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Q96CS4

- ZN689_HUMAN

UniProt

Q96CS4 - ZN689_HUMAN

Protein

Zinc finger protein 689

Gene

ZNF689

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri149 – 17123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri177 – 19923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri205 – 22723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri233 – 25523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri261 – 28323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri373 – 39523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri429 – 45123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri457 – 47721C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. skeletal muscle cell differentiation Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 689
    Gene namesi
    Name:ZNF689
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25173. ZNF689.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670488.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Zinc finger protein 689PRO_0000234008Add
    BLAST

    Proteomic databases

    MaxQBiQ96CS4.
    PaxDbiQ96CS4.
    PeptideAtlasiQ96CS4.
    PRIDEiQ96CS4.

    PTM databases

    PhosphoSiteiQ96CS4.

    Expressioni

    Gene expression databases

    BgeeiQ96CS4.
    CleanExiHS_ZNF689.
    GenevestigatoriQ96CS4.

    Organism-specific databases

    HPAiHPA054095.
    HPA055385.

    Interactioni

    Protein-protein interaction databases

    BioGridi125436. 6 interactions.
    IntActiQ96CS4. 1 interaction.
    STRINGi9606.ENSP00000287461.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96CS4.
    SMRiQ96CS4. Positions 146-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 10072KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri149 – 17123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri177 – 19923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri205 – 22723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri233 – 25523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri261 – 28323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri373 – 39523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri429 – 45123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri457 – 47721C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ96CS4.
    KOiK09228.
    OMAiHKCSPRA.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ96CS4.
    TreeFamiTF336948.

    Family and domain databases

    Gene3Di3.30.160.60. 11 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96CS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPSAPLPA QGPGKARPSR KRGRRPRALK FVDVAVYFSP EEWGCLRPAQ    50
    RALYRDVMRE TYGHLGALGC AGPKPALISW LERNTDDWEP AALDPQEYPR 100
    GLTVQRKSRT RKKNGEKEVF PPKEAPRKGK RGRRPSKPRL IPRQTSGGPI 150
    CPDCGCTFPD HQALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS 200
    GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN 250
    HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECNRRFRQ 300
    RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACEHC 350
    EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL 400
    HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLAQHQLL 450
    HTGEKPFPCL ECGRCFRQRW SLAVHKCSPK APNCSPRSAI GGSSQRGNAH 500
    Length:500
    Mass (Da):56,907
    Last modified:December 1, 2001 - v1
    Checksum:i921B675BBD40EBAE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074896 mRNA. Translation: BAC11275.1.
    BC014000 mRNA. Translation: AAH14000.1.
    AL834299 mRNA. Translation: CAH56363.1.
    CCDSiCCDS10686.1.
    RefSeqiNP_612456.1. NM_138447.2.
    UniGeneiHs.454685.

    Genome annotation databases

    EnsembliENST00000287461; ENSP00000287461; ENSG00000156853.
    GeneIDi115509.
    KEGGihsa:115509.
    UCSCiuc002dyx.4. human.

    Polymorphism databases

    DMDMi74760770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK074896 mRNA. Translation: BAC11275.1 .
    BC014000 mRNA. Translation: AAH14000.1 .
    AL834299 mRNA. Translation: CAH56363.1 .
    CCDSi CCDS10686.1.
    RefSeqi NP_612456.1. NM_138447.2.
    UniGenei Hs.454685.

    3D structure databases

    ProteinModelPortali Q96CS4.
    SMRi Q96CS4. Positions 146-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125436. 6 interactions.
    IntActi Q96CS4. 1 interaction.
    STRINGi 9606.ENSP00000287461.

    PTM databases

    PhosphoSitei Q96CS4.

    Polymorphism databases

    DMDMi 74760770.

    Proteomic databases

    MaxQBi Q96CS4.
    PaxDbi Q96CS4.
    PeptideAtlasi Q96CS4.
    PRIDEi Q96CS4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000287461 ; ENSP00000287461 ; ENSG00000156853 .
    GeneIDi 115509.
    KEGGi hsa:115509.
    UCSCi uc002dyx.4. human.

    Organism-specific databases

    CTDi 115509.
    GeneCardsi GC16M030613.
    HGNCi HGNC:25173. ZNF689.
    HPAi HPA054095.
    HPA055385.
    neXtProti NX_Q96CS4.
    PharmGKBi PA142670488.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q96CS4.
    KOi K09228.
    OMAi HKCSPRA.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q96CS4.
    TreeFami TF336948.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 115509.
    NextBioi 79603.
    PROi Q96CS4.

    Gene expression databases

    Bgeei Q96CS4.
    CleanExi HS_ZNF689.
    Genevestigatori Q96CS4.

    Family and domain databases

    Gene3Di 3.30.160.60. 11 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 284-500.
      Tissue: Melanoma.

    Entry informationi

    Entry nameiZN689_HUMAN
    AccessioniPrimary (citable) accession number: Q96CS4
    Secondary accession number(s): Q658J5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3