Q96D42 (HAVR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hepatitis A virus cellular receptor 1
Short name=HAVcr-1

Alternative name(s):
Kidney injury molecule 1
Short name=KIM-1
T-cell immunoglobulin and mucin domain-containing protein 1
Short name=TIMD-1
T-cell membrane protein 1
TIM-1
Short name=TIM

Gene names

Name:	HAVCR1
Synonyms:	KIM1, TIM1, TIMD1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 By similarity. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. Ref.1 Ref.6
Subcellular location	Membrane; Single-pass type I membrane protein Probable.
Tissue specificity	Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. Ref.1
Induction	Up-regulated in the kidney in renal diseases (at protein level). Ref.6
Polymorphism	Infection by hepatitis A virus (HAV) protects individuals from atopy if they carry insertion of the variants Met-Thr-Thr-Val-Pro-157 and Met-Thr-Thr-Thr-Val-Pro-157. Modernisation has led to a reduction in HAV seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and atopic dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans.
Miscellaneous	The extracellular part of the protein can be cleaved and detected in urine and is in correlation with the expression in the kidney.
Sequence similarities	Belongs to the immunoglobulin superfamily. TIM family. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Host cell receptor for virus entry Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 359	339	Hepatitis A virus cellular receptor 1		PRO_0000014981
Regions
	Topological domain	21 – 290	270	Extracellular Potential
	Transmembrane	291 – 311	21	Helical; Potential
	Topological domain	312 – 359	48	Cytoplasmic Potential
	Domain	21 – 121	101	Ig-like V-type
	Repeat	138 – 143	6	1
	Repeat	144 – 149	6	2
	Repeat	150 – 155	6	3
	Repeat	156 – 160	5	4
	Repeat	161 – 166	6	5
	Repeat	167 – 172	6	6
	Repeat	173 – 178	6	7
	Repeat	179 – 184	6	8
	Repeat	185 – 190	6	9
	Repeat	191 – 196	6	10
	Repeat	197 – 202	6	11
	Region	138 – 202	65	11 X 6 AA approximate tandem repeats of V-P-T-T-T-T]
	Compositional bias	130 – 205	76	Thr-rich
Amino acid modifications
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
	Glycosylation	258	1	N-linked (GlcNAc...) Potential
	Glycosylation	272	1	N-linked (GlcNAc...) Potential
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Disulfide bond	36 ↔ 105		By similarity
	Disulfide bond	46 ↔ 57		By similarity
	Disulfide bond	52 ↔ 104		By similarity
Natural variations
	Natural variant	51	1	S → L. Corresponds to variant rs2270922 [ dbSNP | Ensembl ].		VAR_056080
	Natural variant	157	1	P → PMTTTVP.		VAR_023321
	Natural variant	157	1	P → PMTTVP.		VAR_023322
	Natural variant	195	1	Missing. Ref.8		VAR_023323
Experimental info
	Sequence conflict	174	1	L → P in AAC39862. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96D42 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: D24BA2C932903ECA	FASTA	359	38,720
	10 20 30 40 50 60 MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG SCSLFTCQNG 70 80 90 100 110 120 IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV 130 140 150 160 170 180 SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPTTT VPTTMSIPTT TTVLTTMTVS 190 200 210 220 230 240 TTTSVPTTTS IPTTTSVPVT TTVSTFVPPM PLPRQNHEPV ATSPSSPQPA ETHPTTLQGA 250 260 270 280 290 300 IRREPTSSPL YSYTTDGNDT VTESSDGLWN NNQTQLFLEH SLLTANTTKG IYAGVCISVL 310 320 330 340 350 VLLALLGVII AKKYFFKKEV QQLSVSFSSL QIKALQNAVE KEVQAEDNIY IENSLYATD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor." Feigelstock D., Thompson P., Mattoo P., Zhang Y., Kaplan G.G. J. Virol. 72:6621-6628(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS A HAV RECEPTOR, TISSUE SPECIFICITY. Tissue: Liver.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-THR-THR-VAL-PRO-157 INS.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-THR-THR-VAL-PRO-157 INS. Tissue: Kidney.
[5]	"Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions." Tami C., Silberstein E., Manangeeswaran M., Freeman G.J., Umetsu S.E., DeKruyff R.H., Umetsu D.T., Kaplan G.G. J. Virol. 81:3437-3446(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IMMUNOGLUBULIN A.
[6]	"Tubular kidney injury molecule-1 (KIM-1) in human renal disease." van Timmeren M.M., van den Heuvel M.C., Bailly V., Bakker S.J., van Goor H., Stegeman C.A. J. Pathol. 212:209-217(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Hepatitis A virus link to atopic disease." McIntire J.J., Umetsu S.E., Macaubas C., Hoyte E.G., Cinnioglu C., Cavalli-Sforza L.L., Barsh G.S., Hallmayer J.F., Underhill P.A., Risch N.J., Freeman G.J., DeKruyff R.H., Umetsu D.T. Nature 425:576-576(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MET-THR-THR-THR-VAL-PRO-157 INS AND THR-195 DEL.
[9]	Umetsu D.T. Submitted (SEP-2005) to UniProtKB Cited for: VARIANT MET-THR-THR-VAL-PRO-157 INS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF043724 mRNA. Translation: AAC39862.1. CR457114 mRNA. Translation: CAG33395.1. AC026777 Genomic DNA. No translation available. BC013325 mRNA. Translation: AAH13325.1.
IPI	IPI00101048.
RefSeq	NP_001092884.1. NM_001099414.1. NP_001166864.1. NM_001173393.1. NP_036338.2. NM_012206.2.
UniGene	Hs.129711.
3D structure databases
ProteinModelPortal	Q96D42.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96D42. 1 interaction.
MINT	MINT-2872051.
STRING	9606.ENSP00000344844.
PTM databases
PhosphoSite	Q96D42.
Polymorphism databases
DMDM	73919877.
Proteomic databases
PRIDE	Q96D42.
Protocols and materials databases
DNASU	26762.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339252; ENSP00000344844; ENSG00000113249. ENST00000523175; ENSP00000427898; ENSG00000113249. ENST00000544197; ENSP00000440258; ENSG00000113249.
GeneID	26762.
KEGG	hsa:26762.
UCSC	uc003lwi.2. human.
Organism-specific databases
CTD	26762.
GeneCards	GC05M156456.
HGNC	HGNC:17866. HAVCR1.
MIM	606518. gene.
neXtProt	NX_Q96D42.
PharmGKB	PA134924567.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44399.
InParanoid	Q96D42.
Gene expression databases
ArrayExpress	Q96D42.
Bgee	Q96D42.
CleanEx	HS_HAVCR1.
Genevestigator	Q96D42.
GermOnline	ENSG00000113249. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1741306.
GenomeRNAi	26762.
NextBio	49123.
SOURCE	Search...

Entry information

Entry name

HAVR1_HUMAN

Accession

Primary (citable) accession number: Q96D42
Secondary accession number(s): O43656

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.