Q96CD2 (COAC_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 82.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphopantothenoylcysteine decarboxylase Short name=PPC-DC EC=4.1.1.36 Alternative name(s): CoaC | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 204 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine. Ref.6 Ref.7 |
| Catalytic activity | N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2. |
| Cofactor | Binds 1 FMN per subunit. |
| Pathway | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5. |
| Subunit structure | Homotrimer Potential. |
| Sequence similarities | Belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Coenzyme A biosynthesis |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Ligand | FMN Flavoprotein |
| Molecular function | Decarboxylase Lyase |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW pantothenate metabolic processTraceable author statement. Source: Reactome |
| Cellular component | cytosol Traceable author statement. Source: Reactome |
| Molecular function | phosphopantothenoylcysteine decarboxylase activity Traceable author statement. Source: Reactome |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||||
| Isoform 1 (identifier: Q96CD2-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||||
| Isoform 2 (identifier: Q96CD2-2) The sequence of this isoform differs from the canonical sequence as follows: 1-77: Missing. 78-78: I → M | ||||||||
| Note: Produced only in the presence of the Met-1 variant. | ||||||||
Sequence annotation (Features) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||
| Natural variant | 1 | 1 | M → I. Corresponds to variant rs2304899 [ dbSNP | Ensembl ]. | |||||
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 204 | 204 | Phosphopantothenoylcysteine decarboxylase | PRO_0000182030 | |||||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 104 – 107 | 4 | FMN | ||||||||||||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||||||||||||
| Active site | 173 | 1 | Proton donor | ||||||||||||||||||||||||||||||||||||
| Binding site | 59 | 1 | FMN | ||||||||||||||||||||||||||||||||||||
| Binding site | 140 | 1 | Substrate By similarity | ||||||||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||||||||
| Alternative sequence | 1 – 77 | 77 | Missing in isoform 2. | VSP_014003 | |||||||||||||||||||||||||||||||||||
| Alternative sequence | 78 | 1 | I → M in isoform 2. | VSP_039201 | |||||||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 49 | 1 | A → S in BAB55151. Ref.3 | ||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 16 – 24 | 9 | |||||||||||||||||||||||||||||||||||||
| Helix | 28 – 31 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 33 – 40 | 8 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 46 – 52 | 7 | |||||||||||||||||||||||||||||||||||||
| Helix | 55 – 58 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 62 – 64 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 72 – 77 | 6 | |||||||||||||||||||||||||||||||||||||
| Helix | 87 – 92 | 6 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 96 – 103 | 8 | |||||||||||||||||||||||||||||||||||||
| Helix | 105 – 112 | 8 | |||||||||||||||||||||||||||||||||||||
| Helix | 119 – 125 | 7 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 135 – 137 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 141 – 144 | 4 | |||||||||||||||||||||||||||||||||||||
| Helix | 149 – 157 | 9 | |||||||||||||||||||||||||||||||||||||
| Helix | 186 – 191 | 6 | |||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients." Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Hematopoietic stem cell. |
| [2] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [4] | "Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. Nusbaum C.Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye. |
| [6] | "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics." Daugherty M., Polanuyer B., Farrell M., Scholle M., Lykidis A., de Crecy-Lagard V., Osterman A. J. Biol. Chem. 277:21431-21439(2002) [PubMed: 11923312] [Abstract] Cited for: IDENTIFICATION, FUNCTION. |
| [7] | "Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent." Strauss E., Zhai H., Brand L.A., McLafferty F.W., Begley T.P. Biochemistry 43:15520-15533(2004) [PubMed: 15581364] [Abstract] Cited for: FUNCTION, MASS SPECTROMETRY. |
| [8] | "Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase." Manoj N., Ealick S.E. Acta Crystallogr. D 59:1762-1766(2003) [PubMed: 14501115] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS) IN COMPLEX WITH FMN. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF182419 mRNA. Translation: AAG14955.1. AY358848 mRNA. Translation: AAQ89207.1. AK027491 mRNA. Translation: BAB55151.1. AC015720 Genomic DNA. No translation available. BC014409 mRNA. Translation: AAH14409.1. | ||||||||||||
| IPI | IPI00303962. IPI00604702. | ||||||||||||
| RefSeq | NP_068595.3. NM_021823.3. | ||||||||||||
| UniGene | Hs.458922. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | Q96CD2. | ||||||||||||
| SMR | Q96CD2. Positions 14-194. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q96CD2. 3 interactions. | ||||||||||||
| MINT | MINT-1394867. | ||||||||||||
| STRING | Q96CD2. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 296434457. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q96CD2. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000342932; ENSP00000343190; ENSG00000138621. | ||||||||||||
| GeneID | 60490. | ||||||||||||
| KEGG | hsa:60490. | ||||||||||||
| UCSC | uc002azo.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 60490. | ||||||||||||
| GeneCards | GC15P075315. | ||||||||||||
| H-InvDB | HIX0202140. | ||||||||||||
| HGNC | HGNC:28107. PPCDC. | ||||||||||||
| MIM | 609854. gene. | ||||||||||||
| neXtProt | NX_Q96CD2. | ||||||||||||
| PharmGKB | PA142671157. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG10187. | ||||||||||||
| GeneTree | ENSGT00440000038107. | ||||||||||||
| HOGENOM | HBG523890. | ||||||||||||
| HOVERGEN | HBG054722. | ||||||||||||
| InParanoid | Q96CD2. | ||||||||||||
| OMA | APLMERK. | ||||||||||||
| OrthoDB | EOG42NJ1C. | ||||||||||||
| PhylomeDB | Q96CD2. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Reactome | REACT_111217. Metabolism. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q96CD2. | ||||||||||||
| Bgee | Q96CD2. | ||||||||||||
| CleanEx | HS_PPCDC. | ||||||||||||
| Genevestigator | Q96CD2. | ||||||||||||
| GermOnline | ENSG00000138621. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR003382. Flavoprotein. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.40.50.1950. Flavoprotein. 1 hit. | ||||||||||||
| KO | K01598. | ||||||||||||
| Pfam | PF02441. Flavoprotein. 1 hit. [Graphical view] | ||||||||||||
| SUPFAM | SSF52507. Flavoprotein. 1 hit. | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 65379. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | COAC_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96CD2 Secondary accession number(s): Q96SX0, Q9HC17 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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