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Protein

Calcium release-activated calcium channel protein 1

Gene

ORAI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.9 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • store-operated calcium channel activity Source: UniProtKB

GO - Biological processi

  • blood coagulation Source: Reactome
  • immune system process Source: UniProtKB-KW
  • positive regulation of calcium ion transport Source: UniProtKB
  • regulation of calcium ion transport Source: UniProtKB
  • store-operated calcium entry Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Adaptive immunity, Calcium transport, Immunity, Ion transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_162. Elevation of cytosolic Ca2+ levels.

Protein family/group databases

TCDBi1.A.52.1.1. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium release-activated calcium channel protein 1
Alternative name(s):
Protein orai-1
Transmembrane protein 142A
Gene namesi
Name:ORAI1
Synonyms:CRACM1, TMEM142A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25896. ORAI1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8787Cytoplasmic1 PublicationAdd
BLAST
Transmembranei88 – 10518HelicalSequence AnalysisAdd
BLAST
Topological domaini106 – 11914ExtracellularSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Topological domaini141 – 17333CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Topological domaini195 – 23440ExtracellularSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST
Topological domaini256 – 30146Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • autophagosome Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB-KW
  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 9 (IMD9)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn immune disorder characterized by recurrent infections, impaired activation and proliferative response of T-cells, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhidrosis and non-progressive myopathy may be observed.

See also OMIM:612782
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911R → W in IMD9. 1 Publication
VAR_026226
Myopathy, tubular aggregate, 2 (TAM2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare congenital myopathy characterized by regular arrays of membrane tubules on muscle biopsies without additional histopathological hallmarks. Tubular aggregates in muscle are structures of variable appearance consisting of an outer tubule containing either one or more microtubule-like structures or amorphous material. TAM2 patients have myopathy and pupillary abnormalities.

See also OMIM:615883
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti245 – 2451P → L in TAM2; increases activation of the Ca2+ release-activated Ca2+ (CRAC) channel. 1 Publication
VAR_071473

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi85 – 873KLK → ALA: Impairs interaction with CRACR2A/EFCAB4B. 1 Publication
Mutagenesisi281 – 2811R → A: Strongly reduces calcium current. 1 Publication
Mutagenesisi284 – 2841D → A: Reduces the maximum current; when associated with A-287 and A-291. 1 Publication
Mutagenesisi286 – 2861L → S: Strongly reduces calcium current. 1 Publication
Mutagenesisi287 – 2871D → A: Reduces the maximum current; when associated with A-284 and A-291. 1 Publication
Mutagenesisi289 – 2891R → A: Strongly reduces calcium current. 1 Publication
Mutagenesisi291 – 2911D → A: Reduces the maximum current; when associated with A-284 and A-287. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi612782. phenotype.
615883. phenotype.
Orphaneti317428. Combined immunodeficiency due to ORAI1 deficiency.
2593. Tubular aggregate myopathy.
PharmGKBiPA162398445.

Polymorphism and mutation databases

DMDMi97180269.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Calcium release-activated calcium channel protein 1PRO_0000234381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
Modified residuei295 – 2951Phosphothreonine1 Publication
Modified residuei298 – 2981Phosphoserine1 Publication

Post-translational modificationi

N-glycosylated.1 Publication
Ubiquitinated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ96D31.
PaxDbiQ96D31.
PRIDEiQ96D31.

PTM databases

PhosphoSiteiQ96D31.

Expressioni

Gene expression databases

BgeeiQ96D31.
CleanExiHS_ORAI1.
ExpressionAtlasiQ96D31. baseline and differential.
GenevisibleiQ96D31. HS.

Organism-specific databases

HPAiHPA016583.
HPA061823.

Interactioni

Subunit structurei

Interacts with STIM1 and STIM2; this regulates channel activity. Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity. Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca2+. Forms a complex with CRACR2A/EFCAB4B and STIM1 at low concentration of Ca2+, the complex dissociates at elevated Ca2+ concentrations. Interacts with ASPH (isoform 8). Interacts with SLC35G1. Interacts with UBQLN1.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-2291476,EBI-2291476
ATP2C2O7518510EBI-2291476,EBI-2939806
CRACR2AQ9BSW26EBI-2291476,EBI-739773
ORAI3Q9BRQ53EBI-2291476,EBI-4279484
STIM1Q1358616EBI-2291476,EBI-448878

Protein-protein interaction databases

BioGridi124321. 4 interactions.
DIPiDIP-46289N.
IntActiQ96D31. 5 interactions.
MINTiMINT-6780078.
STRINGi9606.ENSP00000328216.

Structurei

Secondary structure

1
301
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi76 – 8611Combined sources
Helixi272 – 28817Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MAKNMR-B/D272-292[»]
4EHQX-ray1.90G69-88[»]
ProteinModelPortaliQ96D31.
SMRiQ96D31. Positions 74-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 9021Interaction with STIM1Add
BLAST
Regioni272 – 29221Interaction with STIM1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 4745Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263788.
GeneTreeiENSGT00390000015354.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ96D31.
KOiK16056.
OMAiITSTSIM.
OrthoDBiEOG7G1V73.
PhylomeDBiQ96D31.
TreeFamiTF313576.

Family and domain databases

InterProiIPR012446. CRAC_channel.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform alpha (identifier: Q96D31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPEPAPPPS RSSPELPPSG GSTTSGSRRS RRRSGDGEPP GAPPPPPSAV
60 70 80 90 100
TYPDWIGQSY SEVMSLNEHS MQALSWRKLY LSRAKLKASS RTSALLSGFA
110 120 130 140 150
MVAMVEVQLD ADHDYPPGLL IAFSACTTVL VAVHLFALMI STCILPNIEA
160 170 180 190 200
VSNVHNLNSV KESPHERMHR HIELAWAFST VIGTLLFLAE VVLLCWVKFL
210 220 230 240 250
PLKKQPGQPR PTSKPPASGA AANVSTSGIT PGQAAAIAST TIMVPFGLIF
260 270 280 290 300
IVFAVHFYRS LVSHKTDRQF QELNELAEFA RLQDQLDHRG DHPLTPGSHY

A
Length:301
Mass (Da):32,668
Last modified:May 16, 2006 - v2
Checksum:iF85F7C06F36628D4
GO
Isoform beta (identifier: Q96D31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Show »
Length:231
Mass (Da):25,337
Checksum:i0F7EEBB6DADB9005
GO

Sequence cautioni

The sequence AAH13386.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI04634.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55068.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551V → F in BAB55068 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911R → W in IMD9. 1 Publication
VAR_026226
Natural varianti218 – 2181S → G.2 Publications
Corresponds to variant rs3741596 [ dbSNP | Ensembl ].
VAR_038608
Natural varianti245 – 2451P → L in TAM2; increases activation of the Ca2+ release-activated Ca2+ (CRAC) channel. 1 Publication
VAR_071473

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7070Missing in isoform beta. CuratedVSP_044421Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013386 mRNA. Translation: AAH13386.1. Different initiation.
BC015369 mRNA. Translation: AAH15369.2.
BC075831 mRNA. Translation: AAH75831.1.
BC104633 mRNA. Translation: AAI04634.1. Different initiation.
AK027372 mRNA. Translation: BAB55068.1. Different initiation.
RefSeqiNP_116179.2. NM_032790.3. [Q96D31-1]
UniGeneiHs.55148.

Genome annotation databases

EnsembliENST00000616379; ENSP00000480616; ENSG00000276045.
GeneIDi84876.
KEGGihsa:84876.
UCSCiuc021rff.1. human. [Q96D31-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Web resourcesi

ORAI1base

ORAI1 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013386 mRNA. Translation: AAH13386.1. Different initiation.
BC015369 mRNA. Translation: AAH15369.2.
BC075831 mRNA. Translation: AAH75831.1.
BC104633 mRNA. Translation: AAI04634.1. Different initiation.
AK027372 mRNA. Translation: BAB55068.1. Different initiation.
RefSeqiNP_116179.2. NM_032790.3. [Q96D31-1]
UniGeneiHs.55148.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MAKNMR-B/D272-292[»]
4EHQX-ray1.90G69-88[»]
ProteinModelPortaliQ96D31.
SMRiQ96D31. Positions 74-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124321. 4 interactions.
DIPiDIP-46289N.
IntActiQ96D31. 5 interactions.
MINTiMINT-6780078.
STRINGi9606.ENSP00000328216.

Chemistry

ChEMBLiCHEMBL3038476.

Protein family/group databases

TCDBi1.A.52.1.1. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

PTM databases

PhosphoSiteiQ96D31.

Polymorphism and mutation databases

DMDMi97180269.

Proteomic databases

MaxQBiQ96D31.
PaxDbiQ96D31.
PRIDEiQ96D31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000616379; ENSP00000480616; ENSG00000276045.
GeneIDi84876.
KEGGihsa:84876.
UCSCiuc021rff.1. human. [Q96D31-1]

Organism-specific databases

CTDi84876.
GeneCardsiGC12P122064.
HGNCiHGNC:25896. ORAI1.
HPAiHPA016583.
HPA061823.
MIMi610277. gene.
612782. phenotype.
615883. phenotype.
neXtProtiNX_Q96D31.
Orphaneti317428. Combined immunodeficiency due to ORAI1 deficiency.
2593. Tubular aggregate myopathy.
PharmGKBiPA162398445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG263788.
GeneTreeiENSGT00390000015354.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ96D31.
KOiK16056.
OMAiITSTSIM.
OrthoDBiEOG7G1V73.
PhylomeDBiQ96D31.
TreeFamiTF313576.

Enzyme and pathway databases

ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_162. Elevation of cytosolic Ca2+ levels.

Miscellaneous databases

GeneWikiiORAI1.
GenomeRNAii84876.
NextBioi75181.
PROiQ96D31.
SOURCEiSearch...

Gene expression databases

BgeeiQ96D31.
CleanExiHS_ORAI1.
ExpressionAtlasiQ96D31. baseline and differential.
GenevisibleiQ96D31. HS.

Family and domain databases

InterProiIPR012446. CRAC_channel.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA), VARIANT GLY-218.
    Tissue: Bone marrow, Ovary, Prostate and Uterus.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-301 (ISOFORM ALPHA), VARIANT GLY-218.
    Tissue: Mammary gland.
  3. "A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients."
    Feske S., Prakriya M., Rao A., Lewis R.S.
    J. Exp. Med. 202:651-662(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN IMD9.
  4. "Orai1 and STIM reconstitute store-operated calcium channel function."
    Soboloff J., Spassova M.A., Tang X.D., Hewavitharana T., Xu W., Gill D.L.
    J. Biol. Chem. 281:20661-20665(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1."
    Mercer J.C., Dehaven W.I., Smyth J.T., Wedel B., Boyles R.R., Bird G.S., Putney J.W. Jr.
    J. Biol. Chem. 281:24979-24990(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: FUNCTION.
  7. "CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry."
    Vig M., Peinelt C., Beck A., Koomoa D.L., Rabah D., Koblan-Huberson M., Kraft S., Turner H., Fleig A., Penner R., Kinet J.-P.
    Science 312:1220-1223(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation."
    Parvez S., Beck A., Peinelt C., Soboloff J., Lis A., Monteilh-Zoller M., Gill D.L., Fleig A., Penner R.
    FASEB J. 22:752-761(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STIM1 AND STIM2.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-295 AND SER-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1."
    Park C.Y., Hoover P.J., Mullins F.M., Bachhawat P., Covington E.D., Raunser S., Walz T., Garcia K.C., Dolmetsch R.E., Lewis R.S.
    Cell 136:876-890(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH STIM1, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT, GLYCOSYLATION.
  11. "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."
    Krapivinsky G., Krapivinsky L., Stotz S.C., Manasian Y., Clapham D.E.
    Proc. Natl. Acad. Sci. U.S.A. 108:19234-19239(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SLC35G1.
  12. "Alternative translation initiation gives rise to two isoforms of orai1 with distinct plasma membrane mobilities."
    Fukushima M., Tomita T., Janoshazi A., Putney J.W.
    J. Cell Sci. 125:4354-4361(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE INITIATION, SUBCELLULAR LOCATION.
  13. "Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)."
    Srikanth S., Jew M., Kim K.D., Yee M.K., Abramson J., Gwack Y.
    Proc. Natl. Acad. Sci. U.S.A. 109:8682-8687(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ASPH.
  14. "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
    Srikanth S., Jung H.J., Kim K.D., Souda P., Whitelegge J., Gwack Y.
    Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRACR2A, MUTAGENESIS OF 85-LYS--LYS-87.
  15. "Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization."
    Lee J.E., Jeon I.S., Han N.E., Song H.J., Kim E.G., Choi J.W., Song K.D., Lee H.K., Choi J.K.
    Mol. Cells 35:41-46(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH UBQLN1, SUBCELLULAR LOCATION, UBIQUITINATION.
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  17. "Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis."
    Nesin V., Wiley G., Kousi M., Ong E.C., Lehmann T., Nicholl D.J., Suri M., Shahrizaila N., Katsanis N., Gaffney P.M., Wierenga K.J., Tsiokas L.
    Proc. Natl. Acad. Sci. U.S.A. 111:4197-4202(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INVOLVEMENT IN TAM2, VARIANT TAM2 LEU-245, CHARACTERIZATION OF VARIANT TAM2 LEU-245.
  18. "Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode."
    Liu Y., Zheng X., Mueller G.A., Sobhany M., DeRose E.F., Zhang Y., London R.E., Birnbaumer L.
    J. Biol. Chem. 287:43030-43041(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 69-88 IN COMPLEX WITH CALM, INTERACTION WITH CALM.
  19. "STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry."
    Stathopulos P.B., Schindl R., Fahrner M., Zheng L., Gasmi-Seabrook G.M., Muik M., Romanin C., Ikura M.
    Nat. Commun. 4:2963-2963(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 272-292 IN COMPLEX WITH STIM1, INTERACTION WITH STIM1, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-281; ASP-284; LEU-286; ASP-287; ARG-289 AND ASP-291.
  20. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
    Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.-H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A.
    Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT IMD9 TRP-91, SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiCRCM1_HUMAN
AccessioniPrimary (citable) accession number: Q96D31
Secondary accession number(s): Q3MHV3
, Q6DHX2, Q96BP7, Q96K71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 22, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.