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Protein

Acyl-CoA synthetase family member 2, mitochondrial

Gene

ACSF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei493ATPBy similarity1
Binding sitei508ATPBy similarity1
Binding sitei599ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi263 – 271ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-75105. Fatty Acyl-CoA Biosynthesis.

Chemistry databases

SwissLipidsiSLP:000001145.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA synthetase family member 2, mitochondrial (EC:6.2.1.-)
Gene namesi
Name:ACSF2
ORF Names:UNQ493/PRO1009
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26101. ACSF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167107.
PharmGKBiPA162375338.

Polymorphism and mutation databases

BioMutaiACSF2.
DMDMi166198367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
ChainiPRO_000031579342 – 615Acyl-CoA synthetase family member 2, mitochondrialAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei179N6-acetyllysineBy similarity1
Modified residuei182N6-acetyllysine; alternateBy similarity1
Modified residuei182N6-succinyllysine; alternateBy similarity1
Modified residuei340N6-acetyllysineBy similarity1
Modified residuei398N6-acetyllysineBy similarity1
Modified residuei478N6-succinyllysineBy similarity1
Modified residuei510N6-acetyllysineBy similarity1
Modified residuei544N6-acetyllysine; alternateBy similarity1
Modified residuei544N6-succinyllysine; alternateBy similarity1
Modified residuei570N6-acetyllysine; alternateBy similarity1
Modified residuei570N6-succinyllysine; alternateBy similarity1
Modified residuei599N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96CM8.
MaxQBiQ96CM8.
PaxDbiQ96CM8.
PeptideAtlasiQ96CM8.
PRIDEiQ96CM8.
TopDownProteomicsiQ96CM8-1. [Q96CM8-1]

PTM databases

iPTMnetiQ96CM8.
PhosphoSitePlusiQ96CM8.

Expressioni

Inductioni

By PPARG.1 Publication

Gene expression databases

BgeeiENSG00000167107.
CleanExiHS_ACSF2.
ExpressionAtlasiQ96CM8. baseline and differential.
GenevisibleiQ96CM8. HS.

Organism-specific databases

HPAiHPA024693.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-2876502,EBI-741181
ARL6IP1Q150414EBI-2876502,EBI-714543
CMTM5Q96DZ94EBI-2876502,EBI-2548702

Protein-protein interaction databases

BioGridi123187. 13 interactors.
IntActiQ96CM8. 6 interactors.
STRINGi9606.ENSP00000300441.

Structurei

3D structure databases

ProteinModelPortaliQ96CM8.
SMRiQ96CM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1177. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00760000119304.
HOGENOMiHOG000229999.
HOVERGENiHBG103408.
InParanoidiQ96CM8.
KOiK00666.
OMAiITQTRVD.
OrthoDBiEOG091G0XVH.
PhylomeDBiQ96CM8.
TreeFamiTF313466.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CM8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVYVGMLRL GRLCAGSSGV LGARAALSRS WQEARLQGVR FLSSREVDRM
60 70 80 90 100
VSTPIGGLSY VQGCTKKHLN SKTVGQCLET TAQRVPEREA LVVLHEDVRL
110 120 130 140 150
TFAQLKEEVD KAASGLLSIG LCKGDRLGMW GPNSYAWVLM QLATAQAGII
160 170 180 190 200
LVSVNPAYQA MELEYVLKKV GCKALVFPKQ FKTQQYYNVL KQICPEVENA
210 220 230 240 250
QPGALKSQRL PDLTTVISVD APLPGTLLLD EVVAAGSTRQ HLDQLQYNQQ
260 270 280 290 300
FLSCHDPINI QFTSGTTGSP KGATLSHYNI VNNSNILGER LKLHEKTPEQ
310 320 330 340 350
LRMILPNPLY HCLGSVAGTM MCLMYGATLI LASPIFNGKK ALEAISRERG
360 370 380 390 400
TFLYGTPTMF VDILNQPDFS SYDISTMCGG VIAGSPAPPE LIRAIINKIN
410 420 430 440 450
MKDLVVAYGT TENSPVTFAH FPEDTVEQKA ESVGRIMPHT EARIMNMEAG
460 470 480 490 500
TLAKLNTPGE LCIRGYCVML GYWGEPQKTE EAVDQDKWYW TGDVATMNEQ
510 520 530 540 550
GFCKIVGRSK DMIIRGGENI YPAELEDFFH THPKVQEVQV VGVKDDRMGE
560 570 580 590 600
EICACIRLKD GEETTVEEIK AFCKGKISHF KIPKYIVFVT NYPLTISGKI
610
QKFKLREQME RHLNL
Length:615
Mass (Da):68,125
Last modified:January 15, 2008 - v2
Checksum:iA3356EEA7C14730B
GO
Isoform 2 (identifier: Q96CM8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: S → SARGGMEAGRQRISVPSSFTASAAAH

Note: No experimental confirmation available.
Show »
Length:640
Mass (Da):70,623
Checksum:iDD1F4E5DEBDE9CE0
GO
Isoform 3 (identifier: Q96CM8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-158: Missing.

Note: No experimental confirmation available.
Show »
Length:602
Mass (Da):66,798
Checksum:iCF7D0940C1611AC2
GO
Isoform 4 (identifier: Q96CM8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-160: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):50,880
Checksum:i61FC83503081C5C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03830475G → V.1 PublicationCorresponds to variant rs17856448dbSNPEnsembl.1
Natural variantiVAR_038305316V → M.Corresponds to variant rs3744523dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558031 – 160Missing in isoform 4. 1 PublicationAdd BLAST160
Alternative sequenceiVSP_05580443S → SARGGMEAGRQRISVPSSFT ASAAAH in isoform 2. 1 Publication1
Alternative sequenceiVSP_055805146 – 158Missing in isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358660 mRNA. Translation: AAQ89023.1.
AK024573 mRNA. Translation: BAB14930.1.
AK294205 mRNA. Translation: BAG57517.1.
AK295258 mRNA. Translation: BAG58247.1.
AK300625 mRNA. Translation: BAG62317.1.
AC004707 Genomic DNA. No translation available.
AC021491 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94612.1.
BC012053 mRNA. Translation: AAH12053.1.
BC014123 mRNA. Translation: AAH14123.1.
CCDSiCCDS11567.1. [Q96CM8-1]
CCDS74103.1. [Q96CM8-2]
CCDS74104.1. [Q96CM8-3]
RefSeqiNP_001275897.1. NM_001288968.1. [Q96CM8-2]
NP_001275898.1. NM_001288969.1. [Q96CM8-3]
NP_001275899.1. NM_001288970.1.
NP_001275900.1. NM_001288971.1. [Q96CM8-4]
NP_001275901.1. NM_001288972.1. [Q96CM8-4]
NP_079425.3. NM_025149.5. [Q96CM8-1]
UniGeneiHs.288959.

Genome annotation databases

EnsembliENST00000300441; ENSP00000300441; ENSG00000167107. [Q96CM8-1]
ENST00000427954; ENSP00000401831; ENSG00000167107. [Q96CM8-2]
ENST00000502667; ENSP00000421884; ENSG00000167107. [Q96CM8-3]
GeneIDi80221.
KEGGihsa:80221.
UCSCiuc002iqu.4. human. [Q96CM8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358660 mRNA. Translation: AAQ89023.1.
AK024573 mRNA. Translation: BAB14930.1.
AK294205 mRNA. Translation: BAG57517.1.
AK295258 mRNA. Translation: BAG58247.1.
AK300625 mRNA. Translation: BAG62317.1.
AC004707 Genomic DNA. No translation available.
AC021491 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94612.1.
BC012053 mRNA. Translation: AAH12053.1.
BC014123 mRNA. Translation: AAH14123.1.
CCDSiCCDS11567.1. [Q96CM8-1]
CCDS74103.1. [Q96CM8-2]
CCDS74104.1. [Q96CM8-3]
RefSeqiNP_001275897.1. NM_001288968.1. [Q96CM8-2]
NP_001275898.1. NM_001288969.1. [Q96CM8-3]
NP_001275899.1. NM_001288970.1.
NP_001275900.1. NM_001288971.1. [Q96CM8-4]
NP_001275901.1. NM_001288972.1. [Q96CM8-4]
NP_079425.3. NM_025149.5. [Q96CM8-1]
UniGeneiHs.288959.

3D structure databases

ProteinModelPortaliQ96CM8.
SMRiQ96CM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123187. 13 interactors.
IntActiQ96CM8. 6 interactors.
STRINGi9606.ENSP00000300441.

Chemistry databases

SwissLipidsiSLP:000001145.

PTM databases

iPTMnetiQ96CM8.
PhosphoSitePlusiQ96CM8.

Polymorphism and mutation databases

BioMutaiACSF2.
DMDMi166198367.

Proteomic databases

EPDiQ96CM8.
MaxQBiQ96CM8.
PaxDbiQ96CM8.
PeptideAtlasiQ96CM8.
PRIDEiQ96CM8.
TopDownProteomicsiQ96CM8-1. [Q96CM8-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300441; ENSP00000300441; ENSG00000167107. [Q96CM8-1]
ENST00000427954; ENSP00000401831; ENSG00000167107. [Q96CM8-2]
ENST00000502667; ENSP00000421884; ENSG00000167107. [Q96CM8-3]
GeneIDi80221.
KEGGihsa:80221.
UCSCiuc002iqu.4. human. [Q96CM8-1]

Organism-specific databases

CTDi80221.
GeneCardsiACSF2.
HGNCiHGNC:26101. ACSF2.
HPAiHPA024693.
MIMi610465. gene.
neXtProtiNX_Q96CM8.
OpenTargetsiENSG00000167107.
PharmGKBiPA162375338.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1177. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00760000119304.
HOGENOMiHOG000229999.
HOVERGENiHBG103408.
InParanoidiQ96CM8.
KOiK00666.
OMAiITQTRVD.
OrthoDBiEOG091G0XVH.
PhylomeDBiQ96CM8.
TreeFamiTF313466.

Enzyme and pathway databases

ReactomeiR-HSA-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

ChiTaRSiACSF2. human.
GenomeRNAii80221.
PROiQ96CM8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167107.
CleanExiHS_ACSF2.
ExpressionAtlasiQ96CM8. baseline and differential.
GenevisibleiQ96CM8. HS.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACSF2_HUMAN
AccessioniPrimary (citable) accession number: Q96CM8
Secondary accession number(s): B4DFQ6
, B4DHT5, B4DUF5, Q9H7G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.