Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96CN4 (EVI5L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
EVI5-like protein
Alternative name(s):
Ecotropic viral integration site 5-like protein
Gene names
Name:EVI5L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length794 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as a GTPase-activating protein (GAP) with a broad specificity. Ref.4

Subunit structure

May interact with RAB10.

Domain

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site By similarity.

Sequence similarities

Contains 1 Rab-GAP TBC domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   Molecular functionGTPase activation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionRab GTPase activator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NUDT18Q6ZVK83EBI-749523,EBI-740486

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96CN4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96CN4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     400-400: K → KESAALADRLIQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 794794EVI5-like protein
PRO_0000263097

Regions

Domain115 – 300186Rab-GAP TBC
Coiled coil358 – 44992 Potential
Coiled coil569 – 709141 Potential

Sites

Site1561Arginine finger By similarity
Site1971Glutamine finger By similarity

Natural variations

Alternative sequence4001K → KESAALADRLIQ in isoform 2.
VSP_043456

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 598B06DD2F098664

FASTA79491,376
        10         20         30         40         50         60 
MASPTLSPDS SSQEALSAPT CSPTSDSENL SPDELELLAK LEEQNRLLEA DSKSMRSMNG 

        70         80         90        100        110        120 
SRRNSGSSLV SSSSASSNLS HLEEDTWILW GRIANEWEEW RRRKEKLLKE LIRKGIPHHF 

       130        140        150        160        170        180 
RAIVWQLLCS ATDMPVKNQY SELLKMSSPC EKLIRRDIAR TYPEHEFFKG QDSLGQEVLF 

       190        200        210        220        230        240 
NVMKAYSLVD REVGYCQGSA FIVGLLLMQM PEEEAFCVFV RLMQEYRLRE LFKPSMAELG 

       250        260        270        280        290        300 
LCIYQFEYML QEQLPDLNTH FRSQSFHTSM YASSWFLTLF LTTFPLPVAT RVFDIFMYEG 

       310        320        330        340        350        360 
LEIVFRVGLA LLQVNQAELM QLDMEGMSQY FQRVIPHQFD SCPDKLVLKA YQVKYNPKKM 

       370        380        390        400        410        420 
KRLEKEYAAM KSKEMEEQIE IKRLRTENRL LKQRIETLEK GQVTRAQEAE ENYVIKRELA 

       430        440        450        460        470        480 
VVRQQCSSAA EDLQKAQSTI RQLQEQQENP RLTEDFVSHL ETELEQSRLR ETETLGALRE 

       490        500        510        520        530        540 
MQDKVLDMEK RNSSLPDENN VAQLQEELKA LKVREGQAVA STRELKLQLQ ELSDTWQAHL 

       550        560        570        580        590        600 
ARGGRWKESP RKLVVGELQD ELMSVRLREA QALAEGRELR QRVVELETQD HIHRNLLNRV 

       610        620        630        640        650        660 
EAERAALQEK LQYLAAQNKG LQTQLSESRR KQAEAECKSK EEVMAVRLRE ADSMAAVAEM 

       670        680        690        700        710        720 
RQRIAELEIQ REEGRIQGQL NHSDSSQYIR ELKDQIEELK AEVRLLKGPP PFEDPLAFDG 

       730        740        750        760        770        780 
LSLARHLDED SLPSSDEELL GVGVGAALQD ALYPLSPRDA RFFRRLERPA KDSEGSSDSD 

       790 
ADELAAPYSQ GLDN 

« Hide

Isoform 2 [UniParc].

Checksum: 7A356B302C7CF2E8
Show »

FASTA80592,544

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity."
Ishibashi K., Kanno E., Itoh T., Fukuda M.
Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[4]"Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity."
Itoh T., Satoh M., Kanno E., Fukuda M.
Genes Cells 11:1023-1037(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RAB10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB449874 mRNA. Translation: BAH16617.1.
AC008812 Genomic DNA. No translation available.
AC010336 Genomic DNA. No translation available.
BC014111 mRNA. Translation: AAH14111.1.
RefSeqNP_001153416.1. NM_001159944.2.
NP_660288.1. NM_145245.4.
XP_005272515.1. XM_005272458.2.
UniGeneHs.26870.

3D structure databases

ProteinModelPortalQ96CN4.
SMRQ96CN4. Positions 88-371.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125449. 5 interactions.
IntActQ96CN4. 2 interactions.
STRING9606.ENSP00000270530.

PTM databases

PhosphoSiteQ96CN4.

Polymorphism databases

DMDM74731362.

Proteomic databases

PaxDbQ96CN4.
PRIDEQ96CN4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000270530; ENSP00000270530; ENSG00000142459. [Q96CN4-1]
ENST00000538904; ENSP00000445905; ENSG00000142459. [Q96CN4-2]
GeneID115704.
KEGGhsa:115704.
UCSCuc002min.3. human. [Q96CN4-1]
uc010xjz.2. human. [Q96CN4-2]

Organism-specific databases

CTD115704.
GeneCardsGC19P007895.
H-InvDBHIX0174422.
HGNCHGNC:30464. EVI5L.
HPAHPA043099.
neXtProtNX_Q96CN4.
PharmGKBPA134905968.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5210.
HOGENOMHOG000044859.
HOVERGENHBG081486.
InParanoidQ96CN4.
OMAQVNQMEL.
OrthoDBEOG7PS1DT.
PhylomeDBQ96CN4.
TreeFamTF317184.

Gene expression databases

ArrayExpressQ96CN4.
BgeeQ96CN4.
CleanExHS_EVI5L.
GenevestigatorQ96CN4.

Family and domain databases

InterProIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMSSF47923. SSF47923. 2 hits.
PROSITEPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSEVI5L. human.
GenomeRNAi115704.
NextBio79654.
PROQ96CN4.

Entry information

Entry nameEVI5L_HUMAN
AccessionPrimary (citable) accession number: Q96CN4
Secondary accession number(s): B9A6I9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM