Q96D09 (GASP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor-associated sorting protein 2
Short name=GASP-2

Gene names

Name:

GPRASP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	838 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in regulation of a variety of G-protein coupled receptors. Ref.5
Subunit structure	Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR. Ref.5
Tissue specificity	Expressed in the brain. Ref.5
Sequence similarities	Belongs to the GPRASP family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: LIFEdb
Molecular_function	beta-amyloid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 838	838	G-protein coupled receptor-associated sorting protein 2		PRO_0000239053
Natural variations
	Natural variant	173	1	R → S. Corresponds to variant rs6616421 [ dbSNP | Ensembl ].		VAR_049265

Sequences

	Sequence		Length	Mass (Da)
	Q96D09 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2D30515916B7EACE	FASTA	838	93,773
	10 20 30 40 50 60 MTGAEIEPSA QAKPEKKAGE EVIAGPEREN DVPLVVRPKV RTQATTGARP KTETKSVPAA 70 80 90 100 110 120 RPKTEAQAMS GARPKTEVQV MGGARPKTEA QGITGARPKT DARAVGGARS KTDAKAIPGA 130 140 150 160 170 180 RPKDEAQAWA QSEFGTEAVS QAEGVSQTNA VAWPLATAES GSVTKSKGLS MDRELVNVDA 190 200 210 220 230 240 ETFPGTQGQK GIQPWFGPGE ETNMGSWCYS RPRAREEASN ESGFWSADET STASSFWTGE 250 260 270 280 290 300 ETSVRSWPRE ESNTRSRHRA KHQTNPRSRP RSKQEAYVDS WSGSEDEASN PFSFWVGENT 310 320 330 340 350 360 NNLFRPRVRE EANIRSKLRT NREDCFESES EDEFYKQSWV LPGEEANSRF RHRDKEDPNT 370 380 390 400 410 420 ALKLRAQKDV DSDRVKQEPR FEEEVIIGSW FWAEKEASLE GGASAICESE PGTEEGAIGG 430 440 450 460 470 480 SAYWAEEKSS LGAVAREEAK PESEEEAIFG SWFWDRDEAC FDLNPCPVYK VSDRFRDAAE 490 500 510 520 530 540 ELNASSRPQT WDEVTVEFKP GLFHGVGFRS TSPFGIPEEA SEMLEAKPKN LELSPEGEEQ 550 560 570 580 590 600 ESLLQPDQPS PEFTFQYDPS YRSVREIREH LRARESAESE SWSCSCIQCE LKIGSEEFEE 610 620 630 640 650 660 FLLLMDKIRD PFIHEISKIA MGMRSASQFT RDFIRDSGVV SLIETLLNYP SSRVRTSFLE 670 680 690 700 710 720 NMIHMAPPYP NLNMIETFIC QVCEETLAHS VDSLEQLTGI RMLRHLTMTI DYHTLIANYM 730 740 750 760 770 780 SGFLSLLTTA NARTKFHVLK MLLNLSENPA VAKKLFSAKA LSIFVGLFNI EETNDNIQIV 790 800 810 820 830 IKMFQNISNI IKSGKMSLID DDFSLEPLIS AFREFEELAK QLQAQIDNQN DPEVGQQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Ovary.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 657-838. Tissue: Kidney and Spleen.
[5]	"Identification of a novel family of G protein-coupled receptor associated sorting proteins." Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L. J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH G PROTEIN-COUPLED RECEPTORS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL035427 Genomic DNA. Translation: CAI43060.1. CH471190 Genomic DNA. Translation: EAW54727.1. CH471190 Genomic DNA. Translation: EAW54728.1. CH471190 Genomic DNA. Translation: EAW54729.1. BC013576 mRNA. Translation: AAH13576.1. BC036772 mRNA. Translation: AAH36772.1. AK092981 mRNA. No translation available.
IPI	IPI00069232.
RefSeq	NP_001004051.1. NM_001004051.3. NP_001171803.1. NM_001184874.2. NP_001171804.1. NM_001184875.2. NP_001171805.1. NM_001184876.2. NP_001186747.1. NM_001199818.1. NP_612446.1. NM_138437.5.
UniGene	Hs.522729. Hs.731996.
3D structure databases
ProteinModelPortal	Q96D09.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96D09. 19 interactions.
MINT	MINT-3978622.
STRING	9606.ENSP00000339057.
PTM databases
PhosphoSite	Q96D09.
Polymorphism databases
DMDM	74751808.
Proteomic databases
PaxDb	Q96D09.
PRIDE	Q96D09.
Protocols and materials databases
DNASU	114928.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332262; ENSP00000339057; ENSG00000158301. ENST00000535209; ENSP00000437394; ENSG00000158301. ENST00000543253; ENSP00000437872; ENSG00000158301.
GeneID	100528062. 114928.
KEGG	hsa:100528062. hsa:114928.
UCSC	uc004ejk.3. human.
Organism-specific databases
CTD	100528062. 114928.
GeneCards	GC0XP101979.
HGNC	HGNC:25169. GPRASP2.
HPA	HPA017438.
neXtProt	NX_Q96D09.
PharmGKB	PA134976848.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41843.
HOGENOM	HOG000231409.
HOVERGEN	HBG057167.
InParanoid	Q96D09.
OMA	MAGARPK.
OrthoDB	EOG47PX56.
PhylomeDB	Q96D09.
Gene expression databases
Bgee	Q96D09.
CleanEx	HS_GPRASP2.
Genevestigator	Q96D09.
GermOnline	ENSG00000158301. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR006911. ARM-rpt_dom. IPR016024. ARM-type_fold. [Graphical view]
Pfam	PF04826. Arm_2. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	79448.

Entry information

Entry name

GASP2_HUMAN

Accession

Primary (citable) accession number: Q96D09
Secondary accession number(s): D3DXA0, Q8NAB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.