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Protein

Transmembrane 4 L6 family member 18

Gene

TM4SF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi8.A.75.1.2. the transmembrane 4 superfamily 4 (tm4sf4) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 18
Gene namesi
Name:TM4SF18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25181. TM4SF18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Topological domaini31 – 4919ExtracellularSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Topological domaini71 – 9323CytoplasmicSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 15743ExtracellularSequence analysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Topological domaini179 – 20123CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670801.

Polymorphism and mutation databases

BioMutaiTM4SF18.
DMDMi68053312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Transmembrane 4 L6 family member 18PRO_0000219304Add
BLAST

Proteomic databases

EPDiQ96CE8.
PaxDbiQ96CE8.
PeptideAtlasiQ96CE8.
PRIDEiQ96CE8.

PTM databases

iPTMnetiQ96CE8.
PhosphoSiteiQ96CE8.

Expressioni

Gene expression databases

BgeeiENSG00000163762.
CleanExiHS_TM4SF18.
ExpressionAtlasiQ96CE8. baseline and differential.
GenevisibleiQ96CE8. HS.

Organism-specific databases

HPAiHPA053639.

Interactioni

Protein-protein interaction databases

BioGridi125506. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96CE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IN9K. Eukaryota.
ENOG41116VU. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ96CE8.
OMAiCFSGVMM.
OrthoDBiEOG091G0NDS.
PhylomeDBiQ96CE8.
TreeFamiTF331371.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRKCGGCL SCLLIPLALW SIIVNILLYF PNGQTSYASS NKLTNYVWYF
60 70 80 90 100
EGICFSGIMM LIVTTVLLVL ENNNNYKCCQ SENCSKKYVT LLSIIFSSLG
110 120 130 140 150
IAFSGYCLVI SALGLVQGPY CRTLDGWEYA FEGTAGRFLT DSSIWIQCLE
160 170 180 190 200
PAHVVEWNII LFSILITLSG LQVIICLIRV VMQLSKILCG SYSVIFQPGI

I
Length:201
Mass (Da):22,277
Last modified:December 1, 2001 - v1
Checksum:iA49E70402164D336
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313400 mRNA. Translation: BAG36197.1.
CH471052 Genomic DNA. Translation: EAW78877.1.
CH471052 Genomic DNA. Translation: EAW78878.1.
CH471052 Genomic DNA. Translation: EAW78879.1.
BC014339 mRNA. Translation: AAH14339.1.
CCDSiCCDS3142.1.
RefSeqiNP_001171652.1. NM_001184723.1.
NP_620141.1. NM_138786.3.
UniGeneiHs.22026.

Genome annotation databases

EnsembliENST00000296059; ENSP00000296059; ENSG00000163762.
ENST00000470080; ENSP00000419278; ENSG00000163762.
GeneIDi116441.
KEGGihsa:116441.
UCSCiuc003exa.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313400 mRNA. Translation: BAG36197.1.
CH471052 Genomic DNA. Translation: EAW78877.1.
CH471052 Genomic DNA. Translation: EAW78878.1.
CH471052 Genomic DNA. Translation: EAW78879.1.
BC014339 mRNA. Translation: AAH14339.1.
CCDSiCCDS3142.1.
RefSeqiNP_001171652.1. NM_001184723.1.
NP_620141.1. NM_138786.3.
UniGeneiHs.22026.

3D structure databases

ProteinModelPortaliQ96CE8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125506. 6 interactions.

Protein family/group databases

TCDBi8.A.75.1.2. the transmembrane 4 superfamily 4 (tm4sf4) family.

PTM databases

iPTMnetiQ96CE8.
PhosphoSiteiQ96CE8.

Polymorphism and mutation databases

BioMutaiTM4SF18.
DMDMi68053312.

Proteomic databases

EPDiQ96CE8.
PaxDbiQ96CE8.
PeptideAtlasiQ96CE8.
PRIDEiQ96CE8.

Protocols and materials databases

DNASUi116441.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296059; ENSP00000296059; ENSG00000163762.
ENST00000470080; ENSP00000419278; ENSG00000163762.
GeneIDi116441.
KEGGihsa:116441.
UCSCiuc003exa.3. human.

Organism-specific databases

CTDi116441.
GeneCardsiTM4SF18.
HGNCiHGNC:25181. TM4SF18.
HPAiHPA053639.
neXtProtiNX_Q96CE8.
PharmGKBiPA142670801.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN9K. Eukaryota.
ENOG41116VU. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ96CE8.
OMAiCFSGVMM.
OrthoDBiEOG091G0NDS.
PhylomeDBiQ96CE8.
TreeFamiTF331371.

Miscellaneous databases

GenomeRNAii116441.
PROiQ96CE8.

Gene expression databases

BgeeiENSG00000163762.
CleanExiHS_TM4SF18.
ExpressionAtlasiQ96CE8. baseline and differential.
GenevisibleiQ96CE8. HS.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT4S18_HUMAN
AccessioniPrimary (citable) accession number: Q96CE8
Secondary accession number(s): B2R8K0, D3DNH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.