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Q96CS4

- ZN689_HUMAN

UniProt

Q96CS4 - ZN689_HUMAN

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Protein

Zinc finger protein 689

Gene
ZNF689
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri149 – 17123C2H2-type 1; degenerateAdd
BLAST
Zinc fingeri177 – 19923C2H2-type 2Add
BLAST
Zinc fingeri205 – 22723C2H2-type 3Add
BLAST
Zinc fingeri233 – 25523C2H2-type 4Add
BLAST
Zinc fingeri261 – 28323C2H2-type 5Add
BLAST
Zinc fingeri289 – 31123C2H2-type 6Add
BLAST
Zinc fingeri317 – 33923C2H2-type 7Add
BLAST
Zinc fingeri345 – 36723C2H2-type 8Add
BLAST
Zinc fingeri373 – 39523C2H2-type 9Add
BLAST
Zinc fingeri401 – 42323C2H2-type 10Add
BLAST
Zinc fingeri429 – 45123C2H2-type 11Add
BLAST
Zinc fingeri457 – 47721C2H2-type 12; degenerateAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. skeletal muscle cell differentiation Source: Ensembl
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 689
Gene namesi
Name:ZNF689
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:25173. ZNF689.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Zinc finger protein 689PRO_0000234008Add
BLAST

Proteomic databases

MaxQBiQ96CS4.
PaxDbiQ96CS4.
PeptideAtlasiQ96CS4.
PRIDEiQ96CS4.

PTM databases

PhosphoSiteiQ96CS4.

Expressioni

Gene expression databases

BgeeiQ96CS4.
CleanExiHS_ZNF689.
GenevestigatoriQ96CS4.

Organism-specific databases

HPAiHPA054095.
HPA055385.

Interactioni

Protein-protein interaction databases

BioGridi125436. 6 interactions.
IntActiQ96CS4. 1 interaction.
STRINGi9606.ENSP00000287461.

Structurei

3D structure databases

ProteinModelPortaliQ96CS4.
SMRiQ96CS4. Positions 146-476.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10072KRABAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96CS4.
KOiK09228.
OMAiHKCSPRA.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96CS4.
TreeFamiTF336948.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CS4-1 [UniParc]FASTAAdd to Basket

« Hide

MAPPSAPLPA QGPGKARPSR KRGRRPRALK FVDVAVYFSP EEWGCLRPAQ    50
RALYRDVMRE TYGHLGALGC AGPKPALISW LERNTDDWEP AALDPQEYPR 100
GLTVQRKSRT RKKNGEKEVF PPKEAPRKGK RGRRPSKPRL IPRQTSGGPI 150
CPDCGCTFPD HQALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS 200
GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN 250
HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECNRRFRQ 300
RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACEHC 350
EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL 400
HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLAQHQLL 450
HTGEKPFPCL ECGRCFRQRW SLAVHKCSPK APNCSPRSAI GGSSQRGNAH 500
Length:500
Mass (Da):56,907
Last modified:December 1, 2001 - v1
Checksum:i921B675BBD40EBAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074896 mRNA. Translation: BAC11275.1.
BC014000 mRNA. Translation: AAH14000.1.
AL834299 mRNA. Translation: CAH56363.1.
CCDSiCCDS10686.1.
RefSeqiNP_612456.1. NM_138447.2.
UniGeneiHs.454685.

Genome annotation databases

EnsembliENST00000287461; ENSP00000287461; ENSG00000156853.
GeneIDi115509.
KEGGihsa:115509.
UCSCiuc002dyx.4. human.

Polymorphism databases

DMDMi74760770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074896 mRNA. Translation: BAC11275.1 .
BC014000 mRNA. Translation: AAH14000.1 .
AL834299 mRNA. Translation: CAH56363.1 .
CCDSi CCDS10686.1.
RefSeqi NP_612456.1. NM_138447.2.
UniGenei Hs.454685.

3D structure databases

ProteinModelPortali Q96CS4.
SMRi Q96CS4. Positions 146-476.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125436. 6 interactions.
IntActi Q96CS4. 1 interaction.
STRINGi 9606.ENSP00000287461.

PTM databases

PhosphoSitei Q96CS4.

Polymorphism databases

DMDMi 74760770.

Proteomic databases

MaxQBi Q96CS4.
PaxDbi Q96CS4.
PeptideAtlasi Q96CS4.
PRIDEi Q96CS4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000287461 ; ENSP00000287461 ; ENSG00000156853 .
GeneIDi 115509.
KEGGi hsa:115509.
UCSCi uc002dyx.4. human.

Organism-specific databases

CTDi 115509.
GeneCardsi GC16M030613.
HGNCi HGNC:25173. ZNF689.
HPAi HPA054095.
HPA055385.
neXtProti NX_Q96CS4.
PharmGKBi PA142670488.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q96CS4.
KOi K09228.
OMAi HKCSPRA.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q96CS4.
TreeFami TF336948.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 115509.
NextBioi 79603.
PROi Q96CS4.

Gene expression databases

Bgeei Q96CS4.
CleanExi HS_ZNF689.
Genevestigatori Q96CS4.

Family and domain databases

Gene3Di 3.30.160.60. 11 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 284-500.
    Tissue: Melanoma.

Entry informationi

Entry nameiZN689_HUMAN
AccessioniPrimary (citable) accession number: Q96CS4
Secondary accession number(s): Q658J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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