UniProtKB - Q96CN5 (LRC45_HUMAN)
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Protein
Leucine-rich repeat-containing protein 45
Gene
LRRC45
Organism
Homo sapiens (Human)
Status
Functioni
Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.1 Publication
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 45 |
Gene namesi | Name:LRRC45 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169683.7. |
HGNCi | HGNC:28302. LRRC45. |
neXtProti | NX_Q96CN5. |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000169683. |
PharmGKBi | PA142671505. |
Polymorphism and mutation databases
BioMutai | LRRC45. |
DMDMi | 74760765. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223923 | 1 – 670 | Leucine-rich repeat-containing protein 45Add BLAST | 670 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 661 | Phosphoserine; by NEK21 Publication | 1 |
Post-translational modificationi
Phosphorylated by NEK2 during misosis, phosphorylation reduces centrosomal localization which subsequently leads to centrosome separation.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96CN5. |
MaxQBi | Q96CN5. |
PaxDbi | Q96CN5. |
PeptideAtlasi | Q96CN5. |
PRIDEi | Q96CN5. |
PTM databases
iPTMneti | Q96CN5. |
PhosphoSitePlusi | Q96CN5. |
Expressioni
Gene expression databases
Bgeei | ENSG00000169683. |
CleanExi | HS_LRRC45. |
ExpressionAtlasi | Q96CN5. baseline and differential. |
Genevisiblei | Q96CN5. HS. |
Organism-specific databases
HPAi | HPA023372. HPA023382. HPA024768. |
Interactioni
Subunit structurei
Interacts with CROCC/rootletin and CEP250.1 Publication
Binary interactionsi
Protein-protein interaction databases
BioGridi | 128377. 9 interactors. |
DIPi | DIP-29482N. |
IntActi | Q96CN5. 16 interactors. |
MINTi | Q96CN5. |
STRINGi | 9606.ENSP00000306760. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 58 – 80 | LRR 1Add BLAST | 23 | |
Repeati | 87 – 107 | LRR 2Add BLAST | 21 | |
Repeati | 115 – 136 | LRR 3Add BLAST | 22 | |
Repeati | 145 – 166 | LRR 4Add BLAST | 22 | |
Repeati | 173 – 194 | LRR 5Add BLAST | 22 | |
Repeati | 201 – 212 | LRR 6Add BLAST | 12 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 252 – 645 | Sequence analysisAdd BLAST | 394 |
Keywords - Domaini
Coiled coil, Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG4308. Eukaryota. ENOG410ZBX3. LUCA. |
GeneTreei | ENSGT00730000111270. |
HOGENOMi | HOG000231243. |
HOVERGENi | HBG080193. |
InParanoidi | Q96CN5. |
OMAi | EQAMDHN. |
OrthoDBi | EOG091G05A7. |
PhylomeDBi | Q96CN5. |
TreeFami | TF330983. |
Family and domain databases
Gene3Di | 3.80.10.10. 2 hits. |
InterProi | View protein in InterPro IPR001611. Leu-rich_rpt. IPR032675. LRR_dom_sf. |
Pfami | View protein in Pfam PF13516. LRR_6. 3 hits. |
i Sequence
Sequence statusi: Complete.
Q96CN5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEFRRSYSR LCRESGAEPQ EAVLQQLHQL PRGRLDLATQ SLTVETCRAL
60 70 80 90 100
GKLLPRETLC TELVLSDCML SEEGATLLLR GLCANTVLRF LDLKGNNLRA
110 120 130 140 150
AGAEALGKLL QQNKSIQSLT LEWNSLGTWD DAFATFCGGL AANGALQRLD
160 170 180 190 200
LRNNQISHKG AEELALALKG NTTLQQLDLR WNNVGLLGGR ALMNCLPSNR
210 220 230 240 250
TLWRLDLAGN NIPGDVLRAV EQAMGHSQDR LTTFQENQAR THVLSKEVQH
260 270 280 290 300
LREEKSKQFL DLMETIDKQR EEMAKSSRAS AARVGQLQEA LNERHSIINA
310 320 330 340 350
LKAKLQMTEA ALALSEQKAQ DLGELLATAE QEQLSLSQRQ AKELKLEQQE
360 370 380 390 400
AAERESKLLR DLSAANEKNL LLQNQVDELE RKFRCQQEQL FQTRQEMTSM
410 420 430 440 450
SAELKMRAIQ AEERLDMEKR RCRQSLEDSE SLRIKEVEHM TRHLEESEKA
460 470 480 490 500
MQERVQRLEA ARLSLEEELS RVKAAALSER GQAEEELIKA KSQARLEEQQ
510 520 530 540 550
RLAHLEDKLR LLAQARDEAQ GACLQQKQVV AEAQTRVSQL GLQVEGLRRR
560 570 580 590 600
LEELQQELSL KDQERVAEVS RVRVELQEQN GRLQAELAAQ EALREKAAAL
610 620 630 640 650
ERQLKVMASD HREALLDRES ENASLREKLR LREAEIARIR DEEAQRASFL
660 670
QNAVLAYVQA SPVRTLSPPK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC014109 mRNA. Translation: AAH14109.1. |
CCDSi | CCDS11797.1. |
RefSeqi | NP_659436.1. NM_144999.3. |
UniGenei | Hs.143774. |
Genome annotation databases
Ensembli | ENST00000306688; ENSP00000306760; ENSG00000169683. |
GeneIDi | 201255. |
KEGGi | hsa:201255. |
UCSCi | uc002kde.4. human. |
Similar proteinsi
Entry informationi
Entry namei | LRC45_HUMAN | |
Accessioni | Q96CN5Primary (citable) accession number: Q96CN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |