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Q96CB8

- INT12_HUMAN

UniProt

Q96CB8 - INT12_HUMAN

Protein

Integrator complex subunit 12

Gene

INTS12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri159 – 21557PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. snRNA processing Source: HGNC

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrator complex subunit 12
    Short name:
    Int12
    Alternative name(s):
    PHD finger protein 22
    Gene namesi
    Name:INTS12
    Synonyms:PHF22
    ORF Names:SBBI22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:25067. INTS12.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. integrator complex Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671177.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Integrator complex subunit 12PRO_0000059312Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei128 – 1281Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96CB8.
    PaxDbiQ96CB8.
    PeptideAtlasiQ96CB8.
    PRIDEiQ96CB8.

    PTM databases

    PhosphoSiteiQ96CB8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96CB8.
    BgeeiQ96CB8.
    CleanExiHS_INTS12.
    GenevestigatoriQ96CB8.

    Organism-specific databases

    HPAiHPA035772.

    Interactioni

    Subunit structurei

    Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.1 Publication

    Protein-protein interaction databases

    BioGridi121381. 9 interactions.
    DIPiDIP-48479N.
    IntActiQ96CB8. 2 interactions.
    MINTiMINT-4536610.
    STRINGi9606.ENSP00000265150.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96CB8.
    SMRiQ96CB8. Positions 149-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi270 – 440171Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri159 – 21557PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG247951.
    HOGENOMiHOG000059634.
    HOVERGENiHBG081798.
    InParanoidiQ96CB8.
    KOiK13149.
    OMAiKQEPKIS.
    OrthoDBiEOG7QNVN6.
    PhylomeDBiQ96CB8.
    TreeFamiTF106418.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96CB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS    50
    QKDVEPPKIS STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP 100
    ADKMKSDITE GVDIPKKPRL EKPETQSSPI TVQSSKDLPM ADLSSFEETS 150
    ADDFAMEMGL ACVVCRQMMV ASGNQLVECQ ECHNLYHRDC HKPQVTDKEA 200
    NDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APAVVSVTPA VKDPLVKKPE 250
    TKLKQETTFL AFKRTEVKTS TVISGNSSSA SVSSSVTSGL TGWAAFAAKT 300
    SSAGPSTAKL SSTTQNNTGK PATSSANQKP VGLTGLATSS KGGIGSKIGS 350
    NNSTTPTVPL KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ 400
    LSGNGNSGTS GPSGSTTSKT TSESSSSPSA SLKGPTSQES QLNAMKRLQM 450
    VKKKAAQKKL KK 462
    Length:462
    Mass (Da):48,808
    Last modified:December 1, 2001 - v1
    Checksum:i7AEF952044A3E951
    GO

    Sequence cautioni

    The sequence AAF99604.1 differs from that shown. Reason: Frameshift at position 439.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti323 – 3231T → A.
    Corresponds to variant rs34567094 [ dbSNP | Ensembl ].
    VAR_049629

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242524 mRNA. Translation: AAF99604.1. Frameshift.
    AK314939 mRNA. Translation: BAG37445.1.
    CH471057 Genomic DNA. Translation: EAX06189.1.
    BC014442 mRNA. Translation: AAH14442.1.
    BK005729 mRNA. Translation: DAA05729.1.
    CCDSiCCDS3671.1.
    RefSeqiNP_001135943.1. NM_001142471.1.
    NP_065128.2. NM_020395.3.
    XP_005263205.1. XM_005263148.2.
    XP_005263206.1. XM_005263149.2.
    UniGeneiHs.480454.

    Genome annotation databases

    EnsembliENST00000340139; ENSP00000340737; ENSG00000138785.
    ENST00000394735; ENSP00000378221; ENSG00000138785.
    ENST00000451321; ENSP00000415433; ENSG00000138785.
    GeneIDi57117.
    KEGGihsa:57117.
    UCSCiuc003hxw.3. human.

    Polymorphism databases

    DMDMi73621394.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242524 mRNA. Translation: AAF99604.1 . Frameshift.
    AK314939 mRNA. Translation: BAG37445.1 .
    CH471057 Genomic DNA. Translation: EAX06189.1 .
    BC014442 mRNA. Translation: AAH14442.1 .
    BK005729 mRNA. Translation: DAA05729.1 .
    CCDSi CCDS3671.1.
    RefSeqi NP_001135943.1. NM_001142471.1.
    NP_065128.2. NM_020395.3.
    XP_005263205.1. XM_005263148.2.
    XP_005263206.1. XM_005263149.2.
    UniGenei Hs.480454.

    3D structure databases

    ProteinModelPortali Q96CB8.
    SMRi Q96CB8. Positions 149-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121381. 9 interactions.
    DIPi DIP-48479N.
    IntActi Q96CB8. 2 interactions.
    MINTi MINT-4536610.
    STRINGi 9606.ENSP00000265150.

    PTM databases

    PhosphoSitei Q96CB8.

    Polymorphism databases

    DMDMi 73621394.

    Proteomic databases

    MaxQBi Q96CB8.
    PaxDbi Q96CB8.
    PeptideAtlasi Q96CB8.
    PRIDEi Q96CB8.

    Protocols and materials databases

    DNASUi 57117.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340139 ; ENSP00000340737 ; ENSG00000138785 .
    ENST00000394735 ; ENSP00000378221 ; ENSG00000138785 .
    ENST00000451321 ; ENSP00000415433 ; ENSG00000138785 .
    GeneIDi 57117.
    KEGGi hsa:57117.
    UCSCi uc003hxw.3. human.

    Organism-specific databases

    CTDi 57117.
    GeneCardsi GC04M106603.
    HGNCi HGNC:25067. INTS12.
    HPAi HPA035772.
    MIMi 611355. gene.
    neXtProti NX_Q96CB8.
    PharmGKBi PA142671177.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247951.
    HOGENOMi HOG000059634.
    HOVERGENi HBG081798.
    InParanoidi Q96CB8.
    KOi K13149.
    OMAi KQEPKIS.
    OrthoDBi EOG7QNVN6.
    PhylomeDBi Q96CB8.
    TreeFami TF106418.

    Miscellaneous databases

    GeneWikii INTS12.
    GenomeRNAii 57117.
    NextBioi 62983.
    PROi Q96CB8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96CB8.
    Bgeei Q96CB8.
    CleanExi HS_INTS12.
    Genevestigatori Q96CB8.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hypothetical nuclear factor SBBI22 mRNA."
      Wan T., Li N., Zhang W., Cao X.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    5. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
      Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
      Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX.
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiINT12_HUMAN
    AccessioniPrimary (citable) accession number: Q96CB8
    Secondary accession number(s): B2RC48, Q3B6Z3, Q9HD71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3