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Protein

Probable RNA polymerase II nuclear localization protein SLC7A6OS

Gene

SLC7A6OS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Directs RNA polymerase II nuclear import.By similarity

Miscellaneous

When transfected to S.cerevisiae cells, able to partially restore polymerase II mislocalization and cellular shape in IWR1 mutant cells.1 Publication

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA polymerase II nuclear localization protein SLC7A6OS
Alternative name(s):
ADAMS proteinase-related protein
Solute carrier family 7 member 6 opposite strand transcript
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103061.11.
HGNCiHGNC:25807. SLC7A6OS.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103061.
PharmGKBiPA142670912.

Polymorphism and mutation databases

BioMutaiSLC7A6OS.
DMDMi296452893.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891691 – 309Probable RNA polymerase II nuclear localization protein SLC7A6OSAdd BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei302PhosphoserineCombined sources1
Modified residuei308PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96CW6.
MaxQBiQ96CW6.
PaxDbiQ96CW6.
PeptideAtlasiQ96CW6.
PRIDEiQ96CW6.

PTM databases

iPTMnetiQ96CW6.
PhosphoSitePlusiQ96CW6.
SwissPalmiQ96CW6.

Expressioni

Gene expression databases

BgeeiENSG00000103061.
CleanExiHS_SLC7A6OS.
ExpressionAtlasiQ96CW6. baseline and differential.
GenevisibleiQ96CW6. HS.

Organism-specific databases

HPAiHPA041533.

Interactioni

Protein-protein interaction databases

BioGridi123908. 2 interactors.
IntActiQ96CW6. 1 interactor.
STRINGi9606.ENSP00000263997.

Structurei

3D structure databases

ProteinModelPortaliQ96CW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IWR1/SLC7A6OS family.Curated

Phylogenomic databases

eggNOGiKOG4852. Eukaryota.
ENOG4111M5W. LUCA.
GeneTreeiENSGT00390000015672.
HOGENOMiHOG000136364.
HOVERGENiHBG054901.
InParanoidiQ96CW6.
OMAiSCKTSDP.
OrthoDBiEOG091G170V.
PhylomeDBiQ96CW6.
TreeFamiTF324404.

Family and domain databases

InterProiView protein in InterPro
IPR013883. TF_Iwr1.
PfamiView protein in Pfam
PF08574. Iwr1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96CW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAARTAVLR VKRKRSAEPA EALVLACKRL RSDAVESAAQ KTSEGLERAA
60 70 80 90 100
ENNVFHLVAT VCSQEEPVQP LLREVLRPSR DSQQRVRRNL RASAREVRQE
110 120 130 140 150
GRYRVLSSRR SLGTTSSGQE SEYTPGNPEA AGNSGFQLLD LVHEEGEPEA
160 170 180 190 200
ASAGSCKTSD PDVILCNSVE LIRERLTVSE DGPGVRRQEE QKHDDYVYDI
210 220 230 240 250
YYLETATPGW IENILSVQPY SQEWELVNDD QEPEDIYDDE DDENSENNWR
260 270 280 290 300
NEYPEEESSD GDEDSRGSAD YNSLSEEERG SSRQRMWSKY PLDVQKEFGY

DSPHDLDSD
Length:309
Mass (Da):35,028
Last modified:May 18, 2010 - v2
Checksum:iF1C92B631F33E034
GO

Sequence cautioni

Q96CW6: The sequence AAL79958 differs from that shown. Reason: Frameshift at position 234.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78P → L in BAB14538 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03259124V → M. Corresponds to variant dbSNP:rs35800405Ensembl.1
Natural variantiVAR_03259245G → D2 PublicationsCorresponds to variant dbSNP:rs3803650Ensembl.1
Natural variantiVAR_032593116S → A. Corresponds to variant dbSNP:rs8063446Ensembl.1
Natural variantiVAR_032594220Y → C. Corresponds to variant dbSNP:rs11548855Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078070 mRNA. Translation: AAL79958.1. Frameshift.
AK023353 mRNA. Translation: BAB14538.1.
AC020978 Genomic DNA. No translation available.
BC013778 mRNA. Translation: AAH13778.1.
CCDSiCCDS10865.1.
RefSeqiNP_115554.2. NM_032178.2.
UniGeneiHs.729520.

Genome annotation databases

EnsembliENST00000263997; ENSP00000263997; ENSG00000103061.
GeneIDi84138.
KEGGihsa:84138.
UCSCiuc002evw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS7A6O_HUMAN
AccessioniPrimary (citable) accession number: Q96CW6
Secondary accession number(s): Q8TCZ3, Q9H8R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families