Q96D53 (ADCK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized aarF domain-containing protein kinase 4
EC=2.7.11.-

Gene names

Name:

ADCK4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the protein kinase superfamily. ADCK protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96D53-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96D53-2)

The sequence of this isoform differs from the canonical sequence as follows:
     123-163: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 544	544	Uncharacterized aarF domain-containing protein kinase 4		PRO_0000271797
Regions
	Transmembrane	92 – 108	17	Helical; Potential
	Domain	191 – 423	233	Protein kinase
Natural variations
	Alternative sequence	123 – 163	41	Missing in isoform 2.		VSP_022357
	Natural variant	78	1	R → C. Ref.4 Corresponds to variant rs11538384 [ dbSNP | Ensembl ].		VAR_041420
	Natural variant	174	1	H → R. Ref.4 Corresponds to variant rs3865452 [ dbSNP | Ensembl ].		VAR_029995
	Natural variant	318	1	T → M. Ref.4 Corresponds to variant rs55899516 [ dbSNP | Ensembl ].		VAR_041421
	Natural variant	352	1	T → R. Ref.4 Corresponds to variant rs36012476 [ dbSNP | Ensembl ].		VAR_041422
	Natural variant	462	1	T → M. Ref.4 Corresponds to variant rs56083906 [ dbSNP | Ensembl ].		VAR_041423
Experimental info
	Sequence conflict	164 – 166	3	DNS → GTA in BAB14004. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 4645DF579B9DFA4B	FASTA	544	60,069
	10 20 30 40 50 60 MWLKVGGLLR GTGGQLGQTV GWPCGALGPG PHRWGPCGGS WAQKFYQDGP GRGLGEEDIR 70 80 90 100 110 120 RAREARPRKT PRPQLSDRSR ERKVPASRIS RLANFGGLAV GLGLGVLAEM AKKSMPGGRL 130 140 150 160 170 180 QSEGGSGLDS SPFLSEANAE RIVQTLCTVR GAALKVGQML SIQDNSFISP QLQHIFERVR 190 200 210 220 230 240 QSADFMPRWQ MLRVLEEELG RDWQAKVASL EEVPFAAASI GQVHQGLLRD GTEVAVKIQY 250 260 270 280 290 300 PGIAQSIQSD VQNLLAVLKM SAALPAGLFA EQSLQALQQE LAWECDYRRE AACAQNFRQL 310 320 330 340 350 360 LANDPFFRVP AVVKELCTTR VLGMELAGGV PLDQCQGLSQ DLRNQICFQL LTLCLRELFE 370 380 390 400 410 420 FRFMQTDPNW ANFLYDASSH QVTLLDFGAS REFGTEFTDH YIEVVKAAAD GDRDCVLQKS 430 440 450 460 470 480 RDLKFLTGFE TKAFSDAHVE AVMILGEPFA TQGPYDFGSG ETARRIQDLI PVLLRHRLCP 490 500 510 520 530 540 PPEETYALHR KLAGAFLACA HLRAHIACRD LFQDTYHRYW ASRQPDAATA GSLPTKGDSW VDPS
	Isoform 2 [UniParc]. Checksum: 547A81982FE22A6A	FASTA	503	55,853
	10 20 30 40 50 60 MWLKVGGLLR GTGGQLGQTV GWPCGALGPG PHRWGPCGGS WAQKFYQDGP GRGLGEEDIR 70 80 90 100 110 120 RAREARPRKT PRPQLSDRSR ERKVPASRIS RLANFGGLAV GLGLGVLAEM AKKSMPGGRL 130 140 150 160 170 180 QSDNSFISPQ LQHIFERVRQ SADFMPRWQM LRVLEEELGR DWQAKVASLE EVPFAAASIG 190 200 210 220 230 240 QVHQGLLRDG TEVAVKIQYP GIAQSIQSDV QNLLAVLKMS AALPAGLFAE QSLQALQQEL 250 260 270 280 290 300 AWECDYRREA ACAQNFRQLL ANDPFFRVPA VVKELCTTRV LGMELAGGVP LDQCQGLSQD 310 320 330 340 350 360 LRNQICFQLL TLCLRELFEF RFMQTDPNWA NFLYDASSHQ VTLLDFGASR EFGTEFTDHY 370 380 390 400 410 420 IEVVKAAADG DRDCVLQKSR DLKFLTGFET KAFSDAHVEA VMILGEPFAT QGPYDFGSGE 430 440 450 460 470 480 TARRIQDLIP VLLRHRLCPP PEETYALHRK LAGAFLACAH LRAHIACRDL FQDTYHRYWA 490 500 SRQPDAATAG SLPTKGDSWV DPS

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Lymph and Placenta.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-166 (ISOFORM 1). Tissue: Mammary gland.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-78; ARG-174; MET-318; ARG-352 AND MET-462.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC013114 mRNA. Translation: AAH13114.2. BC027473 mRNA. Translation: AAH27473.1. AK022291 mRNA. Translation: BAB14004.1.
IPI	IPI00178315. IPI00647707.
RefSeq	NP_001136027.1. NM_001142555.2. NP_079152.3. NM_024876.3.
UniGene	Hs.130712.
3D structure databases
ProteinModelPortal	Q96D53.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96D53. 1 interaction.
STRING	9606.ENSP00000315118.
PTM databases
PhosphoSite	Q96D53.
Polymorphism databases
DMDM	74731415.
Proteomic databases
PaxDb	Q96D53.
PRIDE	Q96D53.
Protocols and materials databases
DNASU	79934.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000243583; ENSP00000243583; ENSG00000123815. ENST00000324464; ENSP00000315118; ENSG00000123815. ENST00000450541; ENSP00000412839; ENSG00000123815.
GeneID	79934.
KEGG	hsa:79934.
UCSC	uc002ooq.2. human. uc002oor.2. human.
Organism-specific databases
CTD	79934.
GeneCards	GC19M041199.
HGNC	HGNC:19041. ADCK4.
HPA	HPA027229. HPA027277. HPA027279.
neXtProt	NX_Q96D53.
PharmGKB	PA134988974.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0661.
HOGENOM	HOG000201140.
HOVERGEN	HBG061318.
InParanoid	Q96D53.
KO	K08869.
OMA	LPTKGDS.
OrthoDB	EOG4KKZ2W.
PhylomeDB	Q96D53.
Gene expression databases
Bgee	Q96D53.
CleanEx	HS_ADCK4.
Genevestigator	Q96D53.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR004147. UbiB_dom. [Graphical view]
Pfam	PF03109. ABC1. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q96D53.
ChEMBL	CHEMBL5753.
ChiTaRS	ADCK4. human.
GenomeRNAi	79934.
NextBio	69870.

Entry information

Entry name

ADCK4_HUMAN

Accession

Primary (citable) accession number: Q96D53
Secondary accession number(s): Q8TAJ1, Q9HA52

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.