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Protein

Zinc finger protein 653

Gene

ZNF653

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri467 – 49226C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri586 – 60924C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 653
Alternative name(s):
67 kDa zinc finger protein
Zinc finger protein Zip67
Gene namesi
Name:ZNF653
Synonyms:ZIP67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25196. ZNF653.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989597.

Polymorphism and mutation databases

BioMutaiZNF653.
DMDMi74760763.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615Zinc finger protein 653PRO_0000253344Add
BLAST

Proteomic databases

EPDiQ96CK0.
MaxQBiQ96CK0.
PaxDbiQ96CK0.
PRIDEiQ96CK0.

PTM databases

iPTMnetiQ96CK0.
PhosphoSiteiQ96CK0.

Expressioni

Tissue specificityi

Highly expressed in testis, cerebellum, temporal lobe, hippocampus and the adrenal gland. Moderately expressed in spleen, uterus, thymus, pancreas, kidney, stomach and rectum.

Gene expression databases

BgeeiQ96CK0.
CleanExiHS_ZNF653.
ExpressionAtlasiQ96CK0. baseline and differential.
GenevisibleiQ96CK0. HS.

Organism-specific databases

HPAiHPA023631.
HPA023635.

Interactioni

Subunit structurei

Interacts with NR5A1.1 Publication

Protein-protein interaction databases

BioGridi125464. 1 interaction.
STRINGi9606.ENSP00000293771.

Structurei

3D structure databases

ProteinModelPortaliQ96CK0.
SMRiQ96CK0. Positions 469-614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi107 – 11812Nuclear localization signalSequence analysisAdd
BLAST
Motifi445 – 4517Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi115 – 1184Poly-Arg
Compositional biasi195 – 20713Poly-SerAdd
BLAST
Compositional biasi218 – 2258Poly-Ala

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri467 – 49226C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri556 – 57823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri586 – 60924C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063153.
HOGENOMiHOG000155806.
HOVERGENiHBG082431.
InParanoidiQ96CK0.
OMAiEEVPCAM.
OrthoDBiEOG7SV0TZ.
PhylomeDBiQ96CK0.
TreeFamiTF332664.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERALEPEA EAEAEAGAGG EAAAEEGAAG RKARGRPRLT ESDRARRRLE
60 70 80 90 100
SRKKYDVRRV YLGEAHGPWV DLRRRSGWSD AKLAAYLISL ERGQRSGRHG
110 120 130 140 150
KPWEQVPKKP KRKKRRRRNV NCLKNVVIWY EDHKHRCPYE PHLAELDPTF
160 170 180 190 200
GLYTTAVWQC EAGHRYFQDL HSPLKPLSDS DPDSDKVGNG LVAGSSDSSS
210 220 230 240 250
SGSASDSEES PEGQPVKAAA AAAAATPTSP VGSSGLITQE GVHIPFDVHH
260 270 280 290 300
VESLAEQGTP LCSNPAGNGP EALETVVCVP VPVQVGAGPS ALFENVPQEA
310 320 330 340 350
LGEVVASCPM PGMVPGSQVI IIAGPGYDAL TAEGIHLNMA AGSGVPGSGL
360 370 380 390 400
GEEVPCAMME GVAAYTQTEP EGSQPSTMDA TAVAGIETKK EKEDLCLLKK
410 420 430 440 450
EEKEEPVAPE LATTVPESAE PEAEADGEEL DGSDMSAIIY EIPKEPEKRR
460 470 480 490 500
RSKRSRVMDA DGLLEMFHCP YEGCSQVYVA LSSFQNHVNL VHRKGKTKVC
510 520 530 540 550
PHPGCGKKFY LSNHLRRHMI IHSGVREFTC ETCGKSFKRK NHLEVHRRTH
560 570 580 590 600
TGETPLQCEI CGYQCRQRAS LNWHMKKHTA EVQYNFTCDR CGKRFEKLDS
610
VKFHTLKSHP DHKPT
Length:615
Mass (Da):67,235
Last modified:December 1, 2001 - v1
Checksum:i7208224CD9CDA311
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541K → R.1 Publication
Corresponds to variant rs17851437 [ dbSNP | Ensembl ].
VAR_028076
Natural varianti329 – 3291A → T.
Corresponds to variant rs35556595 [ dbSNP | Ensembl ].
VAR_057438

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072704 mRNA. Translation: AAL66763.1.
BC014187 mRNA. Translation: AAH14187.1.
BC016816 mRNA. Translation: AAH16816.1.
CCDSiCCDS12261.1.
RefSeqiNP_620138.2. NM_138783.3.
UniGeneiHs.465928.

Genome annotation databases

EnsembliENST00000293771; ENSP00000293771; ENSG00000161914.
GeneIDi115950.
KEGGihsa:115950.
UCSCiuc002mrz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072704 mRNA. Translation: AAL66763.1.
BC014187 mRNA. Translation: AAH14187.1.
BC016816 mRNA. Translation: AAH16816.1.
CCDSiCCDS12261.1.
RefSeqiNP_620138.2. NM_138783.3.
UniGeneiHs.465928.

3D structure databases

ProteinModelPortaliQ96CK0.
SMRiQ96CK0. Positions 469-614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125464. 1 interaction.
STRINGi9606.ENSP00000293771.

PTM databases

iPTMnetiQ96CK0.
PhosphoSiteiQ96CK0.

Polymorphism and mutation databases

BioMutaiZNF653.
DMDMi74760763.

Proteomic databases

EPDiQ96CK0.
MaxQBiQ96CK0.
PaxDbiQ96CK0.
PRIDEiQ96CK0.

Protocols and materials databases

DNASUi115950.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293771; ENSP00000293771; ENSG00000161914.
GeneIDi115950.
KEGGihsa:115950.
UCSCiuc002mrz.2. human.

Organism-specific databases

CTDi115950.
GeneCardsiZNF653.
HGNCiHGNC:25196. ZNF653.
HPAiHPA023631.
HPA023635.
MIMi611371. gene.
neXtProtiNX_Q96CK0.
PharmGKBiPA134989597.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063153.
HOGENOMiHOG000155806.
HOVERGENiHBG082431.
InParanoidiQ96CK0.
OMAiEEVPCAM.
OrthoDBiEOG7SV0TZ.
PhylomeDBiQ96CK0.
TreeFamiTF332664.

Miscellaneous databases

GenomeRNAii115950.
PROiQ96CK0.
SOURCEiSearch...

Gene expression databases

BgeeiQ96CK0.
CleanExiHS_ZNF653.
ExpressionAtlasiQ96CK0. baseline and differential.
GenevisibleiQ96CK0. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors."
    Borud B., Mellgren G., Lund J., Bakke M.
    Mol. Endocrinol. 17:2303-2319(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH NR5A1.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-54.
    Tissue: Brain and Eye.

Entry informationi

Entry nameiZN653_HUMAN
AccessioniPrimary (citable) accession number: Q96CK0
Secondary accession number(s): Q96AS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.