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Protein

EP300-interacting inhibitor of differentiation 2B

Gene

EID2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176401-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
EP300-interacting inhibitor of differentiation 2B
Short name:
EID-2B
Alternative name(s):
EID-2-like inhibitor of differentiation 3
Short name:
EID-3
Gene namesi
Name:EID2BImported
Synonyms:EID31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26796. EID2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176401.
PharmGKBiPA162384551.

Polymorphism and mutation databases

BioMutaiEID2B.
DMDMi74731428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003159031 – 161EP300-interacting inhibitor of differentiation 2BAdd BLAST161

Proteomic databases

PaxDbiQ96D98.
PeptideAtlasiQ96D98.
PRIDEiQ96D98.

Expressioni

Gene expression databases

BgeeiENSG00000176401.
CleanExiHS_EID2B.
HS_EID3.
GenevisibleiQ96D98. HS.

Organism-specific databases

HPAiHPA064185.

Interactioni

Subunit structurei

Homodimer and heterodimer with EID2. Interacts with HDAC1 and HDAC2.1 Publication

Protein-protein interaction databases

BioGridi125972. 5 interactors.
IntActiQ96D98. 5 interactors.
STRINGi9606.ENSP00000317564.

Structurei

3D structure databases

ProteinModelPortaliQ96D98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The C-terminal portion of EID2B is required for nuclear localization.1 Publication

Phylogenomic databases

eggNOGiENOG410KEN2. Eukaryota.
ENOG411199A. LUCA.
GeneTreeiENSGT00530000064390.
HOGENOMiHOG000054219.
InParanoidiQ96D98.
OMAiLFVEGCR.
OrthoDBiEOG091G0XPE.
PhylomeDBiQ96D98.
TreeFamiTF337633.

Family and domain databases

InterProiIPR033258. EID.
IPR033259. EID-3.
[Graphical view]
PANTHERiPTHR15556. PTHR15556. 1 hit.
PTHR15556:SF4. PTHR15556:SF4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96D98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPTGLLEM SELPGDSSVP QVGTASGVSD VLRGAVGGGV RVQEAREGPV
60 70 80 90 100
AEAARSMARM PGPVPGPIPS SVPGLASAPD PHQQLAFLEI NRQLLFREYL
110 120 130 140 150
DGSSMIPVRL LRDFEERRRL FVEGCKAREA AFDADPPQMD FAAVAFTVAL
160
TASEALSPLA D
Length:161
Mass (Da):16,985
Last modified:March 1, 2004 - v2
Checksum:iF378CD438AB12661
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096263 mRNA. Translation: BAC04743.1.
CH471126 Genomic DNA. Translation: EAW56908.1.
BC009725 mRNA. Translation: AAH09725.2.
CCDSiCCDS12539.1.
RefSeqiNP_689574.1. NM_152361.2.
UniGeneiHs.135181.

Genome annotation databases

EnsembliENST00000326282; ENSP00000317564; ENSG00000176401.
GeneIDi126272.
KEGGihsa:126272.
UCSCiuc002olz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096263 mRNA. Translation: BAC04743.1.
CH471126 Genomic DNA. Translation: EAW56908.1.
BC009725 mRNA. Translation: AAH09725.2.
CCDSiCCDS12539.1.
RefSeqiNP_689574.1. NM_152361.2.
UniGeneiHs.135181.

3D structure databases

ProteinModelPortaliQ96D98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125972. 5 interactors.
IntActiQ96D98. 5 interactors.
STRINGi9606.ENSP00000317564.

Polymorphism and mutation databases

BioMutaiEID2B.
DMDMi74731428.

Proteomic databases

PaxDbiQ96D98.
PeptideAtlasiQ96D98.
PRIDEiQ96D98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326282; ENSP00000317564; ENSG00000176401.
GeneIDi126272.
KEGGihsa:126272.
UCSCiuc002olz.1. human.

Organism-specific databases

CTDi126272.
GeneCardsiEID2B.
HGNCiHGNC:26796. EID2B.
HPAiHPA064185.
neXtProtiNX_Q96D98.
OpenTargetsiENSG00000176401.
PharmGKBiPA162384551.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KEN2. Eukaryota.
ENOG411199A. LUCA.
GeneTreeiENSGT00530000064390.
HOGENOMiHOG000054219.
InParanoidiQ96D98.
OMAiLFVEGCR.
OrthoDBiEOG091G0XPE.
PhylomeDBiQ96D98.
TreeFamiTF337633.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176401-MONOMER.

Miscellaneous databases

GenomeRNAii126272.
PROiQ96D98.

Gene expression databases

BgeeiENSG00000176401.
CleanExiHS_EID2B.
HS_EID3.
GenevisibleiQ96D98. HS.

Family and domain databases

InterProiIPR033258. EID.
IPR033259. EID-3.
[Graphical view]
PANTHERiPTHR15556. PTHR15556. 1 hit.
PTHR15556:SF4. PTHR15556:SF4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEID2B_HUMAN
AccessioniPrimary (citable) accession number: Q96D98
Secondary accession number(s): Q8N8S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.