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Q96D37

- Q96D37_HUMAN

UniProt

Q96D37 - Q96D37_HUMAN

Protein
Submitted name:

Proto-oncogene vav

Gene

VAV1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factorSAAS annotation

    Keywords - Ligandi

    Metal-bindingSAAS annotation, ZincSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Proto-oncogene vavImported
    Submitted name:
    VAV1 proteinImported
    Gene namesi
    Name:VAV1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:12657. VAV1.

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERBB2P046262EBI-7875353,EBI-641062

    Protein-protein interaction databases

    MINTiMINT-1492278.

    Structurei

    3D structure databases

    SMRiQ96D37. Positions 13-510, 528-725, 729-789.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PH domain.UniRule annotation
    Contains 2 SH3 domains.
    Contains DH (DBL-homology) domain.SAAS annotation
    Contains PH domain.SAAS annotation
    Contains SH2 domain.SAAS annotation
    Contains SHdomain.SAAS annotation

    Keywords - Domaini

    SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG018066.
    KOiK05730.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR001715. CH-domain.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR028530. Vav.
    [Graphical view]
    PANTHERiPTHR22826:SF112. PTHR22826:SF112. 1 hit.
    PfamiPF00130. C1_1. 1 hit.
    PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 2 hits.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTiSM00109. C1. 1 hit.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96D37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVLPLYSRL DKRFLCLKNI RTFLSTCCEK FGLKRSELFE AFDLFDVQDF    50
    GKVIYTLSAL SWTPIAQNRG IMPFPTEEES VGDEDIYSGL SDQIDDTVEE 100
    DEDLYDCVEN EEAEGDEIYE DLMRSEPVSM PPKMTEYDKR CCCLREIQQT 150
    EEKYTDTLGS IQQHFLKPLQ RFLKPQDIEI IFINIEDLLR VHTHFLKEMK 200
    EALGTPGAAN LYQVFIKYKE RFLVYGRYCS QVESASKHLD RVAAAREDVQ 250
    MKLEECSQRA NNGRFTLRDL LMVPMQRVLK YHLLLQELVK HTQEAMEKEN 300
    LRLALDAMRD LAQCVNEVKR DNETLRQITN FQLSIENLDQ SLAHYGRPKI 350
    DGELKITSVE RRSKMDRYAF LLDKALLICK RRGDSYDLKD FVNLHSFQVR 400
    DDSSGDRDNK KWSHMFLLIE DQGAQGYELF FKTRELKKKW MEQFEMAISN 450
    IYPENATANG HDFQMFSFEE TTSCKACQML LRGTFYQGYR CHRCRASAHK 500
    ECLGRVPPCG RHGQDFPGTM KKDKLHRRAQ DKKRNELGLP KMEVFQEYYG 550
    LPPPPGAIGP FLRLNPGDIV ELTKAEAEQN WWEGRNTSTN EIGWFPCNRV 600
    KPYVHGPPQD LSVHLWYAGP MERAGAESIL ANRSDGTFLV RQRVKDAAEF 650
    AISIKYNVEV KHIKIMTAEG LYRITEKKAF RGLTELVEFY QQNSLKDCFK 700
    SLDTTLQFPF KEPEKRTISR PAVGSTKYFG TAKARYDFCA RDRSELSLKE 750
    GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC 790
    Length:790
    Mass (Da):91,991
    Last modified:March 1, 2004 - v2
    Checksum:i4A92899AAA3FDCF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010647 Genomic DNA. No translation available.
    AC020895 Genomic DNA. No translation available.
    AC020954 Genomic DNA. No translation available.
    AC022156 Genomic DNA. No translation available.
    BC013361 mRNA. Translation: AAH13361.2.
    RefSeqiNP_001245135.1. NM_001258206.1.
    NP_001245136.1. NM_001258207.1.
    NP_005419.2. NM_005428.3.
    UniGeneiHs.116237.

    Genome annotation databases

    EnsembliENST00000599806; ENSP00000472803; ENSG00000141968.
    GeneIDi7409.
    KEGGihsa:7409.
    UCSCiuc002mfv.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010647 Genomic DNA. No translation available.
    AC020895 Genomic DNA. No translation available.
    AC020954 Genomic DNA. No translation available.
    AC022156 Genomic DNA. No translation available.
    BC013361 mRNA. Translation: AAH13361.2 .
    RefSeqi NP_001245135.1. NM_001258206.1.
    NP_001245136.1. NM_001258207.1.
    NP_005419.2. NM_005428.3.
    UniGenei Hs.116237.

    3D structure databases

    SMRi Q96D37. Positions 13-510, 528-725, 729-789.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1492278.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000599806 ; ENSP00000472803 ; ENSG00000141968 .
    GeneIDi 7409.
    KEGGi hsa:7409.
    UCSCi uc002mfv.2. human.

    Organism-specific databases

    CTDi 7409.
    HGNCi HGNC:12657. VAV1.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG018066.
    KOi K05730.

    Miscellaneous databases

    GenomeRNAii 7409.
    NextBioi 29008.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR001715. CH-domain.
    IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR028530. Vav.
    [Graphical view ]
    PANTHERi PTHR22826:SF112. PTHR22826:SF112. 1 hit.
    Pfami PF00130. C1_1. 1 hit.
    PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 2 hits.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTi SM00109. C1. 1 hit.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PlacentaImported.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Ensembl
      Submitted (FEB-2013) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ96D37_HUMAN
    AccessioniPrimary (citable) accession number: Q96D37
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3