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Protein

GRIP and coiled-coil domain-containing protein 1

Gene

GCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in maintaining Golgi structure.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179562-MONOMER.
ReactomeiR-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein 1
Alternative name(s):
Golgi coiled-coil protein 1
Gene namesi
Name:GCC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:19095. GCC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79571.
OpenTargetsiENSG00000179562.
PharmGKBiPA38796.

Polymorphism and mutation databases

BioMutaiGCC1.
DMDMi32699595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900721 – 775GRIP and coiled-coil domain-containing protein 1Add BLAST775

Proteomic databases

EPDiQ96CN9.
MaxQBiQ96CN9.
PaxDbiQ96CN9.
PeptideAtlasiQ96CN9.
PRIDEiQ96CN9.

PTM databases

iPTMnetiQ96CN9.
PhosphoSitePlusiQ96CN9.

Expressioni

Gene expression databases

BgeeiENSG00000179562.
CleanExiHS_GCC1.
ExpressionAtlasiQ96CN9. baseline and differential.
GenevisibleiQ96CN9. HS.

Organism-specific databases

HPAiHPA019369.
HPA021323.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-746252,EBI-743598
ATF4P188485EBI-746252,EBI-492498
BIRC2Q134905EBI-746252,EBI-514538
C1orf94Q6P1W53EBI-746252,EBI-946029
CEP57Q86XR84EBI-746252,EBI-308614
CEP70Q8NHQ15EBI-746252,EBI-739624
DNAJA3Q96EY1-23EBI-746252,EBI-3952284
GLI1P081513EBI-746252,EBI-308084
GOLGA2Q083793EBI-746252,EBI-618309
KIAA0753Q2KHM93EBI-746252,EBI-2805604
LZTS2Q9BRK43EBI-746252,EBI-741037
NAB2Q157423EBI-746252,EBI-8641936
NAV1Q8NEY1-43EBI-746252,EBI-10270828
NECAB2H3BTW23EBI-746252,EBI-10172876
OIP5O434823EBI-746252,EBI-536879
PAK7Q8TB933EBI-746252,EBI-741896
TFIP11Q9UBB93EBI-746252,EBI-1105213
TRIM29Q141342EBI-746252,EBI-702370
ZNF276Q8N554-23EBI-746252,EBI-10265849

Protein-protein interaction databases

BioGridi122718. 56 interactors.
IntActiQ96CN9. 81 interactors.
MINTiMINT-1469476.
STRINGi9606.ENSP00000318821.

Structurei

3D structure databases

ProteinModelPortaliQ96CN9.
SMRiQ96CN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini713 – 763GRIPPROSITE-ProRule annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 61Sequence analysisAdd BLAST49
Coiled coili153 – 763Sequence analysisAdd BLAST611

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEHR. Eukaryota.
ENOG410Y6HA. LUCA.
GeneTreeiENSGT00440000039893.
HOGENOMiHOG000252925.
HOVERGENiHBG039459.
InParanoidiQ96CN9.
KOiK20281.
OMAiVEITFLR.
OrthoDBiEOG091G0R8Q.
PhylomeDBiQ96CN9.
TreeFamiTF324186.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE
60 70 80 90 100
ALEASIKVLS VSHEADVGLA GVQLPGLTFP DSVDDRCSTH SEDSTGTATS
110 120 130 140 150
LDTAASLTST KGEFGVEDDR PARGPPPPKS EEASWSESGV SSSSGDGPFA
160 170 180 190 200
GGEVDKRLHQ LKTQLATLTS SLATVTQEKS RMEASYLADK KKMKQDLEDA
210 220 230 240 250
SNKAEEERAR LEGELKGLQE QIAETKARLI TQQHDRAQEQ SDHALMLREL
260 270 280 290 300
QKLLQEERTQ RQDLELRLEE TREALAGRAY AAEQMEGFEL QTKQLTREVE
310 320 330 340 350
ELKSELQAIR DEKNQPDPRL QELQEEAARL KSHFQAQLQQ EMRKTALAED
360 370 380 390 400
QLRQQSQVEE QRVAALENQI SEVSELLGTY EKAKQKDQLA IQKLKERILQ
410 420 430 440 450
LDLENKTLAL AASSRSPLDS HGEESSLDVN VLKDKMEKLK RLLQVAARKS
460 470 480 490 500
QVTLDVEKLC DLEIMPSSEA ADGEKATALY YQQELKQLKE EFERYKMRAQ
510 520 530 540 550
VVLKSKNTKD GNLGKELEAA QEQLAELKEK YISLRLSCEE LEHQHQQEAD
560 570 580 590 600
DWKQELARLQ QLHRQELERC QLDFRDRTLK LEEELHKQRD RALAVLTEKD
610 620 630 640 650
LELEQLRSVA LASGLPGRRS PVGGGGPGDP ADTSSSDSLT QALQLAAANE
660 670 680 690 700
PTFFLYAEQL ARKEVEITSL RKQKHRLEVE VHQLQDRLLE EGERHREEVA
710 720 730 740 750
ALQSHIEKNI RDQSREGANL EYLKNIIYRF LTLPDSLGRQ QTLTAILTIL
760 770
HFSPEEKQVI MRLPTSASWW PSGKR
Length:775
Mass (Da):87,811
Last modified:December 1, 2001 - v1
Checksum:iED72FF26BDF8DAD6
GO

Sequence cautioni

The sequence AAH08902 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAB15218 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02190286R → W.Corresponds to variant rs17151044dbSNPEnsembl.1
Natural variantiVAR_02015787C → W.Corresponds to variant rs2285348dbSNPEnsembl.1
Natural variantiVAR_049259122A → V.Corresponds to variant rs35322201dbSNPEnsembl.1
Natural variantiVAR_049260262Q → R.Corresponds to variant rs35390108dbSNPEnsembl.1
Natural variantiVAR_049261274A → T.Corresponds to variant rs34887879dbSNPEnsembl.1
Natural variantiVAR_049262618R → C.Corresponds to variant rs34883586dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525417 mRNA. Translation: AAM91948.1.
BC008902 mRNA. Translation: AAH08902.2. Sequence problems.
BC014100 mRNA. Translation: AAH14100.1.
BC078665 mRNA. Translation: AAH78665.1.
AK025688 mRNA. Translation: BAB15218.1. Different initiation.
CCDSiCCDS5796.1.
RefSeqiNP_078799.2. NM_024523.5.
UniGeneiHs.521168.

Genome annotation databases

EnsembliENST00000321407; ENSP00000318821; ENSG00000179562.
GeneIDi79571.
KEGGihsa:79571.
UCSCiuc003vma.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525417 mRNA. Translation: AAM91948.1.
BC008902 mRNA. Translation: AAH08902.2. Sequence problems.
BC014100 mRNA. Translation: AAH14100.1.
BC078665 mRNA. Translation: AAH78665.1.
AK025688 mRNA. Translation: BAB15218.1. Different initiation.
CCDSiCCDS5796.1.
RefSeqiNP_078799.2. NM_024523.5.
UniGeneiHs.521168.

3D structure databases

ProteinModelPortaliQ96CN9.
SMRiQ96CN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122718. 56 interactors.
IntActiQ96CN9. 81 interactors.
MINTiMINT-1469476.
STRINGi9606.ENSP00000318821.

PTM databases

iPTMnetiQ96CN9.
PhosphoSitePlusiQ96CN9.

Polymorphism and mutation databases

BioMutaiGCC1.
DMDMi32699595.

Proteomic databases

EPDiQ96CN9.
MaxQBiQ96CN9.
PaxDbiQ96CN9.
PeptideAtlasiQ96CN9.
PRIDEiQ96CN9.

Protocols and materials databases

DNASUi79571.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321407; ENSP00000318821; ENSG00000179562.
GeneIDi79571.
KEGGihsa:79571.
UCSCiuc003vma.4. human.

Organism-specific databases

CTDi79571.
DisGeNETi79571.
GeneCardsiGCC1.
H-InvDBHIX0007045.
HIX0167842.
HGNCiHGNC:19095. GCC1.
HPAiHPA019369.
HPA021323.
MIMi607418. gene.
neXtProtiNX_Q96CN9.
OpenTargetsiENSG00000179562.
PharmGKBiPA38796.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEHR. Eukaryota.
ENOG410Y6HA. LUCA.
GeneTreeiENSGT00440000039893.
HOGENOMiHOG000252925.
HOVERGENiHBG039459.
InParanoidiQ96CN9.
KOiK20281.
OMAiVEITFLR.
OrthoDBiEOG091G0R8Q.
PhylomeDBiQ96CN9.
TreeFamiTF324186.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179562-MONOMER.
ReactomeiR-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

GeneWikiiGCC1.
GenomeRNAii79571.
PROiQ96CN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179562.
CleanExiHS_GCC1.
ExpressionAtlasiQ96CN9. baseline and differential.
GenevisibleiQ96CN9. HS.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCC1_HUMAN
AccessioniPrimary (citable) accession number: Q96CN9
Secondary accession number(s): Q9H6N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.