Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96D09

- GASP2_HUMAN

UniProt

Q96D09 - GASP2_HUMAN

Protein

G-protein coupled receptor-associated sorting protein 2

Gene

GPRASP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play a role in regulation of a variety of G-protein coupled receptors.1 Publication

    GO - Molecular functioni

    1. beta-amyloid binding Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor-associated sorting protein 2
    Short name:
    GASP-2
    Gene namesi
    Name:GPRASP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:25169. GPRASP2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134976848.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 838838G-protein coupled receptor-associated sorting protein 2PRO_0000239053Add
    BLAST

    Proteomic databases

    MaxQBiQ96D09.
    PaxDbiQ96D09.
    PRIDEiQ96D09.

    PTM databases

    PhosphoSiteiQ96D09.

    Expressioni

    Tissue specificityi

    Expressed in the brain.1 Publication

    Gene expression databases

    BgeeiQ96D09.
    CleanExiHS_GPRASP2.
    GenevestigatoriQ96D09.

    Organism-specific databases

    HPAiHPA017438.

    Interactioni

    Subunit structurei

    Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.1 Publication

    Protein-protein interaction databases

    BioGridi125399. 48 interactions.
    IntActiQ96D09. 22 interactions.
    MINTiMINT-3978622.
    STRINGi9606.ENSP00000339057.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96D09.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPRASP family.Curated

    Phylogenomic databases

    eggNOGiNOG41843.
    HOGENOMiHOG000231409.
    HOVERGENiHBG057167.
    InParanoidiQ96D09.
    OMAiWFWDRDE.
    OrthoDBiEOG70PBZ0.
    PhylomeDBiQ96D09.
    TreeFamiTF335652.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    [Graphical view]
    PfamiPF04826. Arm_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96D09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGAEIEPSA QAKPEKKAGE EVIAGPEREN DVPLVVRPKV RTQATTGARP    50
    KTETKSVPAA RPKTEAQAMS GARPKTEVQV MGGARPKTEA QGITGARPKT 100
    DARAVGGARS KTDAKAIPGA RPKDEAQAWA QSEFGTEAVS QAEGVSQTNA 150
    VAWPLATAES GSVTKSKGLS MDRELVNVDA ETFPGTQGQK GIQPWFGPGE 200
    ETNMGSWCYS RPRAREEASN ESGFWSADET STASSFWTGE ETSVRSWPRE 250
    ESNTRSRHRA KHQTNPRSRP RSKQEAYVDS WSGSEDEASN PFSFWVGENT 300
    NNLFRPRVRE EANIRSKLRT NREDCFESES EDEFYKQSWV LPGEEANSRF 350
    RHRDKEDPNT ALKLRAQKDV DSDRVKQEPR FEEEVIIGSW FWAEKEASLE 400
    GGASAICESE PGTEEGAIGG SAYWAEEKSS LGAVAREEAK PESEEEAIFG 450
    SWFWDRDEAC FDLNPCPVYK VSDRFRDAAE ELNASSRPQT WDEVTVEFKP 500
    GLFHGVGFRS TSPFGIPEEA SEMLEAKPKN LELSPEGEEQ ESLLQPDQPS 550
    PEFTFQYDPS YRSVREIREH LRARESAESE SWSCSCIQCE LKIGSEEFEE 600
    FLLLMDKIRD PFIHEISKIA MGMRSASQFT RDFIRDSGVV SLIETLLNYP 650
    SSRVRTSFLE NMIHMAPPYP NLNMIETFIC QVCEETLAHS VDSLEQLTGI 700
    RMLRHLTMTI DYHTLIANYM SGFLSLLTTA NARTKFHVLK MLLNLSENPA 750
    VAKKLFSAKA LSIFVGLFNI EETNDNIQIV IKMFQNISNI IKSGKMSLID 800
    DDFSLEPLIS AFREFEELAK QLQAQIDNQN DPEVGQQS 838
    Length:838
    Mass (Da):93,773
    Last modified:December 1, 2001 - v1
    Checksum:i2D30515916B7EACE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti173 – 1731R → S.
    Corresponds to variant rs6616421 [ dbSNP | Ensembl ].
    VAR_049265

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035427 Genomic DNA. Translation: CAI43060.1.
    CH471190 Genomic DNA. Translation: EAW54727.1.
    CH471190 Genomic DNA. Translation: EAW54728.1.
    CH471190 Genomic DNA. Translation: EAW54729.1.
    BC013576 mRNA. Translation: AAH13576.1.
    BC036772 mRNA. Translation: AAH36772.1.
    AK092981 mRNA. No translation available.
    CCDSiCCDS14501.1.
    RefSeqiNP_001004051.1. NM_001004051.3.
    NP_001171803.1. NM_001184874.2.
    NP_001171804.1. NM_001184875.2.
    NP_001171805.1. NM_001184876.2.
    NP_001186747.1. NM_001199818.1.
    NP_612446.1. NM_138437.5.
    UniGeneiHs.522729.
    Hs.731996.

    Genome annotation databases

    EnsembliENST00000332262; ENSP00000339057; ENSG00000158301.
    ENST00000535209; ENSP00000437394; ENSG00000158301.
    ENST00000543253; ENSP00000437872; ENSG00000158301.
    GeneIDi100528062.
    114928.
    KEGGihsa:100528062.
    hsa:114928.
    UCSCiuc004ejk.3. human.

    Polymorphism databases

    DMDMi74751808.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035427 Genomic DNA. Translation: CAI43060.1 .
    CH471190 Genomic DNA. Translation: EAW54727.1 .
    CH471190 Genomic DNA. Translation: EAW54728.1 .
    CH471190 Genomic DNA. Translation: EAW54729.1 .
    BC013576 mRNA. Translation: AAH13576.1 .
    BC036772 mRNA. Translation: AAH36772.1 .
    AK092981 mRNA. No translation available.
    CCDSi CCDS14501.1.
    RefSeqi NP_001004051.1. NM_001004051.3.
    NP_001171803.1. NM_001184874.2.
    NP_001171804.1. NM_001184875.2.
    NP_001171805.1. NM_001184876.2.
    NP_001186747.1. NM_001199818.1.
    NP_612446.1. NM_138437.5.
    UniGenei Hs.522729.
    Hs.731996.

    3D structure databases

    ProteinModelPortali Q96D09.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125399. 48 interactions.
    IntActi Q96D09. 22 interactions.
    MINTi MINT-3978622.
    STRINGi 9606.ENSP00000339057.

    PTM databases

    PhosphoSitei Q96D09.

    Polymorphism databases

    DMDMi 74751808.

    Proteomic databases

    MaxQBi Q96D09.
    PaxDbi Q96D09.
    PRIDEi Q96D09.

    Protocols and materials databases

    DNASUi 114928.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332262 ; ENSP00000339057 ; ENSG00000158301 .
    ENST00000535209 ; ENSP00000437394 ; ENSG00000158301 .
    ENST00000543253 ; ENSP00000437872 ; ENSG00000158301 .
    GeneIDi 100528062.
    114928.
    KEGGi hsa:100528062.
    hsa:114928.
    UCSCi uc004ejk.3. human.

    Organism-specific databases

    CTDi 100528062.
    114928.
    GeneCardsi GC0XP101985.
    HGNCi HGNC:25169. GPRASP2.
    HPAi HPA017438.
    neXtProti NX_Q96D09.
    PharmGKBi PA134976848.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41843.
    HOGENOMi HOG000231409.
    HOVERGENi HBG057167.
    InParanoidi Q96D09.
    OMAi WFWDRDE.
    OrthoDBi EOG70PBZ0.
    PhylomeDBi Q96D09.
    TreeFami TF335652.

    Miscellaneous databases

    GeneWikii GPRASP2.
    NextBioi 79448.
    PROi Q96D09.

    Gene expression databases

    Bgeei Q96D09.
    CleanExi HS_GPRASP2.
    Genevestigatori Q96D09.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    [Graphical view ]
    Pfami PF04826. Arm_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Ovary.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 657-838.
      Tissue: Kidney and Spleen.
    5. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
      Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
      J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH G PROTEIN-COUPLED RECEPTORS.

    Entry informationi

    Entry nameiGASP2_HUMAN
    AccessioniPrimary (citable) accession number: Q96D09
    Secondary accession number(s): D3DXA0, Q8NAB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3