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Protein

F-box/LRR-repeat protein 8

Gene

FBXL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135722-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 8
Alternative name(s):
F-box and leucine-rich repeat protein 8
F-box protein FBL8
Gene namesi
Name:FBXL8
Synonyms:FBL8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:17875. FBXL8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135722.
PharmGKBiPA28028.

Polymorphism and mutation databases

BioMutaiFBXL8.
DMDMi38257737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198501 – 374F-box/LRR-repeat protein 8Add BLAST374

Proteomic databases

MaxQBiQ96CD0.
PaxDbiQ96CD0.
PeptideAtlasiQ96CD0.
PRIDEiQ96CD0.

Expressioni

Gene expression databases

BgeeiENSG00000135722.
CleanExiHS_FBXL8.
ExpressionAtlasiQ96CD0. baseline and differential.
GenevisibleiQ96CD0. HS.

Organism-specific databases

HPAiHPA035587.
HPA035588.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P6320814EBI-2321097,EBI-307486

Protein-protein interaction databases

BioGridi120617. 6 interactors.
IntActiQ96CD0. 5 interactors.
STRINGi9606.ENSP00000258200.

Structurei

3D structure databases

ProteinModelPortaliQ96CD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 48F-boxPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKPE. Eukaryota.
ENOG4111K6I. LUCA.
GeneTreeiENSGT00420000029943.
HOGENOMiHOG000112553.
HOVERGENiHBG051592.
InParanoidiQ96CD0.
KOiK10274.
OMAiNHALVNS.
OrthoDBiEOG091G07PY.
PhylomeDBiQ96CD0.
TreeFamiTF321665.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPGEGLPE EVLALIFRHL SLRDRAAAAR VCRAWAAAAT CSAVWHDTKI
60 70 80 90 100
SCECELEGML PPYLSACLDH IHNLRLEFEP SRKPSRRAAI ELLMVLAGRA
110 120 130 140 150
PGLRGLRLEC RGEKPLFDAG RDVLEAVHAV CGAASQLRHL DLRRLSFTLD
160 170 180 190 200
DALVLQAARS CPELHSLFLD NSTLVGSVGP GSVLELLEAC PRLRALGLHL
210 220 230 240 250
ASLSHAILEA LAAPDRAPFA LLALRCACPE DARASPLPNE AWVALRRRHP
260 270 280 290 300
GLAVELELEP ALPAESVTRV LQPAVPVAAL RLNLSGDTVG PVRFAAHHYA
310 320 330 340 350
ATLCALEVRA AASAELNAAL EELAARCAAL REVHCFCVVS HSVLDAFRAH
360 370
CPRLRTYTLK LTREPHPWRP TLVA
Length:374
Mass (Da):40,516
Last modified:December 1, 2001 - v1
Checksum:i7B91444E31E95931
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135S → N in BAA92103 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002140 mRNA. Translation: BAA92103.1.
BC014414 mRNA. Translation: AAH14414.1.
CCDSiCCDS10831.1.
RefSeqiNP_060848.2. NM_018378.2.
UniGeneiHs.710714.

Genome annotation databases

EnsembliENST00000258200; ENSP00000258200; ENSG00000135722.
ENST00000519917; ENSP00000430490; ENSG00000135722.
GeneIDi55336.
KEGGihsa:55336.
UCSCiuc002erk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002140 mRNA. Translation: BAA92103.1.
BC014414 mRNA. Translation: AAH14414.1.
CCDSiCCDS10831.1.
RefSeqiNP_060848.2. NM_018378.2.
UniGeneiHs.710714.

3D structure databases

ProteinModelPortaliQ96CD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120617. 6 interactors.
IntActiQ96CD0. 5 interactors.
STRINGi9606.ENSP00000258200.

Polymorphism and mutation databases

BioMutaiFBXL8.
DMDMi38257737.

Proteomic databases

MaxQBiQ96CD0.
PaxDbiQ96CD0.
PeptideAtlasiQ96CD0.
PRIDEiQ96CD0.

Protocols and materials databases

DNASUi55336.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258200; ENSP00000258200; ENSG00000135722.
ENST00000519917; ENSP00000430490; ENSG00000135722.
GeneIDi55336.
KEGGihsa:55336.
UCSCiuc002erk.2. human.

Organism-specific databases

CTDi55336.
GeneCardsiFBXL8.
HGNCiHGNC:17875. FBXL8.
HPAiHPA035587.
HPA035588.
MIMi609077. gene.
neXtProtiNX_Q96CD0.
OpenTargetsiENSG00000135722.
PharmGKBiPA28028.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKPE. Eukaryota.
ENOG4111K6I. LUCA.
GeneTreeiENSGT00420000029943.
HOGENOMiHOG000112553.
HOVERGENiHBG051592.
InParanoidiQ96CD0.
KOiK10274.
OMAiNHALVNS.
OrthoDBiEOG091G07PY.
PhylomeDBiQ96CD0.
TreeFamiTF321665.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135722-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii55336.
PROiQ96CD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135722.
CleanExiHS_FBXL8.
ExpressionAtlasiQ96CD0. baseline and differential.
GenevisibleiQ96CD0. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBXL8_HUMAN
AccessioniPrimary (citable) accession number: Q96CD0
Secondary accession number(s): Q9NUM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

While the gene symbol and protein names are indicative of the presence of LRR repeats, such repeats are not present in this protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.