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Q96CT2 (KLH29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kelch-like protein 29
Alternative name(s):
Kelch repeat and BTB domain-containing protein 9
Gene names
Name:KLHL29
Synonyms:KBTBD9, KIAA1921
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length875 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 6 Kelch repeats.

Caution

Although the complete sequence is not known with certainty, sequence shown here appears to be the most probable in accordance with the mouse sequence ortholog.

Sequence caution

The sequence AAH13982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAH15667.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB67814.1 differs from that shown. Reason: Intron retention.

The sequence CAD39171.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainKelch repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96CT2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96CT2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     703-875: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 875875Kelch-like protein 29
PRO_0000119086

Regions

Domain329 – 40173BTB
Repeat585 – 63551Kelch 1
Repeat637 – 68347Kelch 2
Repeat684 – 73047Kelch 3
Repeat732 – 77847Kelch 4
Repeat779 – 82143Kelch 5
Repeat822 – 87049Kelch 6
Compositional bias260 – 28526Pro-rich

Natural variations

Alternative sequence703 – 875173Missing in isoform 2.
VSP_010403

Experimental info

Sequence conflict3121P → R in CAD39171. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 14, 2014. Version 3.
Checksum: 9B2EBF4F5D0099DD

FASTA87594,228
        10         20         30         40         50         60 
MSRHHSRFER DYRVGWDRRE WSVNGTHGTT SICSVTSGAG GGTASSLSVR PGLLPLPVVP 

        70         80         90        100        110        120 
SRLPTPATAP APCTTGSSEA ITSLVASSAS AVTTKAPGIS KGDSQSQGLA TSIRWGQTPI 

       130        140        150        160        170        180 
NQSTPWDTDE PPSKQMRESD NPGTGPWVTT VAAGNQPTLI AHSYGVAQPP TFSPAVNVQA 

       190        200        210        220        230        240 
PVIGVTPSLP PHVGPQLPLM PGHYSLPQPP SQPLSSVVVN MPAQALYASP QPLAVSTLPG 

       250        260        270        280        290        300 
VGQVARPGPT AVGNGHMAGP LLPPPPPAQP SATLPSGAPA TNGPPTTDSA HGLQMLRTIG 

       310        320        330        340        350        360 
VGKYEFTDPG HPREMLKELN QQRRAKAFTD LKIVVEGREF EVHQNVLASC SLYFKDLIQR 

       370        380        390        400        410        420 
SVQDSGQGGR EKLELVLSNL QADVLELLLE FVYTGSLVID SANAKTLLEA ASKFQFHTFC 

       430        440        450        460        470        480 
KVCVSFLEKQ LTASNCLGVL AMAEAMQCSE LYHMAKAFAL QIFPEVAAQE EILSISKDDF 

       490        500        510        520        530        540 
IAYVSNDSLN TKAEELVYET VIKWIKKDPA TRTQYAAELL AVVRLPFIHP SYLLNVVDNE 

       550        560        570        580        590        600 
ELIKSSEACR DLVNEAKRYH MLPHARQEMQ TPRTRPRLSA GVAEVIVLVG GRQMVGMTQR 

       610        620        630        640        650        660 
SLVAVTCWNP QNNKWYPLAS LPFYDREFFS VVSAGDNIYL SGGMESGVTL ADVWCYMSLL 

       670        680        690        700        710        720 
DNWNLVSRMT VPRCRHNSLV YDGKIYTLGG LGVAGNVDHV ERYDTITNQW EAVAPLPKAV 

       730        740        750        760        770        780 
HSAAATVCGG KIYVFGGVNE AGRAAGVLQS YVPQTNTWSF IESPMIDNKY APAVTLNGFV 

       790        800        810        820        830        840 
FILGGAYARA TTIYDPEKGN IKAGPNMNHS RQFCSAVVLD GKIYATGGIV SSEGPALGNM 

       850        860        870 
EAYEPTTNTW TLLPHMPCPV FRHGCVVIKK YIQSG 

« Hide

Isoform 2 [UniParc].

Checksum: 8C209F6BA8C81231
Show »

FASTA70275,758

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-875 (ISOFORM 2).
Tissue: Melanoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-875 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-875 (ISOFORM 1).
Tissue: Placenta.
[3]"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 360-875 (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL834515 mRNA. Translation: CAD39171.2. Different initiation.
BC013982 mRNA. Translation: AAH13982.1. Different initiation.
BC015667 mRNA. Translation: AAH15667.1. Different initiation.
AB067508 mRNA. Translation: BAB67814.1. Sequence problems.
RefSeqNP_443152.1. NM_052920.1. [Q96CT2-1]
XP_006711992.1. XM_006711929.1. [Q96CT2-1]
UniGeneHs.130593.

3D structure databases

ProteinModelPortalQ96CT2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125369. 1 interaction.
IntActQ96CT2. 1 interaction.

Polymorphism databases

DMDM47605917.

Proteomic databases

MaxQBQ96CT2.
PaxDbQ96CT2.
PRIDEQ96CT2.

Protocols and materials databases

DNASU114818.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000486442; ENSP00000420659; ENSG00000119771.
GeneID114818.
KEGGhsa:114818.
UCSCuc010ykg.2. human. [Q96CT2-1]

Organism-specific databases

CTD114818.
GeneCardsGC02P023608.
H-InvDBHIX0001864.
HGNCHGNC:29404. KLHL29.
HPAHPA049057.
neXtProtNX_Q96CT2.
PharmGKBPA162393486.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313336.
HOGENOMHOG000230815.
HOVERGENHBG096078.
InParanoidQ96CT2.
KOK10465.
PhylomeDBQ96CT2.
TreeFamTF351654.

Gene expression databases

ArrayExpressQ96CT2.
BgeeQ96CT2.
CleanExHS_KLHL29.
GenevestigatorQ96CT2.

Family and domain databases

Gene3D2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLHL29. human.
GenomeRNAi114818.
NextBio79284.
PROQ96CT2.

Entry information

Entry nameKLH29_HUMAN
AccessionPrimary (citable) accession number: Q96CT2
Secondary accession number(s): Q8N388, Q96BF0, Q96PW7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 14, 2014
Last modified: July 9, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM