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Protein

Probable G-protein coupled receptor 146

Gene

GPR146

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164849-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 146
Alternative name(s):
G-protein coupled receptor PGR8
Gene namesi
Name:GPR146
Synonyms:PGR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21718. GPR146.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 65CytoplasmicSequence analysisAdd BLAST14
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 102ExtracellularSequence analysisAdd BLAST16
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 146CytoplasmicSequence analysisAdd BLAST23
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 189ExtracellularSequence analysisAdd BLAST22
Transmembranei190 – 210Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini211 – 233CytoplasmicSequence analysisAdd BLAST23
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 279ExtracellularSequence analysisAdd BLAST25
Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini301 – 333CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164849.
PharmGKBiPA134958088.

Polymorphism and mutation databases

BioMutaiGPR146.
DMDMi67461068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696221 – 333Probable G-protein coupled receptor 146Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96CH1.
PRIDEiQ96CH1.

PTM databases

iPTMnetiQ96CH1.
PhosphoSitePlusiQ96CH1.

Expressioni

Gene expression databases

BgeeiENSG00000164849.
CleanExiHS_GPR146.
ExpressionAtlasiQ96CH1. baseline and differential.
GenevisibleiQ96CH1. HS.

Structurei

3D structure databases

ProteinModelPortaliQ96CH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITRV. Eukaryota.
ENOG410YXU4. LUCA.
GeneTreeiENSGT00530000063910.
HOGENOMiHOG000233609.
HOVERGENiHBG062599.
InParanoidiQ96CH1.
KOiK08431.
OMAiTMPDVYF.
OrthoDBiEOG091G0HRG.
PhylomeDBiQ96CH1.
TreeFamiTF333506.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSCSWFNGT GLVEELPACQ DLQLGLSLLS LLGLVVGVPV GLCYNALLVL
60 70 80 90 100
ANLHSKASMT MPDVYFVNMA VAGLVLSALA PVHLLGPPSS RWALWSVGGE
110 120 130 140 150
VHVALQIPFN VSSLVAMYST ALLSLDHYIE RALPRTYMAS VYNTRHVCGF
160 170 180 190 200
VWGGALLTSF SSLLFYICSH VSTRALECAK MQNAEAADAT LVFIGYVVPA
210 220 230 240 250
LATLYALVLL SRVRREDTPL DRDTGRLEPS AHRLLVATVC TQFGLWTPHY
260 270 280 290 300
LILLGHTVII SRGKPVDAHY LGLLHFVKDF SKLLAFSSSF VTPLLYRYMN
310 320 330
QSFPSKLQRL MKKLPCGDRH CSPDHMGVQQ VLA
Length:333
Mass (Da):36,580
Last modified:December 1, 2001 - v1
Checksum:iBB8D6505A6C2D9F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014241 mRNA. Translation: AAH14241.1.
AY255535 mRNA. Translation: AAO85047.1.
CCDSiCCDS5321.1.
RefSeqiNP_001290402.1. NM_001303473.1.
NP_001290403.1. NM_001303474.1.
NP_612454.1. NM_138445.3.
XP_006715706.1. XM_006715643.2.
UniGeneiHs.585007.
Hs.718624.

Genome annotation databases

EnsembliENST00000397095; ENSP00000380283; ENSG00000164849.
GeneIDi115330.
KEGGihsa:115330.
UCSCiuc003sjx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014241 mRNA. Translation: AAH14241.1.
AY255535 mRNA. Translation: AAO85047.1.
CCDSiCCDS5321.1.
RefSeqiNP_001290402.1. NM_001303473.1.
NP_001290403.1. NM_001303474.1.
NP_612454.1. NM_138445.3.
XP_006715706.1. XM_006715643.2.
UniGeneiHs.585007.
Hs.718624.

3D structure databases

ProteinModelPortaliQ96CH1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96CH1.
PhosphoSitePlusiQ96CH1.

Polymorphism and mutation databases

BioMutaiGPR146.
DMDMi67461068.

Proteomic databases

PaxDbiQ96CH1.
PRIDEiQ96CH1.

Protocols and materials databases

DNASUi115330.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397095; ENSP00000380283; ENSG00000164849.
GeneIDi115330.
KEGGihsa:115330.
UCSCiuc003sjx.5. human.

Organism-specific databases

CTDi115330.
GeneCardsiGPR146.
HGNCiHGNC:21718. GPR146.
neXtProtiNX_Q96CH1.
OpenTargetsiENSG00000164849.
PharmGKBiPA134958088.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITRV. Eukaryota.
ENOG410YXU4. LUCA.
GeneTreeiENSGT00530000063910.
HOGENOMiHOG000233609.
HOVERGENiHBG062599.
InParanoidiQ96CH1.
KOiK08431.
OMAiTMPDVYF.
OrthoDBiEOG091G0HRG.
PhylomeDBiQ96CH1.
TreeFamiTF333506.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164849-MONOMER.

Miscellaneous databases

GeneWikiiGPR146.
GenomeRNAii115330.
PROiQ96CH1.

Gene expression databases

BgeeiENSG00000164849.
CleanExiHS_GPR146.
ExpressionAtlasiQ96CH1. baseline and differential.
GenevisibleiQ96CH1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP146_HUMAN
AccessioniPrimary (citable) accession number: Q96CH1
Secondary accession number(s): Q86SP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.