LRRC45

Functionⁱ

Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.1 Publication

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucine-rich repeat-containing protein 45
Gene namesⁱ	Name:LRRC45
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28302. LRRC45.

HGNCⁱ

HGNC:28302. LRRC45.

Subcellular locationⁱ

Cytoplasm › cytoskeleton › microtubule organizing center › centrosome
1 Publication
Manual assertion based on experiment inⁱ
- Ref.2
  "LRRC45 is a centrosome linker component required for centrosome cohesion."
  He R., Huang N., Bao Y., Zhou H., Teng J., Chen J.
  Cell Rep. 4:1100-1107(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-661, INTERACTION WITH CROCC AND CEP250.

Note:

Localizes to the proteinaceous linker between the proximal ends of the centrioles.1 Publication

GO - Cellular componentⁱ

centrosome
Source: UniProtKB
Inferred from direct assayⁱ
- 21399614
cytosol Source: HPA
nucleoplasm Source: HPA
plasma membrane Source: HPA

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000169683.
PharmGKBⁱ	PA142671505.

Polymorphism and mutation databases

BioMutaⁱ	LRRC45.
DMDMⁱ	74760765.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000223923	1 – 670	Leucine-rich repeat-containing protein 45Add BLAST		670

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	661	Phosphoserine; by NEK21 Publication		1

Post-translational modificationⁱ

Phosphorylated by NEK2 during misosis, phosphorylation reduces centrosomal localization which subsequently leads to centrosome separation.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96CN5.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96CN5.
PaxDbⁱ	Q96CN5.
PeptideAtlas More...PeptideAtlasⁱ	Q96CN5.
PRIDEⁱ	Q96CN5.

PTM databases

iPTMnetⁱ	Q96CN5.
PhosphoSitePlusⁱ	Q96CN5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000169683.
CleanExⁱ	HS_LRRC45.
ExpressionAtlasⁱ	Q96CN5. baseline and differential.
Genevisibleⁱ	Q96CN5. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023372. HPA023382. HPA024768.

HPAⁱ

HPA023372.
HPA023382.
HPA024768.

Interactionⁱ

Subunit structureⁱ

Interacts with CROCC/rootletin and CEP250.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KXD1	Q9BQD3	3	EBI-2805176,EBI-739657

With

Entry

#Exp.

IntAct

Notes

KXD1

Q9BQD3

3

EBI-2805176,EBI-739657

Protein-protein interaction databases

BioGridⁱ	128377. 6 interactors.
Database of interacting proteins More...DIPⁱ	DIP-29482N.
IntActⁱ	Q96CN5. 15 interactors.
STRINGⁱ	9606.ENSP00000306760.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96CN5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	58 – 80	LRR 1Add BLAST	23
Repeatⁱ	87 – 107	LRR 2Add BLAST	21
Repeatⁱ	115 – 136	LRR 3Add BLAST	22
Repeatⁱ	145 – 166	LRR 4Add BLAST	22
Repeatⁱ	173 – 194	LRR 5Add BLAST	22
Repeatⁱ	201 – 212	LRR 6Add BLAST	12

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	252 – 645	Sequence analysisAdd BLAST		394

Keywords - Domainⁱ

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG4308. Eukaryota. ENOG410ZBX3. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111270.
HOGENOMⁱ	HOG000231243.
HOVERGENⁱ	HBG080193.
InParanoidⁱ	Q96CN5.
OMAⁱ	EQAMDHN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05A7.
PhylomeDBⁱ	Q96CN5.
TreeFamⁱ	TF330983.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001611. Leu-rich_rpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13516. LRR_6. 3 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96CN5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEEFRRSYSR LCRESGAEPQ EAVLQQLHQL PRGRLDLATQ SLTVETCRAL 
        60         70         80         90        100
GKLLPRETLC TELVLSDCML SEEGATLLLR GLCANTVLRF LDLKGNNLRA 
       110        120        130        140        150
AGAEALGKLL QQNKSIQSLT LEWNSLGTWD DAFATFCGGL AANGALQRLD 
       160        170        180        190        200
LRNNQISHKG AEELALALKG NTTLQQLDLR WNNVGLLGGR ALMNCLPSNR 
       210        220        230        240        250
TLWRLDLAGN NIPGDVLRAV EQAMGHSQDR LTTFQENQAR THVLSKEVQH 
       260        270        280        290        300
LREEKSKQFL DLMETIDKQR EEMAKSSRAS AARVGQLQEA LNERHSIINA 
       310        320        330        340        350
LKAKLQMTEA ALALSEQKAQ DLGELLATAE QEQLSLSQRQ AKELKLEQQE 
       360        370        380        390        400
AAERESKLLR DLSAANEKNL LLQNQVDELE RKFRCQQEQL FQTRQEMTSM 
       410        420        430        440        450
SAELKMRAIQ AEERLDMEKR RCRQSLEDSE SLRIKEVEHM TRHLEESEKA 
       460        470        480        490        500
MQERVQRLEA ARLSLEEELS RVKAAALSER GQAEEELIKA KSQARLEEQQ 
       510        520        530        540        550
RLAHLEDKLR LLAQARDEAQ GACLQQKQVV AEAQTRVSQL GLQVEGLRRR 
       560        570        580        590        600
LEELQQELSL KDQERVAEVS RVRVELQEQN GRLQAELAAQ EALREKAAAL 
       610        620        630        640        650
ERQLKVMASD HREALLDRES ENASLREKLR LREAEIARIR DEEAQRASFL 
       660        670
QNAVLAYVQA SPVRTLSPPK

Length:670

Mass (Da):75,951

Last modified:December 1, 2001 - v1

Checksum:ⁱ27F5D210721459FB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014109 mRNA. Translation: AAH14109.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11797.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_659436.1. NM_144999.3.
UniGeneⁱ	Hs.143774.

Genome annotation databases

Ensemblⁱ	ENST00000306688; ENSP00000306760; ENSG00000169683.
GeneIDⁱ	201255.
KEGGⁱ	hsa:201255.
UCSC genome browser More...UCSCⁱ	uc002kde.4. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014109 mRNA. Translation: AAH14109.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11797.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_659436.1. NM_144999.3.
UniGeneⁱ	Hs.143774.

3D structure databases

ProteinModelPortalⁱ	Q96CN5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128377. 6 interactors.
Database of interacting proteins More...DIPⁱ	DIP-29482N.
IntActⁱ	Q96CN5. 15 interactors.
STRINGⁱ	9606.ENSP00000306760.

PTM databases

iPTMnetⁱ	Q96CN5.
PhosphoSitePlusⁱ	Q96CN5.

Polymorphism and mutation databases

BioMutaⁱ	LRRC45.
DMDMⁱ	74760765.

Proteomic databases

EPDⁱ	Q96CN5.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96CN5.
PaxDbⁱ	Q96CN5.
PeptideAtlas More...PeptideAtlasⁱ	Q96CN5.
PRIDEⁱ	Q96CN5.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	201255.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000306688; ENSP00000306760; ENSG00000169683.
GeneIDⁱ	201255.
KEGGⁱ	hsa:201255.
UCSC genome browser More...UCSCⁱ	uc002kde.4. human.

Organism-specific databases

CTDⁱ	201255.
GeneCardsⁱ	LRRC45.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28302. LRRC45.
Human Protein Atlas More...HPAⁱ	HPA023372. HPA023382. HPA024768.
neXtProtⁱ	NX_Q96CN5.
Open Targets More...OpenTargetsⁱ	ENSG00000169683.
PharmGKBⁱ	PA142671505.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4308. Eukaryota. ENOG410ZBX3. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111270.
HOGENOMⁱ	HOG000231243.
HOVERGENⁱ	HBG080193.
InParanoidⁱ	Q96CN5.
OMAⁱ	EQAMDHN.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05A7.
PhylomeDBⁱ	Q96CN5.
TreeFamⁱ	TF330983.

Miscellaneous databases

ChiTaRSⁱ	LRRC45. human.
GenomeRNAiⁱ	201255.
Protein Ontology More...PROⁱ	PR:Q96CN5.

Gene expression databases

Bgeeⁱ	ENSG00000169683.
CleanExⁱ	HS_LRRC45.
ExpressionAtlasⁱ	Q96CN5. baseline and differential.
Genevisibleⁱ	Q96CN5. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001611. Leu-rich_rpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13516. LRR_6. 3 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRC45_HUMAN
Accessionⁱ	Q96CN5Primary (citable) accession number: Q96CN5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
	Last sequence update:	December 1, 2001
	Last modified:	April 12, 2017
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96CN5 (LRC45_HUMAN)

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Leucine-rich repeat-containing protein 45

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ