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Protein

Hepatitis A virus cellular receptor 1

Gene

HAVCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair.By similarity1 Publication
(Microbial infection) Acts as a receptor for hepatitis A virus (PubMed:9658108). Acts as a receptor for ebolavirus and marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921).3 Publications

Miscellaneous

The extracellular part of the protein can be cleaved and detected in urine and is in correlation with the expression in the kidney.

GO - Molecular functioni

  • virus receptor activity Source: CACAO

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 1
Short name:
HAVcr-1
Alternative name(s):
Kidney injury molecule 1
Short name:
KIM-1
T-cell immunoglobulin and mucin domain-containing protein 1
Short name:
TIMD-1
T-cell immunoglobulin mucin receptor 1
Short name:
TIM
Short name:
TIM-1
T-cell membrane protein 1
Gene namesi
Name:HAVCR1
Synonyms:KIM1, TIM1, TIMD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113249.12.
HGNCiHGNC:17866. HAVCR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 290ExtracellularSequence analysisAdd BLAST270
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 359CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26762.
MalaCardsiHAVCR1.
PharmGKBiPA134924567.

Polymorphism and mutation databases

BioMutaiHAVCR1.
DMDMi73919877.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001498121 – 359Hepatitis A virus cellular receptor 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 105PROSITE-ProRule annotation
Disulfide bondi46 ↔ 57PROSITE-ProRule annotation
Disulfide bondi52 ↔ 104PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96D42.
PaxDbiQ96D42.
PeptideAtlasiQ96D42.
PRIDEiQ96D42.

PTM databases

iPTMnetiQ96D42.
PhosphoSitePlusiQ96D42.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.1 Publication

Inductioni

Up-regulated in the kidney in renal diseases (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000113249.
CleanExiHS_HAVCR1.
ExpressionAtlasiQ96D42. baseline and differential.
GenevisibleiQ96D42. HS.

Organism-specific databases

HPAiHPA007173.

Interactioni

Subunit structurei

(Microbial infection) Interacts with hepatitis A virus capsid proteins.1 Publication

Protein-protein interaction databases

BioGridi117812. 1 interactor.
IntActiQ96D42. 1 interactor.
MINTiMINT-2872051.
STRINGi9606.ENSP00000344844.

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 30Combined sources9
Beta strandi32 – 34Combined sources3
Beta strandi45 – 50Combined sources6
Turni56 – 59Combined sources4
Beta strandi60 – 64Combined sources5
Beta strandi66 – 74Combined sources9
Helixi83 – 85Combined sources3
Beta strandi90 – 94Combined sources5
Helixi97 – 99Combined sources3
Beta strandi101 – 107Combined sources7
Beta strandi110 – 113Combined sources4
Beta strandi116 – 125Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DZOX-ray1.30A22-127[»]
5F70X-ray1.80A21-123[»]
ProteinModelPortaliQ96D42.
SMRiQ96D42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 121Ig-like V-typeAdd BLAST101
Repeati138 – 14316
Repeati144 – 14926
Repeati150 – 15536
Repeati156 – 16045
Repeati161 – 16656
Repeati167 – 17266
Repeati173 – 17876
Repeati179 – 18486
Repeati185 – 19096
Repeati191 – 196106
Repeati197 – 202116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 20211 X 6 AA approximate tandem repeats of V-P-T-T-T-T]Add BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 205Thr-richAdd BLAST76

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZDR. Eukaryota.
ENOG410YSF7. LUCA.
InParanoidiQ96D42.
KOiK20413.
PhylomeDBiQ96D42.
TreeFamiTF336163.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96D42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG
60 70 80 90 100
SCSLFTCQNG IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS
110 120 130 140 150
GVYCCRVEHR GWFNDMKITV SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV
160 170 180 190 200
PTTTTVPTTT VPTTMSIPTT TTVLTTMTVS TTTSVPTTTS IPTTTSVPVT
210 220 230 240 250
TTVSTFVPPM PLPRQNHEPV ATSPSSPQPA ETHPTTLQGA IRREPTSSPL
260 270 280 290 300
YSYTTDGNDT VTESSDGLWN NNQTQLFLEH SLLTANTTKG IYAGVCISVL
310 320 330 340 350
VLLALLGVII AKKYFFKKEV QQLSVSFSSL QIKALQNAVE KEVQAEDNIY

IENSLYATD
Length:359
Mass (Da):38,720
Last modified:August 30, 2005 - v2
Checksum:iD24BA2C932903ECA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174L → P in AAC39862 (PubMed:9658108).Curated1

Polymorphismi

Infection by hepatitis A virus (HAV) protects individuals from atopy if they carry insertion of the variants Met-Thr-Thr-Val-Pro-157 and Met-Thr-Thr-Thr-Val-Pro-157. Modernisation has led to a reduction in HAV seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and atopic dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05608051S → L. Corresponds to variant dbSNP:rs2270922Ensembl.1
Natural variantiVAR_023321157P → PMTTTVP. 1
Natural variantiVAR_023322157P → PMTTVP3 Publications1
Natural variantiVAR_023323195Missing 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043724 mRNA. Translation: AAC39862.1.
CR457114 mRNA. Translation: CAG33395.1.
AC026777 Genomic DNA. No translation available.
BC013325 mRNA. Translation: AAH13325.1.
RefSeqiNP_001166864.1. NM_001173393.2.
NP_001295085.1. NM_001308156.1.
NP_036338.2. NM_012206.3.
UniGeneiHs.129711.

Genome annotation databases

EnsembliENST00000339252; ENSP00000344844; ENSG00000113249.
ENST00000523175; ENSP00000427898; ENSG00000113249.
GeneIDi26762.
KEGGihsa:26762.
UCSCiuc003lwi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHAVR1_HUMAN
AccessioniPrimary (citable) accession number: Q96D42
Secondary accession number(s): O43656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: October 25, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families