Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96CD2

- COAC_HUMAN

UniProt

Q96CD2 - COAC_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphopantothenoylcysteine decarboxylase

Gene

PPCDC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.2 Publications

Catalytic activityi

N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.

Cofactori

FMNNote: Binds 1 FMN per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591FMN1 Publication
Binding sitei140 – 1401SubstrateBy similarity
Active sitei173 – 1731Proton donor

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1074FMN1 Publication

GO - Molecular functioni

  1. phosphopantothenoylcysteine decarboxylase activity Source: UniProtKB

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB
  2. coenzyme biosynthetic process Source: Reactome
  3. pantothenate metabolic process Source: Reactome
  4. small molecule metabolic process Source: Reactome
  5. vitamin metabolic process Source: Reactome
  6. water-soluble vitamin metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

ReactomeiREACT_11218. Coenzyme A biosynthesis.
SABIO-RKQ96CD2.
UniPathwayiUPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantothenoylcysteine decarboxylase (EC:4.1.1.36)
Short name:
PPC-DC
Alternative name(s):
CoaC
Gene namesi
Name:PPCDC
Synonyms:COAC
ORF Names:MDS018, UNQ9365/PRO34154
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:28107. PPCDC.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Phosphopantothenoylcysteine decarboxylasePRO_0000182030Add
BLAST

Proteomic databases

MaxQBiQ96CD2.
PaxDbiQ96CD2.
PRIDEiQ96CD2.

PTM databases

PhosphoSiteiQ96CD2.

Expressioni

Gene expression databases

BgeeiQ96CD2.
CleanExiHS_PPCDC.
ExpressionAtlasiQ96CD2. baseline and differential.
GenevestigatoriQ96CD2.

Organism-specific databases

HPAiHPA045667.

Interactioni

Subunit structurei

Homotrimer.Curated

Protein-protein interaction databases

BioGridi121921. 1 interaction.
IntActiQ96CD2. 4 interactions.
MINTiMINT-1394867.
STRINGi9606.ENSP00000343190.

Structurei

Secondary structure

1
204
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 249Combined sources
Helixi28 – 314Combined sources
Helixi33 – 408Combined sources
Beta strandi46 – 527Combined sources
Helixi55 – 584Combined sources
Helixi62 – 643Combined sources
Helixi72 – 776Combined sources
Helixi87 – 926Combined sources
Beta strandi96 – 1038Combined sources
Helixi105 – 1128Combined sources
Helixi119 – 1257Combined sources
Beta strandi135 – 1373Combined sources
Helixi141 – 1444Combined sources
Helixi149 – 1579Combined sources
Helixi186 – 1916Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QZUX-ray2.91A/B/C/D1-204[»]
ProteinModelPortaliQ96CD2.
SMRiQ96CD2. Positions 14-194.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96CD2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0452.
GeneTreeiENSGT00440000038107.
HOGENOMiHOG000187629.
HOVERGENiHBG054722.
InParanoidiQ96CD2.
KOiK01598.
OMAiFCENANV.
OrthoDBiEOG738062.
PhylomeDBiQ96CD2.
TreeFamiTF315740.

Family and domain databases

Gene3Di3.40.50.1950. 1 hit.
InterProiIPR003382. Flavoprotein.
[Graphical view]
PfamiPF02441. Flavoprotein. 1 hit.
[Graphical view]
SUPFAMiSSF52507. SSF52507. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96CD2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPKASCPAA APLMERKFHV LVGVTGSVAA LKLPLLVSKL LDIPGLEVAV
60 70 80 90 100
VTTERAKHFY SPQDIPVTLY SDADEWEIWK SRSDPVLHID LRRWADLLLV
110 120 130 140 150
APLDANTLGK VASGICDNLL TCVMRAWDRS KPLLFCPAMN TAMWEHPITA
160 170 180 190 200
QQVDQLKAFG YVEIPCVAKK LVCGDEGLGA MAEVGTIVDK VKEVLFQHSG

FQQS
Length:204
Mass (Da):22,395
Last modified:May 18, 2010 - v2
Checksum:i9E59683480032894
GO
Isoform 2 (identifier: Q96CD2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MEPKASCPAA...LYSDADEWEI → M

Note: The Met-1 codon is associated with a polymorphism (dbSNP:rs2304899) that replaces the initiation ATG codon by an ATA codon.

Show »
Length:127
Mass (Da):14,069
Checksum:i562D659DE77C0AF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491A → S in BAB55151. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781I → M.
Corresponds to variant rs2304899 [ dbSNP | Ensembl ].
VAR_068974

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7878MEPKA…DEWEI → M in isoform 2. 1 PublicationVSP_044802Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182419 mRNA. Translation: AAG14955.1.
AY358848 mRNA. Translation: AAQ89207.1.
AK027491 mRNA. Translation: BAB55151.1.
AC015720 Genomic DNA. No translation available.
BC014409 mRNA. Translation: AAH14409.1.
CCDSiCCDS10275.1. [Q96CD2-1]
RefSeqiNP_001288030.1. NM_001301101.1.
NP_001288031.1. NM_001301102.1.
NP_001288032.1. NM_001301103.1.
NP_001288033.1. NM_001301104.1.
NP_001288034.1. NM_001301105.1.
NP_068595.3. NM_021823.4. [Q96CD2-1]
UniGeneiHs.458922.

Genome annotation databases

EnsembliENST00000342932; ENSP00000343190; ENSG00000138621. [Q96CD2-1]
GeneIDi60490.
KEGGihsa:60490.
UCSCiuc002azo.3. human. [Q96CD2-1]

Polymorphism databases

DMDMi296434457.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182419 mRNA. Translation: AAG14955.1 .
AY358848 mRNA. Translation: AAQ89207.1 .
AK027491 mRNA. Translation: BAB55151.1 .
AC015720 Genomic DNA. No translation available.
BC014409 mRNA. Translation: AAH14409.1 .
CCDSi CCDS10275.1. [Q96CD2-1 ]
RefSeqi NP_001288030.1. NM_001301101.1.
NP_001288031.1. NM_001301102.1.
NP_001288032.1. NM_001301103.1.
NP_001288033.1. NM_001301104.1.
NP_001288034.1. NM_001301105.1.
NP_068595.3. NM_021823.4. [Q96CD2-1 ]
UniGenei Hs.458922.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QZU X-ray 2.91 A/B/C/D 1-204 [» ]
ProteinModelPortali Q96CD2.
SMRi Q96CD2. Positions 14-194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121921. 1 interaction.
IntActi Q96CD2. 4 interactions.
MINTi MINT-1394867.
STRINGi 9606.ENSP00000343190.

PTM databases

PhosphoSitei Q96CD2.

Polymorphism databases

DMDMi 296434457.

Proteomic databases

MaxQBi Q96CD2.
PaxDbi Q96CD2.
PRIDEi Q96CD2.

Protocols and materials databases

DNASUi 60490.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342932 ; ENSP00000343190 ; ENSG00000138621 . [Q96CD2-1 ]
GeneIDi 60490.
KEGGi hsa:60490.
UCSCi uc002azo.3. human. [Q96CD2-1 ]

Organism-specific databases

CTDi 60490.
GeneCardsi GC15P075315.
H-InvDB HIX0202140.
HGNCi HGNC:28107. PPCDC.
HPAi HPA045667.
MIMi 609854. gene.
neXtProti NX_Q96CD2.
PharmGKBi PA142671157.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0452.
GeneTreei ENSGT00440000038107.
HOGENOMi HOG000187629.
HOVERGENi HBG054722.
InParanoidi Q96CD2.
KOi K01598.
OMAi FCENANV.
OrthoDBi EOG738062.
PhylomeDBi Q96CD2.
TreeFami TF315740.

Enzyme and pathway databases

UniPathwayi UPA00241 ; UER00354 .
Reactomei REACT_11218. Coenzyme A biosynthesis.
SABIO-RK Q96CD2.

Miscellaneous databases

EvolutionaryTracei Q96CD2.
GenomeRNAii 60490.
NextBioi 65379.
PROi Q96CD2.
SOURCEi Search...

Gene expression databases

Bgeei Q96CD2.
CleanExi HS_PPCDC.
ExpressionAtlasi Q96CD2. baseline and differential.
Genevestigatori Q96CD2.

Family and domain databases

Gene3Di 3.40.50.1950. 1 hit.
InterProi IPR003382. Flavoprotein.
[Graphical view ]
Pfami PF02441. Flavoprotein. 1 hit.
[Graphical view ]
SUPFAMi SSF52507. SSF52507. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hematopoietic stem cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  6. "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics."
    Daugherty M., Polanuyer B., Farrell M., Scholle M., Lykidis A., de Crecy-Lagard V., Osterman A.
    J. Biol. Chem. 277:21431-21439(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION.
  7. "Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent."
    Strauss E., Zhai H., Brand L.A., McLafferty F.W., Begley T.P.
    Biochemistry 43:15520-15533(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase."
    Manoj N., Ealick S.E.
    Acta Crystallogr. D 59:1762-1766(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS) IN COMPLEX WITH FMN.

Entry informationi

Entry nameiCOAC_HUMAN
AccessioniPrimary (citable) accession number: Q96CD2
Secondary accession number(s): Q96SX0, Q9HC17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3