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Q96CN4

- EVI5L_HUMAN

UniProt

Q96CN4 - EVI5L_HUMAN

Protein

EVI5-like protein

Gene

EVI5L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Functions as a GTPase-activating protein (GAP) with a broad specificity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei156 – 1561Arginine fingerBy similarity
    Sitei197 – 1971Glutamine fingerBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. Rab GTPase activator activity Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EVI5-like protein
    Alternative name(s):
    Ecotropic viral integration site 5-like protein
    Gene namesi
    Name:EVI5L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30464. EVI5L.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134905968.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 794794EVI5-like proteinPRO_0000263097Add
    BLAST

    Proteomic databases

    MaxQBiQ96CN4.
    PaxDbiQ96CN4.
    PRIDEiQ96CN4.

    PTM databases

    PhosphoSiteiQ96CN4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96CN4.
    BgeeiQ96CN4.
    CleanExiHS_EVI5L.
    GenevestigatoriQ96CN4.

    Organism-specific databases

    HPAiHPA043099.

    Interactioni

    Subunit structurei

    May interact with RAB10.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NUDT18Q6ZVK83EBI-749523,EBI-740486

    Protein-protein interaction databases

    BioGridi125449. 5 interactions.
    IntActiQ96CN4. 2 interactions.
    STRINGi9606.ENSP00000270530.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96CN4.
    SMRiQ96CN4. Positions 78-371.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini115 – 300186Rab-GAP TBCPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili358 – 44992Sequence AnalysisAdd
    BLAST
    Coiled coili569 – 709141Sequence AnalysisAdd
    BLAST

    Domaini

    The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

    Sequence similaritiesi

    Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5210.
    HOGENOMiHOG000044859.
    HOVERGENiHBG081486.
    InParanoidiQ96CN4.
    OMAiQVNQMEL.
    OrthoDBiEOG7PS1DT.
    PhylomeDBiQ96CN4.
    TreeFamiTF317184.

    Family and domain databases

    InterProiIPR000195. Rab-GTPase-TBC_dom.
    [Graphical view]
    PfamiPF00566. RabGAP-TBC. 1 hit.
    [Graphical view]
    SMARTiSM00164. TBC. 1 hit.
    [Graphical view]
    SUPFAMiSSF47923. SSF47923. 2 hits.
    PROSITEiPS50086. TBC_RABGAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96CN4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASPTLSPDS SSQEALSAPT CSPTSDSENL SPDELELLAK LEEQNRLLEA    50
    DSKSMRSMNG SRRNSGSSLV SSSSASSNLS HLEEDTWILW GRIANEWEEW 100
    RRRKEKLLKE LIRKGIPHHF RAIVWQLLCS ATDMPVKNQY SELLKMSSPC 150
    EKLIRRDIAR TYPEHEFFKG QDSLGQEVLF NVMKAYSLVD REVGYCQGSA 200
    FIVGLLLMQM PEEEAFCVFV RLMQEYRLRE LFKPSMAELG LCIYQFEYML 250
    QEQLPDLNTH FRSQSFHTSM YASSWFLTLF LTTFPLPVAT RVFDIFMYEG 300
    LEIVFRVGLA LLQVNQAELM QLDMEGMSQY FQRVIPHQFD SCPDKLVLKA 350
    YQVKYNPKKM KRLEKEYAAM KSKEMEEQIE IKRLRTENRL LKQRIETLEK 400
    GQVTRAQEAE ENYVIKRELA VVRQQCSSAA EDLQKAQSTI RQLQEQQENP 450
    RLTEDFVSHL ETELEQSRLR ETETLGALRE MQDKVLDMEK RNSSLPDENN 500
    VAQLQEELKA LKVREGQAVA STRELKLQLQ ELSDTWQAHL ARGGRWKESP 550
    RKLVVGELQD ELMSVRLREA QALAEGRELR QRVVELETQD HIHRNLLNRV 600
    EAERAALQEK LQYLAAQNKG LQTQLSESRR KQAEAECKSK EEVMAVRLRE 650
    ADSMAAVAEM RQRIAELEIQ REEGRIQGQL NHSDSSQYIR ELKDQIEELK 700
    AEVRLLKGPP PFEDPLAFDG LSLARHLDED SLPSSDEELL GVGVGAALQD 750
    ALYPLSPRDA RFFRRLERPA KDSEGSSDSD ADELAAPYSQ GLDN 794
    Length:794
    Mass (Da):91,376
    Last modified:December 1, 2001 - v1
    Checksum:i598B06DD2F098664
    GO
    Isoform 2 (identifier: Q96CN4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         400-400: K → KESAALADRLIQ

    Note: No experimental confirmation available.

    Show »
    Length:805
    Mass (Da):92,544
    Checksum:i7A356B302C7CF2E8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei400 – 4001K → KESAALADRLIQ in isoform 2. 1 PublicationVSP_043456

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB449874 mRNA. Translation: BAH16617.1.
    AC008812 Genomic DNA. No translation available.
    AC010336 Genomic DNA. No translation available.
    BC014111 mRNA. Translation: AAH14111.1.
    CCDSiCCDS12188.1. [Q96CN4-1]
    CCDS54209.1. [Q96CN4-2]
    RefSeqiNP_001153416.1. NM_001159944.2. [Q96CN4-2]
    NP_660288.1. NM_145245.4. [Q96CN4-1]
    XP_005272515.1. XM_005272458.2. [Q96CN4-2]
    UniGeneiHs.26870.

    Genome annotation databases

    EnsembliENST00000270530; ENSP00000270530; ENSG00000142459. [Q96CN4-1]
    ENST00000538904; ENSP00000445905; ENSG00000142459. [Q96CN4-2]
    GeneIDi115704.
    KEGGihsa:115704.
    UCSCiuc002min.3. human. [Q96CN4-1]
    uc010xjz.2. human. [Q96CN4-2]

    Polymorphism databases

    DMDMi74731362.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB449874 mRNA. Translation: BAH16617.1 .
    AC008812 Genomic DNA. No translation available.
    AC010336 Genomic DNA. No translation available.
    BC014111 mRNA. Translation: AAH14111.1 .
    CCDSi CCDS12188.1. [Q96CN4-1 ]
    CCDS54209.1. [Q96CN4-2 ]
    RefSeqi NP_001153416.1. NM_001159944.2. [Q96CN4-2 ]
    NP_660288.1. NM_145245.4. [Q96CN4-1 ]
    XP_005272515.1. XM_005272458.2. [Q96CN4-2 ]
    UniGenei Hs.26870.

    3D structure databases

    ProteinModelPortali Q96CN4.
    SMRi Q96CN4. Positions 78-371.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125449. 5 interactions.
    IntActi Q96CN4. 2 interactions.
    STRINGi 9606.ENSP00000270530.

    PTM databases

    PhosphoSitei Q96CN4.

    Polymorphism databases

    DMDMi 74731362.

    Proteomic databases

    MaxQBi Q96CN4.
    PaxDbi Q96CN4.
    PRIDEi Q96CN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270530 ; ENSP00000270530 ; ENSG00000142459 . [Q96CN4-1 ]
    ENST00000538904 ; ENSP00000445905 ; ENSG00000142459 . [Q96CN4-2 ]
    GeneIDi 115704.
    KEGGi hsa:115704.
    UCSCi uc002min.3. human. [Q96CN4-1 ]
    uc010xjz.2. human. [Q96CN4-2 ]

    Organism-specific databases

    CTDi 115704.
    GeneCardsi GC19P007895.
    H-InvDB HIX0174422.
    HGNCi HGNC:30464. EVI5L.
    HPAi HPA043099.
    neXtProti NX_Q96CN4.
    PharmGKBi PA134905968.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5210.
    HOGENOMi HOG000044859.
    HOVERGENi HBG081486.
    InParanoidi Q96CN4.
    OMAi QVNQMEL.
    OrthoDBi EOG7PS1DT.
    PhylomeDBi Q96CN4.
    TreeFami TF317184.

    Miscellaneous databases

    ChiTaRSi EVI5L. human.
    GenomeRNAii 115704.
    NextBioi 79654.
    PROi Q96CN4.

    Gene expression databases

    ArrayExpressi Q96CN4.
    Bgeei Q96CN4.
    CleanExi HS_EVI5L.
    Genevestigatori Q96CN4.

    Family and domain databases

    InterProi IPR000195. Rab-GTPase-TBC_dom.
    [Graphical view ]
    Pfami PF00566. RabGAP-TBC. 1 hit.
    [Graphical view ]
    SMARTi SM00164. TBC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47923. SSF47923. 2 hits.
    PROSITEi PS50086. TBC_RABGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity."
      Ishibashi K., Kanno E., Itoh T., Fukuda M.
      Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    4. "Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity."
      Itoh T., Satoh M., Kanno E., Fukuda M.
      Genes Cells 11:1023-1037(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RAB10.

    Entry informationi

    Entry nameiEVI5L_HUMAN
    AccessioniPrimary (citable) accession number: Q96CN4
    Secondary accession number(s): B9A6I9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3