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Protein

DNA damage-inducible transcript 4-like protein

Gene

DDIT4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.2 Publications

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DNA damage-inducible transcript 4-like protein
Alternative name(s):
HIF-1 responsive protein RTP801-like
Protein regulated in development and DNA damage response 2
Short name:
REDD-2
Gene namesi
Name:DDIT4L
Synonyms:REDD2, RTP801L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000145358.6
HGNCiHGNC:30555 DDIT4L
MIMi607730 gene
neXtProtiNX_Q96D03

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi115265
OpenTargetsiENSG00000145358
PharmGKBiPA128394749

Polymorphism and mutation databases

BioMutaiDDIT4L
DMDMi74731396

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003072041 – 193DNA damage-inducible transcript 4-like proteinAdd BLAST193

Proteomic databases

PaxDbiQ96D03
PeptideAtlasiQ96D03
PRIDEiQ96D03

PTM databases

iPTMnetiQ96D03
PhosphoSitePlusiQ96D03

Expressioni

Tissue specificityi

Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery.1 Publication

Inductioni

Up-regulated by oxidized LDL and hypoxia in macrophages.1 Publication

Gene expression databases

BgeeiENSG00000145358
CleanExiHS_DDIT4L
ExpressionAtlasiQ96D03 baseline and differential
GenevisibleiQ96D03 HS

Organism-specific databases

HPAiHPA050903

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125421, 7 interactors
IntActiQ96D03, 149 interactors
STRINGi9606.ENSP00000354830

Structurei

3D structure databases

ProteinModelPortaliQ96D03
SMRiQ96D03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DDIT4 family.Curated

Phylogenomic databases

eggNOGiENOG410J0CV Eukaryota
ENOG4111V50 LUCA
GeneTreeiENSGT00530000063652
HOGENOMiHOG000060250
HOVERGENiHBG104439
InParanoidiQ96D03
OMAiLVFKQDG
OrthoDBiEOG091G0LVJ
PhylomeDBiQ96D03
TreeFamiTF105007

Family and domain databases

Gene3Di1.10.490.100, 1 hit
InterProiView protein in InterPro
IPR012918 RTP801-like
IPR038281 RTP801-like_C_sf
PANTHERiPTHR12478 PTHR12478, 1 hit
PfamiView protein in Pfam
PF07809 RTP801_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q96D03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATGSLSSK NPASISELLD CGYHPESLLS DFDYWDYVVP EPNLNEVIFE
60 70 80 90 100
ESTCQNLVKM LENCLSKSKQ TKLGCSKVLV PEKLTQRIAQ DVLRLSSTEP
110 120 130 140 150
CGLRGCVMHV NLEIENVCKK LDRIVCDSSV VPTFELTLVF KQENCSWTSF
160 170 180 190
RDFFFSRGRF SSGFRRTLIL SSGFRLVKKK LYSLIGTTVI EGS
Length:193
Mass (Da):21,740
Last modified:December 1, 2001 - v1
Checksum:i3BEEB3D0530C5BFF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053971161S → F. Corresponds to variant dbSNP:rs11553154Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094236 mRNA Translation: BAC04315.1
AK312926 mRNA Translation: BAG35770.1
AL832277 mRNA Translation: CAI46176.1
CH471057 Genomic DNA Translation: EAX06119.1
BC013592 mRNA Translation: AAH13592.1
CCDSiCCDS34036.1
RefSeqiNP_660287.1, NM_145244.3
UniGeneiHs.480378

Genome annotation databases

EnsembliENST00000273990; ENSP00000354830; ENSG00000145358
GeneIDi115265
KEGGihsa:115265
UCSCiuc003hvq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiDDT4L_HUMAN
AccessioniPrimary (citable) accession number: Q96D03
Secondary accession number(s): B2R7C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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