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Protein

Integrator complex subunit 12

Gene

INTS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri159 – 215PHD-typePROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

  • snRNA processing Source: HGNC
  • snRNA transcription from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138785-MONOMER.
ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 12
Short name:
Int12
Alternative name(s):
PHD finger protein 22
Gene namesi
Name:INTS12
Synonyms:PHF22
ORF Names:SBBI22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25067. INTS12.

Subcellular locationi

GO - Cellular componenti

  • integrator complex Source: HGNC
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57117.
OpenTargetsiENSG00000138785.
PharmGKBiPA142671177.

Polymorphism and mutation databases

BioMutaiINTS12.
DMDMi73621394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593121 – 462Integrator complex subunit 12Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei128PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96CB8.
MaxQBiQ96CB8.
PaxDbiQ96CB8.
PeptideAtlasiQ96CB8.
PRIDEiQ96CB8.

PTM databases

iPTMnetiQ96CB8.
PhosphoSitePlusiQ96CB8.

Expressioni

Gene expression databases

BgeeiENSG00000138785.
CleanExiHS_INTS12.
ExpressionAtlasiQ96CB8. baseline and differential.
GenevisibleiQ96CB8. HS.

Organism-specific databases

HPAiHPA035772.
HPA041814.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.1 Publication

Protein-protein interaction databases

BioGridi121381. 35 interactors.
DIPiDIP-48479N.
IntActiQ96CB8. 11 interactors.
MINTiMINT-4536610.
STRINGi9606.ENSP00000340737.

Structurei

3D structure databases

ProteinModelPortaliQ96CB8.
SMRiQ96CB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi270 – 440Ser-richAdd BLAST171

Sequence similaritiesi

Belongs to the Integrator subunit 12 family.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri159 – 215PHD-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4323. Eukaryota.
ENOG410XQ6E. LUCA.
GeneTreeiENSGT00390000005218.
HOGENOMiHOG000059634.
HOVERGENiHBG081798.
InParanoidiQ96CB8.
KOiK13149.
OMAiKAISIKQ.
OrthoDBiEOG091G0KPP.
PhylomeDBiQ96CB8.
TreeFamiTF106418.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96CB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS
60 70 80 90 100
QKDVEPPKIS STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP
110 120 130 140 150
ADKMKSDITE GVDIPKKPRL EKPETQSSPI TVQSSKDLPM ADLSSFEETS
160 170 180 190 200
ADDFAMEMGL ACVVCRQMMV ASGNQLVECQ ECHNLYHRDC HKPQVTDKEA
210 220 230 240 250
NDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APAVVSVTPA VKDPLVKKPE
260 270 280 290 300
TKLKQETTFL AFKRTEVKTS TVISGNSSSA SVSSSVTSGL TGWAAFAAKT
310 320 330 340 350
SSAGPSTAKL SSTTQNNTGK PATSSANQKP VGLTGLATSS KGGIGSKIGS
360 370 380 390 400
NNSTTPTVPL KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ
410 420 430 440 450
LSGNGNSGTS GPSGSTTSKT TSESSSSPSA SLKGPTSQES QLNAMKRLQM
460
VKKKAAQKKL KK
Length:462
Mass (Da):48,808
Last modified:December 1, 2001 - v1
Checksum:i7AEF952044A3E951
GO

Sequence cautioni

The sequence AAF99604 differs from that shown. Reason: Frameshift at position 439.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049629323T → A.Corresponds to variant rs34567094dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242524 mRNA. Translation: AAF99604.1. Frameshift.
AK314939 mRNA. Translation: BAG37445.1.
CH471057 Genomic DNA. Translation: EAX06189.1.
BC014442 mRNA. Translation: AAH14442.1.
BK005729 mRNA. Translation: DAA05729.1.
CCDSiCCDS3671.1.
RefSeqiNP_001135943.1. NM_001142471.1.
NP_065128.2. NM_020395.3.
XP_005263205.1. XM_005263148.4.
XP_011530445.1. XM_011532143.2.
XP_011530447.1. XM_011532145.2.
UniGeneiHs.480454.

Genome annotation databases

EnsembliENST00000340139; ENSP00000340737; ENSG00000138785.
ENST00000394735; ENSP00000378221; ENSG00000138785.
ENST00000451321; ENSP00000415433; ENSG00000138785.
GeneIDi57117.
KEGGihsa:57117.
UCSCiuc003hxw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242524 mRNA. Translation: AAF99604.1. Frameshift.
AK314939 mRNA. Translation: BAG37445.1.
CH471057 Genomic DNA. Translation: EAX06189.1.
BC014442 mRNA. Translation: AAH14442.1.
BK005729 mRNA. Translation: DAA05729.1.
CCDSiCCDS3671.1.
RefSeqiNP_001135943.1. NM_001142471.1.
NP_065128.2. NM_020395.3.
XP_005263205.1. XM_005263148.4.
XP_011530445.1. XM_011532143.2.
XP_011530447.1. XM_011532145.2.
UniGeneiHs.480454.

3D structure databases

ProteinModelPortaliQ96CB8.
SMRiQ96CB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121381. 35 interactors.
DIPiDIP-48479N.
IntActiQ96CB8. 11 interactors.
MINTiMINT-4536610.
STRINGi9606.ENSP00000340737.

PTM databases

iPTMnetiQ96CB8.
PhosphoSitePlusiQ96CB8.

Polymorphism and mutation databases

BioMutaiINTS12.
DMDMi73621394.

Proteomic databases

EPDiQ96CB8.
MaxQBiQ96CB8.
PaxDbiQ96CB8.
PeptideAtlasiQ96CB8.
PRIDEiQ96CB8.

Protocols and materials databases

DNASUi57117.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340139; ENSP00000340737; ENSG00000138785.
ENST00000394735; ENSP00000378221; ENSG00000138785.
ENST00000451321; ENSP00000415433; ENSG00000138785.
GeneIDi57117.
KEGGihsa:57117.
UCSCiuc003hxw.4. human.

Organism-specific databases

CTDi57117.
DisGeNETi57117.
GeneCardsiINTS12.
HGNCiHGNC:25067. INTS12.
HPAiHPA035772.
HPA041814.
MIMi611355. gene.
neXtProtiNX_Q96CB8.
OpenTargetsiENSG00000138785.
PharmGKBiPA142671177.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4323. Eukaryota.
ENOG410XQ6E. LUCA.
GeneTreeiENSGT00390000005218.
HOGENOMiHOG000059634.
HOVERGENiHBG081798.
InParanoidiQ96CB8.
KOiK13149.
OMAiKAISIKQ.
OrthoDBiEOG091G0KPP.
PhylomeDBiQ96CB8.
TreeFamiTF106418.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138785-MONOMER.
ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

GeneWikiiINTS12.
GenomeRNAii57117.
PROiQ96CB8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138785.
CleanExiHS_INTS12.
ExpressionAtlasiQ96CB8. baseline and differential.
GenevisibleiQ96CB8. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINT12_HUMAN
AccessioniPrimary (citable) accession number: Q96CB8
Secondary accession number(s): B2RC48, Q3B6Z3, Q9HD71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.