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Protein

Zinc finger protein 501

Gene

ZNF501

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 4423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri50 – 7223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri78 – 10023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri106 – 12823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 15623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 18423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri190 – 21223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri218 – 24023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 501
Alternative name(s):
Zinc finger protein 52
Gene namesi
Name:ZNF501
Synonyms:ZNF52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23717. ZNF501.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134959192.

Polymorphism and mutation databases

BioMutaiZNF501.
DMDMi118597385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Zinc finger protein 501PRO_0000047621Add
BLAST

Proteomic databases

PaxDbiQ96CX3.
PRIDEiQ96CX3.

Expressioni

Gene expression databases

BgeeiQ96CX3.
CleanExiHS_ZNF501.
GenevisibleiQ96CX3. HS.

Organism-specific databases

HPAiHPA044161.

Interactioni

Protein-protein interaction databases

BioGridi125439. 4 interactions.
IntActiQ96CX3. 1 interaction.
STRINGi9606.ENSP00000379363.

Structurei

3D structure databases

ProteinModelPortaliQ96CX3.
SMRiQ96CX3. Positions 20-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 4423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri50 – 7223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri78 – 10023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri106 – 12823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 15623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 18423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri190 – 21223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri218 – 24023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96CX3.
OMAiSVCLTRH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96CX3.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSSQISLRM KHGRVNMQKK PSKCSECGKF FTQRSSLTQH QRIHRGEKPY
60 70 80 90 100
VCSECGSCFR KQSNLTQHLR IHTGEKPYKC NECEKAFQTK AILVQHLRIH
110 120 130 140 150
TGEKPYKCNE CGKAFCQSPS LIKHQRIHTG EKPYKCTECG KAFSQSICLT
160 170 180 190 200
RHQRSHSGDK PFKCNECGKA FNQSACLMQH QRIHSGEKPY TCTECGKAFT
210 220 230 240 250
QNSSLVEHER THTGEKLYKC SECEKTFRKQ AHLSEHYRIH TGEKPYECVG
260 270
CGKSFRHSSA LLRHQRLHAG E
Length:271
Mass (Da):31,179
Last modified:November 28, 2006 - v2
Checksum:i090AA309637BD8AA
GO
Isoform 2 (identifier: Q96CX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-199: Missing.

Note: May be due to exon skipping.
Show »
Length:215
Mass (Da):24,880
Checksum:iF0E671D24ABA4F76
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171M → V.1 Publication
Corresponds to variant rs4682752 [ dbSNP | Ensembl ].
VAR_024219
Natural varianti147 – 1471I → V.
Corresponds to variant rs58211979 [ dbSNP | Ensembl ].
VAR_061952

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei144 – 19956Missing in isoform 2. 1 PublicationVSP_010173Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054613 mRNA. Translation: BAB70773.1.
AK297216 mRNA. Translation: BAG59699.1.
BC013762 mRNA. Translation: AAH13762.2.
CCDSiCCDS2720.2. [Q96CX3-1]
RefSeqiNP_001245209.1. NM_001258280.1. [Q96CX3-1]
NP_659481.2. NM_145044.3. [Q96CX3-1]
UniGeneiHs.401045.

Genome annotation databases

EnsembliENST00000396048; ENSP00000379363; ENSG00000186446. [Q96CX3-1]
ENST00000620116; ENSP00000482632; ENSG00000186446. [Q96CX3-1]
ENST00000625592; ENSP00000485862; ENSG00000281661. [Q96CX3-1]
ENST00000627775; ENSP00000487032; ENSG00000281661. [Q96CX3-1]
GeneIDi115560.
KEGGihsa:115560.
UCSCiuc003cnu.3. human. [Q96CX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054613 mRNA. Translation: BAB70773.1.
AK297216 mRNA. Translation: BAG59699.1.
BC013762 mRNA. Translation: AAH13762.2.
CCDSiCCDS2720.2. [Q96CX3-1]
RefSeqiNP_001245209.1. NM_001258280.1. [Q96CX3-1]
NP_659481.2. NM_145044.3. [Q96CX3-1]
UniGeneiHs.401045.

3D structure databases

ProteinModelPortaliQ96CX3.
SMRiQ96CX3. Positions 20-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125439. 4 interactions.
IntActiQ96CX3. 1 interaction.
STRINGi9606.ENSP00000379363.

Polymorphism and mutation databases

BioMutaiZNF501.
DMDMi118597385.

Proteomic databases

PaxDbiQ96CX3.
PRIDEiQ96CX3.

Protocols and materials databases

DNASUi115560.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396048; ENSP00000379363; ENSG00000186446. [Q96CX3-1]
ENST00000620116; ENSP00000482632; ENSG00000186446. [Q96CX3-1]
ENST00000625592; ENSP00000485862; ENSG00000281661. [Q96CX3-1]
ENST00000627775; ENSP00000487032; ENSG00000281661. [Q96CX3-1]
GeneIDi115560.
KEGGihsa:115560.
UCSCiuc003cnu.3. human. [Q96CX3-1]

Organism-specific databases

CTDi115560.
GeneCardsiZNF501.
HGNCiHGNC:23717. ZNF501.
HPAiHPA044161.
neXtProtiNX_Q96CX3.
PharmGKBiPA134959192.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96CX3.
OMAiSVCLTRH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96CX3.
TreeFamiTF337055.

Miscellaneous databases

GenomeRNAii115560.
NextBioi79616.
PROiQ96CX3.

Gene expression databases

BgeeiQ96CX3.
CleanExiHS_ZNF501.
GenevisibleiQ96CX3. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-17.
    Tissue: Adrenal gland and Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryonic carcinoma and Testis.

Entry informationi

Entry nameiZN501_HUMAN
AccessioniPrimary (citable) accession number: Q96CX3
Secondary accession number(s): B4DLY7, Q96NU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 28, 2006
Last modified: May 11, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.