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Q96DA0

- ZG16B_HUMAN

UniProt

Q96DA0 - ZG16B_HUMAN

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Protein

Zymogen granule protein 16 homolog B

Gene

ZG16B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. retina homeostasis Source: UniProt
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Zymogen granule protein 16 homolog B
Gene namesi
Name:ZG16B
ORF Names:UNQ773/PRO1567
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:30456. ZG16B.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5252Sequence AnalysisAdd
BLAST
Chaini53 – 208156Zymogen granule protein 16 homolog BPRO_0000248073Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96DA0.
PaxDbiQ96DA0.
PRIDEiQ96DA0.

PTM databases

PhosphoSiteiQ96DA0.

Expressioni

Gene expression databases

BgeeiQ96DA0.
ExpressionAtlasiQ96DA0. baseline and differential.
GenevestigatoriQ96DA0.

Organism-specific databases

HPAiHPA041125.
HPA053549.

Interactioni

Protein-protein interaction databases

BioGridi125855. 29 interactions.
IntActiQ96DA0. 2 interactions.
MINTiMINT-2878507.
STRINGi9606.ENSP00000371715.

Structurei

Secondary structure

1
208
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi56 – 583
Beta strandi61 – 655
Beta strandi74 – 818
Beta strandi83 – 9715
Beta strandi106 – 1127
Beta strandi119 – 13719
Beta strandi142 – 1465
Beta strandi150 – 1556
Beta strandi163 – 17210
Beta strandi175 – 18410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AQGX-ray2.75A/B53-208[»]
ProteinModelPortaliQ96DA0.
SMRiQ96DA0. Positions 54-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 469Poly-Leu

Sequence similaritiesi

Belongs to the jacalin lectin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG73975.
GeneTreeiENSGT00530000063886.
HOGENOMiHOG000155786.
InParanoidiQ96DA0.
OMAiWNYPLEE.
OrthoDBiEOG73FQQ7.
PhylomeDBiQ96DA0.
TreeFamiTF333440.

Family and domain databases

Gene3Di2.100.10.30. 1 hit.
InterProiIPR001229. Mannose-bd_lectin.
[Graphical view]
SMARTiSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMiSSF51101. SSF51101. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAQGAQESI KAMWRVPGTT RRPVTGESPG MHRPEAMLLL LTLALLGGPT
60 70 80 90 100
WAGKMYGPGG GKYFSTTEDY DHEITGLRVS VGLLLVKSVQ VKLGDSWDVK
110 120 130 140 150
LGALGGNTQE VTLQPGEYIT KVFVAFQAFL RGMVMYTSKD RYFYFGKLDG
160 170 180 190 200
QISSAYPSQE GQVLVGIYGQ YQLLGIKSIG FEWNYPLEEP TTEPPVNLTY

SANSPVGR
Length:208
Mass (Da):22,739
Last modified:July 10, 2007 - v3
Checksum:i313B0ED64B24CDB2
GO

Sequence cautioni

The sequence AAQ89380.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAG34753.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331M → V.
Corresponds to variant rs35533993 [ dbSNP | Ensembl ].
VAR_060067

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY359021 mRNA. Translation: AAQ89380.1. Different initiation.
AC005361 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85462.1.
BC009722 mRNA. Translation: AAH09722.2.
AK311810 mRNA. Translation: BAG34753.1. Different initiation.
CCDSiCCDS10479.2.
RefSeqiNP_660295.2. NM_145252.2.
UniGeneiHs.105887.

Genome annotation databases

EnsembliENST00000382280; ENSP00000371715; ENSG00000162078.
ENST00000572863; ENSP00000461740; ENSG00000162078.
GeneIDi124220.
KEGGihsa:124220.
UCSCiuc002cru.3. human.

Polymorphism databases

DMDMi152031723.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY359021 mRNA. Translation: AAQ89380.1 . Different initiation.
AC005361 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85462.1 .
BC009722 mRNA. Translation: AAH09722.2 .
AK311810 mRNA. Translation: BAG34753.1 . Different initiation.
CCDSi CCDS10479.2.
RefSeqi NP_660295.2. NM_145252.2.
UniGenei Hs.105887.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3AQG X-ray 2.75 A/B 53-208 [» ]
ProteinModelPortali Q96DA0.
SMRi Q96DA0. Positions 54-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125855. 29 interactions.
IntActi Q96DA0. 2 interactions.
MINTi MINT-2878507.
STRINGi 9606.ENSP00000371715.

PTM databases

PhosphoSitei Q96DA0.

Polymorphism databases

DMDMi 152031723.

Proteomic databases

MaxQBi Q96DA0.
PaxDbi Q96DA0.
PRIDEi Q96DA0.

Protocols and materials databases

DNASUi 124220.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382280 ; ENSP00000371715 ; ENSG00000162078 .
ENST00000572863 ; ENSP00000461740 ; ENSG00000162078 .
GeneIDi 124220.
KEGGi hsa:124220.
UCSCi uc002cru.3. human.

Organism-specific databases

CTDi 124220.
GeneCardsi GC16P002881.
HGNCi HGNC:30456. ZG16B.
HPAi HPA041125.
HPA053549.
neXtProti NX_Q96DA0.
PharmGKBi PA164727732.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73975.
GeneTreei ENSGT00530000063886.
HOGENOMi HOG000155786.
InParanoidi Q96DA0.
OMAi WNYPLEE.
OrthoDBi EOG73FQQ7.
PhylomeDBi Q96DA0.
TreeFami TF333440.

Miscellaneous databases

GeneWikii LOC124220.
GenomeRNAii 124220.
NextBioi 81240.
PROi Q96DA0.

Gene expression databases

Bgeei Q96DA0.
ExpressionAtlasi Q96DA0. baseline and differential.
Genevestigatori Q96DA0.

Family and domain databases

Gene3Di 2.100.10.30. 1 hit.
InterProi IPR001229. Mannose-bd_lectin.
[Graphical view ]
SMARTi SM00915. Jacalin. 1 hit.
[Graphical view ]
SUPFAMi SSF51101. SSF51101. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung carcinoma.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-208.
    Tissue: Trachea.
  6. "Mass spectrometry allows direct identification of proteins in large genomes."
    Kuster B., Mortensen P., Andersen J.S., Mann M.
    Proteomics 1:641-650(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold."
    Kanagawa M., Satoh T., Ikeda A., Nakano Y., Yagi H., Kato K., Kojima-Aikawa K., Yamaguchi Y.
    Biochem. Biophys. Res. Commun. 404:201-205(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 53-208.

Entry informationi

Entry nameiZG16B_HUMAN
AccessioniPrimary (citable) accession number: Q96DA0
Secondary accession number(s): A6NIY1, B2R4F6, Q6UW28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-13 or Met-31 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3