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Protein

60S ribosomal export protein NMD3

Gene

NMD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.2 Publications

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • protein binding, bridging Source: ParkinsonsUK-UCL
  • ribosomal large subunit binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • ribosomal large subunit export from nucleus Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169251-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal export protein NMD3
Short name:
hNMD3
Gene namesi
Name:NMD3
ORF Names:CGI-07
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24250. NMD3.

Subcellular locationi

  • Cytoplasm 2 Publications
  • Nucleus 2 Publications

  • Note: Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner.2 Publications

GO - Cellular componenti

  • cytoplasm Source: ParkinsonsUK-UCL
  • membrane Source: UniProtKB
  • nucleolus Source: ParkinsonsUK-UCL
  • nucleoplasm Source: ParkinsonsUK-UCL
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi405K → A: Reduces accumulation in the nucleus. Loss of nucleolar localization; when associated with A-406. 1 Publication1
Mutagenesisi406K → A: Reduces accumulation in the nucleus. Loss of nucleolar localization; when associated with A-405. 1 Publication1
Mutagenesisi480L → A: Reduces nuclear export. 1 Publication1
Mutagenesisi484L → A: Reduces nuclear export. 2 Publications1
Mutagenesisi487L → A: Reduces nuclear export. 2 Publications1

Organism-specific databases

DisGeNETi51068.
OpenTargetsiENSG00000169251.
PharmGKBiPA134884140.

Polymorphism and mutation databases

BioMutaiNMD3.
DMDMi74731412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003235611 – 50360S ribosomal export protein NMD3Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei433PhosphothreonineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei470PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96D46.
MaxQBiQ96D46.
PaxDbiQ96D46.
PeptideAtlasiQ96D46.
PRIDEiQ96D46.

PTM databases

iPTMnetiQ96D46.
PhosphoSitePlusiQ96D46.

Expressioni

Gene expression databases

BgeeiENSG00000169251.
CleanExiHS_NMD3.
ExpressionAtlasiQ96D46. baseline and differential.
GenevisibleiQ96D46. HS.

Organism-specific databases

HPAiHPA035019.

Interactioni

Subunit structurei

Found in a 60S ribosomal subunit export complex with RAN and XPO1. Interacts with XPO1. Associates with the 60S ribosomal subunit.1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi119259. 66 interactors.
DIPiDIP-53427N.
IntActiQ96D46. 6 interactors.
MINTiMINT-5006543.
STRINGi9606.ENSP00000307525.

Structurei

3D structure databases

ProteinModelPortaliQ96D46.
SMRiQ96D46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni425 – 503Necessary for the nuclear export of the 60S ribosomal subunitAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi405 – 422Nuclear and nucleolar localization signalAdd BLAST18
Motifi480 – 489Nuclear export signal10

Sequence similaritiesi

Belongs to the NMD3 family.Curated

Phylogenomic databases

eggNOGiKOG2613. Eukaryota.
COG1499. LUCA.
GeneTreeiENSGT00390000005104.
HOGENOMiHOG000168152.
HOVERGENiHBG055100.
InParanoidiQ96D46.
KOiK07562.
PhylomeDBiQ96D46.
TreeFamiTF105744.

Family and domain databases

InterProiIPR007064. NMD3.
[Graphical view]
PfamiPF04981. NMD3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96D46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYMAESTDR SPGHILCCEC GVPISPNPAN ICVACLRSKV DISQGIPKQV
60 70 80 90 100
SISFCKQCQR YFQPPGTWIQ CALESRELLA LCLKKIKAPL SKVRLVDAGF
110 120 130 140 150
VWTEPHSKRL KVKLTIQKEV MNGAILQQVF VVDYVVQSQM CGDCHRVEAK
160 170 180 190 200
DFWKAVIQVR QKTLHKKTFY YLEQLILKYG MHQNTLRIKE IHDGLDFYYS
210 220 230 240 250
SKQHAQKMVE FLQCTVPCRY KASQRLISQD IHSNTYNYKS TFSVEIVPIC
260 270 280 290 300
KDNVVCLSPK LAQSLGNMNQ ICVCIRVTSA IHLIDPNTLQ VADIDGSTFW
310 320 330 340 350
SHPFNSLCHP KQLEEFIVME CSIVQDIKRA AGAGMISKKH TLGEVWVQKT
360 370 380 390 400
SEMNTDKQYF CRTHLGHLLN PGDLVLGFDL ANCNLNDEHV NKMNSDRVPD
410 420 430 440 450
VVLIKKSYDR TKRQRRRNWK LKELAREREN MDTDDERQYQ DFLEDLEEDE
460 470 480 490 500
AIRKNVNIYR DSAIPVESDT DDEGAPRISL AEMLEDLHIS QDATGEEGAS

MLT
Length:503
Mass (Da):57,603
Last modified:December 1, 2001 - v1
Checksum:i5CEFD4E41FE2EBC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319M → I in AAD27716 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0395466E → K.1 PublicationCorresponds to variant rs12490341dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132941 mRNA. Translation: AAD27716.1.
CH471052 Genomic DNA. Translation: EAW78618.1.
CH471052 Genomic DNA. Translation: EAW78619.1.
BC013317 mRNA. Translation: AAH13317.1.
CCDSiCCDS3194.1.
RefSeqiNP_057022.2. NM_015938.4.
XP_005247568.1. XM_005247511.1.
XP_005247569.1. XM_005247512.1.
UniGeneiHs.598836.

Genome annotation databases

EnsembliENST00000351193; ENSP00000307525; ENSG00000169251.
ENST00000460469; ENSP00000419004; ENSG00000169251.
GeneIDi51068.
KEGGihsa:51068.
UCSCiuc003feb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132941 mRNA. Translation: AAD27716.1.
CH471052 Genomic DNA. Translation: EAW78618.1.
CH471052 Genomic DNA. Translation: EAW78619.1.
BC013317 mRNA. Translation: AAH13317.1.
CCDSiCCDS3194.1.
RefSeqiNP_057022.2. NM_015938.4.
XP_005247568.1. XM_005247511.1.
XP_005247569.1. XM_005247512.1.
UniGeneiHs.598836.

3D structure databases

ProteinModelPortaliQ96D46.
SMRiQ96D46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119259. 66 interactors.
DIPiDIP-53427N.
IntActiQ96D46. 6 interactors.
MINTiMINT-5006543.
STRINGi9606.ENSP00000307525.

PTM databases

iPTMnetiQ96D46.
PhosphoSitePlusiQ96D46.

Polymorphism and mutation databases

BioMutaiNMD3.
DMDMi74731412.

Proteomic databases

EPDiQ96D46.
MaxQBiQ96D46.
PaxDbiQ96D46.
PeptideAtlasiQ96D46.
PRIDEiQ96D46.

Protocols and materials databases

DNASUi51068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351193; ENSP00000307525; ENSG00000169251.
ENST00000460469; ENSP00000419004; ENSG00000169251.
GeneIDi51068.
KEGGihsa:51068.
UCSCiuc003feb.2. human.

Organism-specific databases

CTDi51068.
DisGeNETi51068.
GeneCardsiNMD3.
H-InvDBHIX0003824.
HGNCiHGNC:24250. NMD3.
HPAiHPA035019.
MIMi611021. gene.
neXtProtiNX_Q96D46.
OpenTargetsiENSG00000169251.
PharmGKBiPA134884140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2613. Eukaryota.
COG1499. LUCA.
GeneTreeiENSGT00390000005104.
HOGENOMiHOG000168152.
HOVERGENiHBG055100.
InParanoidiQ96D46.
KOiK07562.
PhylomeDBiQ96D46.
TreeFamiTF105744.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169251-MONOMER.

Miscellaneous databases

ChiTaRSiNMD3. human.
GeneWikiiNMD3.
GenomeRNAii51068.
PROiQ96D46.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169251.
CleanExiHS_NMD3.
ExpressionAtlasiQ96D46. baseline and differential.
GenevisibleiQ96D46. HS.

Family and domain databases

InterProiIPR007064. NMD3.
[Graphical view]
PfamiPF04981. NMD3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMD3_HUMAN
AccessioniPrimary (citable) accession number: Q96D46
Secondary accession number(s): D3DNM7, Q9Y2Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.