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Q96CN7

- ISOC1_HUMAN

UniProt

Q96CN7 - ISOC1_HUMAN

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Protein

Isochorismatase domain-containing protein 1

Gene

ISOC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. catalytic activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Isochorismatase domain-containing protein 1
Gene namesi
Name:ISOC1
ORF Names:CGI-111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:24254. ISOC1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. peroxisome Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Isochorismatase domain-containing protein 1PRO_0000268664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791N6-succinyllysineBy similarity

Proteomic databases

MaxQBiQ96CN7.
PaxDbiQ96CN7.
PeptideAtlasiQ96CN7.
PRIDEiQ96CN7.

PTM databases

PhosphoSiteiQ96CN7.

Expressioni

Gene expression databases

BgeeiQ96CN7.
CleanExiHS_ISOC1.
ExpressionAtlasiQ96CN7. baseline and differential.
GenevestigatoriQ96CN7.

Organism-specific databases

HPAiHPA040458.
HPA047781.

Interactioni

Protein-protein interaction databases

BioGridi119222. 32 interactions.
IntActiQ96CN7. 5 interactions.
MINTiMINT-5003404.
STRINGi9606.ENSP00000173527.

Structurei

3D structure databases

ProteinModelPortaliQ96CN7.
SMRiQ96CN7. Positions 110-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isochorismatase family.Curated

Phylogenomic databases

eggNOGiCOG1335.
GeneTreeiENSGT00390000006753.
HOGENOMiHOG000231573.
HOVERGENiHBG056777.
InParanoidiQ96CN7.
OMAiFAEEWSQ.
PhylomeDBiQ96CN7.
TreeFamiTF313459.

Family and domain databases

Gene3Di3.40.50.850. 1 hit.
InterProiIPR000868. Isochorismatase-like.
[Graphical view]
PfamiPF00857. Isochorismatase. 1 hit.
[Graphical view]
SUPFAMiSSF52499. SSF52499. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96CN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL
60 70 80 90 100
IQKFLSLYGD QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL
110 120 130 140 150
QIQLTTLGNL TPSSTVFFCC DMQERFRPAI KYFGDIISVG QRLLQGARIL
160 170 180 190 200
GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL PKTKFSMVLP EVEAALAEIP
210 220 230 240 250
GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR SMMDRMFALE
260 270 280 290
RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV
Length:298
Mass (Da):32,237
Last modified:December 12, 2006 - v3
Checksum:i9843DA1A40E1BDA0
GO

Sequence cautioni

The sequence AAH08367.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH14105.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008367 mRNA. Translation: AAH08367.1. Different initiation.
BC014105 mRNA. Translation: AAH14105.2. Different initiation.
CCDSiCCDS43357.1.
RefSeqiNP_057132.2. NM_016048.2.
UniGeneiHs.483296.

Genome annotation databases

EnsembliENST00000173527; ENSP00000173527; ENSG00000066583.
GeneIDi51015.
KEGGihsa:51015.
UCSCiuc003kva.3. human.

Polymorphism databases

DMDMi119371160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008367 mRNA. Translation: AAH08367.1 . Different initiation.
BC014105 mRNA. Translation: AAH14105.2 . Different initiation.
CCDSi CCDS43357.1.
RefSeqi NP_057132.2. NM_016048.2.
UniGenei Hs.483296.

3D structure databases

ProteinModelPortali Q96CN7.
SMRi Q96CN7. Positions 110-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119222. 32 interactions.
IntActi Q96CN7. 5 interactions.
MINTi MINT-5003404.
STRINGi 9606.ENSP00000173527.

PTM databases

PhosphoSitei Q96CN7.

Polymorphism databases

DMDMi 119371160.

Proteomic databases

MaxQBi Q96CN7.
PaxDbi Q96CN7.
PeptideAtlasi Q96CN7.
PRIDEi Q96CN7.

Protocols and materials databases

DNASUi 51015.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000173527 ; ENSP00000173527 ; ENSG00000066583 .
GeneIDi 51015.
KEGGi hsa:51015.
UCSCi uc003kva.3. human.

Organism-specific databases

CTDi 51015.
GeneCardsi GC05P128430.
HGNCi HGNC:24254. ISOC1.
HPAi HPA040458.
HPA047781.
neXtProti NX_Q96CN7.
PharmGKBi PA134973470.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1335.
GeneTreei ENSGT00390000006753.
HOGENOMi HOG000231573.
HOVERGENi HBG056777.
InParanoidi Q96CN7.
OMAi FAEEWSQ.
PhylomeDBi Q96CN7.
TreeFami TF313459.

Miscellaneous databases

GenomeRNAii 51015.
NextBioi 53524.
PROi Q96CN7.

Gene expression databases

Bgeei Q96CN7.
CleanExi HS_ISOC1.
ExpressionAtlasi Q96CN7. baseline and differential.
Genevestigatori Q96CN7.

Family and domain databases

Gene3Di 3.40.50.850. 1 hit.
InterProi IPR000868. Isochorismatase-like.
[Graphical view ]
Pfami PF00857. Isochorismatase. 1 hit.
[Graphical view ]
SUPFAMi SSF52499. SSF52499. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Eye.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiISOC1_HUMAN
AccessioniPrimary (citable) accession number: Q96CN7
Secondary accession number(s): Q7Z770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3