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Protein

Zinc finger protein 689

Gene

ZNF689

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri149 – 17123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri177 – 19923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47721C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 689
Gene namesi
Name:ZNF689
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25173. ZNF689.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670488.

Polymorphism and mutation databases

DMDMi74760770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Zinc finger protein 689PRO_0000234008Add
BLAST

Proteomic databases

MaxQBiQ96CS4.
PaxDbiQ96CS4.
PeptideAtlasiQ96CS4.
PRIDEiQ96CS4.

PTM databases

PhosphoSiteiQ96CS4.

Expressioni

Gene expression databases

BgeeiQ96CS4.
CleanExiHS_ZNF689.
ExpressionAtlasiQ96CS4. baseline and differential.
GenevisibleiQ96CS4. HS.

Organism-specific databases

HPAiHPA054095.
HPA055385.

Interactioni

Protein-protein interaction databases

BioGridi125436. 12 interactions.
IntActiQ96CS4. 1 interaction.
STRINGi9606.ENSP00000287461.

Structurei

3D structure databases

ProteinModelPortaliQ96CS4.
SMRiQ96CS4. Positions 146-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10072KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri149 – 17123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri177 – 19923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47721C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96CS4.
KOiK09228.
OMAiQSHKCAQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96CS4.
TreeFamiTF336948.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPSAPLPA QGPGKARPSR KRGRRPRALK FVDVAVYFSP EEWGCLRPAQ
60 70 80 90 100
RALYRDVMRE TYGHLGALGC AGPKPALISW LERNTDDWEP AALDPQEYPR
110 120 130 140 150
GLTVQRKSRT RKKNGEKEVF PPKEAPRKGK RGRRPSKPRL IPRQTSGGPI
160 170 180 190 200
CPDCGCTFPD HQALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS
210 220 230 240 250
GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN
260 270 280 290 300
HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECNRRFRQ
310 320 330 340 350
RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACEHC
360 370 380 390 400
EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL
410 420 430 440 450
HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLAQHQLL
460 470 480 490 500
HTGEKPFPCL ECGRCFRQRW SLAVHKCSPK APNCSPRSAI GGSSQRGNAH
Length:500
Mass (Da):56,907
Last modified:December 1, 2001 - v1
Checksum:i921B675BBD40EBAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074896 mRNA. Translation: BAC11275.1.
BC014000 mRNA. Translation: AAH14000.1.
AL834299 mRNA. Translation: CAH56363.1.
CCDSiCCDS10686.1.
RefSeqiNP_612456.1. NM_138447.2.
UniGeneiHs.454685.

Genome annotation databases

EnsembliENST00000287461; ENSP00000287461; ENSG00000156853.
GeneIDi115509.
KEGGihsa:115509.
UCSCiuc002dyx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074896 mRNA. Translation: BAC11275.1.
BC014000 mRNA. Translation: AAH14000.1.
AL834299 mRNA. Translation: CAH56363.1.
CCDSiCCDS10686.1.
RefSeqiNP_612456.1. NM_138447.2.
UniGeneiHs.454685.

3D structure databases

ProteinModelPortaliQ96CS4.
SMRiQ96CS4. Positions 146-476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125436. 12 interactions.
IntActiQ96CS4. 1 interaction.
STRINGi9606.ENSP00000287461.

PTM databases

PhosphoSiteiQ96CS4.

Polymorphism and mutation databases

DMDMi74760770.

Proteomic databases

MaxQBiQ96CS4.
PaxDbiQ96CS4.
PeptideAtlasiQ96CS4.
PRIDEiQ96CS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287461; ENSP00000287461; ENSG00000156853.
GeneIDi115509.
KEGGihsa:115509.
UCSCiuc002dyx.4. human.

Organism-specific databases

CTDi115509.
GeneCardsiGC16M030613.
HGNCiHGNC:25173. ZNF689.
HPAiHPA054095.
HPA055385.
neXtProtiNX_Q96CS4.
PharmGKBiPA142670488.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96CS4.
KOiK09228.
OMAiQSHKCAQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96CS4.
TreeFamiTF336948.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii115509.
NextBioi79603.
PROiQ96CS4.

Gene expression databases

BgeeiQ96CS4.
CleanExiHS_ZNF689.
ExpressionAtlasiQ96CS4. baseline and differential.
GenevisibleiQ96CS4. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 284-500.
    Tissue: Melanoma.

Entry informationi

Entry nameiZN689_HUMAN
AccessioniPrimary (citable) accession number: Q96CS4
Secondary accession number(s): Q658J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.