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Protein

EVI5-like protein

Gene

EVI5L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a GTPase-activating protein (GAP) with a broad specificity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156Arginine fingerBy similarity1
Sitei197Glutamine fingerBy similarity1

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142459-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
EVI5-like protein
Alternative name(s):
Ecotropic viral integration site 5-like protein
Gene namesi
Name:EVI5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30464. EVI5L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142459.
PharmGKBiPA134905968.

Polymorphism and mutation databases

BioMutaiEVI5L.
DMDMi74731362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002630971 – 794EVI5-like proteinAdd BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei685PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96CN4.
MaxQBiQ96CN4.
PaxDbiQ96CN4.
PeptideAtlasiQ96CN4.
PRIDEiQ96CN4.

PTM databases

iPTMnetiQ96CN4.
PhosphoSitePlusiQ96CN4.

Expressioni

Gene expression databases

BgeeiENSG00000142459.
CleanExiHS_EVI5L.
ExpressionAtlasiQ96CN4. baseline and differential.
GenevisibleiQ96CN4. HS.

Organism-specific databases

HPAiHPA043099.
HPA043563.

Interactioni

Subunit structurei

May interact with RAB10.

Binary interactionsi

WithEntry#Exp.IntActNotes
NUDT18Q6ZVK83EBI-749523,EBI-740486

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi125449. 24 interactors.
IntActiQ96CN4. 17 interactors.
STRINGi9606.ENSP00000445905.

Structurei

3D structure databases

ProteinModelPortaliQ96CN4.
SMRiQ96CN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 300Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST186

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili358 – 449Sequence analysisAdd BLAST92
Coiled coili569 – 709Sequence analysisAdd BLAST141

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4436. Eukaryota.
ENOG410YWJY. LUCA.
GeneTreeiENSGT00750000117238.
HOGENOMiHOG000044859.
HOVERGENiHBG081486.
InParanoidiQ96CN4.
KOiK20242.
OMAiPELNVHF.
OrthoDBiEOG091G08YC.
PhylomeDBiQ96CN4.
TreeFamiTF317184.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPTLSPDS SSQEALSAPT CSPTSDSENL SPDELELLAK LEEQNRLLEA
60 70 80 90 100
DSKSMRSMNG SRRNSGSSLV SSSSASSNLS HLEEDTWILW GRIANEWEEW
110 120 130 140 150
RRRKEKLLKE LIRKGIPHHF RAIVWQLLCS ATDMPVKNQY SELLKMSSPC
160 170 180 190 200
EKLIRRDIAR TYPEHEFFKG QDSLGQEVLF NVMKAYSLVD REVGYCQGSA
210 220 230 240 250
FIVGLLLMQM PEEEAFCVFV RLMQEYRLRE LFKPSMAELG LCIYQFEYML
260 270 280 290 300
QEQLPDLNTH FRSQSFHTSM YASSWFLTLF LTTFPLPVAT RVFDIFMYEG
310 320 330 340 350
LEIVFRVGLA LLQVNQAELM QLDMEGMSQY FQRVIPHQFD SCPDKLVLKA
360 370 380 390 400
YQVKYNPKKM KRLEKEYAAM KSKEMEEQIE IKRLRTENRL LKQRIETLEK
410 420 430 440 450
GQVTRAQEAE ENYVIKRELA VVRQQCSSAA EDLQKAQSTI RQLQEQQENP
460 470 480 490 500
RLTEDFVSHL ETELEQSRLR ETETLGALRE MQDKVLDMEK RNSSLPDENN
510 520 530 540 550
VAQLQEELKA LKVREGQAVA STRELKLQLQ ELSDTWQAHL ARGGRWKESP
560 570 580 590 600
RKLVVGELQD ELMSVRLREA QALAEGRELR QRVVELETQD HIHRNLLNRV
610 620 630 640 650
EAERAALQEK LQYLAAQNKG LQTQLSESRR KQAEAECKSK EEVMAVRLRE
660 670 680 690 700
ADSMAAVAEM RQRIAELEIQ REEGRIQGQL NHSDSSQYIR ELKDQIEELK
710 720 730 740 750
AEVRLLKGPP PFEDPLAFDG LSLARHLDED SLPSSDEELL GVGVGAALQD
760 770 780 790
ALYPLSPRDA RFFRRLERPA KDSEGSSDSD ADELAAPYSQ GLDN
Length:794
Mass (Da):91,376
Last modified:December 1, 2001 - v1
Checksum:i598B06DD2F098664
GO
Isoform 2 (identifier: Q96CN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-400: K → KESAALADRLIQ

Note: No experimental confirmation available.
Show »
Length:805
Mass (Da):92,544
Checksum:i7A356B302C7CF2E8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043456400K → KESAALADRLIQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449874 mRNA. Translation: BAH16617.1.
AC008812 Genomic DNA. No translation available.
AC010336 Genomic DNA. No translation available.
BC014111 mRNA. Translation: AAH14111.1.
CCDSiCCDS12188.1. [Q96CN4-1]
CCDS54209.1. [Q96CN4-2]
RefSeqiNP_001153416.1. NM_001159944.2. [Q96CN4-2]
NP_660288.1. NM_145245.4. [Q96CN4-1]
XP_005272515.1. XM_005272458.4. [Q96CN4-2]
XP_016881728.1. XM_017026239.1. [Q96CN4-2]
UniGeneiHs.26870.

Genome annotation databases

EnsembliENST00000270530; ENSP00000270530; ENSG00000142459. [Q96CN4-1]
ENST00000538904; ENSP00000445905; ENSG00000142459. [Q96CN4-2]
GeneIDi115704.
KEGGihsa:115704.
UCSCiuc002min.4. human. [Q96CN4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449874 mRNA. Translation: BAH16617.1.
AC008812 Genomic DNA. No translation available.
AC010336 Genomic DNA. No translation available.
BC014111 mRNA. Translation: AAH14111.1.
CCDSiCCDS12188.1. [Q96CN4-1]
CCDS54209.1. [Q96CN4-2]
RefSeqiNP_001153416.1. NM_001159944.2. [Q96CN4-2]
NP_660288.1. NM_145245.4. [Q96CN4-1]
XP_005272515.1. XM_005272458.4. [Q96CN4-2]
XP_016881728.1. XM_017026239.1. [Q96CN4-2]
UniGeneiHs.26870.

3D structure databases

ProteinModelPortaliQ96CN4.
SMRiQ96CN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125449. 24 interactors.
IntActiQ96CN4. 17 interactors.
STRINGi9606.ENSP00000445905.

PTM databases

iPTMnetiQ96CN4.
PhosphoSitePlusiQ96CN4.

Polymorphism and mutation databases

BioMutaiEVI5L.
DMDMi74731362.

Proteomic databases

EPDiQ96CN4.
MaxQBiQ96CN4.
PaxDbiQ96CN4.
PeptideAtlasiQ96CN4.
PRIDEiQ96CN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270530; ENSP00000270530; ENSG00000142459. [Q96CN4-1]
ENST00000538904; ENSP00000445905; ENSG00000142459. [Q96CN4-2]
GeneIDi115704.
KEGGihsa:115704.
UCSCiuc002min.4. human. [Q96CN4-1]

Organism-specific databases

CTDi115704.
GeneCardsiEVI5L.
H-InvDBHIX0174422.
HGNCiHGNC:30464. EVI5L.
HPAiHPA043099.
HPA043563.
neXtProtiNX_Q96CN4.
OpenTargetsiENSG00000142459.
PharmGKBiPA134905968.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4436. Eukaryota.
ENOG410YWJY. LUCA.
GeneTreeiENSGT00750000117238.
HOGENOMiHOG000044859.
HOVERGENiHBG081486.
InParanoidiQ96CN4.
KOiK20242.
OMAiPELNVHF.
OrthoDBiEOG091G08YC.
PhylomeDBiQ96CN4.
TreeFamiTF317184.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142459-MONOMER.

Miscellaneous databases

GenomeRNAii115704.
PROiQ96CN4.

Gene expression databases

BgeeiENSG00000142459.
CleanExiHS_EVI5L.
ExpressionAtlasiQ96CN4. baseline and differential.
GenevisibleiQ96CN4. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEVI5L_HUMAN
AccessioniPrimary (citable) accession number: Q96CN4
Secondary accession number(s): B9A6I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.