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Q96CT2

- KLH29_HUMAN

UniProt

Q96CT2 - KLH29_HUMAN

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Protein
Kelch-like protein 29
Gene
KLHL29, KBTBD9, KIAA1921
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 29
Alternative name(s):
Kelch repeat and BTB domain-containing protein 9
Gene namesi
Name:KLHL29
Synonyms:KBTBD9, KIAA1921
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:29404. KLHL29.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Kelch-like protein 29
PRO_0000119086Add
BLAST

Proteomic databases

MaxQBiQ96CT2.
PaxDbiQ96CT2.
PRIDEiQ96CT2.

Expressioni

Gene expression databases

ArrayExpressiQ96CT2.
BgeeiQ96CT2.
CleanExiHS_KLHL29.
GenevestigatoriQ96CT2.

Organism-specific databases

HPAiHPA049057.

Interactioni

Protein-protein interaction databases

BioGridi125369. 12 interactions.
IntActiQ96CT2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96CT2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini329 – 40173BTB
Add
BLAST
Repeati585 – 63551Kelch 1
Add
BLAST
Repeati637 – 68347Kelch 2
Add
BLAST
Repeati684 – 73047Kelch 3
Add
BLAST
Repeati732 – 77847Kelch 4
Add
BLAST
Repeati779 – 82143Kelch 5
Add
BLAST
Repeati822 – 87049Kelch 6
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi260 – 28526Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG313336.
HOGENOMiHOG000230815.
HOVERGENiHBG096078.
InParanoidiQ96CT2.
KOiK10465.
PhylomeDBiQ96CT2.
TreeFamiTF351654.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96CT2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSRHHSRFER DYRVGWDRRE WSVNGTHGTT SICSVTSGAG GGTASSLSVR    50
PGLLPLPVVP SRLPTPATAP APCTTGSSEA ITSLVASSAS AVTTKAPGIS 100
KGDSQSQGLA TSIRWGQTPI NQSTPWDTDE PPSKQMRESD NPGTGPWVTT 150
VAAGNQPTLI AHSYGVAQPP TFSPAVNVQA PVIGVTPSLP PHVGPQLPLM 200
PGHYSLPQPP SQPLSSVVVN MPAQALYASP QPLAVSTLPG VGQVARPGPT 250
AVGNGHMAGP LLPPPPPAQP SATLPSGAPA TNGPPTTDSA HGLQMLRTIG 300
VGKYEFTDPG HPREMLKELN QQRRAKAFTD LKIVVEGREF EVHQNVLASC 350
SLYFKDLIQR SVQDSGQGGR EKLELVLSNL QADVLELLLE FVYTGSLVID 400
SANAKTLLEA ASKFQFHTFC KVCVSFLEKQ LTASNCLGVL AMAEAMQCSE 450
LYHMAKAFAL QIFPEVAAQE EILSISKDDF IAYVSNDSLN TKAEELVYET 500
VIKWIKKDPA TRTQYAAELL AVVRLPFIHP SYLLNVVDNE ELIKSSEACR 550
DLVNEAKRYH MLPHARQEMQ TPRTRPRLSA GVAEVIVLVG GRQMVGMTQR 600
SLVAVTCWNP QNNKWYPLAS LPFYDREFFS VVSAGDNIYL SGGMESGVTL 650
ADVWCYMSLL DNWNLVSRMT VPRCRHNSLV YDGKIYTLGG LGVAGNVDHV 700
ERYDTITNQW EAVAPLPKAV HSAAATVCGG KIYVFGGVNE AGRAAGVLQS 750
YVPQTNTWSF IESPMIDNKY APAVTLNGFV FILGGAYARA TTIYDPEKGN 800
IKAGPNMNHS RQFCSAVVLD GKIYATGGIV SSEGPALGNM EAYEPTTNTW 850
TLLPHMPCPV FRHGCVVIKK YIQSG 875
Length:875
Mass (Da):94,228
Last modified:May 14, 2014 - v3
Checksum:i9B2EBF4F5D0099DD
GO
Isoform 2 (identifier: Q96CT2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     703-875: Missing.

Show »
Length:702
Mass (Da):75,758
Checksum:i8C209F6BA8C81231
GO

Sequence cautioni

The sequence BAB67814.1 differs from that shown. Reason: Intron retention.
The sequence AAH13982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAH15667.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAD39171.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei703 – 875173Missing in isoform 2.
VSP_010403Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti312 – 3121P → R in CAD39171. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL834515 mRNA. Translation: CAD39171.2. Different initiation.
BC013982 mRNA. Translation: AAH13982.1. Different initiation.
BC015667 mRNA. Translation: AAH15667.1. Different initiation.
AB067508 mRNA. Translation: BAB67814.1. Sequence problems.
CCDSiCCDS54335.1. [Q96CT2-1]
RefSeqiNP_443152.1. NM_052920.1. [Q96CT2-1]
XP_006711992.1. XM_006711929.1. [Q96CT2-1]
UniGeneiHs.130593.

Genome annotation databases

EnsembliENST00000486442; ENSP00000420659; ENSG00000119771.
GeneIDi114818.
KEGGihsa:114818.
UCSCiuc010ykg.2. human. [Q96CT2-1]

Polymorphism databases

DMDMi47605917.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL834515 mRNA. Translation: CAD39171.2 . Different initiation.
BC013982 mRNA. Translation: AAH13982.1 . Different initiation.
BC015667 mRNA. Translation: AAH15667.1 . Different initiation.
AB067508 mRNA. Translation: BAB67814.1 . Sequence problems.
CCDSi CCDS54335.1. [Q96CT2-1 ]
RefSeqi NP_443152.1. NM_052920.1. [Q96CT2-1 ]
XP_006711992.1. XM_006711929.1. [Q96CT2-1 ]
UniGenei Hs.130593.

3D structure databases

ProteinModelPortali Q96CT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125369. 12 interactions.
IntActi Q96CT2. 1 interaction.

Polymorphism databases

DMDMi 47605917.

Proteomic databases

MaxQBi Q96CT2.
PaxDbi Q96CT2.
PRIDEi Q96CT2.

Protocols and materials databases

DNASUi 114818.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000486442 ; ENSP00000420659 ; ENSG00000119771 .
GeneIDi 114818.
KEGGi hsa:114818.
UCSCi uc010ykg.2. human. [Q96CT2-1 ]

Organism-specific databases

CTDi 114818.
GeneCardsi GC02P023608.
H-InvDB HIX0001864.
HGNCi HGNC:29404. KLHL29.
HPAi HPA049057.
neXtProti NX_Q96CT2.
PharmGKBi PA162393486.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313336.
HOGENOMi HOG000230815.
HOVERGENi HBG096078.
InParanoidi Q96CT2.
KOi K10465.
PhylomeDBi Q96CT2.
TreeFami TF351654.

Miscellaneous databases

ChiTaRSi KLHL29. human.
GenomeRNAii 114818.
NextBioi 79284.
PROi Q96CT2.

Gene expression databases

ArrayExpressi Q96CT2.
Bgeei Q96CT2.
CleanExi HS_KLHL29.
Genevestigatori Q96CT2.

Family and domain databases

Gene3Di 2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
[Graphical view ]
Pfami PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view ]
SMARTi SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-875 (ISOFORM 2).
    Tissue: Melanoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-875 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-875 (ISOFORM 1).
    Tissue: Placenta.
  3. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 360-875 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiKLH29_HUMAN
AccessioniPrimary (citable) accession number: Q96CT2
Secondary accession number(s): Q8N388, Q96BF0, Q96PW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 14, 2014
Last modified: September 3, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although the complete sequence is not known with certainty, sequence shown here appears to be the most probable in accordance with the mouse sequence ortholog.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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