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Q96D15

- RCN3_HUMAN

UniProt

Q96D15 - RCN3_HUMAN

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Protein
Reticulocalbin-3
Gene
RCN3, UNQ239/PRO272
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi90 – 101121; possibly ancestral Reviewed prediction
Add
BLAST
Calcium bindingi126 – 137122 Reviewed prediction
Add
BLAST
Calcium bindingi176 – 187123; possibly ancestral Reviewed prediction
Add
BLAST
Calcium bindingi213 – 224124 Reviewed prediction
Add
BLAST
Calcium bindingi254 – 265125 Reviewed prediction
Add
BLAST
Calcium bindingi290 – 301126 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: IntAct
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-3
Alternative name(s):
EF-hand calcium-binding protein RLP49
Gene namesi
Name:RCN3
ORF Names:UNQ239/PRO272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:21145. RCN3.

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 328308Reticulocalbin-3
PRO_0000004151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi140 – 1401N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96D15.
PaxDbiQ96D15.
PRIDEiQ96D15.

2D gel databases

DOSAC-COBS-2DPAGEQ96D15.

PTM databases

PhosphoSiteiQ96D15.

Expressioni

Gene expression databases

ArrayExpressiQ96D15.
BgeeiQ96D15.
CleanExiHS_RCN3.
GenevestigatoriQ96D15.

Organism-specific databases

HPAiHPA043134.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUFUQ9UMX12EBI-746283,EBI-740595

Protein-protein interaction databases

BioGridi121488. 7 interactions.
IntActiQ96D15. 8 interactions.
MINTiMINT-1441769.
STRINGi9606.ENSP00000270645.

Structurei

3D structure databases

ProteinModelPortaliQ96D15.
SMRiQ96D15. Positions 80-306.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 11238EF-hand 1
Add
BLAST
Domaini113 – 14836EF-hand 2
Add
BLAST
Domaini163 – 19836EF-hand 3
Add
BLAST
Domaini200 – 23536EF-hand 4
Add
BLAST
Domaini241 – 27636EF-hand 5
Add
BLAST
Domaini277 – 31236EF-hand 6
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi325 – 3284Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the CREC family.
Contains 6 EF-hand domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG286499.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ96D15.
OMAiSDAPHDD.
OrthoDBiEOG73Z2TD.
PhylomeDBiQ96D15.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96D15-1 [UniParc]FASTAAdd to Basket

« Hide

MMWRPSVLLL LLLLRHGAQG KPSPDAGPHG QGRVHQAAPL SDAPHDDAHG    50
NFQYDHEAFL GREVAKEFDQ LTPEESQARL GRIVDRMDRA GDGDGWVSLA 100
ELRAWIAHTQ QRHIRDSVSA AWDTYDTDRD GRVGWEELRN ATYGHYAPGE 150
EFHDVEDAET YKKMLARDER RFRVADQDGD SMATREELTA FLHPEEFPHM 200
RDIVIAETLE DLDRNKDGYV QVEEYIADLY SAEPGEEEPA WVQTERQQFR 250
DFRDLNKDGH LDGSEVGHWV LPPAQDQPLV EANHLLHESD TDKDGRLSKA 300
EILGNWNMFV GSQATNYGED LTRHHDEL 328
Length:328
Mass (Da):37,493
Last modified:December 1, 2001 - v1
Checksum:iB64EDB28B9610B8D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti250 – 2501R → W.
Corresponds to variant rs34654230 [ dbSNP | Ensembl ].
VAR_033696

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821R → G in AAG09692. 1 Publication
Sequence conflicti93 – 931G → S in AAG09692. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY195859 mRNA. Translation: AAO43054.1.
AF183423 mRNA. Translation: AAG09692.1.
AY358423 mRNA. Translation: AAQ88789.1.
BC013436 mRNA. Translation: AAH13436.1.
CCDSiCCDS12771.1.
RefSeqiNP_065701.2. NM_020650.2.
UniGeneiHs.567550.

Genome annotation databases

EnsembliENST00000270645; ENSP00000270645; ENSG00000142552.
GeneIDi57333.
KEGGihsa:57333.
UCSCiuc002poj.3. human.

Polymorphism databases

DMDMi30316268.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY195859 mRNA. Translation: AAO43054.1 .
AF183423 mRNA. Translation: AAG09692.1 .
AY358423 mRNA. Translation: AAQ88789.1 .
BC013436 mRNA. Translation: AAH13436.1 .
CCDSi CCDS12771.1.
RefSeqi NP_065701.2. NM_020650.2.
UniGenei Hs.567550.

3D structure databases

ProteinModelPortali Q96D15.
SMRi Q96D15. Positions 80-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121488. 7 interactions.
IntActi Q96D15. 8 interactions.
MINTi MINT-1441769.
STRINGi 9606.ENSP00000270645.

PTM databases

PhosphoSitei Q96D15.

Polymorphism databases

DMDMi 30316268.

2D gel databases

DOSAC-COBS-2DPAGE Q96D15.

Proteomic databases

MaxQBi Q96D15.
PaxDbi Q96D15.
PRIDEi Q96D15.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270645 ; ENSP00000270645 ; ENSG00000142552 .
GeneIDi 57333.
KEGGi hsa:57333.
UCSCi uc002poj.3. human.

Organism-specific databases

CTDi 57333.
GeneCardsi GC19P050030.
HGNCi HGNC:21145. RCN3.
HPAi HPA043134.
neXtProti NX_Q96D15.
PharmGKBi PA134880380.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286499.
HOGENOMi HOG000230934.
HOVERGENi HBG002834.
InParanoidi Q96D15.
OMAi SDAPHDD.
OrthoDBi EOG73Z2TD.
PhylomeDBi Q96D15.
TreeFami TF314849.

Miscellaneous databases

ChiTaRSi RCN3. human.
GenomeRNAii 57333.
NextBioi 63442.
PROi Q96D15.

Gene expression databases

ArrayExpressi Q96D15.
Bgeei Q96D15.
CleanExi HS_RCN3.
Genevestigatori Q96D15.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Liu F., Zeng L.-C., Rong Y.-P., Qi X.-F., Ma W.-J., Han Z.-G.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hypothalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-140.
    Tissue: Liver.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRCN3_HUMAN
AccessioniPrimary (citable) accession number: Q96D15
Secondary accession number(s): Q9HBZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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