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Q96CN7 (ISOC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isochorismatase domain-containing protein 1
Gene names
Name:ISOC1
ORF Names:CGI-111
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the isochorismatase family.

Sequence caution

The sequence AAH08367.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH14105.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentperoxisome

Inferred from sequence or structural similarity PubMed 14561759. Source: HGNC

   Molecular_functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Isochorismatase domain-containing protein 1
PRO_0000268664

Amino acid modifications

Modified residue2791N6-succinyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96CN7 [UniParc].

Last modified December 12, 2006. Version 3.
Checksum: 9843DA1A40E1BDA0

FASTA29832,237
        10         20         30         40         50         60 
MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL IQKFLSLYGD 

        70         80         90        100        110        120 
QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL QIQLTTLGNL TPSSTVFFCC 

       130        140        150        160        170        180 
DMQERFRPAI KYFGDIISVG QRLLQGARIL GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL 

       190        200        210        220        230        240 
PKTKFSMVLP EVEAALAEIP GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR 

       250        260        270        280        290 
SMMDRMFALE RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Eye.
[2]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC008367 mRNA. Translation: AAH08367.1. Different initiation.
BC014105 mRNA. Translation: AAH14105.2. Different initiation.
RefSeqNP_057132.2. NM_016048.2.
UniGeneHs.483296.

3D structure databases

ProteinModelPortalQ96CN7.
SMRQ96CN7. Positions 110-295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119222. 32 interactions.
IntActQ96CN7. 5 interactions.
MINTMINT-5003404.
STRING9606.ENSP00000173527.

PTM databases

PhosphoSiteQ96CN7.

Polymorphism databases

DMDM119371160.

Proteomic databases

PaxDbQ96CN7.
PeptideAtlasQ96CN7.
PRIDEQ96CN7.

Protocols and materials databases

DNASU51015.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000173527; ENSP00000173527; ENSG00000066583.
GeneID51015.
KEGGhsa:51015.
UCSCuc003kva.3. human.

Organism-specific databases

CTD51015.
GeneCardsGC05P128430.
HGNCHGNC:24254. ISOC1.
HPAHPA040458.
HPA047781.
neXtProtNX_Q96CN7.
PharmGKBPA134973470.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1335.
HOGENOMHOG000231573.
HOVERGENHBG056777.
InParanoidQ96CN7.
OMAFAEEWSQ.
PhylomeDBQ96CN7.
TreeFamTF313459.

Gene expression databases

ArrayExpressQ96CN7.
BgeeQ96CN7.
CleanExHS_ISOC1.
GenevestigatorQ96CN7.

Family and domain databases

Gene3D3.40.50.850. 1 hit.
InterProIPR000868. Isochorismatase-like.
[Graphical view]
PfamPF00857. Isochorismatase. 1 hit.
[Graphical view]
SUPFAMSSF52499. SSF52499. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi51015.
NextBio53524.
PROQ96CN7.

Entry information

Entry nameISOC1_HUMAN
AccessionPrimary (citable) accession number: Q96CN7
Secondary accession number(s): Q7Z770
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM