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Q96CT2

- KLH29_HUMAN

UniProt

Q96CT2 - KLH29_HUMAN

Protein

Kelch-like protein 29

Gene

KLHL29

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (14 May 2014)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch-like protein 29
    Alternative name(s):
    Kelch repeat and BTB domain-containing protein 9
    Gene namesi
    Name:KLHL29
    Synonyms:KBTBD9, KIAA1921
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:29404. KLHL29.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162393486.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 875875Kelch-like protein 29PRO_0000119086Add
    BLAST

    Proteomic databases

    MaxQBiQ96CT2.
    PaxDbiQ96CT2.
    PRIDEiQ96CT2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96CT2.
    BgeeiQ96CT2.
    CleanExiHS_KLHL29.
    GenevestigatoriQ96CT2.

    Organism-specific databases

    HPAiHPA049057.

    Interactioni

    Protein-protein interaction databases

    BioGridi125369. 12 interactions.
    IntActiQ96CT2. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96CT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini329 – 40173BTBPROSITE-ProRule annotationAdd
    BLAST
    Repeati585 – 63551Kelch 1Add
    BLAST
    Repeati637 – 68347Kelch 2Add
    BLAST
    Repeati684 – 73047Kelch 3Add
    BLAST
    Repeati732 – 77847Kelch 4Add
    BLAST
    Repeati779 – 82143Kelch 5Add
    BLAST
    Repeati822 – 87049Kelch 6Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi260 – 28526Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 6 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG313336.
    HOGENOMiHOG000230815.
    HOVERGENiHBG096078.
    InParanoidiQ96CT2.
    KOiK10465.
    PhylomeDBiQ96CT2.
    TreeFamiTF351654.

    Family and domain databases

    Gene3Di2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view]
    PfamiPF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 2 hits.
    [Graphical view]
    SMARTiSM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96CT2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRHHSRFER DYRVGWDRRE WSVNGTHGTT SICSVTSGAG GGTASSLSVR    50
    PGLLPLPVVP SRLPTPATAP APCTTGSSEA ITSLVASSAS AVTTKAPGIS 100
    KGDSQSQGLA TSIRWGQTPI NQSTPWDTDE PPSKQMRESD NPGTGPWVTT 150
    VAAGNQPTLI AHSYGVAQPP TFSPAVNVQA PVIGVTPSLP PHVGPQLPLM 200
    PGHYSLPQPP SQPLSSVVVN MPAQALYASP QPLAVSTLPG VGQVARPGPT 250
    AVGNGHMAGP LLPPPPPAQP SATLPSGAPA TNGPPTTDSA HGLQMLRTIG 300
    VGKYEFTDPG HPREMLKELN QQRRAKAFTD LKIVVEGREF EVHQNVLASC 350
    SLYFKDLIQR SVQDSGQGGR EKLELVLSNL QADVLELLLE FVYTGSLVID 400
    SANAKTLLEA ASKFQFHTFC KVCVSFLEKQ LTASNCLGVL AMAEAMQCSE 450
    LYHMAKAFAL QIFPEVAAQE EILSISKDDF IAYVSNDSLN TKAEELVYET 500
    VIKWIKKDPA TRTQYAAELL AVVRLPFIHP SYLLNVVDNE ELIKSSEACR 550
    DLVNEAKRYH MLPHARQEMQ TPRTRPRLSA GVAEVIVLVG GRQMVGMTQR 600
    SLVAVTCWNP QNNKWYPLAS LPFYDREFFS VVSAGDNIYL SGGMESGVTL 650
    ADVWCYMSLL DNWNLVSRMT VPRCRHNSLV YDGKIYTLGG LGVAGNVDHV 700
    ERYDTITNQW EAVAPLPKAV HSAAATVCGG KIYVFGGVNE AGRAAGVLQS 750
    YVPQTNTWSF IESPMIDNKY APAVTLNGFV FILGGAYARA TTIYDPEKGN 800
    IKAGPNMNHS RQFCSAVVLD GKIYATGGIV SSEGPALGNM EAYEPTTNTW 850
    TLLPHMPCPV FRHGCVVIKK YIQSG 875
    Length:875
    Mass (Da):94,228
    Last modified:May 14, 2014 - v3
    Checksum:i9B2EBF4F5D0099DD
    GO
    Isoform 2 (identifier: Q96CT2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         703-875: Missing.

    Show »
    Length:702
    Mass (Da):75,758
    Checksum:i8C209F6BA8C81231
    GO

    Sequence cautioni

    The sequence BAB67814.1 differs from that shown. Reason: Intron retention.
    The sequence AAH13982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAH15667.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAD39171.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti312 – 3121P → R in CAD39171. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei703 – 875173Missing in isoform 2. 2 PublicationsVSP_010403Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL834515 mRNA. Translation: CAD39171.2. Different initiation.
    BC013982 mRNA. Translation: AAH13982.1. Different initiation.
    BC015667 mRNA. Translation: AAH15667.1. Different initiation.
    AB067508 mRNA. Translation: BAB67814.1. Sequence problems.
    CCDSiCCDS54335.1. [Q96CT2-1]
    RefSeqiNP_443152.1. NM_052920.1. [Q96CT2-1]
    XP_006711992.1. XM_006711929.1. [Q96CT2-1]
    UniGeneiHs.130593.

    Genome annotation databases

    EnsembliENST00000486442; ENSP00000420659; ENSG00000119771. [Q96CT2-1]
    GeneIDi114818.
    KEGGihsa:114818.
    UCSCiuc010ykg.2. human. [Q96CT2-1]

    Polymorphism databases

    DMDMi47605917.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL834515 mRNA. Translation: CAD39171.2 . Different initiation.
    BC013982 mRNA. Translation: AAH13982.1 . Different initiation.
    BC015667 mRNA. Translation: AAH15667.1 . Different initiation.
    AB067508 mRNA. Translation: BAB67814.1 . Sequence problems.
    CCDSi CCDS54335.1. [Q96CT2-1 ]
    RefSeqi NP_443152.1. NM_052920.1. [Q96CT2-1 ]
    XP_006711992.1. XM_006711929.1. [Q96CT2-1 ]
    UniGenei Hs.130593.

    3D structure databases

    ProteinModelPortali Q96CT2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125369. 12 interactions.
    IntActi Q96CT2. 2 interactions.

    Polymorphism databases

    DMDMi 47605917.

    Proteomic databases

    MaxQBi Q96CT2.
    PaxDbi Q96CT2.
    PRIDEi Q96CT2.

    Protocols and materials databases

    DNASUi 114818.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000486442 ; ENSP00000420659 ; ENSG00000119771 . [Q96CT2-1 ]
    GeneIDi 114818.
    KEGGi hsa:114818.
    UCSCi uc010ykg.2. human. [Q96CT2-1 ]

    Organism-specific databases

    CTDi 114818.
    GeneCardsi GC02P023608.
    H-InvDB HIX0001864.
    HGNCi HGNC:29404. KLHL29.
    HPAi HPA049057.
    neXtProti NX_Q96CT2.
    PharmGKBi PA162393486.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313336.
    HOGENOMi HOG000230815.
    HOVERGENi HBG096078.
    InParanoidi Q96CT2.
    KOi K10465.
    PhylomeDBi Q96CT2.
    TreeFami TF351654.

    Miscellaneous databases

    ChiTaRSi KLHL29. human.
    GenomeRNAii 114818.
    NextBioi 79284.
    PROi Q96CT2.

    Gene expression databases

    ArrayExpressi Q96CT2.
    Bgeei Q96CT2.
    CleanExi HS_KLHL29.
    Genevestigatori Q96CT2.

    Family and domain databases

    Gene3Di 2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view ]
    Pfami PF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 2 hits.
    [Graphical view ]
    SMARTi SM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-875 (ISOFORM 2).
      Tissue: Melanoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-875 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-875 (ISOFORM 1).
      Tissue: Placenta.
    3. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 360-875 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiKLH29_HUMAN
    AccessioniPrimary (citable) accession number: Q96CT2
    Secondary accession number(s): Q8N388, Q96BF0, Q96PW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although the complete sequence is not known with certainty, sequence shown here appears to be the most probable in accordance with the mouse sequence ortholog.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3