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Protein

R3H domain-containing protein 4

Gene

R3HDM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
R3H domain-containing protein 4
Gene namesi
Name:R3HDM4
Synonyms:C19orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28270. R3HDM4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198858.
PharmGKBiPA134902004.

Polymorphism and mutation databases

BioMutaiR3HDM4.
DMDMi74731421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002814311 – 268R3H domain-containing protein 4Add BLAST268

Proteomic databases

EPDiQ96D70.
MaxQBiQ96D70.
PaxDbiQ96D70.
PeptideAtlasiQ96D70.
PRIDEiQ96D70.

PTM databases

iPTMnetiQ96D70.
PhosphoSitePlusiQ96D70.

Expressioni

Gene expression databases

BgeeiENSG00000198858.
CleanExiHS_C19orf22.
ExpressionAtlasiQ96D70. baseline and differential.
GenevisibleiQ96D70. HS.

Organism-specific databases

HPAiHPA043025.
HPA048638.

Interactioni

Protein-protein interaction databases

BioGridi124813. 1 interactor.
STRINGi9606.ENSP00000355385.

Structurei

3D structure databases

ProteinModelPortaliQ96D70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 250R3HPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 184Arg-richAdd BLAST53

Phylogenomic databases

eggNOGiENOG410IG7B. Eukaryota.
ENOG41125BG. LUCA.
GeneTreeiENSGT00390000015467.
HOGENOMiHOG000054211.
HOVERGENiHBG068057.
InParanoidiQ96D70.
OMAiACSNATY.
OrthoDBiEOG091G0T8D.
PhylomeDBiQ96D70.
TreeFamiTF331754.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
InterProiView protein in InterPro
IPR025952. R3H-assoc_dom.
IPR001374. R3H_dom.
PfamiView protein in Pfam
PF01424. R3H. 1 hit.
PF13902. R3H-assoc. 1 hit.
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiView protein in PROSITE
PS51061. R3H. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96D70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALENPECG PEAAEGTPGG RRLLPLPSCL PALASSQVKR LSASRRKQHF
60 70 80 90 100
INQAVRNSDL VPKAKGRKSL QRLENTQYLL TLLETDGGLP GLEDGDLAPP
110 120 130 140 150
ASPGIFAEAC NNATYVEVWN DFMNRSGEEQ ERVLRYLEDE GRSKARRRGP
160 170 180 190 200
GRGEDRRRED PAYTPRECFQ RISRRLRAVL KRSRIPMETL ETWEERLLRF
210 220 230 240 250
FSVSPQAVYT AMLDNSFERL LLHAVCQYMD LISASADLEG KRQMKVSNRH
260
LDFLPPGLLL SAYLEQHS
Length:268
Mass (Da):30,350
Last modified:November 23, 2004 - v3
Checksum:i3F30748230911130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012775 mRNA. No translation available.
CCDSiCCDS12048.1.
RefSeqiNP_620129.2. NM_138774.3.
UniGeneiHs.557655.

Genome annotation databases

EnsembliENST00000361574; ENSP00000355385; ENSG00000198858.
GeneIDi91300.
KEGGihsa:91300.
UCSCiuc002lqg.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiR3HD4_HUMAN
AccessioniPrimary (citable) accession number: Q96D70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 23, 2004
Last modified: July 5, 2017
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM