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Protein

Pleckstrin homology domain-containing family B member 2

Gene

PLEKHB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in retrograde transport of recycling endosomes.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20Phosphatidylserine1

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115762-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family B member 2
Short name:
PH domain-containing family B member 2
Alternative name(s):
Evectin-2
Gene namesi
Name:PLEKHB2
Synonyms:EVT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:19236. PLEKHB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115762.
PharmGKBiPA134885873.

Polymorphism and mutation databases

BioMutaiPLEKHB2.
DMDMi48474928.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538891 – 222Pleckstrin homology domain-containing family B member 2Add BLAST222

Proteomic databases

MaxQBiQ96CS7.
PaxDbiQ96CS7.
PeptideAtlasiQ96CS7.
PRIDEiQ96CS7.

PTM databases

iPTMnetiQ96CS7.
PhosphoSitePlusiQ96CS7.

Expressioni

Gene expression databases

BgeeiENSG00000115762.
CleanExiHS_PLEKHB2.
ExpressionAtlasiQ96CS7. baseline and differential.
GenevisibleiQ96CS7. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLHE40O145033EBI-373552,EBI-711810
C1orf94Q6P1W53EBI-373552,EBI-946029
CDAP323205EBI-373552,EBI-9250559
DAZAP2Q150385EBI-373552,EBI-724310
EPN1Q9Y6I33EBI-373552,EBI-713198
STAM2O758863EBI-373552,EBI-373258

Protein-protein interaction databases

BioGridi120370. 19 interactors.
IntActiQ96CS7. 14 interactors.
MINTiMINT-1180681.
STRINGi9606.ENSP00000385892.

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 12Combined sources9
Beta strandi14 – 16Combined sources3
Beta strandi19 – 26Combined sources8
Beta strandi30 – 37Combined sources8
Beta strandi42 – 48Combined sources7
Helixi49 – 52Combined sources4
Beta strandi53 – 58Combined sources6
Helixi59 – 61Combined sources3
Helixi73 – 75Combined sources3
Beta strandi76 – 81Combined sources6
Beta strandi86 – 90Combined sources5
Helixi94 – 108Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AJ4X-ray1.00A/B1-110[»]
3VIAX-ray1.75A/B1-110[»]
ProteinModelPortaliQ96CS7.
SMRiQ96CS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109PHPROSITE-ProRule annotationAdd BLAST108

Domaini

The PH domain specifically binds phosphatidylserine, which is enriched in recycling endosome membranes, it doesn't recognize PIPs.

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFNJ. Eukaryota.
ENOG4111G6I. LUCA.
GeneTreeiENSGT00390000013989.
HOGENOMiHOG000253945.
HOVERGENiHBG060487.
InParanoidiQ96CS7.
PhylomeDBiQ96CS7.
TreeFamiTF331787.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP
60 70 80 90 100
MDCINIRTGQ ECRDTQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW
110 120 130 140 150
KFTLQDSRTN TAYVGSAVMT DETSVVSSPP PYTAYAAPAP EQAYGYGPYG
160 170 180 190 200
GAYPPGTQVV YAANGQAYAV PYQYPYAGLY GQQPANQVII RERYRDNDSD
210 220
LALGMLAGAA TGMALGSLFW VF
Length:222
Mass (Da):24,736
Last modified:December 1, 2001 - v1
Checksum:i8924F61890D416A5
GO
Isoform 2 (identifier: Q96CS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-222: QAYGYGPYGG...MALGSLFWVF → ELHSKGPKIH...PPPARPPALR

Note: No experimental confirmation available.
Show »
Length:309
Mass (Da):34,154
Checksum:iBB64D755DBDBD100
GO
Isoform 3 (identifier: Q96CS7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-142: Missing.

Note: No experimental confirmation available.
Show »
Length:221
Mass (Da):24,608
Checksum:i6740C7F3A491AB09
GO
Isoform 4 (identifier: Q96CS7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-222: AWKFTLQDSR...MALGSLFWVF → LMAMGHTVVR...CWQEQPRAWP

Show »
Length:170
Mass (Da):19,852
Checksum:i70B6C31C4BD6AA19
GO
Isoform 5 (identifier: Q96CS7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-222: QAYGYGPYGG...MALGSLFWVF → DFMDSSLLTK...CWQEQPRAWP

Show »
Length:178
Mass (Da):20,375
Checksum:i7903B0346AB5F5C0
GO
Isoform 6 (identifier: Q96CS7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-141: E → EVGRTLSLQ

Note: Gene prediction based on EST data.
Show »
Length:230
Mass (Da):25,591
Checksum:i08562F08D30AEE66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172Y → H in BAA91379 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04516399 – 222AWKFT…LFWVF → LMAMGHTVVRTRQELKLSTL RMGRRMPCPTSTHMQDFMDS SLLTKSSFESAIETTTATWH WACWQEQPRAWP in isoform 4. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_047118141E → EVGRTLSLQ in isoform 6. Curated1
Alternative sequenceiVSP_009783142 – 222QAYGY…LFWVF → ELHSKGPKIHTTTSAKTQAV LPTRCFFPSESPIRRSVQIS VLLPAVNIRRRIKLTFPQPA RPRAPRSLCLWQTWFAGKRA PSLPTAATAPALPSCPSPPA PSKALPPSLAGWRSPSSAPL PPEQALAPRSFQLSKHQARP RPHRPGTPPVPAWPGVPPPP PARPPALR in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_045164142 – 222QAYGY…LFWVF → DFMDSSLLTKSSFESAIETT TATWHWACWQEQPRAWP in isoform 5. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_009784142Missing in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000790 mRNA. Translation: BAA91379.1.
AK123710 mRNA. Translation: BAG53942.1.
AK293880 mRNA. Translation: BAG57269.1.
AK302770 mRNA. Translation: BAG63978.1.
AK223338 mRNA. Translation: BAD97058.1.
AC073869 Genomic DNA. No translation available.
AC131180 Genomic DNA. No translation available.
AC009477 Genomic DNA. Translation: AAX93135.1.
CH471250 Genomic DNA. Translation: EAW51261.1.
CH471250 Genomic DNA. Translation: EAW51263.1.
CH471250 Genomic DNA. Translation: EAW51266.1.
BC001428 mRNA. Translation: AAH01428.1.
BC013991 mRNA. Translation: AAH13991.1.
BC050695 mRNA. Translation: AAH50695.2.
CCDSiCCDS2166.1. [Q96CS7-3]
CCDS46413.1. [Q96CS7-1]
CCDS58729.1. [Q96CS7-5]
CCDS58730.1. [Q96CS7-6]
CCDS58731.1. [Q96CS7-4]
RefSeqiNP_001094093.1. NM_001100623.1. [Q96CS7-1]
NP_001253991.1. NM_001267062.1.
NP_001253992.1. NM_001267063.1.
NP_001253993.1. NM_001267064.1.
NP_001253994.1. NM_001267065.1. [Q96CS7-6]
NP_001253995.1. NM_001267066.1. [Q96CS7-5]
NP_001253996.1. NM_001267067.1.
NP_001253997.1. NM_001267068.1. [Q96CS7-4]
NP_001296377.1. NM_001309448.1.
NP_001296379.1. NM_001309450.1.
NP_001296380.1. NM_001309451.1.
NP_001296381.1. NM_001309452.1.
NP_060428.2. NM_017958.2. [Q96CS7-3]
XP_016859900.1. XM_017004411.1. [Q96CS7-6]
XP_016859901.1. XM_017004412.1. [Q96CS7-1]
UniGeneiHs.469944.
Hs.708368.

Genome annotation databases

EnsembliENST00000234115; ENSP00000234115; ENSG00000115762. [Q96CS7-3]
ENST00000409158; ENSP00000386410; ENSG00000115762. [Q96CS7-6]
ENST00000409279; ENSP00000386666; ENSG00000115762. [Q96CS7-1]
ENST00000409612; ENSP00000386662; ENSG00000115762. [Q96CS7-1]
ENST00000438882; ENSP00000401193; ENSG00000115762. [Q96CS7-5]
ENST00000628582; ENSP00000487321; ENSG00000115762. [Q96CS7-4]
GeneIDi55041.
KEGGihsa:55041.
UCSCiuc002tsf.5. human. [Q96CS7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000790 mRNA. Translation: BAA91379.1.
AK123710 mRNA. Translation: BAG53942.1.
AK293880 mRNA. Translation: BAG57269.1.
AK302770 mRNA. Translation: BAG63978.1.
AK223338 mRNA. Translation: BAD97058.1.
AC073869 Genomic DNA. No translation available.
AC131180 Genomic DNA. No translation available.
AC009477 Genomic DNA. Translation: AAX93135.1.
CH471250 Genomic DNA. Translation: EAW51261.1.
CH471250 Genomic DNA. Translation: EAW51263.1.
CH471250 Genomic DNA. Translation: EAW51266.1.
BC001428 mRNA. Translation: AAH01428.1.
BC013991 mRNA. Translation: AAH13991.1.
BC050695 mRNA. Translation: AAH50695.2.
CCDSiCCDS2166.1. [Q96CS7-3]
CCDS46413.1. [Q96CS7-1]
CCDS58729.1. [Q96CS7-5]
CCDS58730.1. [Q96CS7-6]
CCDS58731.1. [Q96CS7-4]
RefSeqiNP_001094093.1. NM_001100623.1. [Q96CS7-1]
NP_001253991.1. NM_001267062.1.
NP_001253992.1. NM_001267063.1.
NP_001253993.1. NM_001267064.1.
NP_001253994.1. NM_001267065.1. [Q96CS7-6]
NP_001253995.1. NM_001267066.1. [Q96CS7-5]
NP_001253996.1. NM_001267067.1.
NP_001253997.1. NM_001267068.1. [Q96CS7-4]
NP_001296377.1. NM_001309448.1.
NP_001296379.1. NM_001309450.1.
NP_001296380.1. NM_001309451.1.
NP_001296381.1. NM_001309452.1.
NP_060428.2. NM_017958.2. [Q96CS7-3]
XP_016859900.1. XM_017004411.1. [Q96CS7-6]
XP_016859901.1. XM_017004412.1. [Q96CS7-1]
UniGeneiHs.469944.
Hs.708368.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AJ4X-ray1.00A/B1-110[»]
3VIAX-ray1.75A/B1-110[»]
ProteinModelPortaliQ96CS7.
SMRiQ96CS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120370. 19 interactors.
IntActiQ96CS7. 14 interactors.
MINTiMINT-1180681.
STRINGi9606.ENSP00000385892.

PTM databases

iPTMnetiQ96CS7.
PhosphoSitePlusiQ96CS7.

Polymorphism and mutation databases

BioMutaiPLEKHB2.
DMDMi48474928.

Proteomic databases

MaxQBiQ96CS7.
PaxDbiQ96CS7.
PeptideAtlasiQ96CS7.
PRIDEiQ96CS7.

Protocols and materials databases

DNASUi55041.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234115; ENSP00000234115; ENSG00000115762. [Q96CS7-3]
ENST00000409158; ENSP00000386410; ENSG00000115762. [Q96CS7-6]
ENST00000409279; ENSP00000386666; ENSG00000115762. [Q96CS7-1]
ENST00000409612; ENSP00000386662; ENSG00000115762. [Q96CS7-1]
ENST00000438882; ENSP00000401193; ENSG00000115762. [Q96CS7-5]
ENST00000628582; ENSP00000487321; ENSG00000115762. [Q96CS7-4]
GeneIDi55041.
KEGGihsa:55041.
UCSCiuc002tsf.5. human. [Q96CS7-1]

Organism-specific databases

CTDi55041.
GeneCardsiPLEKHB2.
HGNCiHGNC:19236. PLEKHB2.
neXtProtiNX_Q96CS7.
OpenTargetsiENSG00000115762.
PharmGKBiPA134885873.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFNJ. Eukaryota.
ENOG4111G6I. LUCA.
GeneTreeiENSGT00390000013989.
HOGENOMiHOG000253945.
HOVERGENiHBG060487.
InParanoidiQ96CS7.
PhylomeDBiQ96CS7.
TreeFamiTF331787.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115762-MONOMER.

Miscellaneous databases

ChiTaRSiPLEKHB2. human.
GeneWikiiPLEKHB2.
GenomeRNAii55041.
PROiQ96CS7.

Gene expression databases

BgeeiENSG00000115762.
CleanExiHS_PLEKHB2.
ExpressionAtlasiQ96CS7. baseline and differential.
GenevisibleiQ96CS7. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKHB2_HUMAN
AccessioniPrimary (citable) accession number: Q96CS7
Secondary accession number(s): B4DF08
, B4DZ66, B8ZZN1, Q53FF1, Q53TH7, Q86W37, Q9BV75, Q9NWK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.