ID   KLH29_HUMAN             Reviewed;         875 AA.
AC   Q96CT2; Q8N388; Q96BF0; Q96PW7;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 3.
DT   27-MAR-2024, entry version 165.
DE   RecName: Full=Kelch-like protein 29;
DE   AltName: Full=Kelch repeat and BTB domain-containing protein 9;
GN   Name=KLHL29; Synonyms=KBTBD9, KIAA1921;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-875 (ISOFORM 2).
RC   TISSUE=Melanoma;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-875 (ISOFORM 2), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-875 (ISOFORM 1).
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 360-875 (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XXI. The
RT   complete sequences of 60 new cDNA clones from brain which code for large
RT   proteins.";
RL   DNA Res. 8:179-187(2001).
CC   -!- INTERACTION:
CC       Q96CT2; Q8IVD9: NUDCD3; NbExp=2; IntAct=EBI-6426370, EBI-744342;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96CT2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96CT2-2; Sequence=VSP_010403;
CC   -!- CAUTION: Although the complete sequence is not known with certainty,
CC       sequence shown here appears to be the most probable in accordance with
CC       the mouse sequence ortholog. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH13982.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH15667.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB67814.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC       Sequence=CAD39171.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL834515; CAD39171.2; ALT_INIT; mRNA.
DR   EMBL; BC013982; AAH13982.1; ALT_INIT; mRNA.
DR   EMBL; BC015667; AAH15667.1; ALT_INIT; mRNA.
DR   EMBL; AB067508; BAB67814.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS54335.1; -. [Q96CT2-1]
DR   RefSeq; NP_443152.1; NM_052920.1. [Q96CT2-1]
DR   RefSeq; XP_006711992.1; XM_006711929.3. [Q96CT2-1]
DR   RefSeq; XP_016858753.1; XM_017003264.1.
DR   AlphaFoldDB; Q96CT2; -.
DR   SMR; Q96CT2; -.
DR   BioGRID; 125369; 25.
DR   ComplexPortal; CPX-8147; CRL3 E3 ubiquitin ligase complex, KLHL29 variant.
DR   IntAct; Q96CT2; 10.
DR   STRING; 9606.ENSP00000420659; -.
DR   GlyGen; Q96CT2; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q96CT2; -.
DR   PhosphoSitePlus; Q96CT2; -.
DR   BioMuta; KLHL29; -.
DR   DMDM; 47605917; -.
DR   EPD; Q96CT2; -.
DR   MassIVE; Q96CT2; -.
DR   PaxDb; 9606-ENSP00000420659; -.
DR   PeptideAtlas; Q96CT2; -.
DR   ProteomicsDB; 76219; -. [Q96CT2-1]
DR   ProteomicsDB; 76220; -. [Q96CT2-2]
DR   TopDownProteomics; Q96CT2-2; -. [Q96CT2-2]
DR   Antibodypedia; 27362; 101 antibodies from 24 providers.
DR   DNASU; 114818; -.
DR   Ensembl; ENST00000486442.6; ENSP00000420659.1; ENSG00000119771.15. [Q96CT2-1]
DR   GeneID; 114818; -.
DR   KEGG; hsa:114818; -.
DR   MANE-Select; ENST00000486442.6; ENSP00000420659.1; NM_052920.2; NP_443152.1.
DR   UCSC; uc010ykg.3; human. [Q96CT2-1]
DR   AGR; HGNC:29404; -.
DR   CTD; 114818; -.
DR   DisGeNET; 114818; -.
DR   GeneCards; KLHL29; -.
DR   HGNC; HGNC:29404; KLHL29.
DR   HPA; ENSG00000119771; Low tissue specificity.
DR   neXtProt; NX_Q96CT2; -.
DR   OpenTargets; ENSG00000119771; -.
DR   PharmGKB; PA162393486; -.
DR   VEuPathDB; HostDB:ENSG00000119771; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000158824; -.
DR   HOGENOM; CLU_004253_4_0_1; -.
DR   InParanoid; Q96CT2; -.
DR   OMA; TWALLPH; -.
DR   OrthoDB; 5472491at2759; -.
DR   PhylomeDB; Q96CT2; -.
DR   TreeFam; TF351654; -.
DR   PathwayCommons; Q96CT2; -.
DR   SignaLink; Q96CT2; -.
DR   BioGRID-ORCS; 114818; 7 hits in 1190 CRISPR screens.
DR   ChiTaRS; KLHL29; human.
DR   GenomeRNAi; 114818; -.
DR   Pharos; Q96CT2; Tbio.
DR   PRO; PR:Q96CT2; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q96CT2; Protein.
DR   Bgee; ENSG00000119771; Expressed in tibia and 171 other cell types or tissues.
DR   ExpressionAtlas; Q96CT2; baseline and differential.
DR   CDD; cd18468; BACK_KLHL29_KBTBD9; 1.
DR   Gene3D; 1.25.40.420; -; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR   PANTHER; PTHR24412:SF10; KELCH-LIKE PROTEIN 29; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   Genevisible; Q96CT2; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..875
FT                   /note="Kelch-like protein 29"
FT                   /id="PRO_0000119086"
FT   DOMAIN          329..401
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REPEAT          585..635
FT                   /note="Kelch 1"
FT   REPEAT          637..683
FT                   /note="Kelch 2"
FT   REPEAT          684..730
FT                   /note="Kelch 3"
FT   REPEAT          732..778
FT                   /note="Kelch 4"
FT   REPEAT          779..821
FT                   /note="Kelch 5"
FT   REPEAT          822..870
FT                   /note="Kelch 6"
FT   REGION          115..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..273
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..291
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         703..875
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_010403"
FT   CONFLICT        312
FT                   /note="P -> R (in Ref. 1; CAD39171)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   875 AA;  94228 MW;  9B2EBF4F5D0099DD CRC64;
     MSRHHSRFER DYRVGWDRRE WSVNGTHGTT SICSVTSGAG GGTASSLSVR PGLLPLPVVP
     SRLPTPATAP APCTTGSSEA ITSLVASSAS AVTTKAPGIS KGDSQSQGLA TSIRWGQTPI
     NQSTPWDTDE PPSKQMRESD NPGTGPWVTT VAAGNQPTLI AHSYGVAQPP TFSPAVNVQA
     PVIGVTPSLP PHVGPQLPLM PGHYSLPQPP SQPLSSVVVN MPAQALYASP QPLAVSTLPG
     VGQVARPGPT AVGNGHMAGP LLPPPPPAQP SATLPSGAPA TNGPPTTDSA HGLQMLRTIG
     VGKYEFTDPG HPREMLKELN QQRRAKAFTD LKIVVEGREF EVHQNVLASC SLYFKDLIQR
     SVQDSGQGGR EKLELVLSNL QADVLELLLE FVYTGSLVID SANAKTLLEA ASKFQFHTFC
     KVCVSFLEKQ LTASNCLGVL AMAEAMQCSE LYHMAKAFAL QIFPEVAAQE EILSISKDDF
     IAYVSNDSLN TKAEELVYET VIKWIKKDPA TRTQYAAELL AVVRLPFIHP SYLLNVVDNE
     ELIKSSEACR DLVNEAKRYH MLPHARQEMQ TPRTRPRLSA GVAEVIVLVG GRQMVGMTQR
     SLVAVTCWNP QNNKWYPLAS LPFYDREFFS VVSAGDNIYL SGGMESGVTL ADVWCYMSLL
     DNWNLVSRMT VPRCRHNSLV YDGKIYTLGG LGVAGNVDHV ERYDTITNQW EAVAPLPKAV
     HSAAATVCGG KIYVFGGVNE AGRAAGVLQS YVPQTNTWSF IESPMIDNKY APAVTLNGFV
     FILGGAYARA TTIYDPEKGN IKAGPNMNHS RQFCSAVVLD GKIYATGGIV SSEGPALGNM
     EAYEPTTNTW TLLPHMPCPV FRHGCVVIKK YIQSG
//