ID   PKHB2_HUMAN             Reviewed;         222 AA.
AC   Q96CS7; B4DF08; B4DZ66; B8ZZN1; Q53FF1; Q53TH7; Q86W37; Q9BV75; Q9NWK1;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 172.
DE   RecName: Full=Pleckstrin homology domain-containing family B member 2;
DE            Short=PH domain-containing family B member 2;
DE   AltName: Full=Evectin-2;
GN   Name=PLEKHB2; Synonyms=EVT2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
RC   TISSUE=Cerebellum, Colon, Lung, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Testis;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Pancreas, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (1.0 ANGSTROMS) OF 1-110, FUNCTION, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=21911378; DOI=10.1073/pnas.1109101108;
RA   Uchida Y., Hasegawa J., Chinnapen D., Inoue T., Okazaki S., Kato R.,
RA   Wakatsuki S., Misaki R., Koike M., Uchiyama Y., Iemura S., Natsume T.,
RA   Kuwahara R., Nakagawa T., Nishikawa K., Mukai K., Miyoshi E., Taniguchi N.,
RA   Sheff D., Lencer W.I., Taguchi T., Arai H.;
RT   "Intracellular phosphatidylserine is essential for retrograde membrane
RT   traffic through endosomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:15846-15851(2011).
RN   [7]
RP   X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 1-110 IN COMPLEX WITH
RP   O-PHOSPHOSERINE, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=22281740; DOI=10.1107/s0907444911051626;
RA   Okazaki S., Kato R., Uchida Y., Taguchi T., Arai H., Wakatsuki S.;
RT   "Structural basis of the strict phospholipid binding specificity of the
RT   pleckstrin homology domain of human evectin-2.";
RL   Acta Crystallogr. D 68:117-123(2012).
CC   -!- FUNCTION: Involved in retrograde transport of recycling endosomes.
CC       {ECO:0000269|PubMed:21911378, ECO:0000269|PubMed:22281740}.
CC   -!- INTERACTION:
CC       Q96CS7; O14503: BHLHE40; NbExp=3; IntAct=EBI-373552, EBI-711810;
CC       Q96CS7; Q6P1W5: C1orf94; NbExp=6; IntAct=EBI-373552, EBI-946029;
CC       Q96CS7; P34810: CD68; NbExp=3; IntAct=EBI-373552, EBI-2826276;
CC       Q96CS7; P32320: CDA; NbExp=6; IntAct=EBI-373552, EBI-9250559;
CC       Q96CS7; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-373552, EBI-12256978;
CC       Q96CS7; Q15038: DAZAP2; NbExp=11; IntAct=EBI-373552, EBI-724310;
CC       Q96CS7; Q96GG9: DCUN1D1; NbExp=5; IntAct=EBI-373552, EBI-740086;
CC       Q96CS7; P54849: EMP1; NbExp=3; IntAct=EBI-373552, EBI-4319440;
CC       Q96CS7; P54852: EMP3; NbExp=3; IntAct=EBI-373552, EBI-3907816;
CC       Q96CS7; Q9Y6I3: EPN1; NbExp=3; IntAct=EBI-373552, EBI-713198;
CC       Q96CS7; O95208-2: EPN2; NbExp=3; IntAct=EBI-373552, EBI-12135243;
CC       Q96CS7; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-373552, EBI-11978259;
CC       Q96CS7; Q6VB84: FOXD4L3; NbExp=3; IntAct=EBI-373552, EBI-11961494;
CC       Q96CS7; Q9NZ52-2: GGA3; NbExp=3; IntAct=EBI-373552, EBI-12075758;
CC       Q96CS7; P29033: GJB2; NbExp=3; IntAct=EBI-373552, EBI-3905204;
CC       Q96CS7; Q9BZE0: GLIS2; NbExp=5; IntAct=EBI-373552, EBI-7251368;
CC       Q96CS7; Q9Y5J3: HEY1; NbExp=3; IntAct=EBI-373552, EBI-7231130;
CC       Q96CS7; Q9NQ87: HEYL; NbExp=3; IntAct=EBI-373552, EBI-751092;
CC       Q96CS7; O14964: HGS; NbExp=3; IntAct=EBI-373552, EBI-740220;
CC       Q96CS7; Q71SY5: MED25; NbExp=3; IntAct=EBI-373552, EBI-394558;
CC       Q96CS7; Q8N3F0: MTURN; NbExp=5; IntAct=EBI-373552, EBI-11980301;
CC       Q96CS7; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-373552, EBI-741158;
CC       Q96CS7; Q96DC9: OTUB2; NbExp=3; IntAct=EBI-373552, EBI-746259;
CC       Q96CS7; Q86T03: PIP4P1; NbExp=3; IntAct=EBI-373552, EBI-6164623;
CC       Q96CS7; P78337: PITX1; NbExp=3; IntAct=EBI-373552, EBI-748265;
CC       Q96CS7; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-373552, EBI-1389308;
CC       Q96CS7; O75360: PROP1; NbExp=3; IntAct=EBI-373552, EBI-9027467;
CC       Q96CS7; Q8TEB9: RHBDD1; NbExp=3; IntAct=EBI-373552, EBI-9916444;
CC       Q96CS7; P62979: RPS27A; NbExp=3; IntAct=EBI-373552, EBI-357375;
CC       Q96CS7; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-373552, EBI-2854842;
CC       Q96CS7; P14678-2: SNRPB; NbExp=3; IntAct=EBI-373552, EBI-372475;
CC       Q96CS7; O75886: STAM2; NbExp=6; IntAct=EBI-373552, EBI-373258;
CC       Q96CS7; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-373552, EBI-12187159;
CC       Q96CS7; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-373552, EBI-529518;
CC       Q96CS7; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-373552, EBI-11988865;
CC       Q96CS7; P62987: UBA52; NbExp=3; IntAct=EBI-373552, EBI-357304;
CC       Q96CS7; Q9BSL1: UBAC1; NbExp=3; IntAct=EBI-373552, EBI-749370;
CC       Q96CS7; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-373552, EBI-2514383;
CC       Q96CS7; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-373552, EBI-7353612;
CC       Q96CS7; P0CG47: UBB; NbExp=3; IntAct=EBI-373552, EBI-413034;
CC       Q96CS7; P0CG48: UBC; NbExp=3; IntAct=EBI-373552, EBI-3390054;
CC       Q96CS7; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-373552, EBI-947187;
CC       Q96CS7; Q9BZV1: UBXN6; NbExp=5; IntAct=EBI-373552, EBI-1993899;
CC       Q96CS7; Q5VVQ6: YOD1; NbExp=5; IntAct=EBI-373552, EBI-2510804;
CC       Q96CS7; Q8N6M9: ZFAND2A; NbExp=3; IntAct=EBI-373552, EBI-3921109;
CC   -!- SUBCELLULAR LOCATION: Recycling endosome membrane
CC       {ECO:0000269|PubMed:21911378, ECO:0000269|PubMed:22281740}; Peripheral
CC       membrane protein {ECO:0000269|PubMed:21911378,
CC       ECO:0000269|PubMed:22281740}. Note=Specifically detected in
CC       tubulovesicular structures, and colocalizes with TFNR.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=6;
CC       Name=1;
CC         IsoId=Q96CS7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96CS7-2; Sequence=VSP_009783;
CC       Name=3;
CC         IsoId=Q96CS7-3; Sequence=VSP_009784;
CC       Name=4;
CC         IsoId=Q96CS7-4; Sequence=VSP_045163;
CC       Name=5;
CC         IsoId=Q96CS7-5; Sequence=VSP_045164;
CC       Name=6;
CC         IsoId=Q96CS7-6; Sequence=VSP_047118;
CC   -!- DOMAIN: The PH domain specifically binds phosphatidylserine, which is
CC       enriched in recycling endosome membranes, it doesn't recognize PIPs.
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DR   EMBL; AK000790; BAA91379.1; -; mRNA.
DR   EMBL; AK123710; BAG53942.1; -; mRNA.
DR   EMBL; AK293880; BAG57269.1; -; mRNA.
DR   EMBL; AK302770; BAG63978.1; -; mRNA.
DR   EMBL; AK223338; BAD97058.1; -; mRNA.
DR   EMBL; AC073869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC131180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC009477; AAX93135.1; -; Genomic_DNA.
DR   EMBL; CH471250; EAW51261.1; -; Genomic_DNA.
DR   EMBL; CH471250; EAW51263.1; -; Genomic_DNA.
DR   EMBL; CH471250; EAW51266.1; -; Genomic_DNA.
DR   EMBL; BC001428; AAH01428.1; -; mRNA.
DR   EMBL; BC013991; AAH13991.1; -; mRNA.
DR   EMBL; BC050695; AAH50695.2; -; mRNA.
DR   CCDS; CCDS2166.1; -. [Q96CS7-3]
DR   CCDS; CCDS46413.1; -. [Q96CS7-1]
DR   CCDS; CCDS58729.1; -. [Q96CS7-5]
DR   CCDS; CCDS58730.1; -. [Q96CS7-6]
DR   CCDS; CCDS58731.1; -. [Q96CS7-4]
DR   RefSeq; NP_001094093.1; NM_001100623.1. [Q96CS7-1]
DR   RefSeq; NP_001253991.1; NM_001267062.1.
DR   RefSeq; NP_001253992.1; NM_001267063.1.
DR   RefSeq; NP_001253993.1; NM_001267064.1.
DR   RefSeq; NP_001253994.1; NM_001267065.1. [Q96CS7-6]
DR   RefSeq; NP_001253995.1; NM_001267066.1. [Q96CS7-5]
DR   RefSeq; NP_001253996.1; NM_001267067.1.
DR   RefSeq; NP_001253997.1; NM_001267068.1. [Q96CS7-4]
DR   RefSeq; NP_001296377.1; NM_001309448.1.
DR   RefSeq; NP_001296379.1; NM_001309450.1.
DR   RefSeq; NP_001296380.1; NM_001309451.1.
DR   RefSeq; NP_001296381.1; NM_001309452.1.
DR   RefSeq; NP_060428.2; NM_017958.2. [Q96CS7-3]
DR   RefSeq; XP_016859900.1; XM_017004411.1.
DR   RefSeq; XP_016859901.1; XM_017004412.1.
DR   PDB; 3AJ4; X-ray; 1.00 A; A/B=1-110.
DR   PDB; 3VIA; X-ray; 1.75 A; A/B=1-110.
DR   PDBsum; 3AJ4; -.
DR   PDBsum; 3VIA; -.
DR   AlphaFoldDB; Q96CS7; -.
DR   SMR; Q96CS7; -.
DR   BioGRID; 120370; 74.
DR   IntAct; Q96CS7; 60.
DR   MINT; Q96CS7; -.
DR   STRING; 9606.ENSP00000385892; -.
DR   iPTMnet; Q96CS7; -.
DR   PhosphoSitePlus; Q96CS7; -.
DR   BioMuta; PLEKHB2; -.
DR   DMDM; 48474928; -.
DR   EPD; Q96CS7; -.
DR   jPOST; Q96CS7; -.
DR   MassIVE; Q96CS7; -.
DR   MaxQB; Q96CS7; -.
DR   PaxDb; 9606-ENSP00000385892; -.
DR   PeptideAtlas; Q96CS7; -.
DR   ProteomicsDB; 3999; -.
DR   ProteomicsDB; 5574; -.
DR   ProteomicsDB; 7407; -.
DR   ProteomicsDB; 76216; -. [Q96CS7-1]
DR   ProteomicsDB; 76217; -. [Q96CS7-2]
DR   ProteomicsDB; 76218; -. [Q96CS7-3]
DR   Pumba; Q96CS7; -.
DR   Antibodypedia; 35075; 83 antibodies from 20 providers.
DR   DNASU; 55041; -.
DR   Ensembl; ENST00000234115.10; ENSP00000234115.6; ENSG00000115762.17. [Q96CS7-3]
DR   Ensembl; ENST00000409158.5; ENSP00000386410.1; ENSG00000115762.17. [Q96CS7-6]
DR   Ensembl; ENST00000409279.1; ENSP00000386666.1; ENSG00000115762.17. [Q96CS7-1]
DR   Ensembl; ENST00000409612.5; ENSP00000386662.1; ENSG00000115762.17. [Q96CS7-1]
DR   Ensembl; ENST00000438882.6; ENSP00000401193.2; ENSG00000115762.17. [Q96CS7-5]
DR   Ensembl; ENST00000628582.2; ENSP00000487321.1; ENSG00000115762.17. [Q96CS7-4]
DR   Ensembl; ENST00000693505.1; ENSP00000510611.1; ENSG00000115762.17. [Q96CS7-1]
DR   GeneID; 55041; -.
DR   KEGG; hsa:55041; -.
DR   MANE-Select; ENST00000693505.1; ENSP00000510611.1; NM_001100623.2; NP_001094093.1.
DR   UCSC; uc002tsf.5; human. [Q96CS7-1]
DR   AGR; HGNC:19236; -.
DR   CTD; 55041; -.
DR   GeneCards; PLEKHB2; -.
DR   HGNC; HGNC:19236; PLEKHB2.
DR   HPA; ENSG00000115762; Low tissue specificity.
DR   MIM; 618452; gene.
DR   neXtProt; NX_Q96CS7; -.
DR   OpenTargets; ENSG00000115762; -.
DR   PharmGKB; PA134885873; -.
DR   VEuPathDB; HostDB:ENSG00000115762; -.
DR   eggNOG; ENOG502S9ZQ; Eukaryota.
DR   GeneTree; ENSGT00390000013989; -.
DR   HOGENOM; CLU_1510070_0_0_1; -.
DR   InParanoid; Q96CS7; -.
DR   OMA; YIGSEVM; -.
DR   OrthoDB; 5400244at2759; -.
DR   PhylomeDB; Q96CS7; -.
DR   TreeFam; TF331787; -.
DR   PathwayCommons; Q96CS7; -.
DR   SignaLink; Q96CS7; -.
DR   BioGRID-ORCS; 55041; 8 hits in 1155 CRISPR screens.
DR   ChiTaRS; PLEKHB2; human.
DR   GeneWiki; PLEKHB2; -.
DR   GenomeRNAi; 55041; -.
DR   Pharos; Q96CS7; Tbio.
DR   PRO; PR:Q96CS7; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q96CS7; Protein.
DR   Bgee; ENSG00000115762; Expressed in pons and 209 other cell types or tissues.
DR   ExpressionAtlas; Q96CS7; baseline and differential.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:GO_Central.
DR   GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central.
DR   CDD; cd13265; PH_evt; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039680; PLEKHB1/2.
DR   PANTHER; PTHR14309; EXPRESSED PROTEIN; 1.
DR   PANTHER; PTHR14309:SF8; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY B MEMBER 2; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   Genevisible; Q96CS7; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Endosome; Membrane; Reference proteome.
FT   CHAIN           1..222
FT                   /note="Pleckstrin homology domain-containing family B
FT                   member 2"
FT                   /id="PRO_0000053889"
FT   DOMAIN          2..109
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   BINDING         20
FT                   /ligand="a 1,2-diacyl-sn-glycero-3-phospho-L-serine"
FT                   /ligand_id="ChEBI:CHEBI:57262"
FT   VAR_SEQ         99..222
FT                   /note="AWKFTLQDSRTNTAYVGSAVMTDETSVVSSPPPYTAYAAPAPEQAYGYGPYG
FT                   GAYPPGTQVVYAANGQAYAVPYQYPYAGLYGQQPANQVIIRERYRDNDSDLALGMLAGA
FT                   ATGMALGSLFWVF -> LMAMGHTVVRTRQELKLSTLRMGRRMPCPTSTHMQDFMDSSL
FT                   LTKSSFESAIETTTATWHWACWQEQPRAWP (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045163"
FT   VAR_SEQ         141
FT                   /note="E -> EVGRTLSLQ (in isoform 6)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_047118"
FT   VAR_SEQ         142..222
FT                   /note="QAYGYGPYGGAYPPGTQVVYAANGQAYAVPYQYPYAGLYGQQPANQVIIRER
FT                   YRDNDSDLALGMLAGAATGMALGSLFWVF -> ELHSKGPKIHTTTSAKTQAVLPTRCF
FT                   FPSESPIRRSVQISVLLPAVNIRRRIKLTFPQPARPRAPRSLCLWQTWFAGKRAPSLPT
FT                   AATAPALPSCPSPPAPSKALPPSLAGWRSPSSAPLPPEQALAPRSFQLSKHQARPRPHR
FT                   PGTPPVPAWPGVPPPPPARPPALR (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_009783"
FT   VAR_SEQ         142..222
FT                   /note="QAYGYGPYGGAYPPGTQVVYAANGQAYAVPYQYPYAGLYGQQPANQVIIRER
FT                   YRDNDSDLALGMLAGAATGMALGSLFWVF -> DFMDSSLLTKSSFESAIETTTATWHW
FT                   ACWQEQPRAWP (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045164"
FT   VAR_SEQ         142
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT                   /id="VSP_009784"
FT   CONFLICT        172
FT                   /note="Y -> H (in Ref. 1; BAA91379)"
FT                   /evidence="ECO:0000305"
FT   STRAND          4..12
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   STRAND          14..16
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   STRAND          19..26
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   STRAND          30..37
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   STRAND          42..48
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   HELIX           49..52
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   STRAND          53..58
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   HELIX           59..61
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   HELIX           73..75
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   STRAND          76..81
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   STRAND          86..90
FT                   /evidence="ECO:0007829|PDB:3AJ4"
FT   HELIX           94..108
FT                   /evidence="ECO:0007829|PDB:3AJ4"
SQ   SEQUENCE   222 AA;  24736 MW;  8924F61890D416A5 CRC64;
     MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP MDCINIRTGQ
     ECRDTQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW KFTLQDSRTN TAYVGSAVMT
     DETSVVSSPP PYTAYAAPAP EQAYGYGPYG GAYPPGTQVV YAANGQAYAV PYQYPYAGLY
     GQQPANQVII RERYRDNDSD LALGMLAGAA TGMALGSLFW VF
//