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Protein

G-protein coupled receptor-associated sorting protein 2

Gene

GPRASP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulation of a variety of G-protein coupled receptors.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 2
Short name:
GASP-2
Gene namesi
Name:GPRASP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000158301.18.
HGNCiHGNC:25169. GPRASP2.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158301.
PharmGKBiPA134976848.

Polymorphism and mutation databases

BioMutaiGPRASP2.
DMDMi74751808.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002390531 – 838G-protein coupled receptor-associated sorting protein 2Add BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei282PhosphoserineHMP:1
Modified residuei284PhosphoserineHMP:1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96D09.
MaxQBiQ96D09.
PaxDbiQ96D09.
PeptideAtlasiQ96D09.
PRIDEiQ96D09.

PTM databases

iPTMnetiQ96D09.
PhosphoSitePlusiQ96D09.

Expressioni

Tissue specificityi

Expressed in the brain.1 Publication

Gene expression databases

BgeeiENSG00000158301.
CleanExiHS_GPRASP2.
GenevisibleiQ96D09. HS.

Organism-specific databases

HPAiHPA017438.

Interactioni

Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125399. 59 interactors.
IntActiQ96D09. 59 interactors.
MINTiMINT-3978622.
STRINGi9606.ENSP00000339057.

Structurei

3D structure databases

ProteinModelPortaliQ96D09.
SMRiQ96D09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPRASP family.IKR:

Phylogenomic databases

eggNOGiENOG410IVHR. Eukaryota.
ENOG410XUVQ. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231409.
HOVERGENiHBG057167.
InParanoidiQ96D09.
OMAiWFWDRDE.
OrthoDBiEOG091G01QA.
PhylomeDBiQ96D09.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
PfamiView protein in Pfam
PF04826. Arm_2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96D09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGAEIEPSA QAKPEKKAGE EVIAGPEREN DVPLVVRPKV RTQATTGARP
60 70 80 90 100
KTETKSVPAA RPKTEAQAMS GARPKTEVQV MGGARPKTEA QGITGARPKT
110 120 130 140 150
DARAVGGARS KTDAKAIPGA RPKDEAQAWA QSEFGTEAVS QAEGVSQTNA
160 170 180 190 200
VAWPLATAES GSVTKSKGLS MDRELVNVDA ETFPGTQGQK GIQPWFGPGE
210 220 230 240 250
ETNMGSWCYS RPRAREEASN ESGFWSADET STASSFWTGE ETSVRSWPRE
260 270 280 290 300
ESNTRSRHRA KHQTNPRSRP RSKQEAYVDS WSGSEDEASN PFSFWVGENT
310 320 330 340 350
NNLFRPRVRE EANIRSKLRT NREDCFESES EDEFYKQSWV LPGEEANSRF
360 370 380 390 400
RHRDKEDPNT ALKLRAQKDV DSDRVKQEPR FEEEVIIGSW FWAEKEASLE
410 420 430 440 450
GGASAICESE PGTEEGAIGG SAYWAEEKSS LGAVAREEAK PESEEEAIFG
460 470 480 490 500
SWFWDRDEAC FDLNPCPVYK VSDRFRDAAE ELNASSRPQT WDEVTVEFKP
510 520 530 540 550
GLFHGVGFRS TSPFGIPEEA SEMLEAKPKN LELSPEGEEQ ESLLQPDQPS
560 570 580 590 600
PEFTFQYDPS YRSVREIREH LRARESAESE SWSCSCIQCE LKIGSEEFEE
610 620 630 640 650
FLLLMDKIRD PFIHEISKIA MGMRSASQFT RDFIRDSGVV SLIETLLNYP
660 670 680 690 700
SSRVRTSFLE NMIHMAPPYP NLNMIETFIC QVCEETLAHS VDSLEQLTGI
710 720 730 740 750
RMLRHLTMTI DYHTLIANYM SGFLSLLTTA NARTKFHVLK MLLNLSENPA
760 770 780 790 800
VAKKLFSAKA LSIFVGLFNI EETNDNIQIV IKMFQNISNI IKSGKMSLID
810 820 830
DDFSLEPLIS AFREFEELAK QLQAQIDNQN DPEVGQQS
Length:838
Mass (Da):93,773
Last modified:December 1, 2001 - v1
Checksum:i2D30515916B7EACE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049265173R → S. Corresponds to variant dbSNP:rs6616421Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035427 Genomic DNA. No translation available.
CH471190 Genomic DNA. Translation: EAW54727.1.
CH471190 Genomic DNA. Translation: EAW54728.1.
CH471190 Genomic DNA. Translation: EAW54729.1.
BC013576 mRNA. Translation: AAH13576.1.
BC036772 mRNA. Translation: AAH36772.1.
AK092981 mRNA. No translation available.
CCDSiCCDS14501.1.
RefSeqiNP_001004051.1. NM_001004051.3.
NP_001171803.1. NM_001184874.2.
NP_001171804.1. NM_001184875.2.
NP_001171805.1. NM_001184876.2.
NP_001186747.1. NM_001199818.1.
NP_612446.1. NM_138437.5.
UniGeneiHs.522729.
Hs.731996.

Genome annotation databases

EnsembliENST00000332262; ENSP00000339057; ENSG00000158301.
ENST00000535209; ENSP00000437394; ENSG00000158301.
ENST00000543253; ENSP00000437872; ENSG00000158301.
GeneIDi100528062.
114928.
KEGGihsa:100528062.
hsa:114928.
UCSCiuc004ejm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGASP2_HUMAN
AccessioniPrimary (citable) accession number: Q96D09
Secondary accession number(s): D3DXA0, Q8NAB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families