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Q96CN7

- ISOC1_HUMAN

UniProt

Q96CN7 - ISOC1_HUMAN

Protein

Isochorismatase domain-containing protein 1

Gene

ISOC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. catalytic activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isochorismatase domain-containing protein 1
    Gene namesi
    Name:ISOC1
    ORF Names:CGI-111
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:24254. ISOC1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. peroxisome Source: HGNC

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134973470.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298Isochorismatase domain-containing protein 1PRO_0000268664Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei279 – 2791N6-succinyllysineBy similarity

    Proteomic databases

    MaxQBiQ96CN7.
    PaxDbiQ96CN7.
    PeptideAtlasiQ96CN7.
    PRIDEiQ96CN7.

    PTM databases

    PhosphoSiteiQ96CN7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96CN7.
    BgeeiQ96CN7.
    CleanExiHS_ISOC1.
    GenevestigatoriQ96CN7.

    Organism-specific databases

    HPAiHPA040458.
    HPA047781.

    Interactioni

    Protein-protein interaction databases

    BioGridi119222. 32 interactions.
    IntActiQ96CN7. 5 interactions.
    MINTiMINT-5003404.
    STRINGi9606.ENSP00000173527.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96CN7.
    SMRiQ96CN7. Positions 110-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isochorismatase family.Curated

    Phylogenomic databases

    eggNOGiCOG1335.
    HOGENOMiHOG000231573.
    HOVERGENiHBG056777.
    InParanoidiQ96CN7.
    OMAiFAEEWSQ.
    PhylomeDBiQ96CN7.
    TreeFamiTF313459.

    Family and domain databases

    Gene3Di3.40.50.850. 1 hit.
    InterProiIPR000868. Isochorismatase-like.
    [Graphical view]
    PfamiPF00857. Isochorismatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52499. SSF52499. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96CN7-1 [UniParc]FASTAAdd to Basket

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    MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL    50
    IQKFLSLYGD QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL 100
    QIQLTTLGNL TPSSTVFFCC DMQERFRPAI KYFGDIISVG QRLLQGARIL 150
    GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL PKTKFSMVLP EVEAALAEIP 200
    GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR SMMDRMFALE 250
    RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV 298
    Length:298
    Mass (Da):32,237
    Last modified:December 12, 2006 - v3
    Checksum:i9843DA1A40E1BDA0
    GO

    Sequence cautioni

    The sequence AAH08367.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH14105.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC008367 mRNA. Translation: AAH08367.1. Different initiation.
    BC014105 mRNA. Translation: AAH14105.2. Different initiation.
    CCDSiCCDS43357.1.
    RefSeqiNP_057132.2. NM_016048.2.
    UniGeneiHs.483296.

    Genome annotation databases

    EnsembliENST00000173527; ENSP00000173527; ENSG00000066583.
    GeneIDi51015.
    KEGGihsa:51015.
    UCSCiuc003kva.3. human.

    Polymorphism databases

    DMDMi119371160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC008367 mRNA. Translation: AAH08367.1 . Different initiation.
    BC014105 mRNA. Translation: AAH14105.2 . Different initiation.
    CCDSi CCDS43357.1.
    RefSeqi NP_057132.2. NM_016048.2.
    UniGenei Hs.483296.

    3D structure databases

    ProteinModelPortali Q96CN7.
    SMRi Q96CN7. Positions 110-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119222. 32 interactions.
    IntActi Q96CN7. 5 interactions.
    MINTi MINT-5003404.
    STRINGi 9606.ENSP00000173527.

    PTM databases

    PhosphoSitei Q96CN7.

    Polymorphism databases

    DMDMi 119371160.

    Proteomic databases

    MaxQBi Q96CN7.
    PaxDbi Q96CN7.
    PeptideAtlasi Q96CN7.
    PRIDEi Q96CN7.

    Protocols and materials databases

    DNASUi 51015.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000173527 ; ENSP00000173527 ; ENSG00000066583 .
    GeneIDi 51015.
    KEGGi hsa:51015.
    UCSCi uc003kva.3. human.

    Organism-specific databases

    CTDi 51015.
    GeneCardsi GC05P128430.
    HGNCi HGNC:24254. ISOC1.
    HPAi HPA040458.
    HPA047781.
    neXtProti NX_Q96CN7.
    PharmGKBi PA134973470.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1335.
    HOGENOMi HOG000231573.
    HOVERGENi HBG056777.
    InParanoidi Q96CN7.
    OMAi FAEEWSQ.
    PhylomeDBi Q96CN7.
    TreeFami TF313459.

    Miscellaneous databases

    GenomeRNAii 51015.
    NextBioi 53524.
    PROi Q96CN7.

    Gene expression databases

    ArrayExpressi Q96CN7.
    Bgeei Q96CN7.
    CleanExi HS_ISOC1.
    Genevestigatori Q96CN7.

    Family and domain databases

    Gene3Di 3.40.50.850. 1 hit.
    InterProi IPR000868. Isochorismatase-like.
    [Graphical view ]
    Pfami PF00857. Isochorismatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52499. SSF52499. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Eye.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiISOC1_HUMAN
    AccessioniPrimary (citable) accession number: Q96CN7
    Secondary accession number(s): Q7Z770
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3