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Protein

Serologically defined colon cancer antigen 3

Gene

SDCCAG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).By similarity2 Publications

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • protein transport Source: UniProtKB-KW
  • regulation of cytokinesis Source: UniProtKB
  • retrograde transport, endosome to plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165689-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serologically defined colon cancer antigen 3
Alternative name(s):
Antigen NY-CO-3
Gene namesi
Name:SDCCAG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10667. SDCCAG3.

Subcellular locationi

  • Cytoplasm By similarity
  • Midbody 1 Publication
  • Early endosome 1 Publication
  • Recycling endosome 1 Publication

  • Note: During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes in a FAM21-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552).

GO - Cellular componenti

  • early endosome Source: UniProtKB
  • endosome Source: UniProtKB
  • midbody Source: UniProtKB
  • recycling endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi190P → A: Disrupts interaction with PTPN13. 1 Publication1
Mutagenesisi194E → A: Disrupts interaction with PTPN13. 1 Publication1

Organism-specific databases

DisGeNETi10807.
OpenTargetsiENSG00000165689.
PharmGKBiPA35597.

Polymorphism and mutation databases

BioMutaiSDCCAG3.
DMDMi172045853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003242851 – 435Serologically defined colon cancer antigen 3Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96C92.
MaxQBiQ96C92.
PaxDbiQ96C92.
PeptideAtlasiQ96C92.
PRIDEiQ96C92.

PTM databases

iPTMnetiQ96C92.
PhosphoSitePlusiQ96C92.

Expressioni

Gene expression databases

BgeeiENSG00000165689.
CleanExiHS_SDCCAG3.
ExpressionAtlasiQ96C92. baseline and differential.
GenevisibleiQ96C92. HS.

Organism-specific databases

HPAiHPA029303.

Interactioni

Subunit structurei

Interacts with PTPN13, GIT1, VPS35 (PubMed:23108400, PubMed:25278552).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AP1M1Q9BXS53EBI-10178036,EBI-541426
DDX6P261963EBI-10178036,EBI-351257
SDCBPO005603EBI-10178036,EBI-727004
TFPTG5E9B53EBI-10178036,EBI-10178002

Protein-protein interaction databases

BioGridi116021. 52 interactors.
IntActiQ96C92. 44 interactors.
MINTiMINT-1375073.
STRINGi9606.ENSP00000349929.

Structurei

3D structure databases

ProteinModelPortaliQ96C92.
SMRiQ96C92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 198Required for interaction with PTPN131 PublicationAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili261 – 371Sequence analysisAdd BLAST111

Sequence similaritiesi

Belongs to the SDCCAG3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHIY. Eukaryota.
ENOG4111TAC. LUCA.
GeneTreeiENSGT00390000000560.
HOVERGENiHBG058095.
InParanoidiQ96C92.
OMAiYERRSCL.
OrthoDBiEOG091G0JQ8.
PhylomeDBiQ96C92.
TreeFamiTF335840.

Family and domain databases

InterProiIPR026757. SDCCAG3.
[Graphical view]
PANTHERiPTHR31259. PTHR31259. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96C92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGYQRRPGA TPLSRARSLA IPDAPAFYER RSCLPQLNCE RPHGRDLDSP
60 70 80 90 100
FFGIRPAFMC YVPSPVLASV GDTDFGYGKG KCSKQSPSGA HGTHFGDDRF
110 120 130 140 150
EDLEEANPFS FREFLKTKNL GLSKEDPASR IYAKEASRHS LGLDHNSPPS
160 170 180 190 200
QTGGYGLEYQ QPFFEDPTGA GDLLDEEEDE DTGWSGAYLP SAIEQTHPER
210 220 230 240 250
VPAGTSPCST YLSFFSTPSE LAGPESLPSW ALSDTDSRVS PASPAGSPSA
260 270 280 290 300
DFAVHGESLG DRHLRTLQIS YDALKDENSK LRRKLNEVQS FSEAQTEMVR
310 320 330 340 350
TLERKLEAKM IKEESDYHDL ESVVQQVEQN LELMTKRAVK AENHVVKLKQ
360 370 380 390 400
EISLLQAQVS NFQRENEALR CGQGASLTVV KQNADVALQN LRVVMNSAQA
410 420 430
SIKQLVSGAE TLNLVAEILK SIDRISEVKD EEEDS
Length:435
Mass (Da):47,961
Last modified:March 18, 2008 - v3
Checksum:i03EBD9512232B5E3
GO
Isoform 2 (identifier: Q96C92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-97: Missing.

Show »
Length:412
Mass (Da):45,626
Checksum:iB246220F62D659E3
GO
Isoform 3 (identifier: Q96C92-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:377
Mass (Da):41,432
Checksum:i771C16B861EE61D1
GO
Isoform 4 (identifier: Q96C92-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-96: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):40,058
Checksum:iEABA3B5233D003EB
GO

Sequence cautioni

The sequence BAA91607 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI13936 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI13942 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI13943 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7R → H in AAH14515 (Ref. 4) Curated1
Sequence conflicti343N → T in AAQ56721 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039687157L → V.Corresponds to variant rs7047681dbSNPEnsembl.1
Natural variantiVAR_039688176E → G.1 PublicationCorresponds to variant rs17851182dbSNPEnsembl.1
Natural variantiVAR_039689304R → Q.1 PublicationCorresponds to variant rs3812577dbSNPEnsembl.1
Natural variantiVAR_039690379V → M.1 PublicationCorresponds to variant rs1131992dbSNPEnsembl.1
Natural variantiVAR_039691428V → I.1 PublicationCorresponds to variant rs17855450dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0321761 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_04047724 – 96Missing in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_03217775 – 97Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY349357 mRNA. Translation: AAQ56721.1.
CR597452 mRNA. No translation available.
AL592301 Genomic DNA. Translation: CAI13936.1. Sequence problems.
AL592301 Genomic DNA. Translation: CAI13940.2.
AL592301 Genomic DNA. Translation: CAI13941.2.
AL592301 Genomic DNA. Translation: CAI13942.2. Sequence problems.
AL592301 Genomic DNA. Translation: CAI13943.2. Sequence problems.
CH471090 Genomic DNA. Translation: EAW88230.1.
CH471090 Genomic DNA. Translation: EAW88231.1.
BC014515 mRNA. Translation: AAH14515.2.
AK001296 mRNA. Translation: BAA91607.1. Different initiation.
AF039688 mRNA. Translation: AAC18037.1.
CCDSiCCDS43903.1. [Q96C92-4]
CCDS43904.1. [Q96C92-1]
CCDS6999.2. [Q96C92-2]
RefSeqiNP_001034796.1. NM_001039707.1. [Q96C92-1]
NP_001034797.1. NM_001039708.1. [Q96C92-4]
NP_006634.3. NM_006643.3. [Q96C92-2]
UniGeneiHs.94300.

Genome annotation databases

EnsembliENST00000298537; ENSP00000298537; ENSG00000165689. [Q96C92-2]
ENST00000357365; ENSP00000349929; ENSG00000165689. [Q96C92-1]
ENST00000371725; ENSP00000360790; ENSG00000165689. [Q96C92-4]
GeneIDi10807.
KEGGihsa:10807.
UCSCiuc004chi.4. human. [Q96C92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY349357 mRNA. Translation: AAQ56721.1.
CR597452 mRNA. No translation available.
AL592301 Genomic DNA. Translation: CAI13936.1. Sequence problems.
AL592301 Genomic DNA. Translation: CAI13940.2.
AL592301 Genomic DNA. Translation: CAI13941.2.
AL592301 Genomic DNA. Translation: CAI13942.2. Sequence problems.
AL592301 Genomic DNA. Translation: CAI13943.2. Sequence problems.
CH471090 Genomic DNA. Translation: EAW88230.1.
CH471090 Genomic DNA. Translation: EAW88231.1.
BC014515 mRNA. Translation: AAH14515.2.
AK001296 mRNA. Translation: BAA91607.1. Different initiation.
AF039688 mRNA. Translation: AAC18037.1.
CCDSiCCDS43903.1. [Q96C92-4]
CCDS43904.1. [Q96C92-1]
CCDS6999.2. [Q96C92-2]
RefSeqiNP_001034796.1. NM_001039707.1. [Q96C92-1]
NP_001034797.1. NM_001039708.1. [Q96C92-4]
NP_006634.3. NM_006643.3. [Q96C92-2]
UniGeneiHs.94300.

3D structure databases

ProteinModelPortaliQ96C92.
SMRiQ96C92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116021. 52 interactors.
IntActiQ96C92. 44 interactors.
MINTiMINT-1375073.
STRINGi9606.ENSP00000349929.

PTM databases

iPTMnetiQ96C92.
PhosphoSitePlusiQ96C92.

Polymorphism and mutation databases

BioMutaiSDCCAG3.
DMDMi172045853.

Proteomic databases

EPDiQ96C92.
MaxQBiQ96C92.
PaxDbiQ96C92.
PeptideAtlasiQ96C92.
PRIDEiQ96C92.

Protocols and materials databases

DNASUi10807.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298537; ENSP00000298537; ENSG00000165689. [Q96C92-2]
ENST00000357365; ENSP00000349929; ENSG00000165689. [Q96C92-1]
ENST00000371725; ENSP00000360790; ENSG00000165689. [Q96C92-4]
GeneIDi10807.
KEGGihsa:10807.
UCSCiuc004chi.4. human. [Q96C92-1]

Organism-specific databases

CTDi10807.
DisGeNETi10807.
GeneCardsiSDCCAG3.
HGNCiHGNC:10667. SDCCAG3.
HPAiHPA029303.
neXtProtiNX_Q96C92.
OpenTargetsiENSG00000165689.
PharmGKBiPA35597.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHIY. Eukaryota.
ENOG4111TAC. LUCA.
GeneTreeiENSGT00390000000560.
HOVERGENiHBG058095.
InParanoidiQ96C92.
OMAiYERRSCL.
OrthoDBiEOG091G0JQ8.
PhylomeDBiQ96C92.
TreeFamiTF335840.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165689-MONOMER.

Miscellaneous databases

ChiTaRSiSDCCAG3. human.
GenomeRNAii10807.
PROiQ96C92.

Gene expression databases

BgeeiENSG00000165689.
CleanExiHS_SDCCAG3.
ExpressionAtlasiQ96C92. baseline and differential.
GenevisibleiQ96C92. HS.

Family and domain databases

InterProiIPR026757. SDCCAG3.
[Graphical view]
PANTHERiPTHR31259. PTHR31259. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSDCG3_HUMAN
AccessioniPrimary (citable) accession number: Q96C92
Secondary accession number(s): A6NCP1
, O60525, Q5SXN1, Q5SXN2, Q5SXN3, Q5SXN4, Q5SXN8, Q6V704, Q9NVY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 30, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.