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Protein

Probable G-protein coupled receptor 146

Gene

GPR146

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 146
Alternative name(s):
G-protein coupled receptor PGR8
Gene namesi
Name:GPR146
Synonyms:PGR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21718. GPR146.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini52 – 6514CytoplasmicSequence analysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini87 – 10216ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini124 – 14623CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 18922ExtracellularSequence analysisAdd
BLAST
Transmembranei190 – 21021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini211 – 23323CytoplasmicSequence analysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini255 – 27925ExtracellularSequence analysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini301 – 33333CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958088.

Polymorphism and mutation databases

BioMutaiGPR146.
DMDMi67461068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Probable G-protein coupled receptor 146PRO_0000069622Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96CH1.
PRIDEiQ96CH1.

PTM databases

iPTMnetiQ96CH1.
PhosphoSiteiQ96CH1.

Expressioni

Gene expression databases

BgeeiQ96CH1.
CleanExiHS_GPR146.
ExpressionAtlasiQ96CH1. baseline and differential.
GenevisibleiQ96CH1. HS.

Structurei

3D structure databases

ProteinModelPortaliQ96CH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITRV. Eukaryota.
ENOG410YXU4. LUCA.
GeneTreeiENSGT00530000063910.
HOGENOMiHOG000233609.
HOVERGENiHBG062599.
InParanoidiQ96CH1.
KOiK08431.
OMAiTMPDVYF.
PhylomeDBiQ96CH1.
TreeFamiTF333506.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSCSWFNGT GLVEELPACQ DLQLGLSLLS LLGLVVGVPV GLCYNALLVL
60 70 80 90 100
ANLHSKASMT MPDVYFVNMA VAGLVLSALA PVHLLGPPSS RWALWSVGGE
110 120 130 140 150
VHVALQIPFN VSSLVAMYST ALLSLDHYIE RALPRTYMAS VYNTRHVCGF
160 170 180 190 200
VWGGALLTSF SSLLFYICSH VSTRALECAK MQNAEAADAT LVFIGYVVPA
210 220 230 240 250
LATLYALVLL SRVRREDTPL DRDTGRLEPS AHRLLVATVC TQFGLWTPHY
260 270 280 290 300
LILLGHTVII SRGKPVDAHY LGLLHFVKDF SKLLAFSSSF VTPLLYRYMN
310 320 330
QSFPSKLQRL MKKLPCGDRH CSPDHMGVQQ VLA
Length:333
Mass (Da):36,580
Last modified:December 1, 2001 - v1
Checksum:iBB8D6505A6C2D9F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014241 mRNA. Translation: AAH14241.1.
AY255535 mRNA. Translation: AAO85047.1.
CCDSiCCDS5321.1.
RefSeqiNP_001290402.1. NM_001303473.1.
NP_001290403.1. NM_001303474.1.
NP_612454.1. NM_138445.3.
XP_006715706.1. XM_006715643.1.
UniGeneiHs.585007.
Hs.718624.

Genome annotation databases

EnsembliENST00000297468; ENSP00000297468; ENSG00000164849.
ENST00000397095; ENSP00000380283; ENSG00000164849.
GeneIDi115330.
KEGGihsa:115330.
UCSCiuc003sjx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014241 mRNA. Translation: AAH14241.1.
AY255535 mRNA. Translation: AAO85047.1.
CCDSiCCDS5321.1.
RefSeqiNP_001290402.1. NM_001303473.1.
NP_001290403.1. NM_001303474.1.
NP_612454.1. NM_138445.3.
XP_006715706.1. XM_006715643.1.
UniGeneiHs.585007.
Hs.718624.

3D structure databases

ProteinModelPortaliQ96CH1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96CH1.
PhosphoSiteiQ96CH1.

Polymorphism and mutation databases

BioMutaiGPR146.
DMDMi67461068.

Proteomic databases

PaxDbiQ96CH1.
PRIDEiQ96CH1.

Protocols and materials databases

DNASUi115330.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297468; ENSP00000297468; ENSG00000164849.
ENST00000397095; ENSP00000380283; ENSG00000164849.
GeneIDi115330.
KEGGihsa:115330.
UCSCiuc003sjx.5. human.

Organism-specific databases

CTDi115330.
GeneCardsiGPR146.
HGNCiHGNC:21718. GPR146.
neXtProtiNX_Q96CH1.
PharmGKBiPA134958088.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITRV. Eukaryota.
ENOG410YXU4. LUCA.
GeneTreeiENSGT00530000063910.
HOGENOMiHOG000233609.
HOVERGENiHBG062599.
InParanoidiQ96CH1.
KOiK08431.
OMAiTMPDVYF.
PhylomeDBiQ96CH1.
TreeFamiTF333506.

Miscellaneous databases

GeneWikiiGPR146.
GenomeRNAii115330.
PROiQ96CH1.

Gene expression databases

BgeeiQ96CH1.
CleanExiHS_GPR146.
ExpressionAtlasiQ96CH1. baseline and differential.
GenevisibleiQ96CH1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-210.

Entry informationi

Entry nameiGP146_HUMAN
AccessioniPrimary (citable) accession number: Q96CH1
Secondary accession number(s): Q86SP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.