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Protein

Coiled-coil domain-containing protein 124

Gene

CCDC124

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper progression of late cytokinetic stages.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 124
Gene namesi
Name:CCDC124
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25171. CCDC124.

Subcellular locationi

  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication
  • Midbody 1 Publication

  • Note: Colocalizes with gamma-tubulin at interphase, prophase, metaphase, and anaphase. Relocates from centrosome to midbody at telophase.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358292.

Polymorphism and mutation databases

BioMutaiCCDC124.
DMDMi74731379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Coiled-coil domain-containing protein 124PRO_0000263735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411PhosphoserineCombined sources1 Publication
Modified residuei194 – 1941PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96CT7.
MaxQBiQ96CT7.
PaxDbiQ96CT7.
PeptideAtlasiQ96CT7.
PRIDEiQ96CT7.

PTM databases

iPTMnetiQ96CT7.
PhosphoSiteiQ96CT7.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ96CT7.
CleanExiHS_CCDC124.
ExpressionAtlasiQ96CT7. baseline and differential.
GenevisibleiQ96CT7. HS.

Organism-specific databases

HPAiHPA041708.
HPA046765.

Interactioni

Subunit structurei

Interacts with RASGEF1B.1 Publication

Protein-protein interaction databases

BioGridi125411. 22 interactions.
IntActiQ96CT7. 16 interactions.
MINTiMINT-5003411.
STRINGi9606.ENSP00000408730.

Structurei

3D structure databases

ProteinModelPortaliQ96CT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili15 – 8268Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC124 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3223. Eukaryota.
ENOG410ZIM9. LUCA.
GeneTreeiENSGT00390000012482.
HOGENOMiHOG000204343.
HOVERGENiHBG080942.
InParanoidiQ96CT7.
OMAiTKKATQE.
OrthoDBiEOG75F4G4.
PhylomeDBiQ96CT7.
TreeFamiTF105913.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR010422. Ccdc124.
IPR009071. HMG_box_dom.
[Graphical view]
PANTHERiPTHR21680:SF0. PTHR21680:SF0. 1 hit.
PfamiPF06244. DUF1014. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE
60 70 80 90 100
QRKEEKEKRR LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI
110 120 130 140 150
EDTLRRDHQL REAPDTAEKA KSHLEVPLEE NVNRRVLEEG SVEARTIEDA
160 170 180 190 200
IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ LPRLKQENPN MRLSQLKQLL
210 220
KKEWLRSPDN PMNQRAVPFN APK
Length:223
Mass (Da):25,835
Last modified:December 1, 2001 - v1
Checksum:iDFC65D526057DE27
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381E → Q.
Corresponds to variant rs8104153 [ dbSNP | Ensembl ].
VAR_053809

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013949 mRNA. Translation: AAH13949.1.
CCDSiCCDS12369.1.
RefSeqiNP_001129675.1. NM_001136203.1.
NP_612451.1. NM_138442.3.
UniGeneiHs.100043.

Genome annotation databases

EnsembliENST00000445755; ENSP00000408730; ENSG00000007080.
ENST00000597436; ENSP00000471455; ENSG00000007080.
GeneIDi115098.
KEGGihsa:115098.
UCSCiuc002nhs.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013949 mRNA. Translation: AAH13949.1.
CCDSiCCDS12369.1.
RefSeqiNP_001129675.1. NM_001136203.1.
NP_612451.1. NM_138442.3.
UniGeneiHs.100043.

3D structure databases

ProteinModelPortaliQ96CT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125411. 22 interactions.
IntActiQ96CT7. 16 interactions.
MINTiMINT-5003411.
STRINGi9606.ENSP00000408730.

PTM databases

iPTMnetiQ96CT7.
PhosphoSiteiQ96CT7.

Polymorphism and mutation databases

BioMutaiCCDC124.
DMDMi74731379.

Proteomic databases

EPDiQ96CT7.
MaxQBiQ96CT7.
PaxDbiQ96CT7.
PeptideAtlasiQ96CT7.
PRIDEiQ96CT7.

Protocols and materials databases

DNASUi115098.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445755; ENSP00000408730; ENSG00000007080.
ENST00000597436; ENSP00000471455; ENSG00000007080.
GeneIDi115098.
KEGGihsa:115098.
UCSCiuc002nhs.4. human.

Organism-specific databases

CTDi115098.
GeneCardsiCCDC124.
HGNCiHGNC:25171. CCDC124.
HPAiHPA041708.
HPA046765.
neXtProtiNX_Q96CT7.
PharmGKBiPA147358292.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3223. Eukaryota.
ENOG410ZIM9. LUCA.
GeneTreeiENSGT00390000012482.
HOGENOMiHOG000204343.
HOVERGENiHBG080942.
InParanoidiQ96CT7.
OMAiTKKATQE.
OrthoDBiEOG75F4G4.
PhylomeDBiQ96CT7.
TreeFamiTF105913.

Miscellaneous databases

ChiTaRSiCCDC124. human.
GenomeRNAii115098.
PROiQ96CT7.

Gene expression databases

BgeeiQ96CT7.
CleanExiHS_CCDC124.
ExpressionAtlasiQ96CT7. baseline and differential.
GenevisibleiQ96CT7. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR010422. Ccdc124.
IPR009071. HMG_box_dom.
[Graphical view]
PANTHERiPTHR21680:SF0. PTHR21680:SF0. 1 hit.
PfamiPF06244. DUF1014. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141 AND SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  5. "Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis."
    Telkoparan P., Erkek S., Yaman E., Alotaibi H., Bayik D., Tazebay U.H.
    PLoS ONE 8:E69289-E69289(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RASGEF1B, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-141.

Entry informationi

Entry nameiCC124_HUMAN
AccessioniPrimary (citable) accession number: Q96CT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.