Belongs to the jacalin lectin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG73975.
    HOGENOMiHOG000155786.
    InParanoidiQ96DA0.
    OMAiWNYPLEE.
    OrthoDBiEOG73FQQ7.
    PhylomeDBiQ96DA0.
    TreeFamiTF333440.

    Family and domain databases

    Gene3Di2.100.10.30. 1 hit.
    InterProiIPR001229. Mannose-bd_lectin.
    [Graphical view]
    SMARTiSM00915. Jacalin. 1 hit.
    [Graphical view]
    SUPFAMiSSF51101. SSF51101. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96DA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAQGAQESI KAMWRVPGTT RRPVTGESPG MHRPEAMLLL LTLALLGGPT    50
    WAGKMYGPGG GKYFSTTEDY DHEITGLRVS VGLLLVKSVQ VKLGDSWDVK 100
    LGALGGNTQE VTLQPGEYIT KVFVAFQAFL RGMVMYTSKD RYFYFGKLDG 150
    QISSAYPSQE GQVLVGIYGQ YQLLGIKSIG FEWNYPLEEP TTEPPVNLTY 200
    SANSPVGR 208
    Length:208
    Mass (Da):22,739
    Last modified:July 10, 2007 - v3
    Checksum:i313B0ED64B24CDB2
    GO

    Sequence cautioni

    The sequence AAQ89380.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAG34753.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331M → V.
    Corresponds to variant rs35533993 [ dbSNP | Ensembl ].
    VAR_060067

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359021 mRNA. Translation: AAQ89380.1. Different initiation.
    AC005361 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85462.1.
    BC009722 mRNA. Translation: AAH09722.2.
    AK311810 mRNA. Translation: BAG34753.1. Different initiation.
    CCDSiCCDS10479.2.
    RefSeqiNP_660295.2. NM_145252.2.
    UniGeneiHs.105887.

    Genome annotation databases

    EnsembliENST00000382280; ENSP00000371715; ENSG00000162078.
    ENST00000572863; ENSP00000461740; ENSG00000162078.
    GeneIDi124220.
    KEGGihsa:124220.
    UCSCiuc002cru.3. human.

    Polymorphism databases

    DMDMi152031723.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359021 mRNA. Translation: AAQ89380.1 . Different initiation.
    AC005361 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85462.1 .
    BC009722 mRNA. Translation: AAH09722.2 .
    AK311810 mRNA. Translation: BAG34753.1 . Different initiation.
    CCDSi CCDS10479.2.
    RefSeqi NP_660295.2. NM_145252.2.
    UniGenei Hs.105887.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AQG X-ray 2.75 A/B 53-208 [» ]
    ProteinModelPortali Q96DA0.
    SMRi Q96DA0. Positions 54-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125855. 4 interactions.
    IntActi Q96DA0. 2 interactions.
    MINTi MINT-2878507.
    STRINGi 9606.ENSP00000371715.

    PTM databases

    PhosphoSitei Q96DA0.

    Polymorphism databases

    DMDMi 152031723.

    Proteomic databases

    MaxQBi Q96DA0.
    PaxDbi Q96DA0.
    PRIDEi Q96DA0.

    Protocols and materials databases

    DNASUi 124220.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382280 ; ENSP00000371715 ; ENSG00000162078 .
    ENST00000572863 ; ENSP00000461740 ; ENSG00000162078 .
    GeneIDi 124220.
    KEGGi hsa:124220.
    UCSCi uc002cru.3. human.

    Organism-specific databases

    CTDi 124220.
    GeneCardsi GC16P002881.
    HGNCi HGNC:30456. ZG16B.
    HPAi HPA041125.
    HPA053549.
    neXtProti NX_Q96DA0.
    PharmGKBi PA164727732.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73975.
    HOGENOMi HOG000155786.
    InParanoidi Q96DA0.
    OMAi WNYPLEE.
    OrthoDBi EOG73FQQ7.
    PhylomeDBi Q96DA0.
    TreeFami TF333440.

    Miscellaneous databases

    GeneWikii LOC124220.
    GenomeRNAii 124220.
    NextBioi 81240.
    PROi Q96DA0.

    Gene expression databases

    ArrayExpressi Q96DA0.
    Bgeei Q96DA0.
    Genevestigatori Q96DA0.

    Family and domain databases

    Gene3Di 2.100.10.30. 1 hit.
    InterProi IPR001229. Mannose-bd_lectin.
    [Graphical view ]
    SMARTi SM00915. Jacalin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51101. SSF51101. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung carcinoma.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-208.
      Tissue: Trachea.
    6. "Mass spectrometry allows direct identification of proteins in large genomes."
      Kuster B., Mortensen P., Andersen J.S., Mann M.
      Proteomics 1:641-650(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold."
      Kanagawa M., Satoh T., Ikeda A., Nakano Y., Yagi H., Kato K., Kojima-Aikawa K., Yamaguchi Y.
      Biochem. Biophys. Res. Commun. 404:201-205(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 53-208.

    Entry informationi

    Entry nameiZG16B_HUMAN
    AccessioniPrimary (citable) accession number: Q96DA0
    Secondary accession number(s): A6NIY1, B2R4F6, Q6UW28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1, Met-13 or Met-31 is the initiator.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3