Q96CN4 (EVI5L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
EVI5-like protein

Alternative name(s):
Ecotropic viral integration site 5-like protein

Gene names

Name:

EVI5L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	794 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as a GTPase-activating protein (GAP) with a broad specificity. Ref.4
Subunit structure	May interact with RAB10.
Sequence similarities	Contains 1 Rab-GAP TBC domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of Rab GTPase activity Inferred from electronic annotation. Source: GOC
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	Rab GTPase activator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NUDT18	Q6ZVK8	3	EBI-749523,EBI-740486

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96CN4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96CN4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     400-400: K → KESAALADRLIQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 794	794	EVI5-like protein		PRO_0000263097
Regions
	Domain	115 – 300	186	Rab-GAP TBC
	Coiled coil	358 – 449	92	Potential
	Coiled coil	569 – 709	141	Potential
Natural variations
	Alternative sequence	400	1	K → KESAALADRLIQ in isoform 2.		VSP_043456

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 598B06DD2F098664	FASTA	794	91,376
	10 20 30 40 50 60 MASPTLSPDS SSQEALSAPT CSPTSDSENL SPDELELLAK LEEQNRLLEA DSKSMRSMNG 70 80 90 100 110 120 SRRNSGSSLV SSSSASSNLS HLEEDTWILW GRIANEWEEW RRRKEKLLKE LIRKGIPHHF 130 140 150 160 170 180 RAIVWQLLCS ATDMPVKNQY SELLKMSSPC EKLIRRDIAR TYPEHEFFKG QDSLGQEVLF 190 200 210 220 230 240 NVMKAYSLVD REVGYCQGSA FIVGLLLMQM PEEEAFCVFV RLMQEYRLRE LFKPSMAELG 250 260 270 280 290 300 LCIYQFEYML QEQLPDLNTH FRSQSFHTSM YASSWFLTLF LTTFPLPVAT RVFDIFMYEG 310 320 330 340 350 360 LEIVFRVGLA LLQVNQAELM QLDMEGMSQY FQRVIPHQFD SCPDKLVLKA YQVKYNPKKM 370 380 390 400 410 420 KRLEKEYAAM KSKEMEEQIE IKRLRTENRL LKQRIETLEK GQVTRAQEAE ENYVIKRELA 430 440 450 460 470 480 VVRQQCSSAA EDLQKAQSTI RQLQEQQENP RLTEDFVSHL ETELEQSRLR ETETLGALRE 490 500 510 520 530 540 MQDKVLDMEK RNSSLPDENN VAQLQEELKA LKVREGQAVA STRELKLQLQ ELSDTWQAHL 550 560 570 580 590 600 ARGGRWKESP RKLVVGELQD ELMSVRLREA QALAEGRELR QRVVELETQD HIHRNLLNRV 610 620 630 640 650 660 EAERAALQEK LQYLAAQNKG LQTQLSESRR KQAEAECKSK EEVMAVRLRE ADSMAAVAEM 670 680 690 700 710 720 RQRIAELEIQ REEGRIQGQL NHSDSSQYIR ELKDQIEELK AEVRLLKGPP PFEDPLAFDG 730 740 750 760 770 780 LSLARHLDED SLPSSDEELL GVGVGAALQD ALYPLSPRDA RFFRRLERPA KDSEGSSDSD 790 ADELAAPYSQ GLDN
	Isoform 2 [UniParc]. Checksum: 7A356B302C7CF2E8	FASTA	805	92,544
	10 20 30 40 50 60 MASPTLSPDS SSQEALSAPT CSPTSDSENL SPDELELLAK LEEQNRLLEA DSKSMRSMNG 70 80 90 100 110 120 SRRNSGSSLV SSSSASSNLS HLEEDTWILW GRIANEWEEW RRRKEKLLKE LIRKGIPHHF 130 140 150 160 170 180 RAIVWQLLCS ATDMPVKNQY SELLKMSSPC EKLIRRDIAR TYPEHEFFKG QDSLGQEVLF 190 200 210 220 230 240 NVMKAYSLVD REVGYCQGSA FIVGLLLMQM PEEEAFCVFV RLMQEYRLRE LFKPSMAELG 250 260 270 280 290 300 LCIYQFEYML QEQLPDLNTH FRSQSFHTSM YASSWFLTLF LTTFPLPVAT RVFDIFMYEG 310 320 330 340 350 360 LEIVFRVGLA LLQVNQAELM QLDMEGMSQY FQRVIPHQFD SCPDKLVLKA YQVKYNPKKM 370 380 390 400 410 420 KRLEKEYAAM KSKEMEEQIE IKRLRTENRL LKQRIETLEK ESAALADRLI QGQVTRAQEA 430 440 450 460 470 480 EENYVIKREL AVVRQQCSSA AEDLQKAQST IRQLQEQQEN PRLTEDFVSH LETELEQSRL 490 500 510 520 530 540 RETETLGALR EMQDKVLDME KRNSSLPDEN NVAQLQEELK ALKVREGQAV ASTRELKLQL 550 560 570 580 590 600 QELSDTWQAH LARGGRWKES PRKLVVGELQ DELMSVRLRE AQALAEGREL RQRVVELETQ 610 620 630 640 650 660 DHIHRNLLNR VEAERAALQE KLQYLAAQNK GLQTQLSESR RKQAEAECKS KEEVMAVRLR 670 680 690 700 710 720 EADSMAAVAE MRQRIAELEI QREEGRIQGQ LNHSDSSQYI RELKDQIEEL KAEVRLLKGP 730 740 750 760 770 780 PPFEDPLAFD GLSLARHLDE DSLPSSDEEL LGVGVGAALQ DALYPLSPRD ARFFRRLERP 790 800 AKDSEGSSDS DADELAAPYS QGLDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity." Ishibashi K., Kanno E., Itoh T., Fukuda M. Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[4]	"Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity." Itoh T., Satoh M., Kanno E., Fukuda M. Genes Cells 11:1023-1037(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH RAB10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB449874 mRNA. Translation: BAH16617.1. AC008812 Genomic DNA. No translation available. AC010336 Genomic DNA. No translation available. BC014111 mRNA. Translation: AAH14111.1.
IPI	IPI00060473. IPI00930364.
RefSeq	NP_001153416.1. NM_001159944.1. NP_660288.1. NM_145245.3.
UniGene	Hs.26870.
3D structure databases
ProteinModelPortal	Q96CN4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96CN4. 1 interaction.
PTM databases
PhosphoSite	Q96CN4.
Polymorphism databases
DMDM	74731362.
Proteomic databases
PaxDb	Q96CN4.
PRIDE	Q96CN4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000270530; ENSP00000270530; ENSG00000142459. ENST00000538904; ENSP00000445905; ENSG00000142459.
GeneID	115704.
KEGG	hsa:115704.
UCSC	uc002min.3. human.
Organism-specific databases
CTD	115704.
GeneCards	GC19P007895.
H-InvDB	HIX0174422.
HGNC	HGNC:30464. EVI5L.
HPA	HPA043099.
neXtProt	NX_Q96CN4.
PharmGKB	PA134905968.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5210.
HOGENOM	HOG000044859.
HOVERGEN	HBG081486.
InParanoid	Q96CN4.
OMA	VNQMELM.
OrthoDB	EOG4548Z6.
PhylomeDB	Q96CN4.
Gene expression databases
Bgee	Q96CN4.
CleanEx	HS_EVI5L.
Genevestigator	Q96CN4.
GermOnline	ENSG00000142459. Homo sapiens.
Family and domain databases
InterPro	IPR000195. Rab-GTPase-TBC_dom. [Graphical view]
Pfam	PF00566. RabGAP-TBC. 1 hit. [Graphical view]
SMART	SM00164. TBC. 1 hit. [Graphical view]
SUPFAM	SSF47923. RabGAP_TBC. 2 hits.
PROSITE	PS50086. TBC_RABGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	EVI5L. human.
GenomeRNAi	115704.
NextBio	79654.

Entry information

Entry name

EVI5L_HUMAN

Accession

Primary (citable) accession number: Q96CN4
Secondary accession number(s): B9A6I9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.