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Q96D31

- CRCM1_HUMAN

UniProt

Q96D31 - CRCM1_HUMAN

Protein

Calcium release-activated calcium channel protein 1

Gene

ORAI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (16 May 2006)
      Previous versions | rss
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    Functioni

    Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.7 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. store-operated calcium channel activity Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. immune system process Source: UniProtKB-KW
    3. positive regulation of calcium ion transport Source: UniProtKB
    4. regulation of calcium ion transport Source: UniProtKB
    5. store-operated calcium entry Source: Ensembl

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Adaptive immunity, Calcium transport, Immunity, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Calmodulin-binding

    Enzyme and pathway databases

    ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_162. Elevation of cytosolic Ca2+ levels.

    Protein family/group databases

    TCDBi1.A.52.1.1. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium release-activated calcium channel protein 1
    Alternative name(s):
    Protein orai-1
    Transmembrane protein 142A
    Gene namesi
    Name:ORAI1
    Synonyms:CRACM1, TMEM142A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25896. ORAI1.

    Subcellular locationi

    Cell membrane 5 Publications; Multi-pass membrane protein 5 Publications
    Note: Isoform beta is more mobile in the plasma membrane.

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. membrane Source: UniProtKB
    3. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Immunodeficiency 9 (IMD9) [MIM:612782]: An immune disorder characterized by recurrent infections, impaired activation and proliferative response of T-cells, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhidrosis and non-progressive myopathy may be observed.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911R → W in IMD9. 1 Publication
    VAR_026226

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi85 – 873KLK → ALA: Impairs interaction with CRACR2A/EFCAB4B. 1 Publication
    Mutagenesisi281 – 2811R → A: Strongly reduces calcium current. 2 Publications
    Mutagenesisi284 – 2841D → A: Reduces the maximum current; when associated with A-287 and A-291. 2 Publications
    Mutagenesisi286 – 2861L → S: Strongly reduces calcium current. 2 Publications
    Mutagenesisi287 – 2871D → A: Reduces the maximum current; when associated with A-284 and A-291. 2 Publications
    Mutagenesisi289 – 2891R → A: Strongly reduces calcium current. 2 Publications
    Mutagenesisi291 – 2911D → A: Reduces the maximum current; when associated with A-284 and A-287. 2 Publications

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi612782. phenotype.
    Orphaneti317428. Combined immunodeficiency due to ORAI1 deficiency.
    PharmGKBiPA162398445.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Calcium release-activated calcium channel protein 1PRO_0000234381Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Modified residuei295 – 2951Phosphothreonine1 Publication
    Modified residuei298 – 2981Phosphoserine1 Publication

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ96D31.
    PaxDbiQ96D31.
    PRIDEiQ96D31.

    PTM databases

    PhosphoSiteiQ96D31.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96D31.
    BgeeiQ96D31.
    CleanExiHS_ORAI1.
    GenevestigatoriQ96D31.

    Organism-specific databases

    HPAiHPA016583.

    Interactioni

    Subunit structurei

    Interacts with STIM1 and STIM2; this regulates channel activity. Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity. Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca2+. Forms a complex with CRACR2A/EFCAB4B and STIM1 at low concentration of Ca2+, the complex dissociates at elevated Ca2+ concentrations. Interacts with ASPH (isoform 8). Interacts with SLC35G1.7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-2291476,EBI-2291476
    ATP2C2O7518510EBI-2291476,EBI-2939806
    EFCAB4BQ9BSW26EBI-2291476,EBI-739773
    STIM1Q1358615EBI-2291476,EBI-448878

    Protein-protein interaction databases

    BioGridi124321. 2 interactions.
    DIPiDIP-46289N.
    IntActiQ96D31. 4 interactions.
    MINTiMINT-6780078.
    STRINGi9606.ENSP00000328216.

    Structurei

    Secondary structure

    1
    301
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi76 – 8611
    Helixi272 – 28817

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2MAKNMR-B/D272-292[»]
    4EHQX-ray1.90G69-88[»]
    ProteinModelPortaliQ96D31.
    SMRiQ96D31. Positions 74-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8787Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini106 – 11914ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 17333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini195 – 23440ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini256 – 30146Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei88 – 10518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 9021Interaction with STIM1Add
    BLAST
    Regioni272 – 29221Interaction with STIM1Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 4745Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orai family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263788.
    HOGENOMiHOG000246925.
    HOVERGENiHBG081343.
    InParanoidiQ96D31.
    KOiK16056.
    OrthoDBiEOG7G1V73.
    PhylomeDBiQ96D31.
    TreeFamiTF313576.

    Family and domain databases

    InterProiIPR012446. CRAC_channel.
    [Graphical view]
    PfamiPF07856. Orai-1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform alpha (identifier: Q96D31-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHPEPAPPPS RSSPELPPSG GSTTSGSRRS RRRSGDGEPP GAPPPPPSAV    50
    TYPDWIGQSY SEVMSLNEHS MQALSWRKLY LSRAKLKASS RTSALLSGFA 100
    MVAMVEVQLD ADHDYPPGLL IAFSACTTVL VAVHLFALMI STCILPNIEA 150
    VSNVHNLNSV KESPHERMHR HIELAWAFST VIGTLLFLAE VVLLCWVKFL 200
    PLKKQPGQPR PTSKPPASGA AANVSTSGIT PGQAAAIAST TIMVPFGLIF 250
    IVFAVHFYRS LVSHKTDRQF QELNELAEFA RLQDQLDHRG DHPLTPGSHY 300
    A 301
    Length:301
    Mass (Da):32,668
    Last modified:May 16, 2006 - v2
    Checksum:iF85F7C06F36628D4
    GO
    Isoform beta (identifier: Q96D31-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-70: Missing.

    Show »
    Length:231
    Mass (Da):25,337
    Checksum:i0F7EEBB6DADB9005
    GO

    Sequence cautioni

    The sequence AAH13386.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI04634.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB55068.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti255 – 2551V → F in BAB55068. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911R → W in IMD9. 1 Publication
    VAR_026226
    Natural varianti218 – 2181S → G.2 Publications
    Corresponds to variant rs3741596 [ dbSNP | Ensembl ].
    VAR_038608

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7070Missing in isoform beta. CuratedVSP_044421Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC013386 mRNA. Translation: AAH13386.1. Different initiation.
    BC015369 mRNA. Translation: AAH15369.2.
    BC075831 mRNA. Translation: AAH75831.1.
    BC104633 mRNA. Translation: AAI04634.1. Different initiation.
    AK027372 mRNA. Translation: BAB55068.1. Different initiation.
    CCDSiCCDS41851.1. [Q96D31-1]
    RefSeqiNP_116179.2. NM_032790.3. [Q96D31-1]
    UniGeneiHs.55148.

    Genome annotation databases

    GeneIDi84876.
    KEGGihsa:84876.
    UCSCiuc021rff.1. human. [Q96D31-1]

    Polymorphism databases

    DMDMi97180269.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Web resourcesi

    ORAI1base

    ORAI1 mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC013386 mRNA. Translation: AAH13386.1 . Different initiation.
    BC015369 mRNA. Translation: AAH15369.2 .
    BC075831 mRNA. Translation: AAH75831.1 .
    BC104633 mRNA. Translation: AAI04634.1 . Different initiation.
    AK027372 mRNA. Translation: BAB55068.1 . Different initiation.
    CCDSi CCDS41851.1. [Q96D31-1 ]
    RefSeqi NP_116179.2. NM_032790.3. [Q96D31-1 ]
    UniGenei Hs.55148.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2MAK NMR - B/D 272-292 [» ]
    4EHQ X-ray 1.90 G 69-88 [» ]
    ProteinModelPortali Q96D31.
    SMRi Q96D31. Positions 74-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124321. 2 interactions.
    DIPi DIP-46289N.
    IntActi Q96D31. 4 interactions.
    MINTi MINT-6780078.
    STRINGi 9606.ENSP00000328216.

    Chemistry

    BindingDBi Q96D31.
    ChEMBLi CHEMBL3038476.

    Protein family/group databases

    TCDBi 1.A.52.1.1. the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family.

    PTM databases

    PhosphoSitei Q96D31.

    Polymorphism databases

    DMDMi 97180269.

    Proteomic databases

    MaxQBi Q96D31.
    PaxDbi Q96D31.
    PRIDEi Q96D31.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 84876.
    KEGGi hsa:84876.
    UCSCi uc021rff.1. human. [Q96D31-1 ]

    Organism-specific databases

    CTDi 84876.
    GeneCardsi GC12P122064.
    HGNCi HGNC:25896. ORAI1.
    HPAi HPA016583.
    MIMi 610277. gene.
    612782. phenotype.
    neXtProti NX_Q96D31.
    Orphaneti 317428. Combined immunodeficiency due to ORAI1 deficiency.
    PharmGKBi PA162398445.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263788.
    HOGENOMi HOG000246925.
    HOVERGENi HBG081343.
    InParanoidi Q96D31.
    KOi K16056.
    OrthoDBi EOG7G1V73.
    PhylomeDBi Q96D31.
    TreeFami TF313576.

    Enzyme and pathway databases

    Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_162. Elevation of cytosolic Ca2+ levels.

    Miscellaneous databases

    GeneWikii ORAI1.
    GenomeRNAii 84876.
    NextBioi 75181.
    PROi Q96D31.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96D31.
    Bgeei Q96D31.
    CleanExi HS_ORAI1.
    Genevestigatori Q96D31.

    Family and domain databases

    InterProi IPR012446. CRAC_channel.
    [Graphical view ]
    Pfami PF07856. Orai-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA), VARIANT GLY-218.
      Tissue: Bone marrow, Ovary, Prostate and Uterus.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-301 (ISOFORM ALPHA), VARIANT GLY-218.
      Tissue: Mammary gland.
    3. "A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients."
      Feske S., Prakriya M., Rao A., Lewis R.S.
      J. Exp. Med. 202:651-662(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN IMD9.
    4. "Orai1 and STIM reconstitute store-operated calcium channel function."
      Soboloff J., Spassova M.A., Tang X.D., Hewavitharana T., Xu W., Gill D.L.
      J. Biol. Chem. 281:20661-20665(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1."
      Mercer J.C., Dehaven W.I., Smyth J.T., Wedel B., Boyles R.R., Bird G.S., Putney J.W. Jr.
      J. Biol. Chem. 281:24979-24990(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: FUNCTION.
    7. "CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry."
      Vig M., Peinelt C., Beck A., Koomoa D.L., Rabah D., Koblan-Huberson M., Kraft S., Turner H., Fleig A., Penner R., Kinet J.-P.
      Science 312:1220-1223(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. "STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation."
      Parvez S., Beck A., Peinelt C., Soboloff J., Lis A., Monteilh-Zoller M., Gill D.L., Fleig A., Penner R.
      FASEB J. 22:752-761(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STIM1 AND STIM2.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-295 AND SER-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1."
      Park C.Y., Hoover P.J., Mullins F.M., Bachhawat P., Covington E.D., Raunser S., Walz T., Garcia K.C., Dolmetsch R.E., Lewis R.S.
      Cell 136:876-890(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH STIM1, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT, GLYCOSYLATION.
    11. "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."
      Krapivinsky G., Krapivinsky L., Stotz S.C., Manasian Y., Clapham D.E.
      Proc. Natl. Acad. Sci. U.S.A. 108:19234-19239(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SLC35G1.
    12. "Alternative translation initiation gives rise to two isoforms of orai1 with distinct plasma membrane mobilities."
      Fukushima M., Tomita T., Janoshazi A., Putney J.W.
      J. Cell Sci. 125:4354-4361(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE INITIATION, SUBCELLULAR LOCATION.
    13. "Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)."
      Srikanth S., Jew M., Kim K.D., Yee M.K., Abramson J., Gwack Y.
      Proc. Natl. Acad. Sci. U.S.A. 109:8682-8687(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ASPH.
    14. "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
      Srikanth S., Jung H.J., Kim K.D., Souda P., Whitelegge J., Gwack Y.
      Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRACR2A, MUTAGENESIS OF 85-LYS--LYS-87.
    15. "Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode."
      Liu Y., Zheng X., Mueller G.A., Sobhany M., DeRose E.F., Zhang Y., London R.E., Birnbaumer L.
      J. Biol. Chem. 287:43030-43041(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 69-88 IN COMPLEX WITH CALM, INTERACTION WITH CALM.
    16. "STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry."
      Stathopulos P.B., Schindl R., Fahrner M., Zheng L., Gasmi-Seabrook G.M., Muik M., Romanin C., Ikura M.
      Nat. Commun. 4:2963-2963(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 272-292 IN COMPLEX WITH STIM1, INTERACTION WITH STIM1, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-281; ASP-284; LEU-286; ASP-287; ARG-289 AND ASP-291.
    17. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
      Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.-H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A.
      Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT IMD9 TRP-91, SUBCELLULAR LOCATION, FUNCTION.

    Entry informationi

    Entry nameiCRCM1_HUMAN
    AccessioniPrimary (citable) accession number: Q96D31
    Secondary accession number(s): Q3MHV3
    , Q6DHX2, Q96BP7, Q96K71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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