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Protein
Submitted name:

Proto-oncogene vav

Gene

VAV1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotation

Keywords - Ligandi

Metal-bindingSAAS annotation, ZincSAAS annotation

Enzyme and pathway databases

SignaLinkiQ96D37.

Names & Taxonomyi

Protein namesi
Submitted name:
Proto-oncogene vavImported
Submitted name:
VAV1 proteinImported
Gene namesi
Name:VAV1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12657. VAV1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Proteomic databases

PRIDEiQ96D37.

Expressioni

Gene expression databases

ExpressionAtlasiQ96D37. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ERBB2P046262EBI-7875353,EBI-641062

Protein-protein interaction databases

IntActiQ96D37. 3 interactions.
MINTiMINT-1492278.
STRINGi9606.ENSP00000472929.

Structurei

3D structure databases

ProteinModelPortaliQ96D37.
SMRiQ96D37. Positions 13-510, 528-725, 729-789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains 2 SH3 domains.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation
Contains SH2 domain.SAAS annotation

Keywords - Domaini

SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00800000124085.
HOVERGENiHBG018066.
KOiK05730.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF112. PTHR22826:SF112. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96D37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVLPLYSRL DKRFLCLKNI RTFLSTCCEK FGLKRSELFE AFDLFDVQDF
60 70 80 90 100
GKVIYTLSAL SWTPIAQNRG IMPFPTEEES VGDEDIYSGL SDQIDDTVEE
110 120 130 140 150
DEDLYDCVEN EEAEGDEIYE DLMRSEPVSM PPKMTEYDKR CCCLREIQQT
160 170 180 190 200
EEKYTDTLGS IQQHFLKPLQ RFLKPQDIEI IFINIEDLLR VHTHFLKEMK
210 220 230 240 250
EALGTPGAAN LYQVFIKYKE RFLVYGRYCS QVESASKHLD RVAAAREDVQ
260 270 280 290 300
MKLEECSQRA NNGRFTLRDL LMVPMQRVLK YHLLLQELVK HTQEAMEKEN
310 320 330 340 350
LRLALDAMRD LAQCVNEVKR DNETLRQITN FQLSIENLDQ SLAHYGRPKI
360 370 380 390 400
DGELKITSVE RRSKMDRYAF LLDKALLICK RRGDSYDLKD FVNLHSFQVR
410 420 430 440 450
DDSSGDRDNK KWSHMFLLIE DQGAQGYELF FKTRELKKKW MEQFEMAISN
460 470 480 490 500
IYPENATANG HDFQMFSFEE TTSCKACQML LRGTFYQGYR CHRCRASAHK
510 520 530 540 550
ECLGRVPPCG RHGQDFPGTM KKDKLHRRAQ DKKRNELGLP KMEVFQEYYG
560 570 580 590 600
LPPPPGAIGP FLRLNPGDIV ELTKAEAEQN WWEGRNTSTN EIGWFPCNRV
610 620 630 640 650
KPYVHGPPQD LSVHLWYAGP MERAGAESIL ANRSDGTFLV RQRVKDAAEF
660 670 680 690 700
AISIKYNVEV KHIKIMTAEG LYRITEKKAF RGLTELVEFY QQNSLKDCFK
710 720 730 740 750
SLDTTLQFPF KEPEKRTISR PAVGSTKYFG TAKARYDFCA RDRSELSLKE
760 770 780 790
GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC
Length:790
Mass (Da):91,991
Last modified:March 1, 2004 - v2
Checksum:i4A92899AAA3FDCF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010647 Genomic DNA. No translation available.
AC020895 Genomic DNA. No translation available.
AC020954 Genomic DNA. No translation available.
AC022156 Genomic DNA. No translation available.
BC013361 mRNA. Translation: AAH13361.2.
RefSeqiNP_001245135.1. NM_001258206.1.
NP_001245136.1. NM_001258207.1.
NP_005419.2. NM_005428.3.
UniGeneiHs.116237.

Genome annotation databases

EnsembliENST00000599806; ENSP00000472803; ENSG00000141968.
GeneIDi7409.
KEGGihsa:7409.
UCSCiuc002mfv.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010647 Genomic DNA. No translation available.
AC020895 Genomic DNA. No translation available.
AC020954 Genomic DNA. No translation available.
AC022156 Genomic DNA. No translation available.
BC013361 mRNA. Translation: AAH13361.2.
RefSeqiNP_001245135.1. NM_001258206.1.
NP_001245136.1. NM_001258207.1.
NP_005419.2. NM_005428.3.
UniGeneiHs.116237.

3D structure databases

ProteinModelPortaliQ96D37.
SMRiQ96D37. Positions 13-510, 528-725, 729-789.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96D37. 3 interactions.
MINTiMINT-1492278.
STRINGi9606.ENSP00000472929.

Proteomic databases

PRIDEiQ96D37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000599806; ENSP00000472803; ENSG00000141968.
GeneIDi7409.
KEGGihsa:7409.
UCSCiuc002mfv.2. human.

Organism-specific databases

CTDi7409.
HGNCiHGNC:12657. VAV1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00800000124085.
HOVERGENiHBG018066.
KOiK05730.

Enzyme and pathway databases

SignaLinkiQ96D37.

Miscellaneous databases

ChiTaRSiVAV1. human.
GenomeRNAii7409.
NextBioi29008.

Gene expression databases

ExpressionAtlasiQ96D37. baseline and differential.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF112. PTHR22826:SF112. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (FEB-2013) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ96D37_HUMAN
AccessioniPrimary (citable) accession number: Q96D37
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: March 1, 2004
Last modified: July 22, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.