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Q96D15 (RCN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulocalbin-3
Alternative name(s):
EF-hand calcium-binding protein RLP49
Gene names
Name:RCN3
ORF Names:UNQ239/PRO272
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum lumen Potential.

Sequence similarities

Belongs to the CREC family.

Contains 6 EF-hand domains.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
   LigandCalcium
Metal-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SUFUQ9UMX12EBI-746283,EBI-740595

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 328308Reticulocalbin-3
PRO_0000004151

Regions

Domain75 – 11238EF-hand 1
Domain113 – 14836EF-hand 2
Domain163 – 19836EF-hand 3
Domain200 – 23536EF-hand 4
Domain241 – 27636EF-hand 5
Domain277 – 31236EF-hand 6
Calcium binding90 – 101121; possibly ancestral Potential
Calcium binding126 – 137122 Potential
Calcium binding176 – 187123; possibly ancestral Potential
Calcium binding213 – 224124 Potential
Calcium binding254 – 265125 Potential
Calcium binding290 – 301126 Potential
Motif325 – 3284Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1401N-linked (GlcNAc...) Ref.5

Natural variations

Natural variant2501R → W.
Corresponds to variant rs34654230 [ dbSNP | Ensembl ].
VAR_033696

Experimental info

Sequence conflict821R → G in AAG09692. Ref.2
Sequence conflict931G → S in AAG09692. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q96D15 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: B64EDB28B9610B8D

FASTA32837,493
        10         20         30         40         50         60 
MMWRPSVLLL LLLLRHGAQG KPSPDAGPHG QGRVHQAAPL SDAPHDDAHG NFQYDHEAFL 

        70         80         90        100        110        120 
GREVAKEFDQ LTPEESQARL GRIVDRMDRA GDGDGWVSLA ELRAWIAHTQ QRHIRDSVSA 

       130        140        150        160        170        180 
AWDTYDTDRD GRVGWEELRN ATYGHYAPGE EFHDVEDAET YKKMLARDER RFRVADQDGD 

       190        200        210        220        230        240 
SMATREELTA FLHPEEFPHM RDIVIAETLE DLDRNKDGYV QVEEYIADLY SAEPGEEEPA 

       250        260        270        280        290        300 
WVQTERQQFR DFRDLNKDGH LDGSEVGHWV LPPAQDQPLV EANHLLHESD TDKDGRLSKA 

       310        320 
EILGNWNMFV GSQATNYGED LTRHHDEL 

« Hide

References

« Hide 'large scale' references
[1]Liu F., Zeng L.-C., Rong Y.-P., Qi X.-F., Ma W.-J., Han Z.-G.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hypothalamus.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-140.
Tissue: Liver.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY195859 mRNA. Translation: AAO43054.1.
AF183423 mRNA. Translation: AAG09692.1.
AY358423 mRNA. Translation: AAQ88789.1.
BC013436 mRNA. Translation: AAH13436.1.
RefSeqNP_065701.2. NM_020650.2.
UniGeneHs.567550.

3D structure databases

ProteinModelPortalQ96D15.
SMRQ96D15. Positions 92-226, 248-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121488. 7 interactions.
IntActQ96D15. 8 interactions.
MINTMINT-1441769.
STRING9606.ENSP00000270645.

PTM databases

PhosphoSiteQ96D15.

Polymorphism databases

DMDM30316268.

2D gel databases

DOSAC-COBS-2DPAGEQ96D15.

Proteomic databases

PaxDbQ96D15.
PRIDEQ96D15.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000270645; ENSP00000270645; ENSG00000142552.
GeneID57333.
KEGGhsa:57333.
UCSCuc002poj.3. human.

Organism-specific databases

CTD57333.
GeneCardsGC19P050030.
HGNCHGNC:21145. RCN3.
HPAHPA043134.
neXtProtNX_Q96D15.
PharmGKBPA134880380.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG286499.
HOGENOMHOG000230934.
HOVERGENHBG002834.
InParanoidQ96D15.
OMASDAPHDD.
OrthoDBEOG73Z2TD.
PhylomeDBQ96D15.
TreeFamTF314849.

Gene expression databases

ArrayExpressQ96D15.
BgeeQ96D15.
CleanExHS_RCN3.
GenevestigatorQ96D15.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRCN3. human.
GenomeRNAi57333.
NextBio63442.
PROQ96D15.

Entry information

Entry nameRCN3_HUMAN
AccessionPrimary (citable) accession number: Q96D15
Secondary accession number(s): Q9HBZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM