ID   ISOC1_HUMAN             Reviewed;         298 AA.
AC   Q96CN7; Q7Z770;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 3.
DT   27-MAR-2024, entry version 157.
DE   RecName: Full=Isochorismatase domain-containing protein 1;
GN   Name=ISOC1; ORFNames=CGI-111;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- INTERACTION:
CC       Q96CN7; Q9P1Z2: CALCOCO1; NbExp=3; IntAct=EBI-2805787, EBI-749920;
CC   -!- SIMILARITY: Belongs to the isochorismatase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH08367.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH14105.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC008367; AAH08367.1; ALT_INIT; mRNA.
DR   EMBL; BC014105; AAH14105.2; ALT_INIT; mRNA.
DR   CCDS; CCDS43357.1; -.
DR   RefSeq; NP_057132.2; NM_016048.2.
DR   AlphaFoldDB; Q96CN7; -.
DR   SMR; Q96CN7; -.
DR   BioGRID; 119222; 79.
DR   IntAct; Q96CN7; 17.
DR   MINT; Q96CN7; -.
DR   STRING; 9606.ENSP00000173527; -.
DR   GlyGen; Q96CN7; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q96CN7; -.
DR   PhosphoSitePlus; Q96CN7; -.
DR   SwissPalm; Q96CN7; -.
DR   BioMuta; ISOC1; -.
DR   DMDM; 119371160; -.
DR   CPTAC; CPTAC-84; -.
DR   CPTAC; CPTAC-85; -.
DR   EPD; Q96CN7; -.
DR   jPOST; Q96CN7; -.
DR   MassIVE; Q96CN7; -.
DR   MaxQB; Q96CN7; -.
DR   PaxDb; 9606-ENSP00000173527; -.
DR   PeptideAtlas; Q96CN7; -.
DR   ProteomicsDB; 76199; -.
DR   Pumba; Q96CN7; -.
DR   ABCD; Q96CN7; 9 sequenced antibodies.
DR   Antibodypedia; 63783; 66 antibodies from 18 providers.
DR   DNASU; 51015; -.
DR   Ensembl; ENST00000173527.6; ENSP00000173527.5; ENSG00000066583.12.
DR   GeneID; 51015; -.
DR   KEGG; hsa:51015; -.
DR   MANE-Select; ENST00000173527.6; ENSP00000173527.5; NM_016048.2; NP_057132.2.
DR   UCSC; uc003kva.4; human.
DR   AGR; HGNC:24254; -.
DR   CTD; 51015; -.
DR   DisGeNET; 51015; -.
DR   GeneCards; ISOC1; -.
DR   HGNC; HGNC:24254; ISOC1.
DR   HPA; ENSG00000066583; Low tissue specificity.
DR   neXtProt; NX_Q96CN7; -.
DR   OpenTargets; ENSG00000066583; -.
DR   PharmGKB; PA134973470; -.
DR   VEuPathDB; HostDB:ENSG00000066583; -.
DR   eggNOG; KOG4044; Eukaryota.
DR   GeneTree; ENSGT00390000006753; -.
DR   HOGENOM; CLU_047255_0_0_1; -.
DR   InParanoid; Q96CN7; -.
DR   OMA; LEVHIIA; -.
DR   OrthoDB; 166875at2759; -.
DR   PhylomeDB; Q96CN7; -.
DR   TreeFam; TF313459; -.
DR   PathwayCommons; Q96CN7; -.
DR   SignaLink; Q96CN7; -.
DR   BioGRID-ORCS; 51015; 14 hits in 1149 CRISPR screens.
DR   ChiTaRS; ISOC1; human.
DR   GenomeRNAi; 51015; -.
DR   Pharos; Q96CN7; Tdark.
DR   PRO; PR:Q96CN7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q96CN7; Protein.
DR   Bgee; ENSG00000066583; Expressed in secondary oocyte and 200 other cell types or tissues.
DR   ExpressionAtlas; Q96CN7; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; ISS:HGNC-UCL.
DR   CDD; cd01012; YcaC_related; 1.
DR   Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   PANTHER; PTHR14119; HYDROLASE; 1.
DR   PANTHER; PTHR14119:SF17; ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
DR   Genevisible; Q96CN7; HS.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..298
FT                   /note="Isochorismatase domain-containing protein 1"
FT                   /id="PRO_0000268664"
FT   MOD_RES         160
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6I7R3"
FT   MOD_RES         279
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91V64"
SQ   SEQUENCE   298 AA;  32237 MW;  9843DA1A40E1BDA0 CRC64;
     MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL IQKFLSLYGD
     QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL QIQLTTLGNL TPSSTVFFCC
     DMQERFRPAI KYFGDIISVG QRLLQGARIL GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL
     PKTKFSMVLP EVEAALAEIP GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR
     SMMDRMFALE RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV
//