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Protein

Zinc finger protein 689

Gene

ZNF689

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 477C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 689
Gene namesi
Name:ZNF689
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000156853.11.
HGNCiHGNC:25173. ZNF689.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi115509.
OpenTargetsiENSG00000156853.
PharmGKBiPA142670488.

Polymorphism and mutation databases

DMDMi74760770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340081 – 500Zinc finger protein 689Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki455Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96CS4.
MaxQBiQ96CS4.
PaxDbiQ96CS4.
PeptideAtlasiQ96CS4.
PRIDEiQ96CS4.

PTM databases

iPTMnetiQ96CS4.
PhosphoSitePlusiQ96CS4.

Expressioni

Gene expression databases

BgeeiENSG00000156853.
CleanExiHS_ZNF689.
GenevisibleiQ96CS4. HS.

Organism-specific databases

HPAiHPA054095.
HPA055385.

Interactioni

Protein-protein interaction databases

BioGridi125436. 27 interactors.
IntActiQ96CS4. 3 interactors.
STRINGi9606.ENSP00000287461.

Structurei

3D structure databases

ProteinModelPortaliQ96CS4.
SMRiQ96CS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 100KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri149 – 171C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri177 – 199C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri205 – 227C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 477C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST21

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96CS4.
KOiK09228.
OMAiQSHKCAQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96CS4.
TreeFamiTF336948.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q96CS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPSAPLPA QGPGKARPSR KRGRRPRALK FVDVAVYFSP EEWGCLRPAQ
60 70 80 90 100
RALYRDVMRE TYGHLGALGC AGPKPALISW LERNTDDWEP AALDPQEYPR
110 120 130 140 150
GLTVQRKSRT RKKNGEKEVF PPKEAPRKGK RGRRPSKPRL IPRQTSGGPI
160 170 180 190 200
CPDCGCTFPD HQALESHKCA QNLKKPYPCP DCGRRFSYPS LLVSHRRAHS
210 220 230 240 250
GECPYVCDQC GKRFSQRKNL SQHQVIHTGE KPYHCPDCGR CFRRSRSLAN
260 270 280 290 300
HRTTHTGEKP HQCPSCGRRF AYPSLLAIHQ RTHTGEKPYT CLECNRRFRQ
310 320 330 340 350
RTALVIHQRI HTGEKPYPCP DCERRFSSSS RLVSHRRVHS GERPYACEHC
360 370 380 390 400
EARFSQRSTL LQHQLLHTGE KPYPCPDCGR AFRRSGSLAI HRSTHTEEKL
410 420 430 440 450
HACDDCGRRF AYPSLLASHR RVHSGERPYA CDLCSKRFAQ WSHLAQHQLL
460 470 480 490 500
HTGEKPFPCL ECGRCFRQRW SLAVHKCSPK APNCSPRSAI GGSSQRGNAH
Length:500
Mass (Da):56,907
Last modified:December 1, 2001 - v1
Checksum:i921B675BBD40EBAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074896 mRNA. Translation: BAC11275.1.
BC014000 mRNA. Translation: AAH14000.1.
AL834299 mRNA. Translation: CAH56363.1.
CCDSiCCDS10686.1.
RefSeqiNP_612456.1. NM_138447.2.
UniGeneiHs.454685.

Genome annotation databases

EnsembliENST00000287461; ENSP00000287461; ENSG00000156853.
GeneIDi115509.
KEGGihsa:115509.
UCSCiuc002dyx.5. human.

Similar proteinsi

Entry informationi

Entry nameiZN689_HUMAN
AccessioniPrimary (citable) accession number: Q96CS4
Secondary accession number(s): Q658J5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families