SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96CB8

- INT12_HUMAN

UniProt

Q96CB8 - INT12_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Integrator complex subunit 12

Gene
INTS12, PHF22, SBBI22
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri159 – 21557PHD-typeAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. snRNA processing Source: HGNC
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 12
Short name:
Int12
Alternative name(s):
PHD finger protein 22
Gene namesi
Name:INTS12
Synonyms:PHF22
ORF Names:SBBI22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:25067. INTS12.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. integrator complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Integrator complex subunit 12PRO_0000059312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96CB8.
PaxDbiQ96CB8.
PeptideAtlasiQ96CB8.
PRIDEiQ96CB8.

PTM databases

PhosphoSiteiQ96CB8.

Expressioni

Gene expression databases

ArrayExpressiQ96CB8.
BgeeiQ96CB8.
CleanExiHS_INTS12.
GenevestigatoriQ96CB8.

Organism-specific databases

HPAiHPA035772.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.1 Publication

Protein-protein interaction databases

BioGridi121381. 9 interactions.
DIPiDIP-48479N.
IntActiQ96CB8. 2 interactions.
MINTiMINT-4536610.
STRINGi9606.ENSP00000265150.

Structurei

3D structure databases

ProteinModelPortaliQ96CB8.
SMRiQ96CB8. Positions 149-225.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi270 – 440171Ser-richAdd
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri159 – 21557PHD-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG247951.
HOGENOMiHOG000059634.
HOVERGENiHBG081798.
InParanoidiQ96CB8.
KOiK13149.
OMAiKQEPKIS.
OrthoDBiEOG7QNVN6.
PhylomeDBiQ96CB8.
TreeFamiTF106418.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CB8-1 [UniParc]FASTAAdd to Basket

« Hide

MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS    50
QKDVEPPKIS STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP 100
ADKMKSDITE GVDIPKKPRL EKPETQSSPI TVQSSKDLPM ADLSSFEETS 150
ADDFAMEMGL ACVVCRQMMV ASGNQLVECQ ECHNLYHRDC HKPQVTDKEA 200
NDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APAVVSVTPA VKDPLVKKPE 250
TKLKQETTFL AFKRTEVKTS TVISGNSSSA SVSSSVTSGL TGWAAFAAKT 300
SSAGPSTAKL SSTTQNNTGK PATSSANQKP VGLTGLATSS KGGIGSKIGS 350
NNSTTPTVPL KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ 400
LSGNGNSGTS GPSGSTTSKT TSESSSSPSA SLKGPTSQES QLNAMKRLQM 450
VKKKAAQKKL KK 462
Length:462
Mass (Da):48,808
Last modified:December 1, 2001 - v1
Checksum:i7AEF952044A3E951
GO

Sequence cautioni

The sequence AAF99604.1 differs from that shown. Reason: Frameshift at position 439.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti323 – 3231T → A.
Corresponds to variant rs34567094 [ dbSNP | Ensembl ].
VAR_049629

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF242524 mRNA. Translation: AAF99604.1. Frameshift.
AK314939 mRNA. Translation: BAG37445.1.
CH471057 Genomic DNA. Translation: EAX06189.1.
BC014442 mRNA. Translation: AAH14442.1.
BK005729 mRNA. Translation: DAA05729.1.
CCDSiCCDS3671.1.
RefSeqiNP_001135943.1. NM_001142471.1.
NP_065128.2. NM_020395.3.
XP_005263205.1. XM_005263148.2.
XP_005263206.1. XM_005263149.2.
UniGeneiHs.480454.

Genome annotation databases

EnsembliENST00000340139; ENSP00000340737; ENSG00000138785.
ENST00000394735; ENSP00000378221; ENSG00000138785.
ENST00000451321; ENSP00000415433; ENSG00000138785.
GeneIDi57117.
KEGGihsa:57117.
UCSCiuc003hxw.3. human.

Polymorphism databases

DMDMi73621394.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF242524 mRNA. Translation: AAF99604.1 . Frameshift.
AK314939 mRNA. Translation: BAG37445.1 .
CH471057 Genomic DNA. Translation: EAX06189.1 .
BC014442 mRNA. Translation: AAH14442.1 .
BK005729 mRNA. Translation: DAA05729.1 .
CCDSi CCDS3671.1.
RefSeqi NP_001135943.1. NM_001142471.1.
NP_065128.2. NM_020395.3.
XP_005263205.1. XM_005263148.2.
XP_005263206.1. XM_005263149.2.
UniGenei Hs.480454.

3D structure databases

ProteinModelPortali Q96CB8.
SMRi Q96CB8. Positions 149-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121381. 9 interactions.
DIPi DIP-48479N.
IntActi Q96CB8. 2 interactions.
MINTi MINT-4536610.
STRINGi 9606.ENSP00000265150.

PTM databases

PhosphoSitei Q96CB8.

Polymorphism databases

DMDMi 73621394.

Proteomic databases

MaxQBi Q96CB8.
PaxDbi Q96CB8.
PeptideAtlasi Q96CB8.
PRIDEi Q96CB8.

Protocols and materials databases

DNASUi 57117.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340139 ; ENSP00000340737 ; ENSG00000138785 .
ENST00000394735 ; ENSP00000378221 ; ENSG00000138785 .
ENST00000451321 ; ENSP00000415433 ; ENSG00000138785 .
GeneIDi 57117.
KEGGi hsa:57117.
UCSCi uc003hxw.3. human.

Organism-specific databases

CTDi 57117.
GeneCardsi GC04M106603.
HGNCi HGNC:25067. INTS12.
HPAi HPA035772.
MIMi 611355. gene.
neXtProti NX_Q96CB8.
PharmGKBi PA142671177.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247951.
HOGENOMi HOG000059634.
HOVERGENi HBG081798.
InParanoidi Q96CB8.
KOi K13149.
OMAi KQEPKIS.
OrthoDBi EOG7QNVN6.
PhylomeDBi Q96CB8.
TreeFami TF106418.

Miscellaneous databases

GeneWikii INTS12.
GenomeRNAii 57117.
NextBioi 62983.
PROi Q96CB8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96CB8.
Bgeei Q96CB8.
CleanExi HS_INTS12.
Genevestigatori Q96CB8.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hypothetical nuclear factor SBBI22 mRNA."
    Wan T., Li N., Zhang W., Cao X.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
    Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
    Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX.
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiINT12_HUMAN
AccessioniPrimary (citable) accession number: Q96CB8
Secondary accession number(s): B2RC48, Q3B6Z3, Q9HD71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi