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Protein

Gamma-tubulin complex component 3

Gene

TUBGCP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: UniProtKB
  • structural molecule activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126216-MONOMER.
ReactomeiR-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 3
Short name:
GCP-3
Short name:
hGCP3
Alternative name(s):
Gamma-ring complex protein 104 kDa
Short name:
h104p
Short name:
hGrip104
Spindle pole body protein Spc98 homolog
Short name:
hSpc98
Gene namesi
Name:TUBGCP3
Synonyms:GCP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:18598. TUBGCP3.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • equatorial microtubule organizing center Source: GO_Central
  • gamma-tubulin small complex Source: GO_Central
  • membrane Source: UniProtKB
  • polar microtubule Source: UniProtKB
  • spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi10426.
OpenTargetsiENSG00000126216.
PharmGKBiPA38597.

Polymorphism and mutation databases

DMDMi21362575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000781182 – 907Gamma-tubulin complex component 3Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96CW5.
MaxQBiQ96CW5.
PaxDbiQ96CW5.
PeptideAtlasiQ96CW5.
PRIDEiQ96CW5.

PTM databases

iPTMnetiQ96CW5.
PhosphoSitePlusiQ96CW5.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000126216.
CleanExiHS_TUBGCP3.
ExpressionAtlasiQ96CW5. baseline and differential.
GenevisibleiQ96CW5. HS.

Organism-specific databases

HPAiHPA043913.

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2.1 Publication

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115695. 155 interactors.
IntActiQ96CW5. 38 interactors.
MINTiMINT-3051799.
STRINGi9606.ENSP00000261965.

Structurei

3D structure databases

ProteinModelPortaliQ96CW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi825 – 829Poly-Glu5

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2000. Eukaryota.
ENOG410XQ5B. LUCA.
GeneTreeiENSGT00850000132278.
HOGENOMiHOG000007959.
HOVERGENiHBG031568.
InParanoidiQ96CW5.
KOiK16570.
OMAiTIDSHAN.
OrthoDBiEOG091G01V2.
PhylomeDBiQ96CW5.
TreeFamiTF300705.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 3 hits.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q96CW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPDQKSPN VLLQNLCCRI LGRSEADVAQ QFQYAVRVIG SNFAPTVERD
60 70 80 90 100
EFLVAEKIKK ELIRQRREAD AALFSELHRK LHSQGVLKNK WSILYLLLSL
110 120 130 140 150
SEDPRRQPSK VSSYATLFAQ ALPRDAHSTP YYYARPQTLP LSYQDRSAQS
160 170 180 190 200
AQSSGSVGSS GISSIGLCAL SGPAPAPQSL LPGQSNQAPG VGDCLRQQLG
210 220 230 240 250
SRLAWTLTAN QPSSQATTSK GVPSAVSRNM TRSRREGDTG GTMEITEAAL
260 270 280 290 300
VRDILYVFQG IDGKNIKMNN TENCYKVEGK ANLSRSLRDT AVRLSELGWL
310 320 330 340 350
HNKIRRYTDQ RSLDRSFGLV GQSFCAALHQ ELREYYRLLS VLHSQLQLED
360 370 380 390 400
DQGVNLGLES SLTLRRLLVW TYDPKIRLKT LAALVDHCQG RKGGELASAV
410 420 430 440 450
HAYTKTGDPY MRSLVQHILS LVSHPVLSFL YRWIYDGELE DTYHEFFVAS
460 470 480 490 500
DPTVKTDRLW HDKYTLRKSM IPSFMTMDQS RKVLLIGKSI NFLHQVCHDQ
510 520 530 540 550
TPTTKMIAVT KSAESPQDAA DLFTDLENAF QGKIDAAYFE TSKYLLDVLN
560 570 580 590 600
KKYSLLDHMQ AMRRYLLLGQ GDFIRHLMDL LKPELVRPAT TLYQHNLTGI
610 620 630 640 650
LETAVRATNA QFDSPEILRR LDVRLLEVSP GDTGWDVFSL DYHVDGPIAT
660 670 680 690 700
VFTRECMSHY LRVFNFLWRA KRMEYILTDI RKGHMCNAKL LRNMPEFSGV
710 720 730 740 750
LHQCHILASE MVHFIHQMQY YITFEVLECS WDELWNKVQQ AQDLDHIIAA
760 770 780 790 800
HEVFLDTIIS RCLLDSDSRA LLNQLRAVFD QIIELQNAQD AIYRAALEEL
810 820 830 840 850
QRRLQFEEKK KQREIEGQWG VTAAEEEEEN KRIGEFKESI PKMCSQLRIL
860 870 880 890 900
THFYQGIVQQ FLVLLTTSSD ESLRFLSFRL DFNEHYKARE PRLRVSLGTR

GRRSSHT
Length:907
Mass (Da):103,571
Last modified:June 6, 2002 - v2
Checksum:i70FE2FDB7C80344D
GO
Isoform 2 (identifier: Q96CW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     817-824: GQWGVTAA → VEMCLYCV
     825-907: Missing.

Show »
Length:824
Mass (Da):93,885
Checksum:iDF5AEDA7A34E531A
GO
Isoform 3 (identifier: Q96CW5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-434: RKGGELASAV...PVLSFLYRWI → PTRVFPTHVF...WHSLCFRTRL
     435-907: Missing.

Show »
Length:434
Mass (Da):48,647
Checksum:i9FB608525458BB54
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361S → I in CAA05832 (PubMed:9566969).Curated1
Sequence conflicti361S → I in CAA05833 (PubMed:9566969).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049251208T → S.1 PublicationCorresponds to variant rs1044287dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001622391 – 434RKGGE…LYRWI → PTRVFPTHVFPTRDFPTRDF PMHVFPTRVFPTRVWHSLCF RTRL in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_001623435 – 907Missing in isoform 3. 1 PublicationAdd BLAST473
Alternative sequenceiVSP_001620817 – 824GQWGVTAA → VEMCLYCV in isoform 2. 3 Publications8
Alternative sequenceiVSP_001621825 – 907Missing in isoform 2. 3 PublicationsAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042378 mRNA. Translation: AAC39727.1.
AJ003061 mRNA. Translation: CAA05832.1.
AJ003062 mRNA. Translation: CAA05833.1.
BT009772 mRNA. Translation: AAP88774.1.
AK314785 mRNA. Translation: BAG37319.1.
AL139384, AL160033 Genomic DNA. Translation: CAI16949.1.
AL139384, AL160033 Genomic DNA. Translation: CAI16950.1.
AL160033, AL139384 Genomic DNA. Translation: CAI14455.1.
AL160033, AL139384 Genomic DNA. Translation: CAI14456.1.
CH471085 Genomic DNA. Translation: EAX09164.1.
BC007763 mRNA. Translation: AAH07763.1.
BC013781 mRNA. Translation: AAH13781.1.
BC046634 mRNA. Translation: AAH46634.1.
CCDSiCCDS66584.1. [Q96CW5-2]
CCDS9525.1. [Q96CW5-1]
RefSeqiNP_001273206.1. NM_001286277.1.
NP_001273207.1. NM_001286278.1. [Q96CW5-2]
NP_001273208.1. NM_001286279.1.
NP_006313.1. NM_006322.5. [Q96CW5-1]
UniGeneiHs.224152.

Genome annotation databases

EnsembliENST00000261965; ENSP00000261965; ENSG00000126216. [Q96CW5-1]
ENST00000375669; ENSP00000364821; ENSG00000126216. [Q96CW5-2]
GeneIDi10426.
KEGGihsa:10426.
UCSCiuc001vse.3. human. [Q96CW5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042378 mRNA. Translation: AAC39727.1.
AJ003061 mRNA. Translation: CAA05832.1.
AJ003062 mRNA. Translation: CAA05833.1.
BT009772 mRNA. Translation: AAP88774.1.
AK314785 mRNA. Translation: BAG37319.1.
AL139384, AL160033 Genomic DNA. Translation: CAI16949.1.
AL139384, AL160033 Genomic DNA. Translation: CAI16950.1.
AL160033, AL139384 Genomic DNA. Translation: CAI14455.1.
AL160033, AL139384 Genomic DNA. Translation: CAI14456.1.
CH471085 Genomic DNA. Translation: EAX09164.1.
BC007763 mRNA. Translation: AAH07763.1.
BC013781 mRNA. Translation: AAH13781.1.
BC046634 mRNA. Translation: AAH46634.1.
CCDSiCCDS66584.1. [Q96CW5-2]
CCDS9525.1. [Q96CW5-1]
RefSeqiNP_001273206.1. NM_001286277.1.
NP_001273207.1. NM_001286278.1. [Q96CW5-2]
NP_001273208.1. NM_001286279.1.
NP_006313.1. NM_006322.5. [Q96CW5-1]
UniGeneiHs.224152.

3D structure databases

ProteinModelPortaliQ96CW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115695. 155 interactors.
IntActiQ96CW5. 38 interactors.
MINTiMINT-3051799.
STRINGi9606.ENSP00000261965.

PTM databases

iPTMnetiQ96CW5.
PhosphoSitePlusiQ96CW5.

Polymorphism and mutation databases

DMDMi21362575.

Proteomic databases

EPDiQ96CW5.
MaxQBiQ96CW5.
PaxDbiQ96CW5.
PeptideAtlasiQ96CW5.
PRIDEiQ96CW5.

Protocols and materials databases

DNASUi10426.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261965; ENSP00000261965; ENSG00000126216. [Q96CW5-1]
ENST00000375669; ENSP00000364821; ENSG00000126216. [Q96CW5-2]
GeneIDi10426.
KEGGihsa:10426.
UCSCiuc001vse.3. human. [Q96CW5-1]

Organism-specific databases

CTDi10426.
DisGeNETi10426.
GeneCardsiTUBGCP3.
HGNCiHGNC:18598. TUBGCP3.
HPAiHPA043913.
neXtProtiNX_Q96CW5.
OpenTargetsiENSG00000126216.
PharmGKBiPA38597.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2000. Eukaryota.
ENOG410XQ5B. LUCA.
GeneTreeiENSGT00850000132278.
HOGENOMiHOG000007959.
HOVERGENiHBG031568.
InParanoidiQ96CW5.
KOiK16570.
OMAiTIDSHAN.
OrthoDBiEOG091G01V2.
PhylomeDBiQ96CW5.
TreeFamiTF300705.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126216-MONOMER.
ReactomeiR-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

ChiTaRSiTUBGCP3. human.
GeneWikiiTUBGCP3.
GenomeRNAii10426.
PROiQ96CW5.

Gene expression databases

BgeeiENSG00000126216.
CleanExiHS_TUBGCP3.
ExpressionAtlasiQ96CW5. baseline and differential.
GenevisibleiQ96CW5. HS.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 3 hits.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCP3_HUMAN
AccessioniPrimary (citable) accession number: Q96CW5
Secondary accession number(s): O43631
, O60852, O60853, Q5T8L2, Q7Z4K1, Q96I79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.