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Protein

Coiled-coil domain-containing protein 124

Gene

CCDC124

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for proper progression of late cytokinetic stages.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 124
Gene namesi
Name:CCDC124
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000007080.10
HGNCiHGNC:25171 CCDC124
neXtProtiNX_Q96CT7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007080
PharmGKBiPA147358292

Polymorphism and mutation databases

BioMutaiCCDC124
DMDMi74731379

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637351 – 223Coiled-coil domain-containing protein 124Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineCombined sources1 Publication1
Modified residuei194PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96CT7
MaxQBiQ96CT7
PaxDbiQ96CT7
PeptideAtlasiQ96CT7
PRIDEiQ96CT7

PTM databases

iPTMnetiQ96CT7
PhosphoSitePlusiQ96CT7

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000007080
CleanExiHS_CCDC124
ExpressionAtlasiQ96CT7 baseline and differential
GenevisibleiQ96CT7 HS

Organism-specific databases

HPAiHPA041708
HPA046765

Interactioni

Subunit structurei

Interacts with RASGEF1B.1 Publication

Protein-protein interaction databases

BioGridi125411, 26 interactors
IntActiQ96CT7, 21 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96CT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 82Sequence analysisAdd BLAST68

Sequence similaritiesi

Belongs to the CCDC124 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3223 Eukaryota
ENOG410ZIM9 LUCA
GeneTreeiENSGT00390000012482
HOGENOMiHOG000204343
HOVERGENiHBG080942
InParanoidiQ96CT7
OMAiENLNRSM
OrthoDBiEOG091G0XXE
PhylomeDBiQ96CT7
TreeFamiTF105913

Family and domain databases

InterProiView protein in InterPro
IPR010422 Ccdc124
PANTHERiPTHR21680 PTHR21680, 1 hit
PfamiView protein in Pfam
PF06244 Ccdc124, 1 hit

Sequencei

Sequence statusi: Complete.

Q96CT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE
60 70 80 90 100
QRKEEKEKRR LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI
110 120 130 140 150
EDTLRRDHQL REAPDTAEKA KSHLEVPLEE NVNRRVLEEG SVEARTIEDA
160 170 180 190 200
IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ LPRLKQENPN MRLSQLKQLL
210 220
KKEWLRSPDN PMNQRAVPFN APK
Length:223
Mass (Da):25,835
Last modified:December 1, 2001 - v1
Checksum:iDFC65D526057DE27
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053809138E → Q. Corresponds to variant dbSNP:rs8104153Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013949 mRNA Translation: AAH13949.1
CCDSiCCDS12369.1
RefSeqiNP_001129675.1, NM_001136203.1
NP_612451.1, NM_138442.3
UniGeneiHs.100043

Genome annotation databases

EnsembliENST00000445755; ENSP00000408730; ENSG00000007080
ENST00000597436; ENSP00000471455; ENSG00000007080
GeneIDi115098
KEGGihsa:115098
UCSCiuc002nhs.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC124_HUMAN
AccessioniPrimary (citable) accession number: Q96CT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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