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Protein

Phosphopantothenoylcysteine decarboxylase

Gene

PPCDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.2 Publications

Catalytic activityi

N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.

Cofactori

FMNNote: Binds 1 FMN per subunit.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase 4 (PANK4), Pantothenate kinase 3 (PANK3), Pantothenate kinase 4, Pantothenate kinase 1 (PANK1), Pantothenate kinase 2, mitochondrial (PANK2), Pantothenate kinase 4 (PANK4), Pantothenate kinase 4
  2. Phosphopantothenate--cysteine ligase (PPCS)
  3. Phosphopantothenoylcysteine decarboxylase (PPCDC)
  4. Bifunctional coenzyme A synthase (COASY)
  5. Bifunctional coenzyme A synthase (COASY)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59FMN1 Publication1
Binding sitei140SubstrateBy similarity1
Active sitei173Proton donor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 107FMN1 Publication4

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • phosphopantothenoylcysteine decarboxylase activity Source: UniProtKB

GO - Biological processi

  • coenzyme A biosynthetic process Source: UniProtKB
  • coenzyme biosynthetic process Source: Reactome

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCoenzyme A biosynthesis
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciMetaCyc:HS13735-MONOMER
ReactomeiR-HSA-196783 Coenzyme A biosynthesis
SABIO-RKiQ96CD2
UniPathwayiUPA00241; UER00354

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantothenoylcysteine decarboxylase (EC:4.1.1.36)
Short name:
PPC-DC
Alternative name(s):
CoaC
Gene namesi
Name:PPCDC
Synonyms:COAC
ORF Names:MDS018, UNQ9365/PRO34154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138621.11
HGNCiHGNC:28107 PPCDC
MIMi609854 gene
neXtProtiNX_Q96CD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi60490
OpenTargetsiENSG00000138621
PharmGKBiPA142671157

Chemistry databases

DrugBankiDB03738 Pantothenoylaminoethenethiol
DB03247 Riboflavin Monophosphate

Polymorphism and mutation databases

BioMutaiPPCDC
DMDMi296434457

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001820301 – 204Phosphopantothenoylcysteine decarboxylaseAdd BLAST204

Proteomic databases

EPDiQ96CD2
MaxQBiQ96CD2
PaxDbiQ96CD2
PeptideAtlasiQ96CD2
PRIDEiQ96CD2

PTM databases

iPTMnetiQ96CD2
PhosphoSitePlusiQ96CD2

Expressioni

Gene expression databases

BgeeiENSG00000138621
CleanExiHS_PPCDC
ExpressionAtlasiQ96CD2 baseline and differential
GenevisibleiQ96CD2 HS

Organism-specific databases

HPAiHPA045667

Interactioni

Subunit structurei

Homotrimer.Curated

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi121921, 8 interactors
IntActiQ96CD2, 14 interactors
MINTiQ96CD2
STRINGi9606.ENSP00000343190

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi16 – 24Combined sources9
Helixi28 – 31Combined sources4
Helixi33 – 40Combined sources8
Beta strandi46 – 52Combined sources7
Helixi55 – 58Combined sources4
Helixi62 – 64Combined sources3
Helixi72 – 77Combined sources6
Helixi87 – 92Combined sources6
Beta strandi96 – 103Combined sources8
Helixi105 – 112Combined sources8
Helixi119 – 125Combined sources7
Beta strandi135 – 137Combined sources3
Helixi141 – 144Combined sources4
Helixi149 – 157Combined sources9
Helixi186 – 191Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QZUX-ray2.91A/B/C/D1-204[»]
ProteinModelPortaliQ96CD2
SMRiQ96CD2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96CD2

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0672 Eukaryota
COG0452 LUCA
GeneTreeiENSGT00440000038107
HOGENOMiHOG000187629
HOVERGENiHBG054722
InParanoidiQ96CD2
KOiK01598
OMAiKHFYSPQ
OrthoDBiEOG091G0SB2
PhylomeDBiQ96CD2
TreeFamiTF315740

Family and domain databases

Gene3Di3.40.50.1950, 1 hit
InterProiView protein in InterPro
IPR036551 Flavin_trans-like
IPR003382 Flavoprotein
PfamiView protein in Pfam
PF02441 Flavoprotein, 1 hit
SUPFAMiSSF52507 SSF52507, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96CD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPKASCPAA APLMERKFHV LVGVTGSVAA LKLPLLVSKL LDIPGLEVAV
60 70 80 90 100
VTTERAKHFY SPQDIPVTLY SDADEWEIWK SRSDPVLHID LRRWADLLLV
110 120 130 140 150
APLDANTLGK VASGICDNLL TCVMRAWDRS KPLLFCPAMN TAMWEHPITA
160 170 180 190 200
QQVDQLKAFG YVEIPCVAKK LVCGDEGLGA MAEVGTIVDK VKEVLFQHSG

FQQS
Length:204
Mass (Da):22,395
Last modified:May 18, 2010 - v2
Checksum:i9E59683480032894
GO
Isoform 2 (identifier: Q96CD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MEPKASCPAA...LYSDADEWEI → M

Note: The Met-1 codon is associated with a polymorphism (dbSNP:rs2304899) that replaces the initiation ATG codon by an ATA codon.
Show »
Length:127
Mass (Da):14,069
Checksum:i562D659DE77C0AF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49A → S in BAB55151 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06897478I → M. Corresponds to variant dbSNP:rs2304899Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0448021 – 78MEPKA…DEWEI → M in isoform 2. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182419 mRNA Translation: AAG14955.1
AY358848 mRNA Translation: AAQ89207.1
AK027491 mRNA Translation: BAB55151.1
AC015720 Genomic DNA No translation available.
BC014409 mRNA Translation: AAH14409.1
CCDSiCCDS10275.1 [Q96CD2-1]
RefSeqiNP_001288030.1, NM_001301101.1
NP_001288031.1, NM_001301102.1
NP_001288032.1, NM_001301103.1
NP_001288033.1, NM_001301104.1
NP_001288034.1, NM_001301105.1
NP_068595.3, NM_021823.4 [Q96CD2-1]
UniGeneiHs.458922

Genome annotation databases

EnsembliENST00000342932; ENSP00000343190; ENSG00000138621 [Q96CD2-1]
GeneIDi60490
KEGGihsa:60490
UCSCiuc002azo.4 human [Q96CD2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOAC_HUMAN
AccessioniPrimary (citable) accession number: Q96CD2
Secondary accession number(s): Q96SX0, Q9HC17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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