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Protein

RING finger protein 183

Gene

RNF183

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 60RING-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 183
Gene namesi
Name:RNF183
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28721. RNF183.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165188.
PharmGKBiPA142671055.

Polymorphism and mutation databases

BioMutaiRNF183.
DMDMi74760778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002473581 – 192RING finger protein 183Add BLAST192

Proteomic databases

PaxDbiQ96D59.
PRIDEiQ96D59.

Expressioni

Gene expression databases

BgeeiENSG00000165188.
CleanExiHS_RNF183.
ExpressionAtlasiQ96D59. baseline and differential.
GenevisibleiQ96D59. HS.

Organism-specific databases

HPAiHPA057675.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126500. 9 interactors.
IntActiQ96D59. 7 interactors.
MINTiMINT-1474323.
STRINGi9606.ENSP00000417176.

Structurei

3D structure databases

ProteinModelPortaliQ96D59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 60RING-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITEM. Eukaryota.
ENOG4111Y1I. LUCA.
GeneTreeiENSGT00530000063798.
HOGENOMiHOG000082461.
HOVERGENiHBG093908.
InParanoidiQ96D59.
OMAiKSRYFLR.
OrthoDBiEOG090A0DEB.
PhylomeDBiQ96D59.
TreeFamiTF337102.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96D59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQQGRELE AECPVCWNPF NNTFHTPKML DCCHSFCVEC LAHLSLVTPA
60 70 80 90 100
RRRLLCPLCR QPTVLASGQP VTDLPTDTAM LALLRLEPHH VILEGHQLCL
110 120 130 140 150
KDQPKSRYFL RQPQVYTLDL GPQPGGQTGP PPDTASATVS TPILIPSHHS
160 170 180 190
LRECFRNPQF RIFAYLMAVI LSVTLLLIFS IFWTKQFLWG VG
Length:192
Mass (Da):21,617
Last modified:April 16, 2014 - v2
Checksum:i51D5B5272DFC9540
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02709582A → T1 PublicationCorresponds to variant dbSNP:rs3750533Ensembl.1
Natural variantiVAR_027096114Q → R1 PublicationCorresponds to variant dbSNP:rs3750534Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL449305 Genomic DNA. No translation available.
BC013036 mRNA. Translation: AAH13036.1.
CCDSiCCDS43866.1.
RefSeqiNP_659488.2. NM_145051.3.
XP_006717015.1. XM_006716952.2.
XP_011516520.1. XM_011518218.1.
XP_011516521.1. XM_011518219.1.
XP_011516522.1. XM_011518220.1.
XP_016869757.1. XM_017014268.1.
UniGeneiHs.729641.

Genome annotation databases

EnsembliENST00000297894; ENSP00000417943; ENSG00000165188.
ENST00000416588; ENSP00000420740; ENSG00000165188.
ENST00000441031; ENSP00000417176; ENSG00000165188.
ENST00000478815; ENSP00000419454; ENSG00000165188.
GeneIDi138065.
KEGGihsa:138065.
UCSCiuc004bgz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL449305 Genomic DNA. No translation available.
BC013036 mRNA. Translation: AAH13036.1.
CCDSiCCDS43866.1.
RefSeqiNP_659488.2. NM_145051.3.
XP_006717015.1. XM_006716952.2.
XP_011516520.1. XM_011518218.1.
XP_011516521.1. XM_011518219.1.
XP_011516522.1. XM_011518220.1.
XP_016869757.1. XM_017014268.1.
UniGeneiHs.729641.

3D structure databases

ProteinModelPortaliQ96D59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126500. 9 interactors.
IntActiQ96D59. 7 interactors.
MINTiMINT-1474323.
STRINGi9606.ENSP00000417176.

Polymorphism and mutation databases

BioMutaiRNF183.
DMDMi74760778.

Proteomic databases

PaxDbiQ96D59.
PRIDEiQ96D59.

Protocols and materials databases

DNASUi138065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297894; ENSP00000417943; ENSG00000165188.
ENST00000416588; ENSP00000420740; ENSG00000165188.
ENST00000441031; ENSP00000417176; ENSG00000165188.
ENST00000478815; ENSP00000419454; ENSG00000165188.
GeneIDi138065.
KEGGihsa:138065.
UCSCiuc004bgz.4. human.

Organism-specific databases

CTDi138065.
GeneCardsiRNF183.
HGNCiHGNC:28721. RNF183.
HPAiHPA057675.
neXtProtiNX_Q96D59.
OpenTargetsiENSG00000165188.
PharmGKBiPA142671055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITEM. Eukaryota.
ENOG4111Y1I. LUCA.
GeneTreeiENSGT00530000063798.
HOGENOMiHOG000082461.
HOVERGENiHBG093908.
InParanoidiQ96D59.
OMAiKSRYFLR.
OrthoDBiEOG090A0DEB.
PhylomeDBiQ96D59.
TreeFamiTF337102.

Miscellaneous databases

GenomeRNAii138065.
PROiQ96D59.

Gene expression databases

BgeeiENSG00000165188.
CleanExiHS_RNF183.
ExpressionAtlasiQ96D59. baseline and differential.
GenevisibleiQ96D59. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13639. zf-RING_2. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRN183_HUMAN
AccessioniPrimary (citable) accession number: Q96D59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: April 16, 2014
Last modified: February 15, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.