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Protein

Nucleoredoxin-like protein 1

Gene

NXNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoredoxin-like protein 1
Alternative name(s):
Thioredoxin-like protein 6
Gene namesi
Name:NXNL1
Synonyms:TXNL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25179. NXNL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398383.

Polymorphism and mutation databases

BioMutaiNXNL1.
DMDMi74731355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Nucleoredoxin-like protein 1PRO_0000319543Add
BLAST

Proteomic databases

PaxDbiQ96CM4.
PRIDEiQ96CM4.

PTM databases

iPTMnetiQ96CM4.
PhosphoSiteiQ96CM4.

Expressioni

Gene expression databases

BgeeiQ96CM4.
CleanExiHS_NXNL1.
GenevisibleiQ96CM4. HS.

Organism-specific databases

HPAiHPA042010.

Interactioni

Protein-protein interaction databases

BioGridi125460. 4 interactions.
IntActiQ96CM4. 4 interactions.
STRINGi9606.ENSP00000305631.

Structurei

3D structure databases

ProteinModelPortaliQ96CM4.
SMRiQ96CM4. Positions 33-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 164164ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi199 – 2035Poly-Gly

Sequence similaritiesi

Belongs to the nucleoredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2501. Eukaryota.
ENOG410ZIWC. LUCA.
GeneTreeiENSGT00530000063279.
HOGENOMiHOG000259431.
HOVERGENiHBG056831.
InParanoidiQ96CM4.
OMAiGPACFAN.
OrthoDBiEOG70W3G2.
PhylomeDBiQ96CM4.
TreeFamiTF331873.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR029520. RdCVF.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR13871:SF25. PTHR13871:SF25. 1 hit.
PfamiPF13905. Thioredoxin_8. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLFSGRIL IRNNSDQDEL DTEAEVSRRL ENRLVLLFFG AGACPQCQAF
60 70 80 90 100
VPILKDFFVR LTDEFYVLRA AQLALVYVSQ DSTEEQQDLF LKDMPKKWLF
110 120 130 140 150
LPFEDDLRRD LGRQFSVERL PAVVVLKPDG DVLTRDGADE IQRLGTACFA
160 170 180 190 200
NWQEAAEVLD RNFQLPEDLE DQEPRSLTEC LRRHKYRVEK AARGGRDPGG
210
GGGEEGGAGG LF
Length:212
Mass (Da):23,943
Last modified:December 1, 2001 - v1
Checksum:iD252BFEFAE90E44C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471106 Genomic DNA. Translation: EAW84608.1.
BC014127 mRNA. Translation: AAH14127.1.
DQ426894 mRNA. Translation: ABD90545.1.
CCDSiCCDS12360.1.
RefSeqiNP_612463.1. NM_138454.1.
UniGeneiHs.661836.

Genome annotation databases

EnsembliENST00000301944; ENSP00000305631; ENSG00000171773.
GeneIDi115861.
KEGGihsa:115861.
UCSCiuc002ngs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471106 Genomic DNA. Translation: EAW84608.1.
BC014127 mRNA. Translation: AAH14127.1.
DQ426894 mRNA. Translation: ABD90545.1.
CCDSiCCDS12360.1.
RefSeqiNP_612463.1. NM_138454.1.
UniGeneiHs.661836.

3D structure databases

ProteinModelPortaliQ96CM4.
SMRiQ96CM4. Positions 33-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125460. 4 interactions.
IntActiQ96CM4. 4 interactions.
STRINGi9606.ENSP00000305631.

PTM databases

iPTMnetiQ96CM4.
PhosphoSiteiQ96CM4.

Polymorphism and mutation databases

BioMutaiNXNL1.
DMDMi74731355.

Proteomic databases

PaxDbiQ96CM4.
PRIDEiQ96CM4.

Protocols and materials databases

DNASUi115861.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301944; ENSP00000305631; ENSG00000171773.
GeneIDi115861.
KEGGihsa:115861.
UCSCiuc002ngs.4. human.

Organism-specific databases

CTDi115861.
GeneCardsiNXNL1.
HGNCiHGNC:25179. NXNL1.
HPAiHPA042010.
MIMi608791. gene.
neXtProtiNX_Q96CM4.
PharmGKBiPA162398383.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2501. Eukaryota.
ENOG410ZIWC. LUCA.
GeneTreeiENSGT00530000063279.
HOGENOMiHOG000259431.
HOVERGENiHBG056831.
InParanoidiQ96CM4.
OMAiGPACFAN.
OrthoDBiEOG70W3G2.
PhylomeDBiQ96CM4.
TreeFamiTF331873.

Miscellaneous databases

GenomeRNAii115861.
PROiQ96CM4.
SOURCEiSearch...

Gene expression databases

BgeeiQ96CM4.
CleanExiHS_NXNL1.
GenevisibleiQ96CM4. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR029520. RdCVF.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR13871:SF25. PTHR13871:SF25. 1 hit.
PfamiPF13905. Thioredoxin_8. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "Mapping of transcription start sites of human retina expressed genes."
    Roni V., Carpio R., Wissinger B.
    BMC Genomics 8:42-42(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-19.
    Tissue: Retina.

Entry informationi

Entry nameiNXNL1_HUMAN
AccessioniPrimary (citable) accession number: Q96CM4
Secondary accession number(s): Q0QD37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.