Q96D05 (CJ035_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C10orf35

Gene names

Name:

C10orf35

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96D05-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96D05-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSPVLSGIHSIYSAWVTSVNITDCKPPSISGAAHQGPTAPGRM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 121	121	Uncharacterized protein C10orf35		PRO_0000089790
Regions
	Transmembrane	92 – 112	21	Helical; Potential
Amino acid modifications
	Modified residue	62	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	1	1	M → MSPVLSGIHSIYSAWVTSVN ITDCKPPSISGAAHQGPTAP GRM in isoform 2.		VSP_042153

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 6326728CAB5375C4	FASTA	121	13,238
	10 20 30 40 50 60 MVRILANGEI VQDDDPRVRT TTQPPRGSIP RQSFFNRGHG APPGGPGPRQ QQAGARLGAA 70 80 90 100 110 120 QSPFNDLNRQ LVNMGFPQWH LGNHAVEPVT SILLLFLLMM LGVRGLLLVG LVYLVSHLSQ R
	Isoform 2 [UniParc]. Checksum: DB1F7BEA8307C5DE	FASTA	163	17,512
	10 20 30 40 50 60 MSPVLSGIHS IYSAWVTSVN ITDCKPPSIS GAAHQGPTAP GRMVRILANG EIVQDDDPRV 70 80 90 100 110 120 RTTTQPPRGS IPRQSFFNRG HGAPPGGPGP RQQQAGARLG AAQSPFNDLN RQLVNMGFPQ 130 140 150 160 WHLGNHAVEP VTSILLLFLL MMLGVRGLLL VGLVYLVSHL SQR

References

[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreas.
[3]	Arakawa T., Carninci P., Fukuda S., Hasegawa A., Hayashida K., Hori F., Kai C., Kawai J., Kojima M., Murata M., Nakamura M., Nishiyori H., Nomura K., Ohno M., Sasaki D., Shibazaki E., Tagami M., Tagami Y., Hayashizaki Y. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-88 (ISOFORM 2). Tissue: Testis.
[4]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL450311 Genomic DNA. Translation: CAH72736.1. BC013587 mRNA. Translation: AAH13587.1. DB456046 mRNA. No translation available.
IPI	IPI00060546.
RefSeq	NP_660349.1. NM_145306.2.
UniGene	Hs.522992.
3D structure databases
ProteinModelPortal	Q96D05.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96D05. 1 interaction.
PTM databases
PhosphoSite	Q96D05.
Polymorphism databases
DMDM	68565253.
Proteomic databases
PRIDE	Q96D05.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373279; ENSP00000362376; ENSG00000171224. ENST00000395055; ENSP00000378495; ENSG00000171224.
GeneID	219738.
KEGG	hsa:219738.
UCSC	uc001jpq.2. human.
Organism-specific databases
CTD	219738.
GeneCards	GC10P071390.
HGNC	HGNC:23519. C10orf35.
HPA	HPA034591.
neXtProt	NX_Q96D05.
PharmGKB	PA134863788.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21400.
GeneTree	ENSGT00390000009341.
HOGENOM	HBG281539.
HOVERGEN	HBG056578.
InParanoid	Q96D05.
OrthoDB	EOG4DZ1WS.
PhylomeDB	Q96D05.
Gene expression databases
ArrayExpress	Q96D05.
Bgee	Q96D05.
CleanEx	HS_C10orf35.
Genevestigator	Q96D05.
GermOnline	ENSG00000171224. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	90730.

Entry information

Entry name

CJ035_HUMAN

Accession

Primary (citable) accession number: Q96D05

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.