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Q96CD2 (COAC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphopantothenoylcysteine decarboxylase

Short name=PPC-DC
EC=4.1.1.36
Alternative name(s):
CoaC
Gene names
Name:PPCDC
Synonyms:COAC
ORF Names:MDS018, UNQ9365/PRO34154
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine. Ref.6 Ref.7

Catalytic activity

N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.

Cofactor

Binds 1 FMN per subunit.

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.

Subunit structure

Homotrimer Potential.

Sequence similarities

Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96CD2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96CD2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MEPKASCPAA...LYSDADEWEI → M
Note: The Met-1 codon is associated with a polymorphism (dbSNP:rs2304899) that replaces the initiation ATG codon by an ATA codon.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Phosphopantothenoylcysteine decarboxylase
PRO_0000182030

Regions

Nucleotide binding104 – 1074FMN

Sites

Active site1731Proton donor
Binding site591FMN
Binding site1401Substrate By similarity

Natural variations

Alternative sequence1 – 7878MEPKA…DEWEI → M in isoform 2.
VSP_044802
Natural variant781I → M.
Corresponds to variant rs2304899 [ dbSNP | Ensembl ].
VAR_068974

Experimental info

Sequence conflict491A → S in BAB55151. Ref.3

Secondary structure

............................... 204
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 9E59683480032894

FASTA20422,395
        10         20         30         40         50         60 
MEPKASCPAA APLMERKFHV LVGVTGSVAA LKLPLLVSKL LDIPGLEVAV VTTERAKHFY 

        70         80         90        100        110        120 
SPQDIPVTLY SDADEWEIWK SRSDPVLHID LRRWADLLLV APLDANTLGK VASGICDNLL 

       130        140        150        160        170        180 
TCVMRAWDRS KPLLFCPAMN TAMWEHPITA QQVDQLKAFG YVEIPCVAKK LVCGDEGLGA 

       190        200 
MAEVGTIVDK VKEVLFQHSG FQQS 

« Hide

Isoform 2 [UniParc].

Checksum: 562D659DE77C0AF5
Show »

FASTA12714,069

References

« Hide 'large scale' references
[1]"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Hematopoietic stem cell.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[6]"Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics."
Daugherty M., Polanuyer B., Farrell M., Scholle M., Lykidis A., de Crecy-Lagard V., Osterman A.
J. Biol. Chem. 277:21431-21439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, FUNCTION.
[7]"Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent."
Strauss E., Zhai H., Brand L.A., McLafferty F.W., Begley T.P.
Biochemistry 43:15520-15533(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY.
[8]"Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase."
Manoj N., Ealick S.E.
Acta Crystallogr. D 59:1762-1766(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS) IN COMPLEX WITH FMN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF182419 mRNA. Translation: AAG14955.1.
AY358848 mRNA. Translation: AAQ89207.1.
AK027491 mRNA. Translation: BAB55151.1.
AC015720 Genomic DNA. No translation available.
BC014409 mRNA. Translation: AAH14409.1.
CCDSCCDS10275.1. [Q96CD2-1]
RefSeqNP_068595.3. NM_021823.3. [Q96CD2-1]
UniGeneHs.458922.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QZUX-ray2.91A/B/C/D1-204[»]
ProteinModelPortalQ96CD2.
SMRQ96CD2. Positions 14-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ96CD2. 4 interactions.
MINTMINT-1394867.
STRING9606.ENSP00000343190.

PTM databases

PhosphoSiteQ96CD2.

Polymorphism databases

DMDM296434457.

Proteomic databases

MaxQBQ96CD2.
PaxDbQ96CD2.
PRIDEQ96CD2.

Protocols and materials databases

DNASU60490.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342932; ENSP00000343190; ENSG00000138621. [Q96CD2-1]
GeneID60490.
KEGGhsa:60490.
UCSCuc002azo.3. human. [Q96CD2-1]

Organism-specific databases

CTD60490.
GeneCardsGC15P075315.
H-InvDBHIX0202140.
HGNCHGNC:28107. PPCDC.
HPAHPA045667.
MIM609854. gene.
neXtProtNX_Q96CD2.
PharmGKBPA142671157.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0452.
HOGENOMHOG000187629.
HOVERGENHBG054722.
InParanoidQ96CD2.
KOK01598.
OMAFCENANV.
OrthoDBEOG738062.
PhylomeDBQ96CD2.
TreeFamTF315740.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.
SABIO-RKQ96CD2.
UniPathwayUPA00241; UER00354.

Gene expression databases

ArrayExpressQ96CD2.
BgeeQ96CD2.
CleanExHS_PPCDC.
GenevestigatorQ96CD2.

Family and domain databases

Gene3D3.40.50.1950. 1 hit.
InterProIPR003382. Flavoprotein.
[Graphical view]
PfamPF02441. Flavoprotein. 1 hit.
[Graphical view]
SUPFAMSSF52507. SSF52507. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ96CD2.
GenomeRNAi60490.
NextBio65379.
PROQ96CD2.
SOURCESearch...

Entry information

Entry nameCOAC_HUMAN
AccessionPrimary (citable) accession number: Q96CD2
Secondary accession number(s): Q96SX0, Q9HC17
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM