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Protein

Reticulocalbin-3

Gene

RCN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi90 – 1011; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi126 – 1372PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi176 – 1873; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi213 – 2244PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi254 – 2655PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi290 – 3016PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-3
Alternative name(s):
EF-hand calcium-binding protein RLP49
Gene namesi
Name:RCN3
ORF Names:UNQ239/PRO272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:21145. RCN3.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi57333.
OpenTargetsiENSG00000142552.
PharmGKBiPA134880380.

Polymorphism and mutation databases

BioMutaiRCN3.
DMDMi30316268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000415121 – 328Reticulocalbin-3Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi140N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96D15.
MaxQBiQ96D15.
PaxDbiQ96D15.
PeptideAtlasiQ96D15.
PRIDEiQ96D15.

2D gel databases

DOSAC-COBS-2DPAGEQ96D15.

PTM databases

iPTMnetiQ96D15.
PhosphoSitePlusiQ96D15.

Expressioni

Gene expression databases

BgeeiENSG00000142552.
CleanExiHS_RCN3.
ExpressionAtlasiQ96D15. baseline and differential.
GenevisibleiQ96D15. HS.

Organism-specific databases

HPAiHPA043134.
HPA050402.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MBD3O959833EBI-746283,EBI-1783068
PACRGLQ8N7B63EBI-746283,EBI-3925298
SUFUQ9UMX14EBI-746283,EBI-740595

Protein-protein interaction databases

BioGridi121488. 9 interactors.
IntActiQ96D15. 12 interactors.
MINTiMINT-1441769.
STRINGi9606.ENSP00000270645.

Structurei

3D structure databases

ProteinModelPortaliQ96D15.
SMRiQ96D15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 112EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini113 – 148EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini163 – 198EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini200 – 235EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini241 – 276EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini277 – 312EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi325 – 328Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ96D15.
OMAiLSNWNMF.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ96D15.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96D15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWRPSVLLL LLLLRHGAQG KPSPDAGPHG QGRVHQAAPL SDAPHDDAHG
60 70 80 90 100
NFQYDHEAFL GREVAKEFDQ LTPEESQARL GRIVDRMDRA GDGDGWVSLA
110 120 130 140 150
ELRAWIAHTQ QRHIRDSVSA AWDTYDTDRD GRVGWEELRN ATYGHYAPGE
160 170 180 190 200
EFHDVEDAET YKKMLARDER RFRVADQDGD SMATREELTA FLHPEEFPHM
210 220 230 240 250
RDIVIAETLE DLDRNKDGYV QVEEYIADLY SAEPGEEEPA WVQTERQQFR
260 270 280 290 300
DFRDLNKDGH LDGSEVGHWV LPPAQDQPLV EANHLLHESD TDKDGRLSKA
310 320
EILGNWNMFV GSQATNYGED LTRHHDEL
Length:328
Mass (Da):37,493
Last modified:December 1, 2001 - v1
Checksum:iB64EDB28B9610B8D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82R → G in AAG09692 (PubMed:10931946).Curated1
Sequence conflicti93G → S in AAG09692 (PubMed:10931946).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033696250R → W.Corresponds to variant rs34654230dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY195859 mRNA. Translation: AAO43054.1.
AF183423 mRNA. Translation: AAG09692.1.
AY358423 mRNA. Translation: AAQ88789.1.
BC013436 mRNA. Translation: AAH13436.1.
CCDSiCCDS12771.1.
RefSeqiNP_065701.2. NM_020650.2.
XP_011525445.1. XM_011527143.1.
XP_016882512.1. XM_017027023.1.
UniGeneiHs.567550.

Genome annotation databases

EnsembliENST00000270645; ENSP00000270645; ENSG00000142552.
GeneIDi57333.
KEGGihsa:57333.
UCSCiuc002poj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY195859 mRNA. Translation: AAO43054.1.
AF183423 mRNA. Translation: AAG09692.1.
AY358423 mRNA. Translation: AAQ88789.1.
BC013436 mRNA. Translation: AAH13436.1.
CCDSiCCDS12771.1.
RefSeqiNP_065701.2. NM_020650.2.
XP_011525445.1. XM_011527143.1.
XP_016882512.1. XM_017027023.1.
UniGeneiHs.567550.

3D structure databases

ProteinModelPortaliQ96D15.
SMRiQ96D15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121488. 9 interactors.
IntActiQ96D15. 12 interactors.
MINTiMINT-1441769.
STRINGi9606.ENSP00000270645.

PTM databases

iPTMnetiQ96D15.
PhosphoSitePlusiQ96D15.

Polymorphism and mutation databases

BioMutaiRCN3.
DMDMi30316268.

2D gel databases

DOSAC-COBS-2DPAGEQ96D15.

Proteomic databases

EPDiQ96D15.
MaxQBiQ96D15.
PaxDbiQ96D15.
PeptideAtlasiQ96D15.
PRIDEiQ96D15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270645; ENSP00000270645; ENSG00000142552.
GeneIDi57333.
KEGGihsa:57333.
UCSCiuc002poj.4. human.

Organism-specific databases

CTDi57333.
DisGeNETi57333.
GeneCardsiRCN3.
HGNCiHGNC:21145. RCN3.
HPAiHPA043134.
HPA050402.
neXtProtiNX_Q96D15.
OpenTargetsiENSG00000142552.
PharmGKBiPA134880380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ96D15.
OMAiLSNWNMF.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ96D15.
TreeFamiTF314849.

Miscellaneous databases

ChiTaRSiRCN3. human.
GenomeRNAii57333.
PROiQ96D15.

Gene expression databases

BgeeiENSG00000142552.
CleanExiHS_RCN3.
ExpressionAtlasiQ96D15. baseline and differential.
GenevisibleiQ96D15. HS.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCN3_HUMAN
AccessioniPrimary (citable) accession number: Q96D15
Secondary accession number(s): Q9HBZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.