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Protein

Zinc finger protein 501

Gene

ZNF501

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 44C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri50 – 72C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri78 – 100C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri106 – 128C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri134 – 156C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 184C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 501
Alternative name(s):
Zinc finger protein 52
Gene namesi
Name:ZNF501
Synonyms:ZNF52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000186446.11.
HGNCiHGNC:23717. ZNF501.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi115560.
OpenTargetsiENSG00000186446.
PharmGKBiPA134959192.

Polymorphism and mutation databases

BioMutaiZNF501.
DMDMi118597385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476211 – 271Zinc finger protein 501Add BLAST271

Proteomic databases

PaxDbiQ96CX3.
PeptideAtlasiQ96CX3.
PRIDEiQ96CX3.

PTM databases

iPTMnetiQ96CX3.
PhosphoSitePlusiQ96CX3.

Expressioni

Gene expression databases

BgeeiENSG00000186446.
CleanExiHS_ZNF501.
GenevisibleiQ96CX3. HS.

Organism-specific databases

HPAiHPA044161.

Interactioni

Protein-protein interaction databases

BioGridi125439. 4 interactors.
IntActiQ96CX3. 1 interactor.
STRINGi9606.ENSP00000379363.

Structurei

3D structure databases

ProteinModelPortaliQ96CX3.
SMRiQ96CX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 44C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri50 – 72C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri78 – 100C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri106 – 128C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri134 – 156C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 184C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139349.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96CX3.
OMAiSVCLTRH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96CX3.
TreeFamiTF337055.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSSQISLRM KHGRVNMQKK PSKCSECGKF FTQRSSLTQH QRIHRGEKPY
60 70 80 90 100
VCSECGSCFR KQSNLTQHLR IHTGEKPYKC NECEKAFQTK AILVQHLRIH
110 120 130 140 150
TGEKPYKCNE CGKAFCQSPS LIKHQRIHTG EKPYKCTECG KAFSQSICLT
160 170 180 190 200
RHQRSHSGDK PFKCNECGKA FNQSACLMQH QRIHSGEKPY TCTECGKAFT
210 220 230 240 250
QNSSLVEHER THTGEKLYKC SECEKTFRKQ AHLSEHYRIH TGEKPYECVG
260 270
CGKSFRHSSA LLRHQRLHAG E
Length:271
Mass (Da):31,179
Last modified:November 28, 2006 - v2
Checksum:i090AA309637BD8AA
GO
Isoform 2 (identifier: Q96CX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-199: Missing.

Note: May be due to exon skipping.
Show »
Length:215
Mass (Da):24,880
Checksum:iF0E671D24ABA4F76
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02421917M → V1 PublicationCorresponds to variant dbSNP:rs4682752Ensembl.1
Natural variantiVAR_061952147I → V. Corresponds to variant dbSNP:rs58211979Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010173144 – 199Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054613 mRNA. Translation: BAB70773.1.
AK297216 mRNA. Translation: BAG59699.1.
BC013762 mRNA. Translation: AAH13762.2.
CCDSiCCDS2720.2. [Q96CX3-1]
RefSeqiNP_001245209.1. NM_001258280.1. [Q96CX3-1]
NP_659481.2. NM_145044.3. [Q96CX3-1]
UniGeneiHs.401045.

Genome annotation databases

EnsembliENST00000396048; ENSP00000379363; ENSG00000186446. [Q96CX3-1]
ENST00000620116; ENSP00000482632; ENSG00000186446. [Q96CX3-1]
ENST00000625592; ENSP00000485862; ENSG00000281661. [Q96CX3-1]
ENST00000627775; ENSP00000487032; ENSG00000281661. [Q96CX3-1]
GeneIDi115560.
KEGGihsa:115560.
UCSCiuc003cnu.3. human. [Q96CX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN501_HUMAN
AccessioniPrimary (citable) accession number: Q96CX3
Secondary accession number(s): B4DLY7, Q96NU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 28, 2006
Last modified: September 27, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families