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Protein

Reticulocalbin-3

Gene

RCN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi90 – 101121; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi126 – 137122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi176 – 187123; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi213 – 224124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi254 – 265125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi290 – 301126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-3
Alternative name(s):
EF-hand calcium-binding protein RLP49
Gene namesi
Name:RCN3
ORF Names:UNQ239/PRO272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:21145. RCN3.

Subcellular locationi

  1. Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880380.

Polymorphism and mutation databases

BioMutaiRCN3.
DMDMi30316268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 328308Reticulocalbin-3PRO_0000004151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi140 – 1401N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96D15.
PaxDbiQ96D15.
PRIDEiQ96D15.

2D gel databases

DOSAC-COBS-2DPAGEQ96D15.

PTM databases

PhosphoSiteiQ96D15.

Expressioni

Gene expression databases

BgeeiQ96D15.
CleanExiHS_RCN3.
ExpressionAtlasiQ96D15. baseline and differential.
GenevestigatoriQ96D15.

Organism-specific databases

HPAiHPA043134.
HPA050402.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MBD3O959833EBI-746283,EBI-1783068
PACRGLQ8N7B63EBI-746283,EBI-3925298
SUFUQ9UMX12EBI-746283,EBI-740595

Protein-protein interaction databases

BioGridi121488. 9 interactions.
IntActiQ96D15. 10 interactions.
MINTiMINT-1441769.
STRINGi9606.ENSP00000270645.

Structurei

3D structure databases

ProteinModelPortaliQ96D15.
SMRiQ96D15. Positions 80-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 11238EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini113 – 14836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini163 – 19836EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini200 – 23536EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini241 – 27636EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini277 – 31236EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi325 – 3284Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG286499.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ96D15.
OMAiDSVSSAW.
OrthoDBiEOG73Z2TD.
PhylomeDBiQ96D15.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96D15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWRPSVLLL LLLLRHGAQG KPSPDAGPHG QGRVHQAAPL SDAPHDDAHG
60 70 80 90 100
NFQYDHEAFL GREVAKEFDQ LTPEESQARL GRIVDRMDRA GDGDGWVSLA
110 120 130 140 150
ELRAWIAHTQ QRHIRDSVSA AWDTYDTDRD GRVGWEELRN ATYGHYAPGE
160 170 180 190 200
EFHDVEDAET YKKMLARDER RFRVADQDGD SMATREELTA FLHPEEFPHM
210 220 230 240 250
RDIVIAETLE DLDRNKDGYV QVEEYIADLY SAEPGEEEPA WVQTERQQFR
260 270 280 290 300
DFRDLNKDGH LDGSEVGHWV LPPAQDQPLV EANHLLHESD TDKDGRLSKA
310 320
EILGNWNMFV GSQATNYGED LTRHHDEL
Length:328
Mass (Da):37,493
Last modified:December 1, 2001 - v1
Checksum:iB64EDB28B9610B8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821R → G in AAG09692 (PubMed:10931946).Curated
Sequence conflicti93 – 931G → S in AAG09692 (PubMed:10931946).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti250 – 2501R → W.
Corresponds to variant rs34654230 [ dbSNP | Ensembl ].
VAR_033696

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY195859 mRNA. Translation: AAO43054.1.
AF183423 mRNA. Translation: AAG09692.1.
AY358423 mRNA. Translation: AAQ88789.1.
BC013436 mRNA. Translation: AAH13436.1.
CCDSiCCDS12771.1.
RefSeqiNP_065701.2. NM_020650.2.
UniGeneiHs.567550.

Genome annotation databases

EnsembliENST00000270645; ENSP00000270645; ENSG00000142552.
GeneIDi57333.
KEGGihsa:57333.
UCSCiuc002poj.3. human.

Polymorphism and mutation databases

BioMutaiRCN3.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY195859 mRNA. Translation: AAO43054.1.
AF183423 mRNA. Translation: AAG09692.1.
AY358423 mRNA. Translation: AAQ88789.1.
BC013436 mRNA. Translation: AAH13436.1.
CCDSiCCDS12771.1.
RefSeqiNP_065701.2. NM_020650.2.
UniGeneiHs.567550.

3D structure databases

ProteinModelPortaliQ96D15.
SMRiQ96D15. Positions 80-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121488. 9 interactions.
IntActiQ96D15. 10 interactions.
MINTiMINT-1441769.
STRINGi9606.ENSP00000270645.

PTM databases

PhosphoSiteiQ96D15.

Polymorphism and mutation databases

BioMutaiRCN3.
DMDMi30316268.

2D gel databases

DOSAC-COBS-2DPAGEQ96D15.

Proteomic databases

MaxQBiQ96D15.
PaxDbiQ96D15.
PRIDEiQ96D15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270645; ENSP00000270645; ENSG00000142552.
GeneIDi57333.
KEGGihsa:57333.
UCSCiuc002poj.3. human.

Organism-specific databases

CTDi57333.
GeneCardsiGC19P050030.
HGNCiHGNC:21145. RCN3.
HPAiHPA043134.
HPA050402.
neXtProtiNX_Q96D15.
PharmGKBiPA134880380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG286499.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ96D15.
OMAiDSVSSAW.
OrthoDBiEOG73Z2TD.
PhylomeDBiQ96D15.
TreeFamiTF314849.

Miscellaneous databases

ChiTaRSiRCN3. human.
GenomeRNAii57333.
NextBioi63442.
PROiQ96D15.

Gene expression databases

BgeeiQ96D15.
CleanExiHS_RCN3.
ExpressionAtlasiQ96D15. baseline and differential.
GenevestigatoriQ96D15.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Liu F., Zeng L.-C., Rong Y.-P., Qi X.-F., Ma W.-J., Han Z.-G.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hypothalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-140.
    Tissue: Liver.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRCN3_HUMAN
AccessioniPrimary (citable) accession number: Q96D15
Secondary accession number(s): Q9HBZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.