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Q96CN4

- EVI5L_HUMAN

UniProt

Q96CN4 - EVI5L_HUMAN

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Protein

EVI5-like protein

Gene

EVI5L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a GTPase-activating protein (GAP) with a broad specificity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561Arginine fingerBy similarity
Sitei197 – 1971Glutamine fingerBy similarity

GO - Molecular functioni

  1. Rab GTPase activator activity Source: UniProtKB
  2. Rab GTPase binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of cilium assembly Source: UniProtKB
  2. positive regulation of GTP catabolic process Source: UniProtKB
  3. positive regulation of Rab GTPase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
EVI5-like protein
Alternative name(s):
Ecotropic viral integration site 5-like protein
Gene namesi
Name:EVI5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:30464. EVI5L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905968.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 794794EVI5-like proteinPRO_0000263097Add
BLAST

Proteomic databases

MaxQBiQ96CN4.
PaxDbiQ96CN4.
PRIDEiQ96CN4.

PTM databases

PhosphoSiteiQ96CN4.

Expressioni

Gene expression databases

BgeeiQ96CN4.
CleanExiHS_EVI5L.
ExpressionAtlasiQ96CN4. baseline and differential.
GenevestigatoriQ96CN4.

Organism-specific databases

HPAiHPA043099.

Interactioni

Subunit structurei

May interact with RAB10.

Binary interactionsi

WithEntry#Exp.IntActNotes
NUDT18Q6ZVK83EBI-749523,EBI-740486

Protein-protein interaction databases

BioGridi125449. 8 interactions.
IntActiQ96CN4. 2 interactions.
STRINGi9606.ENSP00000270530.

Structurei

3D structure databases

ProteinModelPortaliQ96CN4.
SMRiQ96CN4. Positions 108-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 300186Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili358 – 44992Sequence AnalysisAdd
BLAST
Coiled coili569 – 709141Sequence AnalysisAdd
BLAST

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5210.
GeneTreeiENSGT00750000117238.
HOGENOMiHOG000044859.
HOVERGENiHBG081486.
InParanoidiQ96CN4.
OMAiQVNQMEL.
OrthoDBiEOG7PS1DT.
PhylomeDBiQ96CN4.
TreeFamiTF317184.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96CN4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPTLSPDS SSQEALSAPT CSPTSDSENL SPDELELLAK LEEQNRLLEA
60 70 80 90 100
DSKSMRSMNG SRRNSGSSLV SSSSASSNLS HLEEDTWILW GRIANEWEEW
110 120 130 140 150
RRRKEKLLKE LIRKGIPHHF RAIVWQLLCS ATDMPVKNQY SELLKMSSPC
160 170 180 190 200
EKLIRRDIAR TYPEHEFFKG QDSLGQEVLF NVMKAYSLVD REVGYCQGSA
210 220 230 240 250
FIVGLLLMQM PEEEAFCVFV RLMQEYRLRE LFKPSMAELG LCIYQFEYML
260 270 280 290 300
QEQLPDLNTH FRSQSFHTSM YASSWFLTLF LTTFPLPVAT RVFDIFMYEG
310 320 330 340 350
LEIVFRVGLA LLQVNQAELM QLDMEGMSQY FQRVIPHQFD SCPDKLVLKA
360 370 380 390 400
YQVKYNPKKM KRLEKEYAAM KSKEMEEQIE IKRLRTENRL LKQRIETLEK
410 420 430 440 450
GQVTRAQEAE ENYVIKRELA VVRQQCSSAA EDLQKAQSTI RQLQEQQENP
460 470 480 490 500
RLTEDFVSHL ETELEQSRLR ETETLGALRE MQDKVLDMEK RNSSLPDENN
510 520 530 540 550
VAQLQEELKA LKVREGQAVA STRELKLQLQ ELSDTWQAHL ARGGRWKESP
560 570 580 590 600
RKLVVGELQD ELMSVRLREA QALAEGRELR QRVVELETQD HIHRNLLNRV
610 620 630 640 650
EAERAALQEK LQYLAAQNKG LQTQLSESRR KQAEAECKSK EEVMAVRLRE
660 670 680 690 700
ADSMAAVAEM RQRIAELEIQ REEGRIQGQL NHSDSSQYIR ELKDQIEELK
710 720 730 740 750
AEVRLLKGPP PFEDPLAFDG LSLARHLDED SLPSSDEELL GVGVGAALQD
760 770 780 790
ALYPLSPRDA RFFRRLERPA KDSEGSSDSD ADELAAPYSQ GLDN
Length:794
Mass (Da):91,376
Last modified:December 1, 2001 - v1
Checksum:i598B06DD2F098664
GO
Isoform 2 (identifier: Q96CN4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-400: K → KESAALADRLIQ

Note: No experimental confirmation available.

Show »
Length:805
Mass (Da):92,544
Checksum:i7A356B302C7CF2E8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei400 – 4001K → KESAALADRLIQ in isoform 2. 1 PublicationVSP_043456

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB449874 mRNA. Translation: BAH16617.1.
AC008812 Genomic DNA. No translation available.
AC010336 Genomic DNA. No translation available.
BC014111 mRNA. Translation: AAH14111.1.
CCDSiCCDS12188.1. [Q96CN4-1]
CCDS54209.1. [Q96CN4-2]
RefSeqiNP_001153416.1. NM_001159944.2. [Q96CN4-2]
NP_660288.1. NM_145245.4. [Q96CN4-1]
XP_005272515.1. XM_005272458.2. [Q96CN4-2]
UniGeneiHs.26870.

Genome annotation databases

EnsembliENST00000270530; ENSP00000270530; ENSG00000142459. [Q96CN4-1]
ENST00000538904; ENSP00000445905; ENSG00000142459. [Q96CN4-2]
GeneIDi115704.
KEGGihsa:115704.
UCSCiuc002min.3. human. [Q96CN4-1]
uc010xjz.2. human. [Q96CN4-2]

Polymorphism databases

DMDMi74731362.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB449874 mRNA. Translation: BAH16617.1 .
AC008812 Genomic DNA. No translation available.
AC010336 Genomic DNA. No translation available.
BC014111 mRNA. Translation: AAH14111.1 .
CCDSi CCDS12188.1. [Q96CN4-1 ]
CCDS54209.1. [Q96CN4-2 ]
RefSeqi NP_001153416.1. NM_001159944.2. [Q96CN4-2 ]
NP_660288.1. NM_145245.4. [Q96CN4-1 ]
XP_005272515.1. XM_005272458.2. [Q96CN4-2 ]
UniGenei Hs.26870.

3D structure databases

ProteinModelPortali Q96CN4.
SMRi Q96CN4. Positions 108-371.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125449. 8 interactions.
IntActi Q96CN4. 2 interactions.
STRINGi 9606.ENSP00000270530.

PTM databases

PhosphoSitei Q96CN4.

Polymorphism databases

DMDMi 74731362.

Proteomic databases

MaxQBi Q96CN4.
PaxDbi Q96CN4.
PRIDEi Q96CN4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270530 ; ENSP00000270530 ; ENSG00000142459 . [Q96CN4-1 ]
ENST00000538904 ; ENSP00000445905 ; ENSG00000142459 . [Q96CN4-2 ]
GeneIDi 115704.
KEGGi hsa:115704.
UCSCi uc002min.3. human. [Q96CN4-1 ]
uc010xjz.2. human. [Q96CN4-2 ]

Organism-specific databases

CTDi 115704.
GeneCardsi GC19P007895.
H-InvDB HIX0174422.
HGNCi HGNC:30464. EVI5L.
HPAi HPA043099.
neXtProti NX_Q96CN4.
PharmGKBi PA134905968.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5210.
GeneTreei ENSGT00750000117238.
HOGENOMi HOG000044859.
HOVERGENi HBG081486.
InParanoidi Q96CN4.
OMAi QVNQMEL.
OrthoDBi EOG7PS1DT.
PhylomeDBi Q96CN4.
TreeFami TF317184.

Miscellaneous databases

ChiTaRSi EVI5L. human.
GenomeRNAii 115704.
NextBioi 79654.
PROi Q96CN4.

Gene expression databases

Bgeei Q96CN4.
CleanExi HS_EVI5L.
ExpressionAtlasi Q96CN4. baseline and differential.
Genevestigatori Q96CN4.

Family and domain databases

InterProi IPR000195. Rab-GTPase-TBC_dom.
[Graphical view ]
Pfami PF00566. RabGAP-TBC. 1 hit.
[Graphical view ]
SMARTi SM00164. TBC. 1 hit.
[Graphical view ]
SUPFAMi SSF47923. SSF47923. 2 hits.
PROSITEi PS50086. TBC_RABGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity."
    Ishibashi K., Kanno E., Itoh T., Fukuda M.
    Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  4. "Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity."
    Itoh T., Satoh M., Kanno E., Fukuda M.
    Genes Cells 11:1023-1037(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAB10.

Entry informationi

Entry nameiEVI5L_HUMAN
AccessioniPrimary (citable) accession number: Q96CN4
Secondary accession number(s): B9A6I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3