Q96CN7 (ISOC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isochorismatase domain-containing protein 1

Gene names

Name:	ISOC1
ORF Names:	CGI-111

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the isochorismatase family.
Sequence caution	The sequence AAH08367.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH14105.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	peroxisome Inferred from sequence or structural similarity PubMed 14561759. Source: HGNC
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Isochorismatase domain-containing protein 1		PRO_0000268664

Sequences

	Sequence		Length	Mass (Da)
	Q96CN7 [UniParc]. Last modified December 12, 2006. Version 3. Checksum: 9843DA1A40E1BDA0	FASTA	298	32,237
	10 20 30 40 50 60 MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL IQKFLSLYGD 70 80 90 100 110 120 QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL QIQLTTLGNL TPSSTVFFCC 130 140 150 160 170 180 DMQERFRPAI KYFGDIISVG QRLLQGARIL GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL 190 200 210 220 230 240 PKTKFSMVLP EVEAALAEIP GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR 250 260 270 280 290 SMMDRMFALE RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Eye.
[2]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC008367 mRNA. Translation: AAH08367.1. Different initiation. BC014105 mRNA. Translation: AAH14105.2. Different initiation.
IPI	IPI00304082.
RefSeq	NP_057132.2. NM_016048.2.
UniGene	Hs.483296.
3D structure databases
HSSP	HSSP built from PDB template 2B34 based on UniProtKB Q20062.
ProteinModelPortal	Q96CN7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96CN7. 5 interactions.
PTM databases
PhosphoSite	Q96CN7.
Polymorphism databases
DMDM	119371160.
Proteomic databases
PaxDb	Q96CN7.
PeptideAtlas	Q96CN7.
PRIDE	Q96CN7.
Protocols and materials databases
DNASU	51015.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000173527; ENSP00000173527; ENSG00000066583.
GeneID	51015.
KEGG	hsa:51015.
UCSC	uc003kva.3. human.
Organism-specific databases
CTD	51015.
GeneCards	GC05P128430.
HGNC	HGNC:24254. ISOC1.
HPA	HPA040458. HPA047781.
neXtProt	NX_Q96CN7.
PharmGKB	PA134973470.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1335.
HOGENOM	HOG000231573.
HOVERGEN	HBG056777.
InParanoid	Q96CN7.
OMA	STVPHGA.
OrthoDB	EOG4KKZ3N.
Gene expression databases
ArrayExpress	Q96CN7.
Bgee	Q96CN7.
CleanEx	HS_ISOC1.
Genevestigator	Q96CN7.
GermOnline	ENSG00000066583. Homo sapiens.
Family and domain databases
Gene3D	3.40.50.850. 1 hit.
InterPro	IPR000868. Isochorismatase-like. [Graphical view]
Pfam	PF00857. Isochorismatase. 1 hit. [Graphical view]
SUPFAM	SSF52499. Iscrsm_hydrolase. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	51015.
NextBio	53524.

Entry information

Entry name

ISOC1_HUMAN

Accession

Primary (citable) accession number: Q96CN7
Secondary accession number(s): Q7Z770

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.