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Protein

Coiled-coil domain-containing protein 124

Gene

CCDC124

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper progression of late cytokinetic stages.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 124
Gene namesi
Name:CCDC124
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000007080.10.
HGNCiHGNC:25171. CCDC124.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007080.
PharmGKBiPA147358292.

Polymorphism and mutation databases

BioMutaiCCDC124.
DMDMi74731379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637351 – 223Coiled-coil domain-containing protein 124Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineCombined sources1 Publication1
Modified residuei194PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96CT7.
MaxQBiQ96CT7.
PaxDbiQ96CT7.
PeptideAtlasiQ96CT7.
PRIDEiQ96CT7.

PTM databases

iPTMnetiQ96CT7.
PhosphoSitePlusiQ96CT7.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000007080.
CleanExiHS_CCDC124.
ExpressionAtlasiQ96CT7. baseline and differential.
GenevisibleiQ96CT7. HS.

Organism-specific databases

HPAiHPA041708.
HPA046765.

Interactioni

Subunit structurei

Interacts with RASGEF1B.1 Publication

Protein-protein interaction databases

BioGridi125411. 24 interactors.
IntActiQ96CT7. 18 interactors.
MINTiMINT-5003411.

Structurei

3D structure databases

ProteinModelPortaliQ96CT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 82Sequence analysisAdd BLAST68

Sequence similaritiesi

Belongs to the CCDC124 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3223. Eukaryota.
ENOG410ZIM9. LUCA.
GeneTreeiENSGT00390000012482.
HOGENOMiHOG000204343.
HOVERGENiHBG080942.
InParanoidiQ96CT7.
OMAiENLNRSM.
OrthoDBiEOG091G0XXE.
PhylomeDBiQ96CT7.
TreeFamiTF105913.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR010422. Ccdc124.
IPR036910. HMG_box_dom_sf.
PANTHERiPTHR21680. PTHR21680. 1 hit.
PfamiView protein in Pfam
PF06244. Ccdc124. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96CT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE
60 70 80 90 100
QRKEEKEKRR LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI
110 120 130 140 150
EDTLRRDHQL REAPDTAEKA KSHLEVPLEE NVNRRVLEEG SVEARTIEDA
160 170 180 190 200
IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ LPRLKQENPN MRLSQLKQLL
210 220
KKEWLRSPDN PMNQRAVPFN APK
Length:223
Mass (Da):25,835
Last modified:December 1, 2001 - v1
Checksum:iDFC65D526057DE27
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053809138E → Q. Corresponds to variant dbSNP:rs8104153Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013949 mRNA. Translation: AAH13949.1.
CCDSiCCDS12369.1.
RefSeqiNP_001129675.1. NM_001136203.1.
NP_612451.1. NM_138442.3.
UniGeneiHs.100043.

Genome annotation databases

EnsembliENST00000445755; ENSP00000408730; ENSG00000007080.
ENST00000597436; ENSP00000471455; ENSG00000007080.
GeneIDi115098.
KEGGihsa:115098.
UCSCiuc002nhs.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC124_HUMAN
AccessioniPrimary (citable) accession number: Q96CT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families