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Protein

DNA damage-inducible transcript 4-like protein

Gene

DDIT4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.2 Publications

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
DNA damage-inducible transcript 4-like protein
Alternative name(s):
HIF-1 responsive protein RTP801-like
Protein regulated in development and DNA damage response 2
Short name:
REDD-2
Gene namesi
Name:DDIT4L
Synonyms:REDD2, RTP801L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:30555. DDIT4L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394749.

Polymorphism and mutation databases

BioMutaiDDIT4L.
DMDMi74731396.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193DNA damage-inducible transcript 4-like proteinPRO_0000307204Add
BLAST

Proteomic databases

PaxDbiQ96D03.
PRIDEiQ96D03.

PTM databases

iPTMnetiQ96D03.
PhosphoSiteiQ96D03.

Expressioni

Tissue specificityi

Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery.1 Publication

Inductioni

Up-regulated by oxidized LDL and hypoxia in macrophages.1 Publication

Gene expression databases

BgeeiQ96D03.
CleanExiHS_DDIT4L.
ExpressionAtlasiQ96D03. baseline and differential.
GenevisibleiQ96D03. HS.

Organism-specific databases

HPAiHPA050903.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-742054,EBI-739580
LSM7Q9UK453EBI-742054,EBI-348372
MORF4L2Q150143EBI-742054,EBI-399257
SNRPGP623084EBI-742054,EBI-624585

Protein-protein interaction databases

BioGridi125421. 7 interactions.
IntActiQ96D03. 5 interactions.
MINTiMINT-1438761.
STRINGi9606.ENSP00000354830.

Structurei

3D structure databases

ProteinModelPortaliQ96D03.
SMRiQ96D03. Positions 50-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DDIT4 family.Curated

Phylogenomic databases

eggNOGiENOG410J0CV. Eukaryota.
ENOG4111V50. LUCA.
GeneTreeiENSGT00530000063652.
HOGENOMiHOG000060250.
HOVERGENiHBG104439.
InParanoidiQ96D03.
OMAiEETTCQN.
OrthoDBiEOG7P2XTF.
PhylomeDBiQ96D03.
TreeFamiTF105007.

Family and domain databases

InterProiIPR012918. RTP801-like.
[Graphical view]
PANTHERiPTHR12478. PTHR12478. 1 hit.
PfamiPF07809. RTP801_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96D03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATGSLSSK NPASISELLD CGYHPESLLS DFDYWDYVVP EPNLNEVIFE
60 70 80 90 100
ESTCQNLVKM LENCLSKSKQ TKLGCSKVLV PEKLTQRIAQ DVLRLSSTEP
110 120 130 140 150
CGLRGCVMHV NLEIENVCKK LDRIVCDSSV VPTFELTLVF KQENCSWTSF
160 170 180 190
RDFFFSRGRF SSGFRRTLIL SSGFRLVKKK LYSLIGTTVI EGS
Length:193
Mass (Da):21,740
Last modified:December 1, 2001 - v1
Checksum:i3BEEB3D0530C5BFF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti161 – 1611S → F.
Corresponds to variant rs11553154 [ dbSNP | Ensembl ].
VAR_053971

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094236 mRNA. Translation: BAC04315.1.
AK312926 mRNA. Translation: BAG35770.1.
AL832277 mRNA. Translation: CAI46176.1.
CH471057 Genomic DNA. Translation: EAX06119.1.
BC013592 mRNA. Translation: AAH13592.1.
CCDSiCCDS34036.1.
RefSeqiNP_660287.1. NM_145244.3.
XP_005262778.1. XM_005262721.1.
UniGeneiHs.480378.

Genome annotation databases

EnsembliENST00000273990; ENSP00000354830; ENSG00000145358.
GeneIDi115265.
KEGGihsa:115265.
UCSCiuc003hvq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094236 mRNA. Translation: BAC04315.1.
AK312926 mRNA. Translation: BAG35770.1.
AL832277 mRNA. Translation: CAI46176.1.
CH471057 Genomic DNA. Translation: EAX06119.1.
BC013592 mRNA. Translation: AAH13592.1.
CCDSiCCDS34036.1.
RefSeqiNP_660287.1. NM_145244.3.
XP_005262778.1. XM_005262721.1.
UniGeneiHs.480378.

3D structure databases

ProteinModelPortaliQ96D03.
SMRiQ96D03. Positions 50-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125421. 7 interactions.
IntActiQ96D03. 5 interactions.
MINTiMINT-1438761.
STRINGi9606.ENSP00000354830.

PTM databases

iPTMnetiQ96D03.
PhosphoSiteiQ96D03.

Polymorphism and mutation databases

BioMutaiDDIT4L.
DMDMi74731396.

Proteomic databases

PaxDbiQ96D03.
PRIDEiQ96D03.

Protocols and materials databases

DNASUi115265.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273990; ENSP00000354830; ENSG00000145358.
GeneIDi115265.
KEGGihsa:115265.
UCSCiuc003hvq.4. human.

Organism-specific databases

CTDi115265.
GeneCardsiDDIT4L.
HGNCiHGNC:30555. DDIT4L.
HPAiHPA050903.
MIMi607730. gene.
neXtProtiNX_Q96D03.
PharmGKBiPA128394749.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0CV. Eukaryota.
ENOG4111V50. LUCA.
GeneTreeiENSGT00530000063652.
HOGENOMiHOG000060250.
HOVERGENiHBG104439.
InParanoidiQ96D03.
OMAiEETTCQN.
OrthoDBiEOG7P2XTF.
PhylomeDBiQ96D03.
TreeFamiTF105007.

Miscellaneous databases

GenomeRNAii115265.
PROiQ96D03.
SOURCEiSearch...

Gene expression databases

BgeeiQ96D03.
CleanExiHS_DDIT4L.
ExpressionAtlasiQ96D03. baseline and differential.
GenevisibleiQ96D03. HS.

Family and domain databases

InterProiIPR012918. RTP801-like.
[Graphical view]
PANTHERiPTHR12478. PTHR12478. 1 hit.
PfamiPF07809. RTP801_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum and Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph node.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species."
    Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H., Minda K., Oliner J.D., McKeon F., Haber D.A.
    Mol. Cell 10:995-1005(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: TISSUE SPECIFICITY, INDUCTION.
  7. "Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex."
    Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H., Hafen E., Witters L.A., Ellisen L.W., Kaelin W.G. Jr.
    Genes Dev. 18:2893-2904(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway."
    Corradetti M.N., Inoki K., Guan K.-L.
    J. Biol. Chem. 280:9769-9772(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiDDT4L_HUMAN
AccessioniPrimary (citable) accession number: Q96D03
Secondary accession number(s): B2R7C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.