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Q96CW1

- AP2M1_HUMAN

UniProt

Q96CW1 - AP2M1_HUMAN

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Protein
AP-2 complex subunit mu
Gene
AP2M1, CLAPM1, KIAA0109
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 By similarity. Plays a role in endocytosis of frizzled family members upon Wnt signaling By similarity.7 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei341 – 3411Phosphatidylinositol lipid headgroup By similarity
Binding sitei343 – 3431Phosphatidylinositol lipid headgroup By similarity
Binding sitei345 – 3451Phosphatidylinositol lipid headgroup By similarity
Binding sitei354 – 3541Phosphatidylinositol lipid headgroup By similarity
Binding sitei356 – 3561Phosphatidylinositol lipid headgroup By similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. transporter activity Source: ProtInc

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. axon guidance Source: Reactome
  3. endocytosis Source: UniProtKB-KW
  4. epidermal growth factor receptor signaling pathway Source: Reactome
  5. intracellular protein transport Source: InterPro
  6. membrane organization Source: Reactome
  7. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  8. neurotrophin TRK receptor signaling pathway Source: Reactome
  9. regulation of defense response to virus by virus Source: Reactome
  10. synaptic transmission Source: Reactome
  11. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_11035. Gap junction degradation.
REACT_11049. Formation of annular gap junctions.
REACT_11139. Nef mediated downregulation of CD28 cell surface expression.
REACT_11166. Nef Mediated CD4 Down-regulation.
REACT_11200. Nef Mediated CD8 Down-regulation.
REACT_121399. MHC class II antigen presentation.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12484. EGFR downregulation.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_18422. Trafficking of GluR2-containing AMPA receptors.
REACT_22365. Recycling pathway of L1.
SignaLinkiQ96CW1.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit mu
Alternative name(s):
AP-2 mu chain
Adaptin-mu2
Adaptor protein complex AP-2 subunit mu
Adaptor-related protein complex 2 subunit mu
Clathrin assembly protein complex 2 mu medium chain
Clathrin coat assembly protein AP50
Clathrin coat-associated protein AP50
HA2 50 kDa subunit
Plasma membrane adaptor AP-2 50 kDa protein
Gene namesi
Name:AP2M1
Synonyms:CLAPM1, KIAA0109
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:564. AP2M1.

Subcellular locationi

Cell membrane. Membranecoated pit; Peripheral membrane protein; Cytoplasmic side
Note: AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV By similarity.

GO - Cellular componenti

  1. clathrin adaptor complex Source: InterPro
  2. clathrin-coated endocytic vesicle membrane Source: Reactome
  3. coated pit Source: UniProtKB-SubCell
  4. cytosol Source: Reactome
  5. endocytic vesicle membrane Source: Reactome
  6. extracellular vesicular exosome Source: UniProt
  7. lysosomal membrane Source: Reactome
  8. mitochondrion Source: Ensembl
  9. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435AP-2 complex subunit mu
PRO_0000193774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Phosphoserine1 Publication
Modified residuei156 – 1561Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96CW1.
PaxDbiQ96CW1.
PRIDEiQ96CW1.

PTM databases

PhosphoSiteiQ96CW1.

Expressioni

Gene expression databases

ArrayExpressiQ96CW1.
BgeeiQ96CW1.
CleanExiHS_AP2M1.
GenevestigatoriQ96CW1.

Organism-specific databases

HPAiHPA036849.

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with ATP6V1H and MEGF10. Interacts with EGFR. Interacts with F2R. Interacts with PIP5K1C; tyrosine phosphorylation of PIP5K1C weakens the interaction By similarity. Interacts with KIAA0319; required for clathrin-mediated endocytosis of KIAA0319. Interacts with DVL2 (via DEP domain) By similarity.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P279584EBI-297683,EBI-6377335From a different organism.
EGFRP005334EBI-297683,EBI-297353

Protein-protein interaction databases

BioGridi107587. 119 interactions.
IntActiQ96CW1. 58 interactions.
MINTiMINT-140451.
STRINGi9606.ENSP00000292807.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi172 – 18514
Beta strandi187 – 1893
Beta strandi193 – 1964
Beta strandi199 – 2057
Beta strandi212 – 2143
Beta strandi271 – 2755
Beta strandi290 – 2945
Beta strandi297 – 30913
Beta strandi317 – 3259
Beta strandi332 – 3365
Beta strandi338 – 3425
Turni346 – 3494
Beta strandi350 – 3589
Beta strandi363 – 3719
Beta strandi386 – 3949
Beta strandi409 – 4124
Helixi415 – 4173
Beta strandi418 – 43316

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H6EX-ray3.60A164-435[»]
ProteinModelPortaliQ96CW1.
SMRiQ96CW1. Positions 1-435.

Miscellaneous databases

EvolutionaryTraceiQ96CW1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 434265MHD
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG315786.
HOGENOMiHOG000173246.
HOVERGENiHBG050516.
InParanoidiQ96CW1.
KOiK11826.
OrthoDBiEOG72RMXV.
PhylomeDBiQ96CW1.
TreeFamiTF300722.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR008968. Clathrin_mu_C.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96CW1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIGGLFIYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI    50
ARTSFFHVKR SNIWLAAVTK QNVNAAMVFE FLYKMCDVMA AYFGKISEEN 100
IKNNFVLIYE LLDEILDFGY PQNSETGALK TFITQQGIKS QHQTKEEQSQ 150
ITSQVTGQIG WRREGIKYRR NELFLDVLES VNLLMSPQGQ VLSAHVSGRV 200
VMKSYLSGMP ECKFGMNDKI VIEKQGKGTA DETSKSGKQS IAIDDCTFHQ 250
CVRLSKFDSE RSISFIPPDG EFELMRYRTT KDIILPFRVI PLVREVGRTK 300
LEVKVVIKSN FKPSLLAQKI EVRIPTPLNT SGVQVICMKG KAKYKASENA 350
IVWKIKRMAG MKESQISAEI ELLPTNDKKK WARPPISMNF EVPFAPSGLK 400
VRYLKVFEPK LNYSDHDVIK WVRYIGRSGI YETRC 435
Length:435
Mass (Da):49,655
Last modified:August 16, 2004 - v2
Checksum:i82803219BA279954
GO
Isoform 2 (identifier: Q96CW1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-142: Missing.

Show »
Length:433
Mass (Da):49,389
Checksum:i76399E78B0AC7E8A
GO

Sequence cautioni

The sequence BAA09762.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei141 – 1422Missing in isoform 2.
VSP_034599

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061V → L in AAA93254. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36188 mRNA. Translation: AAA93254.1.
D63475 mRNA. Translation: BAA09762.2. Different initiation.
BT007308 mRNA. Translation: AAP35972.1.
AC131235 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78290.1.
CH471052 Genomic DNA. Translation: EAW78291.1.
BC004996 mRNA. Translation: AAH04996.1.
BC013796 mRNA. Translation: AAH13796.1.
BC014030 mRNA. Translation: AAH14030.1.
CCDSiCCDS43177.1. [Q96CW1-1]
CCDS43178.1. [Q96CW1-2]
PIRiG02088.
RefSeqiNP_001020376.1. NM_001025205.1. [Q96CW1-2]
NP_004059.2. NM_004068.3. [Q96CW1-1]
UniGeneiHs.518460.

Genome annotation databases

EnsembliENST00000292807; ENSP00000292807; ENSG00000161203. [Q96CW1-1]
ENST00000382456; ENSP00000371894; ENSG00000161203. [Q96CW1-2]
ENST00000439647; ENSP00000409081; ENSG00000161203. [Q96CW1-2]
GeneIDi1173.
KEGGihsa:1173.
UCSCiuc003fmw.3. human. [Q96CW1-2]
uc011bqy.2. human. [Q96CW1-1]

Polymorphism databases

DMDMi51316978.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36188 mRNA. Translation: AAA93254.1 .
D63475 mRNA. Translation: BAA09762.2 . Different initiation.
BT007308 mRNA. Translation: AAP35972.1 .
AC131235 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78290.1 .
CH471052 Genomic DNA. Translation: EAW78291.1 .
BC004996 mRNA. Translation: AAH04996.1 .
BC013796 mRNA. Translation: AAH13796.1 .
BC014030 mRNA. Translation: AAH14030.1 .
CCDSi CCDS43177.1. [Q96CW1-1 ]
CCDS43178.1. [Q96CW1-2 ]
PIRi G02088.
RefSeqi NP_001020376.1. NM_001025205.1. [Q96CW1-2 ]
NP_004059.2. NM_004068.3. [Q96CW1-1 ]
UniGenei Hs.518460.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1H6E X-ray 3.60 A 164-435 [» ]
ProteinModelPortali Q96CW1.
SMRi Q96CW1. Positions 1-435.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107587. 119 interactions.
IntActi Q96CW1. 58 interactions.
MINTi MINT-140451.
STRINGi 9606.ENSP00000292807.

PTM databases

PhosphoSitei Q96CW1.

Polymorphism databases

DMDMi 51316978.

Proteomic databases

MaxQBi Q96CW1.
PaxDbi Q96CW1.
PRIDEi Q96CW1.

Protocols and materials databases

DNASUi 1173.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292807 ; ENSP00000292807 ; ENSG00000161203 . [Q96CW1-1 ]
ENST00000382456 ; ENSP00000371894 ; ENSG00000161203 . [Q96CW1-2 ]
ENST00000439647 ; ENSP00000409081 ; ENSG00000161203 . [Q96CW1-2 ]
GeneIDi 1173.
KEGGi hsa:1173.
UCSCi uc003fmw.3. human. [Q96CW1-2 ]
uc011bqy.2. human. [Q96CW1-1 ]

Organism-specific databases

CTDi 1173.
GeneCardsi GC03P183892.
HGNCi HGNC:564. AP2M1.
HPAi HPA036849.
MIMi 601024. gene.
neXtProti NX_Q96CW1.
PharmGKBi PA24855.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315786.
HOGENOMi HOG000173246.
HOVERGENi HBG050516.
InParanoidi Q96CW1.
KOi K11826.
OrthoDBi EOG72RMXV.
PhylomeDBi Q96CW1.
TreeFami TF300722.

Enzyme and pathway databases

Reactomei REACT_11035. Gap junction degradation.
REACT_11049. Formation of annular gap junctions.
REACT_11139. Nef mediated downregulation of CD28 cell surface expression.
REACT_11166. Nef Mediated CD4 Down-regulation.
REACT_11200. Nef Mediated CD8 Down-regulation.
REACT_121399. MHC class II antigen presentation.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12484. EGFR downregulation.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_18422. Trafficking of GluR2-containing AMPA receptors.
REACT_22365. Recycling pathway of L1.
SignaLinki Q96CW1.

Miscellaneous databases

ChiTaRSi AP2M1. human.
EvolutionaryTracei Q96CW1.
GeneWikii AP2M1.
GenomeRNAii 1173.
NextBioi 4844.
PROi Q96CW1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96CW1.
Bgeei Q96CW1.
CleanExi HS_AP2M1.
Genevestigatori Q96CW1.

Family and domain databases

InterProi IPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR008968. Clathrin_mu_C.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view ]
Pfami PF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view ]
PIRSFi PIRSF005992. Clathrin_mu. 1 hit.
PRINTSi PR00314. CLATHRINADPT.
SUPFAMi SSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEi PS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequence analysis of the cDNA for human 50 kDa subunit of the clathrin assembly complex AP-2 (AP50)."
    Tsui S.K.W., Waye M.M.Y., Liew C.C., Fung K., Lee C.Y.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney, Placenta and Skin.
  7. "Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery."
    Geyer M., Yu H., Mandic R., Linnemann T., Zheng Y.-H., Fackler O.T., Peterlin B.M.
    J. Biol. Chem. 277:28521-28529(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATP6V1H.
  8. "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network."
    Nakatsu F., Ohno H.
    Cell Struct. Funct. 28:419-429(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  9. "Clathrin-mediated endocytosis in AP-2-depleted cells."
    Motley A., Bright N.A., Seaman M.N.J., Robinson M.S.
    J. Cell Biol. 162:909-918(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  10. "Endocytosis of the viral chemokine receptor US28 does not require beta-arrestins but is dependent on the clathrin-mediated pathway."
    Fraile-Ramos A., Kohout T.A., Waldhoer M., Marsh M.
    Traffic 4:243-253(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  11. "Adaptors for clathrin coats: structure and function."
    Owen D.J., Collins B.M., Evans P.R.
    Annu. Rev. Cell Dev. Biol. 20:153-191(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  12. "Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference."
    Huang F., Khvorova A., Marshall W., Sorkin A.
    J. Biol. Chem. 279:16657-16661(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  13. "Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization."
    Paing M.M., Johnston C.A., Siderovski D.P., Trejo J.
    Mol. Cell. Biol. 26:3231-3242(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN RECEPTOR INTERNALIZATION, INTERACTION WITH F2R.
  14. "MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation."
    Suzuki E., Nakayama M.
    Exp. Cell Res. 313:3729-3742(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MEGF10.
  15. "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway."
    Lau A.W., Chou M.M.
    J. Cell Sci. 121:4008-4017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE AP-2 COMPLEX IN NON-CLATHRIN-DEPENDENT ENDOCYTOSIS.
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND THR-156, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway."
    Levecque C., Velayos-Baeza A., Holloway Z.G., Monaco A.P.
    Am. J. Physiol. 297:C160-C168(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIAA0319.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28."
    Follows E.R., McPheat J.C., Minshull C., Moore N.C., Pauptit R.A., Rowsell S., Stacey C.L., Stanway J.J., Taylor I.W.F., Abbott W.M.
    Biochem. J. 359:427-434(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 167-435 IN COMPLEX WITH CTLA4 INTERNALIZATION SIGNAL.

Entry informationi

Entry nameiAP2M1_HUMAN
AccessioniPrimary (citable) accession number: Q96CW1
Secondary accession number(s): A6NE12
, D3DNT1, P20172, P53679
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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