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Protein

Leucine-rich repeat-containing protein 45

Gene

LRRC45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 45
Gene namesi
Name:LRRC45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28302. LRRC45.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671505.

Polymorphism and mutation databases

BioMutaiLRRC45.
DMDMi74760765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Leucine-rich repeat-containing protein 45PRO_0000223923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei661 – 6611Phosphoserine; by NEK21 Publication

Post-translational modificationi

Phosphorylated by NEK2 during misosis, phosphorylation reduces centrosomal localization which subsequently leads to centrosome separation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96CN5.
MaxQBiQ96CN5.
PaxDbiQ96CN5.
PRIDEiQ96CN5.

PTM databases

iPTMnetiQ96CN5.
PhosphoSiteiQ96CN5.

Expressioni

Gene expression databases

BgeeiQ96CN5.
CleanExiHS_LRRC45.
ExpressionAtlasiQ96CN5. baseline and differential.
GenevisibleiQ96CN5. HS.

Organism-specific databases

HPAiHPA023372.
HPA023382.
HPA024768.

Interactioni

Subunit structurei

Interacts with CROCC/rootletin and CEP250.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KXD1Q9BQD33EBI-2805176,EBI-739657

Protein-protein interaction databases

BioGridi128377. 6 interactions.
IntActiQ96CN5. 9 interactions.
STRINGi9606.ENSP00000306760.

Structurei

3D structure databases

ProteinModelPortaliQ96CN5.
SMRiQ96CN5. Positions 1-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 8023LRR 1Add
BLAST
Repeati87 – 10721LRR 2Add
BLAST
Repeati115 – 13622LRR 3Add
BLAST
Repeati145 – 16622LRR 4Add
BLAST
Repeati173 – 19422LRR 5Add
BLAST
Repeati201 – 21212LRR 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili252 – 645394Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00730000111270.
HOGENOMiHOG000231243.
HOVERGENiHBG080193.
InParanoidiQ96CN5.
OMAiEQAMDHN.
OrthoDBiEOG74J97W.
PhylomeDBiQ96CN5.
TreeFamiTF330983.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEFRRSYSR LCRESGAEPQ EAVLQQLHQL PRGRLDLATQ SLTVETCRAL
60 70 80 90 100
GKLLPRETLC TELVLSDCML SEEGATLLLR GLCANTVLRF LDLKGNNLRA
110 120 130 140 150
AGAEALGKLL QQNKSIQSLT LEWNSLGTWD DAFATFCGGL AANGALQRLD
160 170 180 190 200
LRNNQISHKG AEELALALKG NTTLQQLDLR WNNVGLLGGR ALMNCLPSNR
210 220 230 240 250
TLWRLDLAGN NIPGDVLRAV EQAMGHSQDR LTTFQENQAR THVLSKEVQH
260 270 280 290 300
LREEKSKQFL DLMETIDKQR EEMAKSSRAS AARVGQLQEA LNERHSIINA
310 320 330 340 350
LKAKLQMTEA ALALSEQKAQ DLGELLATAE QEQLSLSQRQ AKELKLEQQE
360 370 380 390 400
AAERESKLLR DLSAANEKNL LLQNQVDELE RKFRCQQEQL FQTRQEMTSM
410 420 430 440 450
SAELKMRAIQ AEERLDMEKR RCRQSLEDSE SLRIKEVEHM TRHLEESEKA
460 470 480 490 500
MQERVQRLEA ARLSLEEELS RVKAAALSER GQAEEELIKA KSQARLEEQQ
510 520 530 540 550
RLAHLEDKLR LLAQARDEAQ GACLQQKQVV AEAQTRVSQL GLQVEGLRRR
560 570 580 590 600
LEELQQELSL KDQERVAEVS RVRVELQEQN GRLQAELAAQ EALREKAAAL
610 620 630 640 650
ERQLKVMASD HREALLDRES ENASLREKLR LREAEIARIR DEEAQRASFL
660 670
QNAVLAYVQA SPVRTLSPPK
Length:670
Mass (Da):75,951
Last modified:December 1, 2001 - v1
Checksum:i27F5D210721459FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014109 mRNA. Translation: AAH14109.1.
CCDSiCCDS11797.1.
RefSeqiNP_659436.1. NM_144999.3.
UniGeneiHs.143774.

Genome annotation databases

EnsembliENST00000306688; ENSP00000306760; ENSG00000169683.
GeneIDi201255.
KEGGihsa:201255.
UCSCiuc002kde.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014109 mRNA. Translation: AAH14109.1.
CCDSiCCDS11797.1.
RefSeqiNP_659436.1. NM_144999.3.
UniGeneiHs.143774.

3D structure databases

ProteinModelPortaliQ96CN5.
SMRiQ96CN5. Positions 1-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128377. 6 interactions.
IntActiQ96CN5. 9 interactions.
STRINGi9606.ENSP00000306760.

PTM databases

iPTMnetiQ96CN5.
PhosphoSiteiQ96CN5.

Polymorphism and mutation databases

BioMutaiLRRC45.
DMDMi74760765.

Proteomic databases

EPDiQ96CN5.
MaxQBiQ96CN5.
PaxDbiQ96CN5.
PRIDEiQ96CN5.

Protocols and materials databases

DNASUi201255.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306688; ENSP00000306760; ENSG00000169683.
GeneIDi201255.
KEGGihsa:201255.
UCSCiuc002kde.4. human.

Organism-specific databases

CTDi201255.
GeneCardsiLRRC45.
HGNCiHGNC:28302. LRRC45.
HPAiHPA023372.
HPA023382.
HPA024768.
neXtProtiNX_Q96CN5.
PharmGKBiPA142671505.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00730000111270.
HOGENOMiHOG000231243.
HOVERGENiHBG080193.
InParanoidiQ96CN5.
OMAiEQAMDHN.
OrthoDBiEOG74J97W.
PhylomeDBiQ96CN5.
TreeFamiTF330983.

Miscellaneous databases

ChiTaRSiLRRC45. human.
GenomeRNAii201255.
PROiQ96CN5.

Gene expression databases

BgeeiQ96CN5.
CleanExiHS_LRRC45.
ExpressionAtlasiQ96CN5. baseline and differential.
GenevisibleiQ96CN5. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  2. "LRRC45 is a centrosome linker component required for centrosome cohesion."
    He R., Huang N., Bao Y., Zhou H., Teng J., Chen J.
    Cell Rep. 4:1100-1107(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-661, INTERACTION WITH CROCC AND CEP250.

Entry informationi

Entry nameiLRC45_HUMAN
AccessioniPrimary (citable) accession number: Q96CN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.