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Protein

HAUS augmin-like complex subunit 1

Gene

HAUS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.3 Publications

Miscellaneous

HAUS1-depleted cells retain functional cell cycle checkpoints, but the depletion decreases the G2/M cell cycle compartment and induces apoptosis. The protein level remains constant through the cell cycle.

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome cycle Source: UniProtKB
  • ciliary basal body-plasma membrane docking Source: Reactome
  • G2/M transition of mitotic cell cycle Source: Reactome
  • regulation of G2/M transition of mitotic cell cycle Source: Reactome
  • spindle assembly Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380284. Loss of proteins required for interphase microtubule organization from the centrosome.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 1
Alternative name(s):
Coiled-coil domain-containing protein 5
Enhancer of invasion-cluster
Short name:
HEI-C
Gene namesi
Name:HAUS1
Synonyms:CCDC5, HEIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000152240.12.
HGNCiHGNC:25174. HAUS1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152240.
PharmGKBiPA165429013.

Polymorphism and mutation databases

BioMutaiHAUS1.
DMDMi50400607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000893951 – 278HAUS augmin-like complex subunit 1Add BLAST278

Proteomic databases

EPDiQ96CS2.
MaxQBiQ96CS2.
PaxDbiQ96CS2.
PeptideAtlasiQ96CS2.
PRIDEiQ96CS2.

PTM databases

iPTMnetiQ96CS2.
PhosphoSitePlusiQ96CS2.

Expressioni

Tissue specificityi

Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed in lung, brain and placenta.1 Publication

Gene expression databases

BgeeiENSG00000152240.
CleanExiHS_CCDC5.
ExpressionAtlasiQ96CS2. baseline and differential.
GenevisibleiQ96CS2. HS.

Organism-specific databases

HPAiHPA040601.
HPA040652.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AK8Q96MA63EBI-2514791,EBI-8466265
ARFIP2P533653EBI-2514791,EBI-638194
BLOC1S6Q9UL453EBI-2514791,EBI-465781
C3orf62Q6ZUJ43EBI-2514791,EBI-2837036
CAGE1Q8TC203EBI-2514791,EBI-10196469
CCDC114Q96M633EBI-2514791,EBI-10173858
CCDC136Q96JN2-23EBI-2514791,EBI-10171416
CCDC57Q2TAC23EBI-2514791,EBI-2808286
CCHCR1Q8TD31-35EBI-2514791,EBI-10175300
CDR2Q018503EBI-2514791,EBI-1181367
CEP170P1Q96L143EBI-2514791,EBI-743488
CEP44Q9C0F14EBI-2514791,EBI-744115
CEP55Q53EZ43EBI-2514791,EBI-747776
CEP57L1Q8IYX8-23EBI-2514791,EBI-10181988
CEP63Q96MT84EBI-2514791,EBI-741977
CEP70Q8NHQ13EBI-11742270,EBI-739624
CRSP9Q6IAZ53EBI-2514791,EBI-10283772
DCTN2Q135613EBI-2514791,EBI-715074
DMDP115323EBI-2514791,EBI-295827
DTNBP1Q96EV83EBI-2514791,EBI-465804
FGFR1OP2Q9NVK53EBI-2514791,EBI-1104764
GOLGA2Q083793EBI-2514791,EBI-618309
HAUS4Q9H6D711EBI-2514791,EBI-2558168
HAUS6Q7Z4H711EBI-2514791,EBI-2558196
IFIT3O148793EBI-2514791,EBI-745127
IFT20Q8IY315EBI-2514791,EBI-744203
INCA1Q0VD863EBI-2514791,EBI-6509505
KDM1AO603412EBI-2514791,EBI-710124
KIFC3Q9BVG83EBI-2514791,EBI-2125614
KRT15P190123EBI-2514791,EBI-739566
KRT18P057833EBI-2514791,EBI-297888
KRT19P087273EBI-2514791,EBI-742756
KRT31Q153233EBI-2514791,EBI-948001
KRT38O760153EBI-2514791,EBI-1047263
KRT40Q6A1623EBI-2514791,EBI-10171697
KXD1Q9BQD33EBI-2514791,EBI-739657
LDOC1O957513EBI-2514791,EBI-740738
LURAP1Q96LR23EBI-2514791,EBI-741355
MAD1L1Q9Y6D93EBI-2514791,EBI-742610
MAGEA6P433603EBI-2514791,EBI-1045155
MED4Q9NPJ63EBI-2514791,EBI-394607
MIPOL1Q8TD103EBI-2514791,EBI-2548751
MTUS2Q5JR593EBI-2514791,EBI-742948
NDC80O147773EBI-2514791,EBI-715849
NECAB2Q7Z6G3-23EBI-2514791,EBI-10172876
NINLQ9Y2I63EBI-2514791,EBI-719716
NUP54Q7Z3B43EBI-2514791,EBI-741048
NUP62P371983EBI-2514791,EBI-347978
PDE4DIPQ5VU433EBI-2514791,EBI-1105124
SPAG5Q96R063EBI-2514791,EBI-413317
SPERTQ8NA613EBI-2514791,EBI-741724
STX11O755583EBI-2514791,EBI-714135
SYCE1Q8N0S23EBI-2514791,EBI-6872807
SYCE3A1L1903EBI-2514791,EBI-10283466
TFIP11Q9UBB93EBI-2514791,EBI-1105213
TFPTP0C1Z6-23EBI-2514791,EBI-10178002
TRAF1Q130773EBI-2514791,EBI-359224
TRIM23P364063EBI-2514791,EBI-740098
TRIM27P143733EBI-2514791,EBI-719493
TRIM54Q9BYV23EBI-2514791,EBI-2130429
TRIM69Q86WT63EBI-2514791,EBI-749955
TSG101Q998165EBI-2514791,EBI-346882
USHBP1Q8N6Y03EBI-2514791,EBI-739895
VPS52Q8N1B43EBI-2514791,EBI-2799833
WASHC3Q9Y3C010EBI-2514791,EBI-712969

Protein-protein interaction databases

BioGridi125412. 140 interactors.
CORUMiQ96CS2.
DIPiDIP-48835N.
IntActiQ96CS2. 109 interactors.
MINTiMINT-1202070.
STRINGi9606.ENSP00000282058.

Structurei

3D structure databases

ProteinModelPortaliQ96CS2.
SMRiQ96CS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 79Sequence analysisAdd BLAST31
Coiled coili124 – 177Sequence analysisAdd BLAST54
Coiled coili249 – 277Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the HAUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEUK. Eukaryota.
ENOG4111SPA. LUCA.
GeneTreeiENSGT00390000006029.
HOGENOMiHOG000220811.
InParanoidiQ96CS2.
KOiK16584.
OMAiPQYEVNA.
OrthoDBiEOG091G0I5X.
PhylomeDBiQ96CS2.
TreeFamiTF331717.

Family and domain databases

InterProiView protein in InterPro
IPR026243. HAUS1.
PRINTSiPR02087. HAUSAUGMINL1.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPQEERETQ VAAWLKKIFG DHPIPQYEVN PRTTEILHHL SERNRVRDRD
60 70 80 90 100
VYLVIEDLKQ KASEYESEAK YLQDLLMESV NFSPANLSST GSRYLNALVD
110 120 130 140 150
SAVALETKDT SLASFIPAVN DLTSDLFRTK SKSEEIKIEL EKLEKNLTAT
160 170 180 190 200
LVLEKCLQED VKKAELHLST ERAKVDNRRQ NMDFLKAKSE EFRFGIKAAE
210 220 230 240 250
EQLSARGMDA SLSHQSLVAL SEKLARLKQQ TIPLKKKLES YLDLMPNPSL
260 270
AQVKIEEAKR ELDSIEAELT RRVDMMEL
Length:278
Mass (Da):31,863
Last modified:December 1, 2001 - v1
Checksum:i06F6A1B9FCF0698A
GO
Isoform 2 (identifier: Q96CS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):22,744
Checksum:i9DD7AC01253BEFB7
GO

Sequence cautioni

The sequence BAC05036 differs from that shown. Reason: Frameshift at position 15.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107811 – 76Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360137 mRNA. Translation: AAQ63649.1.
AK097403 mRNA. Translation: BAC05036.1. Frameshift.
AK315605 mRNA. Translation: BAG37974.1.
BC005958 mRNA. Translation: AAH05958.1.
BC014003 mRNA. Translation: AAH14003.1.
CCDSiCCDS11928.1. [Q96CS2-1]
RefSeqiNP_612452.1. NM_138443.3. [Q96CS2-1]
UniGeneiHs.436617.

Genome annotation databases

EnsembliENST00000282058; ENSP00000282058; ENSG00000152240. [Q96CS2-1]
GeneIDi115106.
KEGGihsa:115106.
UCSCiuc002lbu.3. human. [Q96CS2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHAUS1_HUMAN
AccessioniPrimary (citable) accession number: Q96CS2
Secondary accession number(s): B2RDM7, Q8N837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families