Q96CH1 (GP146_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 146

Alternative name(s):
G-protein coupled receptor PGR8

Gene names

Name:	GPR146
Synonyms:	PGR8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Probable G-protein coupled receptor 146		PRO_0000069622
Regions
	Topological domain	1 – 30	30	Extracellular Potential
	Transmembrane	31 – 51	21	Helical; Name=1; Potential
	Topological domain	52 – 65	14	Cytoplasmic Potential
	Transmembrane	66 – 86	21	Helical; Name=2; Potential
	Topological domain	87 – 102	16	Extracellular Potential
	Transmembrane	103 – 123	21	Helical; Name=3; Potential
	Topological domain	124 – 146	23	Cytoplasmic Potential
	Transmembrane	147 – 167	21	Helical; Name=4; Potential
	Topological domain	168 – 189	22	Extracellular Potential
	Transmembrane	190 – 210	21	Helical; Name=5; Potential
	Topological domain	211 – 233	23	Cytoplasmic Potential
	Transmembrane	234 – 254	21	Helical; Name=6; Potential
	Topological domain	255 – 279	25	Extracellular Potential
	Transmembrane	280 – 300	21	Helical; Name=7; Potential
	Topological domain	301 – 333	33	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q96CH1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: BB8D6505A6C2D9F4	FASTA	333	36,580
	10 20 30 40 50 60 MWSCSWFNGT GLVEELPACQ DLQLGLSLLS LLGLVVGVPV GLCYNALLVL ANLHSKASMT 70 80 90 100 110 120 MPDVYFVNMA VAGLVLSALA PVHLLGPPSS RWALWSVGGE VHVALQIPFN VSSLVAMYST 130 140 150 160 170 180 ALLSLDHYIE RALPRTYMAS VYNTRHVCGF VWGGALLTSF SSLLFYICSH VSTRALECAK 190 200 210 220 230 240 MQNAEAADAT LVFIGYVVPA LATLYALVLL SRVRREDTPL DRDTGRLEPS AHRLLVATVC 250 260 270 280 290 300 TQFGLWTPHY LILLGHTVII SRGKPVDAHY LGLLHFVKDF SKLLAFSSSF VTPLLYRYMN 310 320 330 QSFPSKLQRL MKKLPCGDRH CSPDHMGVQQ VLA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[2]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-210.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC014241 mRNA. Translation: AAH14241.1. AY255535 mRNA. Translation: AAO85047.1.
IPI	IPI00060424.
RefSeq	NP_612454.1. NM_138445.2.
UniGene	Hs.585007. Hs.718624.
3D structure databases
ProteinModelPortal	Q96CH1.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q96CH1.
Polymorphism databases
DMDM	67461068.
Proteomic databases
PRIDE	Q96CH1.
Protocols and materials databases
DNASU	115330.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297468; ENSP00000297468; ENSG00000164849. ENST00000397095; ENSP00000380283; ENSG00000164849.
GeneID	115330.
KEGG	hsa:115330.
UCSC	uc003sjx.4. human.
Organism-specific databases
CTD	115330.
GeneCards	GC07P001084.
HGNC	HGNC:21718. GPR146.
neXtProt	NX_Q96CH1.
PharmGKB	PA134958088.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46917.
HOGENOM	HOG000233609.
HOVERGEN	HBG062599.
InParanoid	Q96CH1.
KO	K08431.
OMA	MPDVYFV.
PhylomeDB	Q96CH1.
Gene expression databases
ArrayExpress	Q96CH1.
Bgee	Q96CH1.
CleanEx	HS_GPR146.
Genevestigator	Q96CH1.
GermOnline	ENSG00000164849. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	115330.
NextBio	79566.

Entry information

Entry name

GP146_HUMAN

Accession

Primary (citable) accession number: Q96CH1
Secondary accession number(s): Q86SP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.