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Q96D96

- HVCN1_HUMAN

UniProt

Q96D96 - HVCN1_HUMAN

Protein

Voltage-gated hydrogen channel 1

Gene

HVCN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.3 Publications

    Enzyme regulationi

    The dimers display cooperative channel gating By similarity. The channel activity is inhibited by zinc ions.By similarity2 Publications

    GO - Molecular functioni

    1. voltage-gated cation channel activity Source: Reactome
    2. voltage-gated proton channel activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to pH Source: UniProtKB
    2. cellular response to zinc ion Source: UniProtKB
    3. multicellular organism reproduction Source: Reactome
    4. proton transport Source: UniProtKB
    5. response to pH Source: HGNC
    6. response to zinc ion Source: HGNC
    7. single fertilization Source: Reactome
    8. sperm-egg recognition Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_163875. Sperm Motility And Taxes.

    Protein family/group databases

    TCDBi1.A.51.1.2. the voltage-gated proton channel (vpc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-gated hydrogen channel 1
    Alternative name(s):
    Hydrogen voltage-gated channel 1
    Short name:
    HV1
    Voltage sensor domain-only protein
    Gene namesi
    Name:HVCN1
    Synonyms:VSOP
    ORF Names:UNQ578/PRO1140
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:28240. HVCN1.

    Subcellular locationi

    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
    Note: Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.

    GO - Cellular componenti

    1. integral component of membrane Source: HGNC
    2. integral component of plasma membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi29 – 291T → A: Loss of a phosphorylation site. Reduces phosphorylation. 1 Publication
    Mutagenesisi97 – 971S → A: Loss of a phosphorylation site. Strongly reduces phosphorylation. 1 Publication
    Mutagenesisi112 – 1121D → A, F, N or S: Alters channel selectivity. Converts the proton channel to an anion channel. 1 Publication
    Mutagenesisi112 – 1121D → E: No effect on channel activity and proton selectivity. 1 Publication
    Mutagenesisi112 – 1121D → V: Abolishes channel activity. 1 Publication
    Mutagenesisi140 – 1401H → A: Exhibits selectivity to protons but sensitivity to zinc ions is abolished; when associated with A-193. 2 Publications
    Mutagenesisi193 – 1931H → A: Exhibits selectivity to protons but sensitivity to zinc ions is abolished; when associated with A-140. 2 Publications
    Mutagenesisi205 – 2051R → A: Faster channel activation and deactivation kinetics. 1 Publication
    Mutagenesisi208 – 2081R → A: Faster channel activation and deactivation kinetics. 1 Publication
    Mutagenesisi211 – 2111R → A: Faster channel deactivation kinetics. 1 Publication

    Organism-specific databases

    PharmGKBiPA144596422.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Voltage-gated hydrogen channel 1PRO_0000342187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei29 – 291Phosphothreonine1 Publication
    Modified residuei97 – 971Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation may enhance channel gating.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96D96.
    PaxDbiQ96D96.
    PRIDEiQ96D96.

    PTM databases

    PhosphoSiteiQ96D96.

    Expressioni

    Tissue specificityi

    Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ96D96.
    BgeeiQ96D96.
    CleanExiHS_HVCN1.
    GenevestigatoriQ96D96.

    Organism-specific databases

    HPAiHPA039329.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi124053. 1 interaction.
    DIPiDIP-46112N.
    MINTiMINT-4724965.
    STRINGi9606.ENSP00000349181.

    Structurei

    Secondary structure

    1
    273
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi227 – 26539

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3A2AX-ray2.00A/B/C/D221-273[»]
    ProteinModelPortaliQ96D96.
    SMRiQ96D96. Positions 88-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 100100CytoplasmicBy similarityAdd
    BLAST
    Topological domaini122 – 13817ExtracellularBy similarityAdd
    BLAST
    Topological domaini162 – 1698CytoplasmicBy similarity
    Topological domaini191 – 1977ExtracellularBy similarity
    Topological domaini219 – 27355CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei101 – 12121Helical; Name=Segment S1By similarityAdd
    BLAST
    Transmembranei139 – 16123Helical; Name=Segment S2By similarityAdd
    BLAST
    Transmembranei170 – 19021Helical; Name=Segment S3By similarityAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=Segment S4By similarityAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili223 – 266441 PublicationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi46 – 5510Poly-Glu
    Compositional biasi176 – 1805Poly-Val

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain.1 Publication
    The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is essential for normal subcellular localization.1 Publication

    Sequence similaritiesi

    Belongs to the hydrogen channel family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46709.
    HOGENOMiHOG000067871.
    HOVERGENiHBG102207.
    InParanoidiQ96D96.
    OMAiEFSCSEK.
    OrthoDBiEOG789CDV.
    PhylomeDBiQ96D96.
    TreeFamiTF332056.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    [Graphical view]
    PfamiPF00520. Ion_trans. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96D96-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATWDEKAVT RRAKVAPAER MSKFLRHFTV VGDDYHAWNI NYKKWENEEE    50
    EEEEEQPPPT PVSGEEGRAA APDVAPAPGP APRAPLDFRG MLRKLFSSHR 100
    FQVIIICLVV LDALLVLAEL ILDLKIIQPD KNNYAAMVFH YMSITILVFF 150
    MMEIIFKLFV FRLEFFHHKF EILDAVVVVV SFILDIVLLF QEHQFEALGL 200
    LILLRLWRVA RIINGIIISV KTRSERQLLR LKQMNVQLAA KIQHLEFSCS 250
    EKEQEIERLN KLLRQHGLLG EVN 273
    Length:273
    Mass (Da):31,683
    Last modified:December 1, 2001 - v1
    Checksum:i0F93B428AECBBC4F
    GO
    Isoform 2 (identifier: Q96D96-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         66-102: Missing.

    Show »
    Length:236
    Mass (Da):27,713
    Checksum:i1AD13F7D49A62C4D
    GO
    Isoform 3 (identifier: Q96D96-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         253-273: EQEIERLNKLLRQHGLLGEVN → PLD

    Note: No experimental confirmation available.

    Show »
    Length:255
    Mass (Da):29,538
    Checksum:i092B095DD219550A
    GO
    Isoform 4 (identifier: Q96D96-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:253
    Mass (Da):29,415
    Checksum:iF1349C26BCC164F1
    GO

    Sequence cautioni

    The sequence AAQ89413.1 differs from that shown. Reason: Frameshift at positions 164 and 175.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti165 – 1651F → Y in BAG57024. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2020Missing in isoform 4. 1 PublicationVSP_045052Add
    BLAST
    Alternative sequencei66 – 10237Missing in isoform 2. 1 PublicationVSP_034395Add
    BLAST
    Alternative sequencei253 – 27321EQEIE…LGEVN → PLD in isoform 3. 1 PublicationVSP_034396Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359054 mRNA. Translation: AAQ89413.1. Frameshift.
    AK293543 mRNA. Translation: BAG57024.1.
    AC144522 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97935.1.
    CH471054 Genomic DNA. Translation: EAW97936.1.
    BC007277 mRNA. Translation: AAH07277.1.
    BC009731 mRNA. Translation: AAH09731.1.
    BC032672 mRNA. Translation: AAH32672.1.
    CCDSiCCDS31900.1. [Q96D96-1]
    CCDS58278.1. [Q96D96-4]
    RefSeqiNP_001035196.1. NM_001040107.1. [Q96D96-1]
    NP_001243342.1. NM_001256413.1. [Q96D96-4]
    NP_115745.2. NM_032369.3. [Q96D96-1]
    XP_005254005.1. XM_005253948.1. [Q96D96-1]
    XP_005254006.1. XM_005253949.1. [Q96D96-2]
    XP_006719703.1. XM_006719640.1. [Q96D96-1]
    UniGeneiHs.211511.
    Hs.334637.

    Genome annotation databases

    EnsembliENST00000242607; ENSP00000242607; ENSG00000122986. [Q96D96-1]
    ENST00000356742; ENSP00000349181; ENSG00000122986. [Q96D96-1]
    ENST00000439744; ENSP00000412052; ENSG00000122986. [Q96D96-4]
    ENST00000548312; ENSP00000449601; ENSG00000122986. [Q96D96-3]
    GeneIDi84329.
    KEGGihsa:84329.
    UCSCiuc001trq.1. human. [Q96D96-3]
    uc001trs.2. human. [Q96D96-1]

    Polymorphism databases

    DMDMi74751810.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY359054 mRNA. Translation: AAQ89413.1 . Frameshift.
    AK293543 mRNA. Translation: BAG57024.1 .
    AC144522 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97935.1 .
    CH471054 Genomic DNA. Translation: EAW97936.1 .
    BC007277 mRNA. Translation: AAH07277.1 .
    BC009731 mRNA. Translation: AAH09731.1 .
    BC032672 mRNA. Translation: AAH32672.1 .
    CCDSi CCDS31900.1. [Q96D96-1 ]
    CCDS58278.1. [Q96D96-4 ]
    RefSeqi NP_001035196.1. NM_001040107.1. [Q96D96-1 ]
    NP_001243342.1. NM_001256413.1. [Q96D96-4 ]
    NP_115745.2. NM_032369.3. [Q96D96-1 ]
    XP_005254005.1. XM_005253948.1. [Q96D96-1 ]
    XP_005254006.1. XM_005253949.1. [Q96D96-2 ]
    XP_006719703.1. XM_006719640.1. [Q96D96-1 ]
    UniGenei Hs.211511.
    Hs.334637.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3A2A X-ray 2.00 A/B/C/D 221-273 [» ]
    ProteinModelPortali Q96D96.
    SMRi Q96D96. Positions 88-266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124053. 1 interaction.
    DIPi DIP-46112N.
    MINTi MINT-4724965.
    STRINGi 9606.ENSP00000349181.

    Chemistry

    GuidetoPHARMACOLOGYi 746.

    Protein family/group databases

    TCDBi 1.A.51.1.2. the voltage-gated proton channel (vpc) family.

    PTM databases

    PhosphoSitei Q96D96.

    Polymorphism databases

    DMDMi 74751810.

    Proteomic databases

    MaxQBi Q96D96.
    PaxDbi Q96D96.
    PRIDEi Q96D96.

    Protocols and materials databases

    DNASUi 84329.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000242607 ; ENSP00000242607 ; ENSG00000122986 . [Q96D96-1 ]
    ENST00000356742 ; ENSP00000349181 ; ENSG00000122986 . [Q96D96-1 ]
    ENST00000439744 ; ENSP00000412052 ; ENSG00000122986 . [Q96D96-4 ]
    ENST00000548312 ; ENSP00000449601 ; ENSG00000122986 . [Q96D96-3 ]
    GeneIDi 84329.
    KEGGi hsa:84329.
    UCSCi uc001trq.1. human. [Q96D96-3 ]
    uc001trs.2. human. [Q96D96-1 ]

    Organism-specific databases

    CTDi 84329.
    GeneCardsi GC12M111086.
    H-InvDB HIX0011039.
    HGNCi HGNC:28240. HVCN1.
    HPAi HPA039329.
    MIMi 611227. gene.
    neXtProti NX_Q96D96.
    PharmGKBi PA144596422.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46709.
    HOGENOMi HOG000067871.
    HOVERGENi HBG102207.
    InParanoidi Q96D96.
    OMAi EFSCSEK.
    OrthoDBi EOG789CDV.
    PhylomeDBi Q96D96.
    TreeFami TF332056.

    Enzyme and pathway databases

    Reactomei REACT_163875. Sperm Motility And Taxes.

    Miscellaneous databases

    ChiTaRSi HVCN1. human.
    GeneWikii HVCN1.
    GenomeRNAii 84329.
    NextBioi 74079.
    PROi Q96D96.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96D96.
    Bgeei Q96D96.
    CleanExi HS_HVCN1.
    Genevestigatori Q96D96.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    [Graphical view ]
    Pfami PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Cerebellum.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye, Lung and Testis.
    6. "A voltage-gated proton-selective channel lacking the pore domain."
      Ramsey I.S., Moran M.M., Chong J.A., Clapham D.E.
      Nature 440:1213-1216(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ENZYME REGULATION, MUTAGENESIS OF HIS-140; HIS-193; ARG-205; ARG-208 AND ARG-211.
    7. "Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes."
      Musset B., Capasso M., Cherny V.V., Morgan D., Bhamrah M., Dyer M.J., DeCoursey T.E.
      J. Biol. Chem. 285:5117-5121(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-29 AND SER-97, MUTAGENESIS OF THR-29 AND SER-97, FUNCTION, SUBCELLULAR LOCATION.
    8. "Aspartate 112 is the selectivity filter of the human voltage-gated proton channel."
      Musset B., Smith S.M., Rajan S., Morgan D., Cherny V.V., Decoursey T.E.
      Nature 480:273-277(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF ASP-112; HIS-140 AND HIS-193, SUBCELLULAR LOCATION, ENZYME REGULATION.
    9. "The role and structure of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1."
      Li S.J., Zhao Q., Zhou Q., Unno H., Zhai Y., Sun F.
      J. Biol. Chem. 285:12047-12054(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 221-273, SUBUNIT, SUBCELLULAR LOCATION, COILED COIL, DOMAIN.

    Entry informationi

    Entry nameiHVCN1_HUMAN
    AccessioniPrimary (citable) accession number: Q96D96
    Secondary accession number(s): A8MQ37
    , B4DEB3, F8WCH5, Q6UW11, Q96IS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3