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Protein

Probable E3 ubiquitin-protein ligase RNF183

Gene

RNF183

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 60RING-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: UniProtKB

GO - Biological processi

  • protein polyubiquitination Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase RNF183 (EC:2.3.2.27)
Gene namesi
Name:RNF183
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165188.13.
HGNCiHGNC:28721. RNF183.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi13C → A: Abolishes autoubiquitination; when associated with A-59. 1 Publication1
Mutagenesisi59C → A: Abolishes autoubiquitination; when associated with A-13. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000165188.
PharmGKBiPA142671055.

Polymorphism and mutation databases

BioMutaiRNF183.
DMDMi74760778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002473581 – 192Probable E3 ubiquitin-protein ligase RNF183Add BLAST192

Post-translational modificationi

Autoubiquitinated (in vitro).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ96D59.
PRIDEiQ96D59.

Expressioni

Gene expression databases

BgeeiENSG00000165188.
CleanExiHS_RNF183.
ExpressionAtlasiQ96D59. baseline and differential.
GenevisibleiQ96D59. HS.

Organism-specific databases

HPAiHPA057675.

Interactioni

Subunit structurei

Interacts with FATE1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126500. 9 interactors.
IntActiQ96D59. 8 interactors.
MINTiMINT-1474323.

Structurei

3D structure databases

ProteinModelPortaliQ96D59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 60RING-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITEM. Eukaryota.
ENOG4111Y1I. LUCA.
GeneTreeiENSGT00530000063798.
HOGENOMiHOG000082461.
HOVERGENiHBG093908.
InParanoidiQ96D59.
OMAiCWNPFNN.
OrthoDBiEOG091G0Q9E.
PhylomeDBiQ96D59.
TreeFamiTF337102.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96D59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQQGRELE AECPVCWNPF NNTFHTPKML DCCHSFCVEC LAHLSLVTPA
60 70 80 90 100
RRRLLCPLCR QPTVLASGQP VTDLPTDTAM LALLRLEPHH VILEGHQLCL
110 120 130 140 150
KDQPKSRYFL RQPQVYTLDL GPQPGGQTGP PPDTASATVS TPILIPSHHS
160 170 180 190
LRECFRNPQF RIFAYLMAVI LSVTLLLIFS IFWTKQFLWG VG
Length:192
Mass (Da):21,617
Last modified:April 16, 2014 - v2
Checksum:i51D5B5272DFC9540
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02709582A → T1 PublicationCorresponds to variant dbSNP:rs3750533Ensembl.1
Natural variantiVAR_027096114Q → R1 PublicationCorresponds to variant dbSNP:rs3750534Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL449305 Genomic DNA. No translation available.
BC013036 mRNA. Translation: AAH13036.1.
CCDSiCCDS43866.1.
RefSeqiNP_659488.2. NM_145051.3.
XP_006717015.1. XM_006716952.2.
XP_011516520.1. XM_011518218.1.
XP_011516521.1. XM_011518219.1.
XP_011516522.1. XM_011518220.1.
XP_016869757.1. XM_017014268.1.
UniGeneiHs.729641.

Genome annotation databases

EnsembliENST00000297894; ENSP00000417943; ENSG00000165188.
ENST00000416588; ENSP00000420740; ENSG00000165188.
ENST00000441031; ENSP00000417176; ENSG00000165188.
ENST00000478815; ENSP00000419454; ENSG00000165188.
GeneIDi138065.
KEGGihsa:138065.
UCSCiuc004bgz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRN183_HUMAN
AccessioniPrimary (citable) accession number: Q96D59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 16, 2014
Last modified: September 27, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways