Q96CY4 (Q96CY4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Neurotrophic tyrosine kinase, receptor, type 3 EMBL AAH13693.1

Submitted name:
Neurotrophic tyrosine kinase, receptor, type 3, isoform CRA_e EMBL EAX01993.1

Gene names

Name:	NTRK3 EMBL AAH13693.1
ORF Names:	hCG_26627 EMBL EAX01993.1

Organism

Homo sapiens (Human) EMBL AAH13693.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	612 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 LRRCT domain. SAAS SAAS013098

Ontologies

Keywords
Domain	Immunoglobulin domain SAAS SAAS000483 Leucine-rich repeat SAAS SAAS000372 Repeat SAAS SAAS000483
Molecular function	Kinase EMBL AAH13693.1 Receptor EMBL AAH13693.1 Transferase
PTM	Disulfide bond SAAS SAAS000372
Gene Ontology (GO)
Biological_process	transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro neurotrophin receptor activity Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q96CY4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F2E84DC71B8E4DB3	FASTA	612	68,452
	10 20 30 40 50 60 MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 70 80 90 100 110 120 DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP 130 140 150 160 170 180 RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA 190 200 210 220 230 240 KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 250 260 270 280 290 300 VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 310 320 330 340 350 360 VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE 370 380 390 400 410 420 GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILF DEVSPTPPIT 430 440 450 460 470 480 VTHKPEEDTF GVSIAVGLAA FACVLLVVLF VMINKYGRRS KFGMKGPVAV ISGEEDSASP 490 500 510 520 530 540 LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTWV FSNIDNHGIL 550 560 570 580 590 600 NLKDNRDHLV PSTHYIYEEP EVQSGEVSYP RSHGFREIML NPISLPGHSK PLNHGIYVED 610 VNVYFSKGRH GF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of human full-length CDSs in BD Creator(TM) System Donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAH13693.1.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC013693 mRNA. Translation: AAH13693.1. BT007291 mRNA. Translation: AAP35955.1. CH471101 Genomic DNA. Translation: EAX01993.1.
IPI	IPI00185466.
RefSeq	NP_001007157.1. NM_001007156.2.
UniGene	Hs.410969. Hs.706364.
3D structure databases
HSSP	HSSP built from PDB template 1WWC based on UniProtKB Q16288.
ProteinModelPortal	Q96CY4.
SMR	Q96CY4. Positions 32-401.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96CY4.
Proteomic databases
PRIDE	Q96CY4.
Protocols and materials databases
DNASU	4916.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4916.
KEGG	hsa:4916.
UCSC	uc002bmg.3. human.
Organism-specific databases
CTD	4916.
PharmGKB	PA31819.
Phylogenomic databases
HOGENOM	HOG000264255.
HOVERGEN	HBG056735.
KO	K05101.
Gene expression databases
ArrayExpress	Q96CY4.
Bgee	Q96CY4.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR001611. Leu-rich_rpt. IPR000372. LRR-contain_N. IPR020446. Tyr_kin_neurotrophic_rcpt_3. IPR020777. Tyr_kinase_NGF_rcpt. [Graphical view]
Pfam	PF07679. I-set. 2 hits. PF01462. LRRNT. 1 hit. [Graphical view]
PRINTS	PR01939. NTKRECEPTOR. PR01942. NTKRECEPTOR3.
SMART	SM00409. IG. 1 hit. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS51450. LRR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NTRK3. human.
GenomeRNAi	4916.
NextBio	18927.

Entry information

Entry name

Q96CY4_HUMAN

Accession

Primary (citable) accession number: Q96CY4

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	March 6, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.