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Q96D09

- GASP2_HUMAN

UniProt

Q96D09 - GASP2_HUMAN

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Protein

G-protein coupled receptor-associated sorting protein 2

Gene

GPRASP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in regulation of a variety of G-protein coupled receptors.1 Publication

GO - Molecular functioni

  1. beta-amyloid binding Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 2
Short name:
GASP-2
Gene namesi
Name:GPRASP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:25169. GPRASP2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134976848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 838838G-protein coupled receptor-associated sorting protein 2PRO_0000239053Add
BLAST

Proteomic databases

MaxQBiQ96D09.
PaxDbiQ96D09.
PRIDEiQ96D09.

PTM databases

PhosphoSiteiQ96D09.

Expressioni

Tissue specificityi

Expressed in the brain.1 Publication

Gene expression databases

BgeeiQ96D09.
CleanExiHS_GPRASP2.
GenevestigatoriQ96D09.

Organism-specific databases

HPAiHPA017438.

Interactioni

Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.1 Publication

Protein-protein interaction databases

BioGridi125399. 53 interactions.
IntActiQ96D09. 22 interactions.
MINTiMINT-3978622.
STRINGi9606.ENSP00000339057.

Structurei

3D structure databases

ProteinModelPortaliQ96D09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPRASP family.Curated

Phylogenomic databases

eggNOGiNOG41843.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231409.
HOVERGENiHBG057167.
InParanoidiQ96D09.
OMAiWFWDRDE.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ96D09.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96D09-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGAEIEPSA QAKPEKKAGE EVIAGPEREN DVPLVVRPKV RTQATTGARP
60 70 80 90 100
KTETKSVPAA RPKTEAQAMS GARPKTEVQV MGGARPKTEA QGITGARPKT
110 120 130 140 150
DARAVGGARS KTDAKAIPGA RPKDEAQAWA QSEFGTEAVS QAEGVSQTNA
160 170 180 190 200
VAWPLATAES GSVTKSKGLS MDRELVNVDA ETFPGTQGQK GIQPWFGPGE
210 220 230 240 250
ETNMGSWCYS RPRAREEASN ESGFWSADET STASSFWTGE ETSVRSWPRE
260 270 280 290 300
ESNTRSRHRA KHQTNPRSRP RSKQEAYVDS WSGSEDEASN PFSFWVGENT
310 320 330 340 350
NNLFRPRVRE EANIRSKLRT NREDCFESES EDEFYKQSWV LPGEEANSRF
360 370 380 390 400
RHRDKEDPNT ALKLRAQKDV DSDRVKQEPR FEEEVIIGSW FWAEKEASLE
410 420 430 440 450
GGASAICESE PGTEEGAIGG SAYWAEEKSS LGAVAREEAK PESEEEAIFG
460 470 480 490 500
SWFWDRDEAC FDLNPCPVYK VSDRFRDAAE ELNASSRPQT WDEVTVEFKP
510 520 530 540 550
GLFHGVGFRS TSPFGIPEEA SEMLEAKPKN LELSPEGEEQ ESLLQPDQPS
560 570 580 590 600
PEFTFQYDPS YRSVREIREH LRARESAESE SWSCSCIQCE LKIGSEEFEE
610 620 630 640 650
FLLLMDKIRD PFIHEISKIA MGMRSASQFT RDFIRDSGVV SLIETLLNYP
660 670 680 690 700
SSRVRTSFLE NMIHMAPPYP NLNMIETFIC QVCEETLAHS VDSLEQLTGI
710 720 730 740 750
RMLRHLTMTI DYHTLIANYM SGFLSLLTTA NARTKFHVLK MLLNLSENPA
760 770 780 790 800
VAKKLFSAKA LSIFVGLFNI EETNDNIQIV IKMFQNISNI IKSGKMSLID
810 820 830
DDFSLEPLIS AFREFEELAK QLQAQIDNQN DPEVGQQS
Length:838
Mass (Da):93,773
Last modified:December 1, 2001 - v1
Checksum:i2D30515916B7EACE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti173 – 1731R → S.
Corresponds to variant rs6616421 [ dbSNP | Ensembl ].
VAR_049265

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035427 Genomic DNA. Translation: CAI43060.1.
CH471190 Genomic DNA. Translation: EAW54727.1.
CH471190 Genomic DNA. Translation: EAW54728.1.
CH471190 Genomic DNA. Translation: EAW54729.1.
BC013576 mRNA. Translation: AAH13576.1.
BC036772 mRNA. Translation: AAH36772.1.
AK092981 mRNA. No translation available.
CCDSiCCDS14501.1.
RefSeqiNP_001004051.1. NM_001004051.3.
NP_001171803.1. NM_001184874.2.
NP_001171804.1. NM_001184875.2.
NP_001171805.1. NM_001184876.2.
NP_001186747.1. NM_001199818.1.
NP_612446.1. NM_138437.5.
UniGeneiHs.522729.
Hs.731996.

Genome annotation databases

EnsembliENST00000332262; ENSP00000339057; ENSG00000158301.
ENST00000535209; ENSP00000437394; ENSG00000158301.
ENST00000543253; ENSP00000437872; ENSG00000158301.
GeneIDi100528062.
114928.
KEGGihsa:100528062.
hsa:114928.
UCSCiuc004ejk.3. human.

Polymorphism databases

DMDMi74751808.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035427 Genomic DNA. Translation: CAI43060.1 .
CH471190 Genomic DNA. Translation: EAW54727.1 .
CH471190 Genomic DNA. Translation: EAW54728.1 .
CH471190 Genomic DNA. Translation: EAW54729.1 .
BC013576 mRNA. Translation: AAH13576.1 .
BC036772 mRNA. Translation: AAH36772.1 .
AK092981 mRNA. No translation available.
CCDSi CCDS14501.1.
RefSeqi NP_001004051.1. NM_001004051.3.
NP_001171803.1. NM_001184874.2.
NP_001171804.1. NM_001184875.2.
NP_001171805.1. NM_001184876.2.
NP_001186747.1. NM_001199818.1.
NP_612446.1. NM_138437.5.
UniGenei Hs.522729.
Hs.731996.

3D structure databases

ProteinModelPortali Q96D09.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125399. 53 interactions.
IntActi Q96D09. 22 interactions.
MINTi MINT-3978622.
STRINGi 9606.ENSP00000339057.

PTM databases

PhosphoSitei Q96D09.

Polymorphism databases

DMDMi 74751808.

Proteomic databases

MaxQBi Q96D09.
PaxDbi Q96D09.
PRIDEi Q96D09.

Protocols and materials databases

DNASUi 114928.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332262 ; ENSP00000339057 ; ENSG00000158301 .
ENST00000535209 ; ENSP00000437394 ; ENSG00000158301 .
ENST00000543253 ; ENSP00000437872 ; ENSG00000158301 .
GeneIDi 100528062.
114928.
KEGGi hsa:100528062.
hsa:114928.
UCSCi uc004ejk.3. human.

Organism-specific databases

CTDi 100528062.
114928.
GeneCardsi GC0XP101985.
HGNCi HGNC:25169. GPRASP2.
HPAi HPA017438.
neXtProti NX_Q96D09.
PharmGKBi PA134976848.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41843.
GeneTreei ENSGT00550000074488.
HOGENOMi HOG000231409.
HOVERGENi HBG057167.
InParanoidi Q96D09.
OMAi WFWDRDE.
OrthoDBi EOG70PBZ0.
PhylomeDBi Q96D09.
TreeFami TF335652.

Miscellaneous databases

GeneWikii GPRASP2.
NextBioi 79448.
PROi Q96D09.

Gene expression databases

Bgeei Q96D09.
CleanExi HS_GPRASP2.
Genevestigatori Q96D09.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view ]
Pfami PF04826. Arm_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Ovary.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 657-838.
    Tissue: Kidney and Spleen.
  5. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
    Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
    J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH G PROTEIN-COUPLED RECEPTORS.

Entry informationi

Entry nameiGASP2_HUMAN
AccessioniPrimary (citable) accession number: Q96D09
Secondary accession number(s): D3DXA0, Q8NAB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3