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Protein

Leucine-rich repeat-containing protein 58

Gene

LRRC58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163428-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 58
Gene namesi
Name:LRRC58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26968. LRRC58.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163428.
PharmGKBiPA142671517.

Polymorphism and mutation databases

BioMutaiLRRC58.
DMDMi162416229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003120171 – 371Leucine-rich repeat-containing protein 58Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96CX6.
MaxQBiQ96CX6.
PaxDbiQ96CX6.
PeptideAtlasiQ96CX6.
PRIDEiQ96CX6.

PTM databases

iPTMnetiQ96CX6.
PhosphoSitePlusiQ96CX6.

Expressioni

Gene expression databases

BgeeiENSG00000163428.
CleanExiHS_LRRC58.
GenevisibleiQ96CX6. HS.

Organism-specific databases

HPAiHPA057574.

Interactioni

Protein-protein interaction databases

BioGridi125468. 6 interactors.
IntActiQ96CX6. 2 interactors.
MINTiMINT-2813855.
STRINGi9606.ENSP00000295628.

Structurei

3D structure databases

ProteinModelPortaliQ96CX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 66LRR 1Add BLAST22
Repeati69 – 91LRR 2Add BLAST23
Repeati92 – 113LRR 3Add BLAST22
Repeati121 – 143LRR 4Add BLAST23
Repeati144 – 166LRR 5Add BLAST23
Repeati167 – 189LRR 6Add BLAST23
Repeati190 – 211LRR 7Add BLAST22
Repeati213 – 234LRR 8Add BLAST22
Repeati236 – 256LRR 9Add BLAST21

Sequence similaritiesi

Contains 9 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000063533.
HOGENOMiHOG000008054.
HOVERGENiHBG108100.
InParanoidiQ96CX6.
OMAiCKGVFFD.
OrthoDBiEOG091G0BVZ.
PhylomeDBiQ96CX6.
TreeFamiTF351911.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAGAAVVT AGEAELNWSR LSVSTETLES ELEARGEERR GAREALLRLL
60 70 80 90 100
LPHNRLVSLP RALGSGFPHL QLLDVSGNAL TALGPELLAL RGLRTLLAKN
110 120 130 140 150
NRLGGPSALP KGLAQSPLCR SLQVLNLSGN CFQEVPASLL ELRALQTLSL
160 170 180 190 200
GGNQLQSIPA EIENLQSLEC LYLGGNFIKE IPPELGNLPS LNYLVLCDNK
210 220 230 240 250
IQSIPPQLSQ LHSLRSLSLH NNLLTYLPRE ILNLIHLEEL SLRGNPLVVR
260 270 280 290 300
FVRDLTYDPP TLLELAARTI KIRNISYTPY DLPGNLLRYL GSASNCPNPK
310 320 330 340 350
CGGVYFDCCV RQIKFVDFCG KYRLPLMHYL CSPECSSPCS SASHSSTSQS
360 370
ESDSEDEASV AARRMQKVLL G
Length:371
Mass (Da):40,586
Last modified:December 4, 2007 - v2
Checksum:i89C66EAD62CBE55C
GO

Sequence cautioni

The sequence AAH13757 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013757 mRNA. Translation: AAH13757.1. Different initiation.
CCDSiCCDS46892.1.
RefSeqiNP_001093148.1. NM_001099678.1.
UniGeneiHs.518084.

Genome annotation databases

EnsembliENST00000295628; ENSP00000295628; ENSG00000163428.
GeneIDi116064.
KEGGihsa:116064.
UCSCiuc003edr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013757 mRNA. Translation: AAH13757.1. Different initiation.
CCDSiCCDS46892.1.
RefSeqiNP_001093148.1. NM_001099678.1.
UniGeneiHs.518084.

3D structure databases

ProteinModelPortaliQ96CX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125468. 6 interactors.
IntActiQ96CX6. 2 interactors.
MINTiMINT-2813855.
STRINGi9606.ENSP00000295628.

PTM databases

iPTMnetiQ96CX6.
PhosphoSitePlusiQ96CX6.

Polymorphism and mutation databases

BioMutaiLRRC58.
DMDMi162416229.

Proteomic databases

EPDiQ96CX6.
MaxQBiQ96CX6.
PaxDbiQ96CX6.
PeptideAtlasiQ96CX6.
PRIDEiQ96CX6.

Protocols and materials databases

DNASUi116064.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295628; ENSP00000295628; ENSG00000163428.
GeneIDi116064.
KEGGihsa:116064.
UCSCiuc003edr.3. human.

Organism-specific databases

CTDi116064.
GeneCardsiLRRC58.
HGNCiHGNC:26968. LRRC58.
HPAiHPA057574.
neXtProtiNX_Q96CX6.
OpenTargetsiENSG00000163428.
PharmGKBiPA142671517.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00530000063533.
HOGENOMiHOG000008054.
HOVERGENiHBG108100.
InParanoidiQ96CX6.
OMAiCKGVFFD.
OrthoDBiEOG091G0BVZ.
PhylomeDBiQ96CX6.
TreeFamiTF351911.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163428-MONOMER.

Miscellaneous databases

ChiTaRSiLRRC58. human.
GenomeRNAii116064.
PROiQ96CX6.

Gene expression databases

BgeeiENSG00000163428.
CleanExiHS_LRRC58.
GenevisibleiQ96CX6. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC58_HUMAN
AccessioniPrimary (citable) accession number: Q96CX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.