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Q96CB9

- NSUN4_HUMAN

UniProt

Q96CB9 - NSUN4_HUMAN

Protein

5-methylcytosine rRNA methyltransferase NSUN4

Gene

NSUN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei237 – 2371S-adenosyl-L-methionine1 PublicationPROSITE-ProRule annotation
    Binding sitei255 – 2551S-adenosyl-L-methionine1 PublicationPROSITE-ProRule annotation
    Active sitei310 – 3101Nucleophile1 PublicationPROSITE-ProRule annotation

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Keywords - Ligandi

    RNA-binding, rRNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-methylcytosine rRNA methyltransferase NSUN4 (EC:2.1.1.-)
    Alternative name(s):
    NOL1/NOP2/Sun domain family member 4
    Gene namesi
    Name:NSUN4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:31802. NSUN4.

    Subcellular locationi

    Mitochondrion 3 Publications

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi65 – 651V → R: Disrupts complex with MTERFD2; when associated with A-136, R-139 and A-141. 1 Publication
    Mutagenesisi136 – 1361R → A: Disrupts complex with MTERFD2; when associated with R-65, R-139 and A-141. 1 Publication
    Mutagenesisi139 – 1391I → R: Disrupts complex with MTERFD2; when associated with R-65, A-136, and A-141. 1 Publication
    Mutagenesisi141 – 1411R → A: Disrupts complex with MTERFD2; when associated with R-65, A-136 and R-139. 1 Publication

    Organism-specific databases

    PharmGKBiPA134953046.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525Mitochondrion1 PublicationAdd
    BLAST
    Chaini26 – 3843595-methylcytosine rRNA methyltransferase NSUN4PRO_0000289234Add
    BLAST

    Proteomic databases

    MaxQBiQ96CB9.
    PaxDbiQ96CB9.
    PRIDEiQ96CB9.

    PTM databases

    PhosphoSiteiQ96CB9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96CB9.
    BgeeiQ96CB9.
    CleanExiHS_NSUN4.
    GenevestigatoriQ96CB9.

    Organism-specific databases

    HPAiHPA027958.
    HPA028489.

    Interactioni

    Protein-protein interaction databases

    BioGridi132288. 8 interactions.
    DIPiDIP-58104N.
    IntActiQ96CB9. 6 interactions.
    MINTiMINT-1474456.
    STRINGi9606.ENSP00000419740.

    Structurei

    Secondary structure

    1
    384
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi40 – 5617
    Helixi57 – 593
    Helixi60 – 678
    Beta strandi74 – 774
    Helixi79 – 813
    Helixi83 – 9210
    Helixi98 – 1047
    Turni105 – 1073
    Helixi121 – 1244
    Beta strandi131 – 1333
    Beta strandi151 – 1588
    Helixi160 – 1623
    Helixi163 – 1697
    Beta strandi175 – 1817
    Helixi186 – 1938
    Beta strandi197 – 2037
    Helixi207 – 22014
    Turni223 – 2275
    Beta strandi228 – 2347
    Helixi238 – 2403
    Helixi241 – 2444
    Beta strandi249 – 2557
    Helixi261 – 2644
    Helixi275 – 2773
    Helixi278 – 2825
    Helixi284 – 29714
    Beta strandi299 – 31012
    Turni314 – 3174
    Helixi318 – 33215
    Beta strandi336 – 3383
    Helixi342 – 3487
    Turni349 – 3513
    Beta strandi359 – 3657
    Beta strandi375 – 3828

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FP9X-ray2.90A/C/D/F26-384[»]
    4FZVX-ray2.00A26-384[»]
    ProteinModelPortaliQ96CB9.
    SMRiQ96CB9. Positions 38-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni181 – 1877S-adenosyl-L-methionine binding

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0144.
    HOGENOMiHOG000017426.
    HOVERGENiHBG106892.
    InParanoidiQ96CB9.
    OMAiACSPNLR.
    OrthoDBiEOG789CB3.
    PhylomeDBiQ96CB9.
    TreeFamiTF321304.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR001678. Fmu/NOL1/Nop2p.
    IPR023267. RCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01189. Nol1_Nop2_Fmu. 1 hit.
    [Graphical view]
    PRINTSiPR02008. RCMTFAMILY.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51686. SAM_MT_RSMB_NOP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96CB9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAALTLRGVR ELLKRVDLAT VPRRHRYKKK WAATEPKFPA VRLALQNFDM    50
    TYSVQFGDLW PSIRVSLLSE QKYGALVNNF AAWDHVSAKL EQLSAKDFVN 100
    EAISHWELQS EGGQSAAPSP ASWACSPNLR CFTFDRGDIS RFPPARPGSL 150
    GVMEYYLMDA ASLLPVLALG LQPGDIVLDL CAAPGGKTLA LLQTGCCRNL 200
    AANDLSPSRI ARLQKILHSY VPEEIRDGNQ VRVTSWDGRK WGELEGDTYD 250
    RVLVDVPCTT DRHSLHEEEN NIFKRSRKKE RQILPVLQVQ LLAAGLLATK 300
    PGGHVVYSTC SLSHLQNEYV VQGAIELLAN QYSIQVQVED LTHFRRVFMD 350
    TFCFFSSCQV GELVIPNLMA NFGPMYFCKM RRLT 384
    Length:384
    Mass (Da):43,089
    Last modified:May 29, 2007 - v2
    Checksum:i4D83B6D55D65C27F
    GO
    Isoform 2 (identifier: Q96CB9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         147-384: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:146
    Mass (Da):16,507
    Checksum:iE49A839AA5937FB5
    GO
    Isoform 3 (identifier: Q96CB9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-198: Missing.
         199-219: NLAANDLSPSRIARLQKILHS → MLPPCCLFWPSACSLGTSCLT

    Note: No experimental confirmation available.

    Show »
    Length:186
    Mass (Da):21,240
    Checksum:i4186007A46B086CD
    GO
    Isoform 4 (identifier: Q96CB9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-49: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:335
    Mass (Da):37,374
    Checksum:i85AACD29E9DDB7D7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti282 – 2821Q → R in BAG51912. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511T → A.2 Publications
    Corresponds to variant rs3737744 [ dbSNP | Ensembl ].
    VAR_032606
    Natural varianti128 – 1281N → K.
    Corresponds to variant rs17102152 [ dbSNP | Ensembl ].
    VAR_032607
    Natural varianti325 – 3251I → T.
    Corresponds to variant rs13374337 [ dbSNP | Ensembl ].
    VAR_032608
    Natural varianti365 – 3651I → V.1 Publication
    Corresponds to variant rs9865 [ dbSNP | Ensembl ].
    VAR_032609

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 198198Missing in isoform 3. 1 PublicationVSP_025971Add
    BLAST
    Alternative sequencei1 – 4949Missing in isoform 4. 1 PublicationVSP_045053Add
    BLAST
    Alternative sequencei147 – 384238Missing in isoform 2. 1 PublicationVSP_025972Add
    BLAST
    Alternative sequencei199 – 21921NLAAN…KILHS → MLPPCCLFWPSACSLGTSCL T in isoform 3. 1 PublicationVSP_025973Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021577 mRNA. Translation: BAB13847.1.
    AK057420 mRNA. Translation: BAG51912.1.
    AK291741 mRNA. Translation: BAF84430.1.
    AK295003 mRNA. Translation: BAG58065.1.
    AL122001 Genomic DNA. Translation: CAI21962.1.
    CH471059 Genomic DNA. Translation: EAX06917.1.
    BC014441 mRNA. Translation: AAH14441.1.
    BC016907 mRNA. Translation: AAH16907.1.
    CCDSiCCDS534.1. [Q96CB9-1]
    CCDS57996.1. [Q96CB9-4]
    RefSeqiNP_001243056.1. NM_001256127.1. [Q96CB9-4]
    NP_001243057.1. NM_001256128.1. [Q96CB9-4]
    NP_950245.2. NM_199044.3. [Q96CB9-1]
    UniGeneiHs.163424.

    Genome annotation databases

    EnsembliENST00000474844; ENSP00000419740; ENSG00000117481. [Q96CB9-1]
    ENST00000537428; ENSP00000437758; ENSG00000117481. [Q96CB9-4]
    GeneIDi387338.
    KEGGihsa:387338.
    UCSCiuc001cpr.2. human. [Q96CB9-1]

    Polymorphism databases

    DMDMi152125805.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK021577 mRNA. Translation: BAB13847.1 .
    AK057420 mRNA. Translation: BAG51912.1 .
    AK291741 mRNA. Translation: BAF84430.1 .
    AK295003 mRNA. Translation: BAG58065.1 .
    AL122001 Genomic DNA. Translation: CAI21962.1 .
    CH471059 Genomic DNA. Translation: EAX06917.1 .
    BC014441 mRNA. Translation: AAH14441.1 .
    BC016907 mRNA. Translation: AAH16907.1 .
    CCDSi CCDS534.1. [Q96CB9-1 ]
    CCDS57996.1. [Q96CB9-4 ]
    RefSeqi NP_001243056.1. NM_001256127.1. [Q96CB9-4 ]
    NP_001243057.1. NM_001256128.1. [Q96CB9-4 ]
    NP_950245.2. NM_199044.3. [Q96CB9-1 ]
    UniGenei Hs.163424.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FP9 X-ray 2.90 A/C/D/F 26-384 [» ]
    4FZV X-ray 2.00 A 26-384 [» ]
    ProteinModelPortali Q96CB9.
    SMRi Q96CB9. Positions 38-384.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132288. 8 interactions.
    DIPi DIP-58104N.
    IntActi Q96CB9. 6 interactions.
    MINTi MINT-1474456.
    STRINGi 9606.ENSP00000419740.

    PTM databases

    PhosphoSitei Q96CB9.

    Polymorphism databases

    DMDMi 152125805.

    Proteomic databases

    MaxQBi Q96CB9.
    PaxDbi Q96CB9.
    PRIDEi Q96CB9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000474844 ; ENSP00000419740 ; ENSG00000117481 . [Q96CB9-1 ]
    ENST00000537428 ; ENSP00000437758 ; ENSG00000117481 . [Q96CB9-4 ]
    GeneIDi 387338.
    KEGGi hsa:387338.
    UCSCi uc001cpr.2. human. [Q96CB9-1 ]

    Organism-specific databases

    CTDi 387338.
    GeneCardsi GC01P046805.
    HGNCi HGNC:31802. NSUN4.
    HPAi HPA027958.
    HPA028489.
    MIMi 615394. gene.
    neXtProti NX_Q96CB9.
    PharmGKBi PA134953046.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0144.
    HOGENOMi HOG000017426.
    HOVERGENi HBG106892.
    InParanoidi Q96CB9.
    OMAi ACSPNLR.
    OrthoDBi EOG789CB3.
    PhylomeDBi Q96CB9.
    TreeFami TF321304.

    Miscellaneous databases

    GenomeRNAii 387338.
    NextBioi 101304.
    PROi Q96CB9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96CB9.
    Bgeei Q96CB9.
    CleanExi HS_NSUN4.
    Genevestigatori Q96CB9.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR001678. Fmu/NOL1/Nop2p.
    IPR023267. RCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01189. Nol1_Nop2_Fmu. 1 hit.
    [Graphical view ]
    PRINTSi PR02008. RCMTFAMILY.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51686. SAM_MT_RSMB_NOP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANTS ALA-51 AND VAL-365.
      Tissue: Brain, Embryo, Placenta and Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-384 (ISOFORM 2), VARIANT ALA-51.
      Tissue: Colon and Duodenum.
    5. Cited for: PARTIAL PROTEIN SEQUENCE, TRANSIT PEPTIDE CLEAVAGE SITE, FUNCTION, INTERACTION WITH MTERF4, SUBCELLULAR LOCATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis."
      Spahr H., Habermann B., Gustafsson C.M., Larsson N.G., Hallberg B.M.
      Proc. Natl. Acad. Sci. U.S.A. 109:15253-15258(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 26-384 IN COMPLEX WITH MTERFD2, ACTIVE SITE, SUBCELLULAR LOCATION, MUTAGENESIS OF VAL-65; ARG-136; ILE-139 AND ARG-141.
    9. "Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification."
      Yakubovskaya E., Guja K.E., Mejia E., Castano S., Hambardjieva E., Choi W.S., Garcia-Diaz M.
      Structure 20:1940-1947(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 26-384 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE AND MTERFD2, FUNCTION IN METHYLATION OF 16S RRNA, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiNSUN4_HUMAN
    AccessioniPrimary (citable) accession number: Q96CB9
    Secondary accession number(s): A8K6S6
    , B3KQ50, B4DHA4, Q5TDF7, Q96AN8, Q9HAJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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