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Q96CT2 (KLH29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kelch-like protein 29
Alternative name(s):
Kelch repeat and BTB domain-containing protein 9
Gene names
Name:KLHL29
Synonyms:KBTBD9, KIAA1921
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length655 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 6 Kelch repeats.

Caution

Although the complete sequence is not known with certainty, sequence shown here appears to be the most probable in accordance with the mouse sequence ortholog.

Sequence caution

The sequence AAH13982.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH15667.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAD39171.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainKelch repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96CT2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96CT2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     483-655: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 655655Kelch-like protein 29
PRO_0000119086

Regions

Domain109 – 18173BTB
Repeat365 – 41551Kelch 1
Repeat417 – 46347Kelch 2
Repeat464 – 51047Kelch 3
Repeat512 – 55847Kelch 4
Repeat559 – 60143Kelch 5
Repeat602 – 65049Kelch 6
Compositional bias40 – 6526Pro-rich

Natural variations

Alternative sequence483 – 655173Missing in isoform 2.
VSP_010403

Experimental info

Sequence conflict921P → R in CAD39171. Ref.1
Sequence conflict111 – 13929LKIVV…KDLIQ → PRCAGRSSPVRKRHGGRRAG GKDTLVSVP Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: 64325D0DE5B9AA9C

FASTA65571,468
        10         20         30         40         50         60 
MPAQALYASP QPLAVSTLPG VGQVARPGPT AVGNGHMAGP LLPPPPPAQP SATLPSGAPA 

        70         80         90        100        110        120 
TNGPPTTDSA HGLQMLRTIG VGKYEFTDPG HPREMLKELN QQRRAKAFTD LKIVVEGREF 

       130        140        150        160        170        180 
EVHQNVLASC SLYFKDLIQR SVQDSGQGGR EKLELVLSNL QADVLELLLE FVYTGSLVID 

       190        200        210        220        230        240 
SANAKTLLEA ASKFQFHTFC KVCVSFLEKQ LTASNCLGVL AMAEAMQCSE LYHMAKAFAL 

       250        260        270        280        290        300 
QIFPEVAAQE EILSISKDDF IAYVSNDSLN TKAEELVYET VIKWIKKDPA TRTQYAAELL 

       310        320        330        340        350        360 
AVVRLPFIHP SYLLNVVDNE ELIKSSEACR DLVNEAKRYH MLPHARQEMQ TPRTRPRLSA 

       370        380        390        400        410        420 
GVAEVIVLVG GRQMVGMTQR SLVAVTCWNP QNNKWYPLAS LPFYDREFFS VVSAGDNIYL 

       430        440        450        460        470        480 
SGGMESGVTL ADVWCYMSLL DNWNLVSRMT VPRCRHNSLV YDGKIYTLGG LGVAGNVDHV 

       490        500        510        520        530        540 
ERYDTITNQW EAVAPLPKAV HSAAATVCGG KIYVFGGVNE AGRAAGVLQS YVPQTNTWSF 

       550        560        570        580        590        600 
IESPMIDNKY APAVTLNGFV FILGGAYARA TTIYDPEKGN IKAGPNMNHS RQFCSAVVLD 

       610        620        630        640        650 
GKIYATGGIV SSEGPALGNM EAYEPTTNTW TLLPHMPCPV FRHGCVVIKK YIQSG 

« Hide

Isoform 2 [UniParc].

Checksum: EBA6F79270AC11DF
Show »

FASTA48252,998

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Melanoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Placenta.
[3]"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-655 (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL834515 mRNA. Translation: CAD39171.2. Different initiation.
BC013982 mRNA. Translation: AAH13982.1. Different initiation.
BC015667 mRNA. Translation: AAH15667.1. Different initiation.
AB067508 mRNA. Translation: BAB67814.1.
RefSeqNP_443152.1. NM_052920.1.
UniGeneHs.130593.

3D structure databases

ProteinModelPortalQ96CT2.
SMRQ96CT2. Positions 85-342, 349-636.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125369. 1 interaction.
IntActQ96CT2. 1 interaction.

Polymorphism databases

DMDM47605917.

Proteomic databases

PaxDbQ96CT2.
PRIDEQ96CT2.

Protocols and materials databases

DNASU114818.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000486442; ENSP00000420659; ENSG00000119771.
GeneID114818.
KEGGhsa:114818.
UCSCuc010ykg.2. human. [Q96CT2-1]

Organism-specific databases

CTD114818.
GeneCardsGC02P023608.
H-InvDBHIX0001864.
HGNCHGNC:29404. KLHL29.
HPAHPA049057.
neXtProtNX_Q96CT2.
PharmGKBPA162393486.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313336.
HOGENOMHOG000230815.
HOVERGENHBG096078.
InParanoidQ96CT2.
KOK10465.
PhylomeDBQ96CT2.
TreeFamTF351654.

Gene expression databases

ArrayExpressQ96CT2.
BgeeQ96CT2.
CleanExHS_KLHL29.
GenevestigatorQ96CT2.

Family and domain databases

Gene3D2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin-typ.
IPR006652. Kelch_1.
[Graphical view]
PfamPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLHL29. human.
GenomeRNAi114818.
NextBio79284.
PROQ96CT2.

Entry information

Entry nameKLH29_HUMAN
AccessionPrimary (citable) accession number: Q96CT2
Secondary accession number(s): Q8N388, Q96BF0, Q96PW7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 16, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM