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Q96D15

- RCN3_HUMAN

UniProt

Q96D15 - RCN3_HUMAN

Protein

Reticulocalbin-3

Gene

RCN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi90 – 101121; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi126 – 137122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi176 – 187123; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi213 – 224124PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi254 – 265125PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi290 – 301126PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: IntAct

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulocalbin-3
    Alternative name(s):
    EF-hand calcium-binding protein RLP49
    Gene namesi
    Name:RCN3
    ORF Names:UNQ239/PRO272
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:21145. RCN3.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134880380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 328308Reticulocalbin-3PRO_0000004151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi140 – 1401N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ96D15.
    PaxDbiQ96D15.
    PRIDEiQ96D15.

    2D gel databases

    DOSAC-COBS-2DPAGEQ96D15.

    PTM databases

    PhosphoSiteiQ96D15.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96D15.
    BgeeiQ96D15.
    CleanExiHS_RCN3.
    GenevestigatoriQ96D15.

    Organism-specific databases

    HPAiHPA043134.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SUFUQ9UMX12EBI-746283,EBI-740595

    Protein-protein interaction databases

    BioGridi121488. 7 interactions.
    IntActiQ96D15. 8 interactions.
    MINTiMINT-1441769.
    STRINGi9606.ENSP00000270645.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96D15.
    SMRiQ96D15. Positions 80-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini75 – 11238EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini113 – 14836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini163 – 19836EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini200 – 23536EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini241 – 27636EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini277 – 31236EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi325 – 3284Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the CREC family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG286499.
    HOGENOMiHOG000230934.
    HOVERGENiHBG002834.
    InParanoidiQ96D15.
    OMAiSDAPHDD.
    OrthoDBiEOG73Z2TD.
    PhylomeDBiQ96D15.
    TreeFamiTF314849.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96D15-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMWRPSVLLL LLLLRHGAQG KPSPDAGPHG QGRVHQAAPL SDAPHDDAHG    50
    NFQYDHEAFL GREVAKEFDQ LTPEESQARL GRIVDRMDRA GDGDGWVSLA 100
    ELRAWIAHTQ QRHIRDSVSA AWDTYDTDRD GRVGWEELRN ATYGHYAPGE 150
    EFHDVEDAET YKKMLARDER RFRVADQDGD SMATREELTA FLHPEEFPHM 200
    RDIVIAETLE DLDRNKDGYV QVEEYIADLY SAEPGEEEPA WVQTERQQFR 250
    DFRDLNKDGH LDGSEVGHWV LPPAQDQPLV EANHLLHESD TDKDGRLSKA 300
    EILGNWNMFV GSQATNYGED LTRHHDEL 328
    Length:328
    Mass (Da):37,493
    Last modified:December 1, 2001 - v1
    Checksum:iB64EDB28B9610B8D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821R → G in AAG09692. (PubMed:10931946)Curated
    Sequence conflicti93 – 931G → S in AAG09692. (PubMed:10931946)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti250 – 2501R → W.
    Corresponds to variant rs34654230 [ dbSNP | Ensembl ].
    VAR_033696

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY195859 mRNA. Translation: AAO43054.1.
    AF183423 mRNA. Translation: AAG09692.1.
    AY358423 mRNA. Translation: AAQ88789.1.
    BC013436 mRNA. Translation: AAH13436.1.
    CCDSiCCDS12771.1.
    RefSeqiNP_065701.2. NM_020650.2.
    UniGeneiHs.567550.

    Genome annotation databases

    EnsembliENST00000270645; ENSP00000270645; ENSG00000142552.
    GeneIDi57333.
    KEGGihsa:57333.
    UCSCiuc002poj.3. human.

    Polymorphism databases

    DMDMi30316268.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY195859 mRNA. Translation: AAO43054.1 .
    AF183423 mRNA. Translation: AAG09692.1 .
    AY358423 mRNA. Translation: AAQ88789.1 .
    BC013436 mRNA. Translation: AAH13436.1 .
    CCDSi CCDS12771.1.
    RefSeqi NP_065701.2. NM_020650.2.
    UniGenei Hs.567550.

    3D structure databases

    ProteinModelPortali Q96D15.
    SMRi Q96D15. Positions 80-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121488. 7 interactions.
    IntActi Q96D15. 8 interactions.
    MINTi MINT-1441769.
    STRINGi 9606.ENSP00000270645.

    PTM databases

    PhosphoSitei Q96D15.

    Polymorphism databases

    DMDMi 30316268.

    2D gel databases

    DOSAC-COBS-2DPAGE Q96D15.

    Proteomic databases

    MaxQBi Q96D15.
    PaxDbi Q96D15.
    PRIDEi Q96D15.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270645 ; ENSP00000270645 ; ENSG00000142552 .
    GeneIDi 57333.
    KEGGi hsa:57333.
    UCSCi uc002poj.3. human.

    Organism-specific databases

    CTDi 57333.
    GeneCardsi GC19P050030.
    HGNCi HGNC:21145. RCN3.
    HPAi HPA043134.
    neXtProti NX_Q96D15.
    PharmGKBi PA134880380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286499.
    HOGENOMi HOG000230934.
    HOVERGENi HBG002834.
    InParanoidi Q96D15.
    OMAi SDAPHDD.
    OrthoDBi EOG73Z2TD.
    PhylomeDBi Q96D15.
    TreeFami TF314849.

    Miscellaneous databases

    ChiTaRSi RCN3. human.
    GenomeRNAii 57333.
    NextBioi 63442.
    PROi Q96D15.

    Gene expression databases

    ArrayExpressi Q96D15.
    Bgeei Q96D15.
    CleanExi HS_RCN3.
    Genevestigatori Q96D15.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Liu F., Zeng L.-C., Rong Y.-P., Qi X.-F., Ma W.-J., Han Z.-G.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hypothalamus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-140.
      Tissue: Liver.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRCN3_HUMAN
    AccessioniPrimary (citable) accession number: Q96D15
    Secondary accession number(s): Q9HBZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3