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Protein

Isochorismatase domain-containing protein 1

Gene

ISOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Isochorismatase domain-containing protein 1
Gene namesi
Name:ISOC1
ORF Names:CGI-111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24254. ISOC1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • peroxisome Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973470.

Polymorphism and mutation databases

BioMutaiISOC1.
DMDMi119371160.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Isochorismatase domain-containing protein 1PRO_0000268664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791N6-succinyllysineBy similarity

Proteomic databases

MaxQBiQ96CN7.
PaxDbiQ96CN7.
PeptideAtlasiQ96CN7.
PRIDEiQ96CN7.

PTM databases

PhosphoSiteiQ96CN7.

Expressioni

Gene expression databases

BgeeiQ96CN7.
CleanExiHS_ISOC1.
ExpressionAtlasiQ96CN7. baseline and differential.
GenevisibleiQ96CN7. HS.

Organism-specific databases

HPAiHPA040458.
HPA047781.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO1Q9P1Z23EBI-2805787,EBI-749920

Protein-protein interaction databases

BioGridi119222. 32 interactions.
IntActiQ96CN7. 6 interactions.
MINTiMINT-5003404.
STRINGi9606.ENSP00000173527.

Structurei

3D structure databases

ProteinModelPortaliQ96CN7.
SMRiQ96CN7. Positions 110-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isochorismatase family.Curated

Phylogenomic databases

eggNOGiCOG1335.
GeneTreeiENSGT00390000006753.
HOGENOMiHOG000231573.
HOVERGENiHBG056777.
InParanoidiQ96CN7.
OMAiFAEEWSQ.
PhylomeDBiQ96CN7.
TreeFamiTF313459.

Family and domain databases

Gene3Di3.40.50.850. 1 hit.
InterProiIPR000868. Isochorismatase-like.
[Graphical view]
PfamiPF00857. Isochorismatase. 1 hit.
[Graphical view]
SUPFAMiSSF52499. SSF52499. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96CN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL
60 70 80 90 100
IQKFLSLYGD QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL
110 120 130 140 150
QIQLTTLGNL TPSSTVFFCC DMQERFRPAI KYFGDIISVG QRLLQGARIL
160 170 180 190 200
GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL PKTKFSMVLP EVEAALAEIP
210 220 230 240 250
GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR SMMDRMFALE
260 270 280 290
RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV
Length:298
Mass (Da):32,237
Last modified:December 12, 2006 - v3
Checksum:i9843DA1A40E1BDA0
GO

Sequence cautioni

The sequence AAH08367.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH14105.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008367 mRNA. Translation: AAH08367.1. Different initiation.
BC014105 mRNA. Translation: AAH14105.2. Different initiation.
CCDSiCCDS43357.1.
RefSeqiNP_057132.2. NM_016048.2.
UniGeneiHs.483296.

Genome annotation databases

EnsembliENST00000173527; ENSP00000173527; ENSG00000066583.
GeneIDi51015.
KEGGihsa:51015.
UCSCiuc003kva.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008367 mRNA. Translation: AAH08367.1. Different initiation.
BC014105 mRNA. Translation: AAH14105.2. Different initiation.
CCDSiCCDS43357.1.
RefSeqiNP_057132.2. NM_016048.2.
UniGeneiHs.483296.

3D structure databases

ProteinModelPortaliQ96CN7.
SMRiQ96CN7. Positions 110-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119222. 32 interactions.
IntActiQ96CN7. 6 interactions.
MINTiMINT-5003404.
STRINGi9606.ENSP00000173527.

PTM databases

PhosphoSiteiQ96CN7.

Polymorphism and mutation databases

BioMutaiISOC1.
DMDMi119371160.

Proteomic databases

MaxQBiQ96CN7.
PaxDbiQ96CN7.
PeptideAtlasiQ96CN7.
PRIDEiQ96CN7.

Protocols and materials databases

DNASUi51015.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000173527; ENSP00000173527; ENSG00000066583.
GeneIDi51015.
KEGGihsa:51015.
UCSCiuc003kva.3. human.

Organism-specific databases

CTDi51015.
GeneCardsiGC05P128430.
HGNCiHGNC:24254. ISOC1.
HPAiHPA040458.
HPA047781.
neXtProtiNX_Q96CN7.
PharmGKBiPA134973470.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1335.
GeneTreeiENSGT00390000006753.
HOGENOMiHOG000231573.
HOVERGENiHBG056777.
InParanoidiQ96CN7.
OMAiFAEEWSQ.
PhylomeDBiQ96CN7.
TreeFamiTF313459.

Miscellaneous databases

GenomeRNAii51015.
NextBioi53524.
PROiQ96CN7.

Gene expression databases

BgeeiQ96CN7.
CleanExiHS_ISOC1.
ExpressionAtlasiQ96CN7. baseline and differential.
GenevisibleiQ96CN7. HS.

Family and domain databases

Gene3Di3.40.50.850. 1 hit.
InterProiIPR000868. Isochorismatase-like.
[Graphical view]
PfamiPF00857. Isochorismatase. 1 hit.
[Graphical view]
SUPFAMiSSF52499. SSF52499. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Eye.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiISOC1_HUMAN
AccessioniPrimary (citable) accession number: Q96CN7
Secondary accession number(s): Q7Z770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: July 22, 2015
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.