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Protein

GRAM domain-containing protein 1A

Gene

GRAMD1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GRAM domain-containing protein 1A
Gene namesi
Name:GRAMD1A
Synonyms:KIAA1533
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29305. GRAMD1A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei610 – 63021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869487.

Polymorphism and mutation databases

BioMutaiGRAMD1A.
DMDMi121944494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724GRAM domain-containing protein 1APRO_0000287446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei263 – 2631PhosphoserineCombined sources
Modified residuei267 – 2671PhosphoserineCombined sources
Modified residuei271 – 2711PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96CP6.
MaxQBiQ96CP6.
PaxDbiQ96CP6.
PRIDEiQ96CP6.

PTM databases

iPTMnetiQ96CP6.
PhosphoSiteiQ96CP6.

Expressioni

Gene expression databases

BgeeiQ96CP6.
CleanExiHS_GRAMD1A.
ExpressionAtlasiQ96CP6. baseline and differential.
GenevisibleiQ96CP6. HS.

Organism-specific databases

HPAiHPA008852.
HPA012570.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FLJ13057Q53SE73EBI-1384139,EBI-10172181

Protein-protein interaction databases

BioGridi121690. 27 interactions.
IntActiQ96CP6. 6 interactions.
STRINGi9606.ENSP00000441032.

Structurei

3D structure databases

ProteinModelPortaliQ96CP6.
SMRiQ96CP6. Positions 93-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 15868GRAMAdd
BLAST
Domaini367 – 538172VAStPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GRAM domain.Curated
Contains 1 VASt domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1032. Eukaryota.
ENOG410XRQQ. LUCA.
GeneTreeiENSGT00580000081380.
HOVERGENiHBG062004.
InParanoidiQ96CP6.
PhylomeDBiQ96CP6.
TreeFamiTF327695.

Family and domain databases

InterProiIPR031968. DUF4782.
IPR004182. GRAM.
[Graphical view]
PfamiPF16016. DUF4782. 1 hit.
PF02893. GRAM. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
PROSITEiPS51778. VAST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFDTTPHSGR STPSSSPSLR KRLQLLPPSR PPPEPEPGTM VEKGSDSSSE
60 70 80 90 100
KGGVPGTPST QSLGSRNFIR NSKKMQSWYS MLSPTYKQRN EDFRKLFSKL
110 120 130 140 150
PEAERLIVDY SCALQREILL QGRLYLSENW ICFYSNIFRW ETTISIQLKE
160 170 180 190 200
VTCLKKEKTA KLIPNAIQIC TESEKHFFTS FGARDRCFLL IFRLWQNALL
210 220 230 240 250
EKTLSPRELW HLVHQCYGSE LGLTSEDEDY VSPLQLNGLG TPKEVGDVIA
260 270 280 290 300
LSDITSSGAA DRSQEPSPVG SRRGHVTPNL SRASSDADHG AEEDKEEQVD
310 320 330 340 350
SQPDASSSQT VTPVAEPPST EPTQPDGPTT LGPLDLLPSE ELLTDTSNSS
360 370 380 390 400
SSTGEEADLA ALLPDLSGRL LINSVFHVGA ERLQQMLFSD SPFLQGFLQQ
410 420 430 440 450
CKFTDVTLSP WSGDSKCHQR RVLTYTIPIS NPLGPKSASV VETQTLFRRG
460 470 480 490 500
PQAGGCVVDS EVLTQGIPYQ DYFYTAHRYC ILGLARNKAR LRVSSEIRYR
510 520 530 540 550
KQPWSLVKSL IEKNSWSGIE DYFHHLEREL AKAEKLSLEE GGKDARGLLS
560 570 580 590 600
GLRRRKRPLS WRAHGDGPQH PDPDPCARAG IHTSGSLSSR FSEPSVDQGP
610 620 630 640 650
GAGIPSALVL ISIVICVSLI ILIALNVLLF YRLWSLERTA HTFESWHSLA
660 670 680 690 700
LAKGKFPQTA TEWAEILALQ KQFHSVEVHK WRQILRASVE LLDEMKFSLE
710 720
KLHQGITVSD PPFDTQPRPD DSFS
Length:724
Mass (Da):80,680
Last modified:May 16, 2006 - v2
Checksum:i39D988FAD1327D14
GO
Isoform 2 (identifier: Q96CP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-80: Missing.
     615-618: Missing.

Note: No experimental confirmation available.
Show »
Length:713
Mass (Da):79,367
Checksum:i989A7DE6BFE30B6F
GO
Isoform 3 (identifier: Q96CP6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-618: Missing.

Note: No experimental confirmation available.
Show »
Length:720
Mass (Da):80,278
Checksum:iEDC6C302C76CCA4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti439 – 4391S → P in BAC11289 (PubMed:16303743).Curated
Sequence conflicti477 – 4771H → R in BAC11289 (PubMed:16303743).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei74 – 807Missing in isoform 2. 1 PublicationVSP_025465
Alternative sequencei615 – 6184Missing in isoform 2 and isoform 3. 2 PublicationsVSP_025466

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074914 mRNA. Translation: BAC11289.1.
AC020907 Genomic DNA. No translation available.
BC014077 mRNA. Translation: AAH14077.2.
AB040966 mRNA. Translation: BAA96057.1.
CCDSiCCDS42546.1. [Q96CP6-1]
CCDS46046.1. [Q96CP6-2]
RefSeqiNP_001129671.1. NM_001136199.2. [Q96CP6-2]
NP_001306963.1. NM_001320034.1. [Q96CP6-3]
NP_001306964.1. NM_001320035.1.
NP_001306965.1. NM_001320036.1.
NP_065946.2. NM_020895.4. [Q96CP6-1]
UniGeneiHs.515351.

Genome annotation databases

EnsembliENST00000317991; ENSP00000441032; ENSG00000089351. [Q96CP6-1]
ENST00000411896; ENSP00000439267; ENSG00000089351. [Q96CP6-2]
GeneIDi57655.
KEGGihsa:57655.
UCSCiuc002nxk.3. human. [Q96CP6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074914 mRNA. Translation: BAC11289.1.
AC020907 Genomic DNA. No translation available.
BC014077 mRNA. Translation: AAH14077.2.
AB040966 mRNA. Translation: BAA96057.1.
CCDSiCCDS42546.1. [Q96CP6-1]
CCDS46046.1. [Q96CP6-2]
RefSeqiNP_001129671.1. NM_001136199.2. [Q96CP6-2]
NP_001306963.1. NM_001320034.1. [Q96CP6-3]
NP_001306964.1. NM_001320035.1.
NP_001306965.1. NM_001320036.1.
NP_065946.2. NM_020895.4. [Q96CP6-1]
UniGeneiHs.515351.

3D structure databases

ProteinModelPortaliQ96CP6.
SMRiQ96CP6. Positions 93-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121690. 27 interactions.
IntActiQ96CP6. 6 interactions.
STRINGi9606.ENSP00000441032.

PTM databases

iPTMnetiQ96CP6.
PhosphoSiteiQ96CP6.

Polymorphism and mutation databases

BioMutaiGRAMD1A.
DMDMi121944494.

Proteomic databases

EPDiQ96CP6.
MaxQBiQ96CP6.
PaxDbiQ96CP6.
PRIDEiQ96CP6.

Protocols and materials databases

DNASUi57655.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317991; ENSP00000441032; ENSG00000089351. [Q96CP6-1]
ENST00000411896; ENSP00000439267; ENSG00000089351. [Q96CP6-2]
GeneIDi57655.
KEGGihsa:57655.
UCSCiuc002nxk.3. human. [Q96CP6-1]

Organism-specific databases

CTDi57655.
GeneCardsiGRAMD1A.
HGNCiHGNC:29305. GRAMD1A.
HPAiHPA008852.
HPA012570.
neXtProtiNX_Q96CP6.
PharmGKBiPA134869487.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1032. Eukaryota.
ENOG410XRQQ. LUCA.
GeneTreeiENSGT00580000081380.
HOVERGENiHBG062004.
InParanoidiQ96CP6.
PhylomeDBiQ96CP6.
TreeFamiTF327695.

Miscellaneous databases

ChiTaRSiGRAMD1A. human.
GenomeRNAii57655.
NextBioi64409.
PROiQ96CP6.

Gene expression databases

BgeeiQ96CP6.
CleanExiHS_GRAMD1A.
ExpressionAtlasiQ96CP6. baseline and differential.
GenevisibleiQ96CP6. HS.

Family and domain databases

InterProiIPR031968. DUF4782.
IPR004182. GRAM.
[Graphical view]
PfamiPF16016. DUF4782. 1 hit.
PF02893. GRAM. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
PROSITEiPS51778. VAST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-724 (ISOFORM 3).
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 AND SER-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGRM1A_HUMAN
AccessioniPrimary (citable) accession number: Q96CP6
Secondary accession number(s): A6NKY7, Q8NC77, Q9P1Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 16, 2006
Last modified: May 11, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.