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Q96CS4 (ZN689_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 689
Gene names
Name:ZNF689
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 12 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Zinc finger protein 689
PRO_0000234008

Regions

Domain29 – 10072KRAB
Zinc finger149 – 17123C2H2-type 1; degenerate
Zinc finger177 – 19923C2H2-type 2
Zinc finger205 – 22723C2H2-type 3
Zinc finger233 – 25523C2H2-type 4
Zinc finger261 – 28323C2H2-type 5
Zinc finger289 – 31123C2H2-type 6
Zinc finger317 – 33923C2H2-type 7
Zinc finger345 – 36723C2H2-type 8
Zinc finger373 – 39523C2H2-type 9
Zinc finger401 – 42323C2H2-type 10
Zinc finger429 – 45123C2H2-type 11
Zinc finger457 – 47721C2H2-type 12; degenerate

Sequences

Sequence LengthMass (Da)Tools
Q96CS4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 921B675BBD40EBAE

FASTA50056,907
        10         20         30         40         50         60 
MAPPSAPLPA QGPGKARPSR KRGRRPRALK FVDVAVYFSP EEWGCLRPAQ RALYRDVMRE 

        70         80         90        100        110        120 
TYGHLGALGC AGPKPALISW LERNTDDWEP AALDPQEYPR GLTVQRKSRT RKKNGEKEVF 

       130        140        150        160        170        180 
PPKEAPRKGK RGRRPSKPRL IPRQTSGGPI CPDCGCTFPD HQALESHKCA QNLKKPYPCP 

       190        200        210        220        230        240 
DCGRRFSYPS LLVSHRRAHS GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR 

       250        260        270        280        290        300 
CFRRSRSLAN HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECNRRFRQ 

       310        320        330        340        350        360 
RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACEHC EARFSQRSTL 

       370        380        390        400        410        420 
LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL HACDDCGRRF AYPSLLASHR 

       430        440        450        460        470        480 
RVHSGERPYA CDLCSKRFAQ WSHLAQHQLL HTGEKPFPCL ECGRCFRQRW SLAVHKCSPK 

       490        500 
APNCSPRSAI GGSSQRGNAH 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Teratocarcinoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 284-500.
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074896 mRNA. Translation: BAC11275.1.
BC014000 mRNA. Translation: AAH14000.1.
AL834299 mRNA. Translation: CAH56363.1.
RefSeqNP_612456.1. NM_138447.2.
UniGeneHs.454685.

3D structure databases

ProteinModelPortalQ96CS4.
SMRQ96CS4. Positions 23-77, 151-479.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125436. 6 interactions.
IntActQ96CS4. 1 interaction.
STRING9606.ENSP00000287461.

PTM databases

PhosphoSiteQ96CS4.

Polymorphism databases

DMDM74760770.

Proteomic databases

PaxDbQ96CS4.
PeptideAtlasQ96CS4.
PRIDEQ96CS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000287461; ENSP00000287461; ENSG00000156853.
GeneID115509.
KEGGhsa:115509.
UCSCuc002dyx.4. human.

Organism-specific databases

CTD115509.
GeneCardsGC16M030613.
HGNCHGNC:25173. ZNF689.
HPAHPA054095.
HPA055385.
neXtProtNX_Q96CS4.
PharmGKBPA142670488.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ96CS4.
KOK09228.
OMAHKCSPRA.
OrthoDBEOG7KSX7Q.
PhylomeDBQ96CS4.
TreeFamTF336948.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeQ96CS4.
CleanExHS_ZNF689.
GenevestigatorQ96CS4.

Family and domain databases

Gene3D3.30.160.60. 11 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi115509.
NextBio79603.
PROQ96CS4.

Entry information

Entry nameZN689_HUMAN
AccessionPrimary (citable) accession number: Q96CS4
Secondary accession number(s): Q658J5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM