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Q96CT2

- KLH29_HUMAN

UniProt

Q96CT2 - KLH29_HUMAN

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Protein

Kelch-like protein 29

Gene

KLHL29

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 29
Alternative name(s):
Kelch repeat and BTB domain-containing protein 9
Gene namesi
Name:KLHL29
Synonyms:KBTBD9, KIAA1921
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:29404. KLHL29.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Kelch-like protein 29PRO_0000119086Add
BLAST

Proteomic databases

MaxQBiQ96CT2.
PaxDbiQ96CT2.
PRIDEiQ96CT2.

Expressioni

Gene expression databases

BgeeiQ96CT2.
CleanExiHS_KLHL29.
ExpressionAtlasiQ96CT2. baseline and differential.
GenevestigatoriQ96CT2.

Organism-specific databases

HPAiHPA049057.

Interactioni

Protein-protein interaction databases

BioGridi125369. 12 interactions.
IntActiQ96CT2. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96CT2.
SMRiQ96CT2. Positions 305-562, 569-869.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini329 – 40173BTBPROSITE-ProRule annotationAdd
BLAST
Repeati585 – 63551Kelch 1Add
BLAST
Repeati637 – 68347Kelch 2Add
BLAST
Repeati684 – 73047Kelch 3Add
BLAST
Repeati732 – 77847Kelch 4Add
BLAST
Repeati779 – 82143Kelch 5Add
BLAST
Repeati822 – 87049Kelch 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi260 – 28526Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG313336.
GeneTreeiENSGT00770000120450.
HOGENOMiHOG000230815.
HOVERGENiHBG096078.
InParanoidiQ96CT2.
KOiK10465.
PhylomeDBiQ96CT2.
TreeFamiTF351654.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96CT2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRHHSRFER DYRVGWDRRE WSVNGTHGTT SICSVTSGAG GGTASSLSVR
60 70 80 90 100
PGLLPLPVVP SRLPTPATAP APCTTGSSEA ITSLVASSAS AVTTKAPGIS
110 120 130 140 150
KGDSQSQGLA TSIRWGQTPI NQSTPWDTDE PPSKQMRESD NPGTGPWVTT
160 170 180 190 200
VAAGNQPTLI AHSYGVAQPP TFSPAVNVQA PVIGVTPSLP PHVGPQLPLM
210 220 230 240 250
PGHYSLPQPP SQPLSSVVVN MPAQALYASP QPLAVSTLPG VGQVARPGPT
260 270 280 290 300
AVGNGHMAGP LLPPPPPAQP SATLPSGAPA TNGPPTTDSA HGLQMLRTIG
310 320 330 340 350
VGKYEFTDPG HPREMLKELN QQRRAKAFTD LKIVVEGREF EVHQNVLASC
360 370 380 390 400
SLYFKDLIQR SVQDSGQGGR EKLELVLSNL QADVLELLLE FVYTGSLVID
410 420 430 440 450
SANAKTLLEA ASKFQFHTFC KVCVSFLEKQ LTASNCLGVL AMAEAMQCSE
460 470 480 490 500
LYHMAKAFAL QIFPEVAAQE EILSISKDDF IAYVSNDSLN TKAEELVYET
510 520 530 540 550
VIKWIKKDPA TRTQYAAELL AVVRLPFIHP SYLLNVVDNE ELIKSSEACR
560 570 580 590 600
DLVNEAKRYH MLPHARQEMQ TPRTRPRLSA GVAEVIVLVG GRQMVGMTQR
610 620 630 640 650
SLVAVTCWNP QNNKWYPLAS LPFYDREFFS VVSAGDNIYL SGGMESGVTL
660 670 680 690 700
ADVWCYMSLL DNWNLVSRMT VPRCRHNSLV YDGKIYTLGG LGVAGNVDHV
710 720 730 740 750
ERYDTITNQW EAVAPLPKAV HSAAATVCGG KIYVFGGVNE AGRAAGVLQS
760 770 780 790 800
YVPQTNTWSF IESPMIDNKY APAVTLNGFV FILGGAYARA TTIYDPEKGN
810 820 830 840 850
IKAGPNMNHS RQFCSAVVLD GKIYATGGIV SSEGPALGNM EAYEPTTNTW
860 870
TLLPHMPCPV FRHGCVVIKK YIQSG
Length:875
Mass (Da):94,228
Last modified:May 14, 2014 - v3
Checksum:i9B2EBF4F5D0099DD
GO
Isoform 2 (identifier: Q96CT2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     703-875: Missing.

Show »
Length:702
Mass (Da):75,758
Checksum:i8C209F6BA8C81231
GO

Sequence cautioni

The sequence AAH13982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH15667.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB67814.1 differs from that shown. Reason: Intron retention.Curated
The sequence CAD39171.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti312 – 3121P → R in CAD39171. (PubMed:17974005)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei703 – 875173Missing in isoform 2. 2 PublicationsVSP_010403Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834515 mRNA. Translation: CAD39171.2. Different initiation.
BC013982 mRNA. Translation: AAH13982.1. Different initiation.
BC015667 mRNA. Translation: AAH15667.1. Different initiation.
AB067508 mRNA. Translation: BAB67814.1. Sequence problems.
CCDSiCCDS54335.1. [Q96CT2-1]
RefSeqiNP_443152.1. NM_052920.1. [Q96CT2-1]
XP_006711992.1. XM_006711929.1. [Q96CT2-1]
UniGeneiHs.130593.

Genome annotation databases

EnsembliENST00000486442; ENSP00000420659; ENSG00000119771. [Q96CT2-1]
GeneIDi114818.
KEGGihsa:114818.
UCSCiuc010ykg.2. human. [Q96CT2-1]

Polymorphism databases

DMDMi47605917.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834515 mRNA. Translation: CAD39171.2 . Different initiation.
BC013982 mRNA. Translation: AAH13982.1 . Different initiation.
BC015667 mRNA. Translation: AAH15667.1 . Different initiation.
AB067508 mRNA. Translation: BAB67814.1 . Sequence problems.
CCDSi CCDS54335.1. [Q96CT2-1 ]
RefSeqi NP_443152.1. NM_052920.1. [Q96CT2-1 ]
XP_006711992.1. XM_006711929.1. [Q96CT2-1 ]
UniGenei Hs.130593.

3D structure databases

ProteinModelPortali Q96CT2.
SMRi Q96CT2. Positions 305-562, 569-869.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125369. 12 interactions.
IntActi Q96CT2. 2 interactions.

Polymorphism databases

DMDMi 47605917.

Proteomic databases

MaxQBi Q96CT2.
PaxDbi Q96CT2.
PRIDEi Q96CT2.

Protocols and materials databases

DNASUi 114818.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000486442 ; ENSP00000420659 ; ENSG00000119771 . [Q96CT2-1 ]
GeneIDi 114818.
KEGGi hsa:114818.
UCSCi uc010ykg.2. human. [Q96CT2-1 ]

Organism-specific databases

CTDi 114818.
GeneCardsi GC02P023608.
H-InvDB HIX0001864.
HGNCi HGNC:29404. KLHL29.
HPAi HPA049057.
neXtProti NX_Q96CT2.
PharmGKBi PA162393486.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313336.
GeneTreei ENSGT00770000120450.
HOGENOMi HOG000230815.
HOVERGENi HBG096078.
InParanoidi Q96CT2.
KOi K10465.
PhylomeDBi Q96CT2.
TreeFami TF351654.

Miscellaneous databases

ChiTaRSi KLHL29. human.
GenomeRNAii 114818.
NextBioi 79284.
PROi Q96CT2.

Gene expression databases

Bgeei Q96CT2.
CleanExi HS_KLHL29.
ExpressionAtlasi Q96CT2. baseline and differential.
Genevestigatori Q96CT2.

Family and domain databases

Gene3Di 2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
[Graphical view ]
Pfami PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view ]
SMARTi SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-875 (ISOFORM 2).
    Tissue: Melanoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-875 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-875 (ISOFORM 1).
    Tissue: Placenta.
  3. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 360-875 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiKLH29_HUMAN
AccessioniPrimary (citable) accession number: Q96CT2
Secondary accession number(s): Q8N388, Q96BF0, Q96PW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 14, 2014
Last modified: November 26, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although the complete sequence is not known with certainty, sequence shown here appears to be the most probable in accordance with the mouse sequence ortholog.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3