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Q96D37 (Q96D37_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length790 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 PH domain. RuleBase RU003350

Contains 2 SH3 domains. RuleBase RU003338

Contains DH (DBL-homology) domain. SAAS SAAS001331

Contains PH domain. SAAS SAAS000219

Contains SH2 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ERBB2P046262EBI-7875353,EBI-641062

Sequences

Sequence LengthMass (Da)Tools
Q96D37 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 4A92899AAA3FDCF5

FASTA79091,991
        10         20         30         40         50         60 
MIVLPLYSRL DKRFLCLKNI RTFLSTCCEK FGLKRSELFE AFDLFDVQDF GKVIYTLSAL 

        70         80         90        100        110        120 
SWTPIAQNRG IMPFPTEEES VGDEDIYSGL SDQIDDTVEE DEDLYDCVEN EEAEGDEIYE 

       130        140        150        160        170        180 
DLMRSEPVSM PPKMTEYDKR CCCLREIQQT EEKYTDTLGS IQQHFLKPLQ RFLKPQDIEI 

       190        200        210        220        230        240 
IFINIEDLLR VHTHFLKEMK EALGTPGAAN LYQVFIKYKE RFLVYGRYCS QVESASKHLD 

       250        260        270        280        290        300 
RVAAAREDVQ MKLEECSQRA NNGRFTLRDL LMVPMQRVLK YHLLLQELVK HTQEAMEKEN 

       310        320        330        340        350        360 
LRLALDAMRD LAQCVNEVKR DNETLRQITN FQLSIENLDQ SLAHYGRPKI DGELKITSVE 

       370        380        390        400        410        420 
RRSKMDRYAF LLDKALLICK RRGDSYDLKD FVNLHSFQVR DDSSGDRDNK KWSHMFLLIE 

       430        440        450        460        470        480 
DQGAQGYELF FKTRELKKKW MEQFEMAISN IYPENATANG HDFQMFSFEE TTSCKACQML 

       490        500        510        520        530        540 
LRGTFYQGYR CHRCRASAHK ECLGRVPPCG RHGQDFPGTM KKDKLHRRAQ DKKRNELGLP 

       550        560        570        580        590        600 
KMEVFQEYYG LPPPPGAIGP FLRLNPGDIV ELTKAEAEQN WWEGRNTSTN EIGWFPCNRV 

       610        620        630        640        650        660 
KPYVHGPPQD LSVHLWYAGP MERAGAESIL ANRSDGTFLV RQRVKDAAEF AISIKYNVEV 

       670        680        690        700        710        720 
KHIKIMTAEG LYRITEKKAF RGLTELVEFY QQNSLKDCFK SLDTTLQFPF KEPEKRTISR 

       730        740        750        760        770        780 
PAVGSTKYFG TAKARYDFCA RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN 

       790 
YVEEDYSEYC 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta EMBL AAH13361.2.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]Ensembl
Submitted (FEB-2013) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010647 Genomic DNA. No translation available.
AC020895 Genomic DNA. No translation available.
AC020954 Genomic DNA. No translation available.
AC022156 Genomic DNA. No translation available.
BC013361 mRNA. Translation: AAH13361.2.
RefSeqNP_001245135.1. NM_001258206.1.
NP_001245136.1. NM_001258207.1.
NP_005419.2. NM_005428.3.
UniGeneHs.116237.

3D structure databases

ProteinModelPortalQ96D37.
SMRQ96D37. Positions 13-510, 528-725, 729-789.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ96D37. 3 interactions.
MINTMINT-1492278.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000599806; ENSP00000472803; ENSG00000141968.
GeneID7409.
KEGGhsa:7409.
UCSCuc002mfv.2. human.

Organism-specific databases

CTD7409.
HGNCHGNC:12657. VAV1.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG018066.
KOK05730.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR028530. Vav.
[Graphical view]
PANTHERPTHR22826:SF112. PTHR22826:SF112. 1 hit.
PfamPF00130. C1_1. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7409.
NextBio29008.

Entry information

Entry nameQ96D37_HUMAN
AccessionPrimary (citable) accession number: Q96D37
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: March 1, 2004
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.