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Protein

Isochorismatase domain-containing protein 1

Gene

ISOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Isochorismatase domain-containing protein 1
Gene namesi
Name:ISOC1
ORF Names:CGI-111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000066583.11
HGNCiHGNC:24254 ISOC1
neXtProtiNX_Q96CN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000066583
PharmGKBiPA134973470

Polymorphism and mutation databases

BioMutaiISOC1
DMDMi119371160

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686641 – 298Isochorismatase domain-containing protein 1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphotyrosineBy similarity1
Modified residuei279N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96CN7
MaxQBiQ96CN7
PaxDbiQ96CN7
PeptideAtlasiQ96CN7
PRIDEiQ96CN7

PTM databases

iPTMnetiQ96CN7
PhosphoSitePlusiQ96CN7

Expressioni

Gene expression databases

BgeeiENSG00000066583
CleanExiHS_ISOC1
ExpressionAtlasiQ96CN7 baseline and differential
GenevisibleiQ96CN7 HS

Organism-specific databases

HPAiHPA070307

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO1Q9P1Z23EBI-2805787,EBI-749920

Protein-protein interaction databases

BioGridi119222, 42 interactors
IntActiQ96CN7, 13 interactors
MINTiQ96CN7
STRINGi9606.ENSP00000173527

Structurei

3D structure databases

ProteinModelPortaliQ96CN7
SMRiQ96CN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isochorismatase family.Curated

Phylogenomic databases

eggNOGiKOG4044 Eukaryota
ENOG4111I3F LUCA
GeneTreeiENSGT00390000006753
HOGENOMiHOG000231573
HOVERGENiHBG056777
InParanoidiQ96CN7
OMAiEWSQYID
OrthoDBiEOG091G0LXB
PhylomeDBiQ96CN7
TreeFamiTF313459

Family and domain databases

Gene3Di3.40.50.850, 1 hit
InterProiView protein in InterPro
IPR000868 Isochorismatase-like
IPR036380 Isochorismatase-like_sf
PfamiView protein in Pfam
PF00857 Isochorismatase, 1 hit
SUPFAMiSSF52499 SSF52499, 1 hit

Sequencei

Sequence statusi: Complete.

Q96CN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL
60 70 80 90 100
IQKFLSLYGD QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL
110 120 130 140 150
QIQLTTLGNL TPSSTVFFCC DMQERFRPAI KYFGDIISVG QRLLQGARIL
160 170 180 190 200
GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL PKTKFSMVLP EVEAALAEIP
210 220 230 240 250
GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR SMMDRMFALE
260 270 280 290
RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV
Length:298
Mass (Da):32,237
Last modified:December 12, 2006 - v3
Checksum:i9843DA1A40E1BDA0
GO

Sequence cautioni

The sequence AAH08367 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH14105 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008367 mRNA Translation: AAH08367.1 Different initiation.
BC014105 mRNA Translation: AAH14105.2 Different initiation.
CCDSiCCDS43357.1
RefSeqiNP_057132.2, NM_016048.2
UniGeneiHs.483296

Genome annotation databases

EnsembliENST00000173527; ENSP00000173527; ENSG00000066583
GeneIDi51015
KEGGihsa:51015
UCSCiuc003kva.4 human

Similar proteinsi

Entry informationi

Entry nameiISOC1_HUMAN
AccessioniPrimary (citable) accession number: Q96CN7
Secondary accession number(s): Q7Z770
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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