Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GRIP and coiled-coil domain-containing protein 1

Gene

GCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in maintaining Golgi structure.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein 1
Alternative name(s):
Golgi coiled-coil protein 1
Gene namesi
Name:GCC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000179562.2.
HGNCiHGNC:19095. GCC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79571.
OpenTargetsiENSG00000179562.
PharmGKBiPA38796.

Polymorphism and mutation databases

BioMutaiGCC1.
DMDMi32699595.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900721 – 775GRIP and coiled-coil domain-containing protein 1Add BLAST775

Proteomic databases

EPDiQ96CN9.
MaxQBiQ96CN9.
PaxDbiQ96CN9.
PeptideAtlasiQ96CN9.
PRIDEiQ96CN9.

PTM databases

iPTMnetiQ96CN9.
PhosphoSitePlusiQ96CN9.

Expressioni

Gene expression databases

BgeeiENSG00000179562.
CleanExiHS_GCC1.
ExpressionAtlasiQ96CN9. baseline and differential.
GenevisibleiQ96CN9. HS.

Organism-specific databases

HPAiHPA019369.
HPA021323.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122718. 56 interactors.
IntActiQ96CN9. 89 interactors.
MINTiMINT-1469476.
STRINGi9606.ENSP00000318821.

Structurei

3D structure databases

ProteinModelPortaliQ96CN9.
SMRiQ96CN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini713 – 763GRIPPROSITE-ProRule annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 61Sequence analysisAdd BLAST49
Coiled coili153 – 763Sequence analysisAdd BLAST611

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEHR. Eukaryota.
ENOG410Y6HA. LUCA.
GeneTreeiENSGT00440000039893.
HOGENOMiHOG000252925.
HOVERGENiHBG039459.
InParanoidiQ96CN9.
KOiK20281.
OMAiVVRAYKS.
OrthoDBiEOG091G0R8Q.
PhylomeDBiQ96CN9.
TreeFamiTF324186.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiView protein in InterPro
IPR000237. GRIP_dom.
PfamiView protein in Pfam
PF01465. GRIP. 1 hit.
SMARTiView protein in SMART
SM00755. Grip. 1 hit.
PROSITEiView protein in PROSITE
PS50913. GRIP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96CN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE
60 70 80 90 100
ALEASIKVLS VSHEADVGLA GVQLPGLTFP DSVDDRCSTH SEDSTGTATS
110 120 130 140 150
LDTAASLTST KGEFGVEDDR PARGPPPPKS EEASWSESGV SSSSGDGPFA
160 170 180 190 200
GGEVDKRLHQ LKTQLATLTS SLATVTQEKS RMEASYLADK KKMKQDLEDA
210 220 230 240 250
SNKAEEERAR LEGELKGLQE QIAETKARLI TQQHDRAQEQ SDHALMLREL
260 270 280 290 300
QKLLQEERTQ RQDLELRLEE TREALAGRAY AAEQMEGFEL QTKQLTREVE
310 320 330 340 350
ELKSELQAIR DEKNQPDPRL QELQEEAARL KSHFQAQLQQ EMRKTALAED
360 370 380 390 400
QLRQQSQVEE QRVAALENQI SEVSELLGTY EKAKQKDQLA IQKLKERILQ
410 420 430 440 450
LDLENKTLAL AASSRSPLDS HGEESSLDVN VLKDKMEKLK RLLQVAARKS
460 470 480 490 500
QVTLDVEKLC DLEIMPSSEA ADGEKATALY YQQELKQLKE EFERYKMRAQ
510 520 530 540 550
VVLKSKNTKD GNLGKELEAA QEQLAELKEK YISLRLSCEE LEHQHQQEAD
560 570 580 590 600
DWKQELARLQ QLHRQELERC QLDFRDRTLK LEEELHKQRD RALAVLTEKD
610 620 630 640 650
LELEQLRSVA LASGLPGRRS PVGGGGPGDP ADTSSSDSLT QALQLAAANE
660 670 680 690 700
PTFFLYAEQL ARKEVEITSL RKQKHRLEVE VHQLQDRLLE EGERHREEVA
710 720 730 740 750
ALQSHIEKNI RDQSREGANL EYLKNIIYRF LTLPDSLGRQ QTLTAILTIL
760 770
HFSPEEKQVI MRLPTSASWW PSGKR
Length:775
Mass (Da):87,811
Last modified:December 1, 2001 - v1
Checksum:iED72FF26BDF8DAD6
GO

Sequence cautioni

The sequence AAH08902 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAB15218 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02190286R → W. Corresponds to variant dbSNP:rs17151044Ensembl.1
Natural variantiVAR_02015787C → W. Corresponds to variant dbSNP:rs2285348Ensembl.1
Natural variantiVAR_049259122A → V. Corresponds to variant dbSNP:rs35322201Ensembl.1
Natural variantiVAR_049260262Q → R. Corresponds to variant dbSNP:rs35390108Ensembl.1
Natural variantiVAR_049261274A → T. Corresponds to variant dbSNP:rs34887879Ensembl.1
Natural variantiVAR_049262618R → C. Corresponds to variant dbSNP:rs34883586Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525417 mRNA. Translation: AAM91948.1.
BC008902 mRNA. Translation: AAH08902.2. Sequence problems.
BC014100 mRNA. Translation: AAH14100.1.
BC078665 mRNA. Translation: AAH78665.1.
AK025688 mRNA. Translation: BAB15218.1. Different initiation.
CCDSiCCDS5796.1.
RefSeqiNP_078799.2. NM_024523.5.
UniGeneiHs.521168.

Genome annotation databases

EnsembliENST00000321407; ENSP00000318821; ENSG00000179562.
GeneIDi79571.
KEGGihsa:79571.
UCSCiuc003vma.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGCC1_HUMAN
AccessioniPrimary (citable) accession number: Q96CN9
Secondary accession number(s): Q9H6N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot