Q96D37 (Q96D37_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Proto-oncogene vav Ensembl ENSP00000472803

Submitted name:
VAV1 protein EMBL AAH13361.2

Gene names

Name:

VAV1 EMBL AAH13361.2 Ensembl ENSP00000472803

Organism

Homo sapiens (Human) [Reference proteome] EMBL AAH13361.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	790 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. SAAS SAAS001331 Contains 1 PH domain. Contains 2 SH3 domains. RuleBase RU003338

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338 SAAS SAAS000980
Ligand	Metal-binding SAAS SAAS002219 Zinc SAAS SAAS002219
PTM	Phosphoprotein SAAS SAAS000980
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q96D37 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: 4A92899AAA3FDCF5	FASTA	790	91,991
	10 20 30 40 50 60 MIVLPLYSRL DKRFLCLKNI RTFLSTCCEK FGLKRSELFE AFDLFDVQDF GKVIYTLSAL 70 80 90 100 110 120 SWTPIAQNRG IMPFPTEEES VGDEDIYSGL SDQIDDTVEE DEDLYDCVEN EEAEGDEIYE 130 140 150 160 170 180 DLMRSEPVSM PPKMTEYDKR CCCLREIQQT EEKYTDTLGS IQQHFLKPLQ RFLKPQDIEI 190 200 210 220 230 240 IFINIEDLLR VHTHFLKEMK EALGTPGAAN LYQVFIKYKE RFLVYGRYCS QVESASKHLD 250 260 270 280 290 300 RVAAAREDVQ MKLEECSQRA NNGRFTLRDL LMVPMQRVLK YHLLLQELVK HTQEAMEKEN 310 320 330 340 350 360 LRLALDAMRD LAQCVNEVKR DNETLRQITN FQLSIENLDQ SLAHYGRPKI DGELKITSVE 370 380 390 400 410 420 RRSKMDRYAF LLDKALLICK RRGDSYDLKD FVNLHSFQVR DDSSGDRDNK KWSHMFLLIE 430 440 450 460 470 480 DQGAQGYELF FKTRELKKKW MEQFEMAISN IYPENATANG HDFQMFSFEE TTSCKACQML 490 500 510 520 530 540 LRGTFYQGYR CHRCRASAHK ECLGRVPPCG RHGQDFPGTM KKDKLHRRAQ DKKRNELGLP 550 560 570 580 590 600 KMEVFQEYYG LPPPPGAIGP FLRLNPGDIV ELTKAEAEQN WWEGRNTSTN EIGWFPCNRV 610 620 630 640 650 660 KPYVHGPPQD LSVHLWYAGP MERAGAESIL ANRSDGTFLV RQRVKDAAEF AISIKYNVEV 670 680 690 700 710 720 KHIKIMTAEG LYRITEKKAF RGLTELVEFY QQNSLKDCFK SLDTTLQFPF KEPEKRTISR 730 740 750 760 770 780 PAVGSTKYFG TAKARYDFCA RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN 790 YVEEDYSEYC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta EMBL AAH13361.2.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Ensembl Submitted (FEB-2013) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC010647 Genomic DNA. No translation available. AC020895 Genomic DNA. No translation available. AC020954 Genomic DNA. No translation available. AC022156 Genomic DNA. No translation available. BC013361 mRNA. Translation: AAH13361.2.
IPI	IPI00011696.
RefSeq	NP_001245135.1. NM_001258206.1. NP_001245136.1. NM_001258207.1. NP_005419.2. NM_005428.3.
UniGene	Hs.116237.
3D structure databases
HSSP	HSSP built from PDB template 1K1Z based on UniProtKB P27870.
ProteinModelPortal	Q96D37.
SMR	Q96D37. Positions 13-80, 134-510, 528-725, 731-785.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1492278.
STRING	Q96D37.
Proteomic databases
PRIDE	Q96D37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000599806; ENSP00000472803; ENSG00000141968.
GeneID	7409.
KEGG	hsa:7409.
UCSC	uc002mfv.1. human.
Organism-specific databases
CTD	7409.
HGNC	HGNC:12657. VAV1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG018066.
KO	K05730.
Gene expression databases
ArrayExpress	Q96D37.
Family and domain databases
Gene3D	1.10.418.10. 1 hit. 1.20.900.10. 1 hit. 2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000980. SH2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00130. C1_1. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 2 hits. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN.
SMART	SM00109. C1. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 2 hits. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit. SSF48065. DH-domain. 1 hit. SSF50044. SH3. 2 hits.
PROSITE	PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 2 hits. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7409.
NextBio	29008.

Entry information

Entry name

Q96D37_HUMAN

Accession

Primary (citable) accession number: Q96D37

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	March 1, 2004
Last modified:	April 3, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.